Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy

Inflammatory bowel disease (IBD) is a life-threatening organ dysfunction amplified by complex interactions between genetic, environmental, and immune factors. Sulfasalazine (Sul), an immunosuppressant, can potentially treat autoinflammation-induced disorders; however, clinical application of Sul is...
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Autor*in:	Sen Lin [verfasserIn] Haosen Zhao [verfasserIn] Chang Xu [verfasserIn] Peng Zhang [verfasserIn] Xifan Mei [verfasserIn] Dingwen Jiang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Inflammatory bowel disease Sulfasalazine Mn doped prussian blue nanoparticles ROS Inflammation

Übergeordnetes Werk:	In: Materials & Design - Elsevier, 2019, 225(2023), Seite 111465-
Übergeordnetes Werk:	volume:225 ; year:2023 ; pages:111465-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.matdes.2022.111465

Katalog-ID:	DOAJ005569451

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520			\|a Inflammatory bowel disease (IBD) is a life-threatening organ dysfunction amplified by complex interactions between genetic, environmental, and immune factors. Sulfasalazine (Sul), an immunosuppressant, can potentially treat autoinflammation-induced disorders; however, clinical application of Sul is hindered by its inability to be directly taken up by cells. To address this challenge, we developed Mn doped prussian blue nanozymes (MPBs) to directly deliver Sul for targeting reactive oxygen species (ROS)-enriched microenvironment. The artificial nanozyme (Sul-MPBs) exhibits reactive oxygen species (ROS)-scavenging properties against hydrogen peroxide (H2O2)-mediated mitochondrial dysfunction and possesses both catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)-like properties in vitro. Furthermore, it significantly enhances therapeutic effects in treating dextran sulfate sodium salt (DSS)-induced IBD via alleviating ROS-mediated inflammatory responses. This study demonstrates good biocompatibility and protective properties of this artificial nanozyme, thus potentially leading to a highly innovative and translational approach to treat IBD efficiently and safely.
650		4	\|a Inflammatory bowel disease
650		4	\|a Sulfasalazine
650		4	\|a Mn doped prussian blue nanoparticles
650		4	\|a ROS
650		4	\|a Inflammation
653		0	\|a Materials of engineering and construction. Mechanics of materials
700	0		\|a Haosen Zhao \|e verfasserin \|4 aut
700	0		\|a Chang Xu \|e verfasserin \|4 aut
700	0		\|a Peng Zhang \|e verfasserin \|4 aut
700	0		\|a Xifan Mei \|e verfasserin \|4 aut
700	0		\|a Dingwen Jiang \|e verfasserin \|4 aut
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allfields	10.1016/j.matdes.2022.111465 doi (DE-627)DOAJ005569451 (DE-599)DOAJac6ab6d0cbd042eeae939abf1bdb7294 DE-627 ger DE-627 rakwb eng TA401-492 Sen Lin verfasserin aut Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inflammatory bowel disease (IBD) is a life-threatening organ dysfunction amplified by complex interactions between genetic, environmental, and immune factors. Sulfasalazine (Sul), an immunosuppressant, can potentially treat autoinflammation-induced disorders; however, clinical application of Sul is hindered by its inability to be directly taken up by cells. To address this challenge, we developed Mn doped prussian blue nanozymes (MPBs) to directly deliver Sul for targeting reactive oxygen species (ROS)-enriched microenvironment. The artificial nanozyme (Sul-MPBs) exhibits reactive oxygen species (ROS)-scavenging properties against hydrogen peroxide (H2O2)-mediated mitochondrial dysfunction and possesses both catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)-like properties in vitro. Furthermore, it significantly enhances therapeutic effects in treating dextran sulfate sodium salt (DSS)-induced IBD via alleviating ROS-mediated inflammatory responses. This study demonstrates good biocompatibility and protective properties of this artificial nanozyme, thus potentially leading to a highly innovative and translational approach to treat IBD efficiently and safely. Inflammatory bowel disease Sulfasalazine Mn doped prussian blue nanoparticles ROS Inflammation Materials of engineering and construction. Mechanics of materials Haosen Zhao verfasserin aut Chang Xu verfasserin aut Peng Zhang verfasserin aut Xifan Mei verfasserin aut Dingwen Jiang verfasserin aut In Materials & Design Elsevier, 2019 225(2023), Seite 111465- (DE-627)32052857X (DE-600)2015480-X 18734197 nnns volume:225 year:2023 pages:111465- https://doi.org/10.1016/j.matdes.2022.111465 kostenfrei https://doaj.org/article/ac6ab6d0cbd042eeae939abf1bdb7294 kostenfrei http://www.sciencedirect.com/science/article/pii/S0264127522010887 kostenfrei https://doaj.org/toc/0264-1275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 225 2023 111465-
spelling	10.1016/j.matdes.2022.111465 doi (DE-627)DOAJ005569451 (DE-599)DOAJac6ab6d0cbd042eeae939abf1bdb7294 DE-627 ger DE-627 rakwb eng TA401-492 Sen Lin verfasserin aut Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inflammatory bowel disease (IBD) is a life-threatening organ dysfunction amplified by complex interactions between genetic, environmental, and immune factors. Sulfasalazine (Sul), an immunosuppressant, can potentially treat autoinflammation-induced disorders; however, clinical application of Sul is hindered by its inability to be directly taken up by cells. To address this challenge, we developed Mn doped prussian blue nanozymes (MPBs) to directly deliver Sul for targeting reactive oxygen species (ROS)-enriched microenvironment. The artificial nanozyme (Sul-MPBs) exhibits reactive oxygen species (ROS)-scavenging properties against hydrogen peroxide (H2O2)-mediated mitochondrial dysfunction and possesses both catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)-like properties in vitro. Furthermore, it significantly enhances therapeutic effects in treating dextran sulfate sodium salt (DSS)-induced IBD via alleviating ROS-mediated inflammatory responses. This study demonstrates good biocompatibility and protective properties of this artificial nanozyme, thus potentially leading to a highly innovative and translational approach to treat IBD efficiently and safely. Inflammatory bowel disease Sulfasalazine Mn doped prussian blue nanoparticles ROS Inflammation Materials of engineering and construction. Mechanics of materials Haosen Zhao verfasserin aut Chang Xu verfasserin aut Peng Zhang verfasserin aut Xifan Mei verfasserin aut Dingwen Jiang verfasserin aut In Materials & Design Elsevier, 2019 225(2023), Seite 111465- (DE-627)32052857X (DE-600)2015480-X 18734197 nnns volume:225 year:2023 pages:111465- https://doi.org/10.1016/j.matdes.2022.111465 kostenfrei https://doaj.org/article/ac6ab6d0cbd042eeae939abf1bdb7294 kostenfrei http://www.sciencedirect.com/science/article/pii/S0264127522010887 kostenfrei https://doaj.org/toc/0264-1275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 225 2023 111465-
allfields_unstemmed	10.1016/j.matdes.2022.111465 doi (DE-627)DOAJ005569451 (DE-599)DOAJac6ab6d0cbd042eeae939abf1bdb7294 DE-627 ger DE-627 rakwb eng TA401-492 Sen Lin verfasserin aut Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inflammatory bowel disease (IBD) is a life-threatening organ dysfunction amplified by complex interactions between genetic, environmental, and immune factors. Sulfasalazine (Sul), an immunosuppressant, can potentially treat autoinflammation-induced disorders; however, clinical application of Sul is hindered by its inability to be directly taken up by cells. To address this challenge, we developed Mn doped prussian blue nanozymes (MPBs) to directly deliver Sul for targeting reactive oxygen species (ROS)-enriched microenvironment. The artificial nanozyme (Sul-MPBs) exhibits reactive oxygen species (ROS)-scavenging properties against hydrogen peroxide (H2O2)-mediated mitochondrial dysfunction and possesses both catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)-like properties in vitro. Furthermore, it significantly enhances therapeutic effects in treating dextran sulfate sodium salt (DSS)-induced IBD via alleviating ROS-mediated inflammatory responses. This study demonstrates good biocompatibility and protective properties of this artificial nanozyme, thus potentially leading to a highly innovative and translational approach to treat IBD efficiently and safely. Inflammatory bowel disease Sulfasalazine Mn doped prussian blue nanoparticles ROS Inflammation Materials of engineering and construction. Mechanics of materials Haosen Zhao verfasserin aut Chang Xu verfasserin aut Peng Zhang verfasserin aut Xifan Mei verfasserin aut Dingwen Jiang verfasserin aut In Materials & Design Elsevier, 2019 225(2023), Seite 111465- (DE-627)32052857X (DE-600)2015480-X 18734197 nnns volume:225 year:2023 pages:111465- https://doi.org/10.1016/j.matdes.2022.111465 kostenfrei https://doaj.org/article/ac6ab6d0cbd042eeae939abf1bdb7294 kostenfrei http://www.sciencedirect.com/science/article/pii/S0264127522010887 kostenfrei https://doaj.org/toc/0264-1275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 225 2023 111465-
allfieldsGer	10.1016/j.matdes.2022.111465 doi (DE-627)DOAJ005569451 (DE-599)DOAJac6ab6d0cbd042eeae939abf1bdb7294 DE-627 ger DE-627 rakwb eng TA401-492 Sen Lin verfasserin aut Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inflammatory bowel disease (IBD) is a life-threatening organ dysfunction amplified by complex interactions between genetic, environmental, and immune factors. Sulfasalazine (Sul), an immunosuppressant, can potentially treat autoinflammation-induced disorders; however, clinical application of Sul is hindered by its inability to be directly taken up by cells. To address this challenge, we developed Mn doped prussian blue nanozymes (MPBs) to directly deliver Sul for targeting reactive oxygen species (ROS)-enriched microenvironment. The artificial nanozyme (Sul-MPBs) exhibits reactive oxygen species (ROS)-scavenging properties against hydrogen peroxide (H2O2)-mediated mitochondrial dysfunction and possesses both catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)-like properties in vitro. Furthermore, it significantly enhances therapeutic effects in treating dextran sulfate sodium salt (DSS)-induced IBD via alleviating ROS-mediated inflammatory responses. This study demonstrates good biocompatibility and protective properties of this artificial nanozyme, thus potentially leading to a highly innovative and translational approach to treat IBD efficiently and safely. Inflammatory bowel disease Sulfasalazine Mn doped prussian blue nanoparticles ROS Inflammation Materials of engineering and construction. Mechanics of materials Haosen Zhao verfasserin aut Chang Xu verfasserin aut Peng Zhang verfasserin aut Xifan Mei verfasserin aut Dingwen Jiang verfasserin aut In Materials & Design Elsevier, 2019 225(2023), Seite 111465- (DE-627)32052857X (DE-600)2015480-X 18734197 nnns volume:225 year:2023 pages:111465- https://doi.org/10.1016/j.matdes.2022.111465 kostenfrei https://doaj.org/article/ac6ab6d0cbd042eeae939abf1bdb7294 kostenfrei http://www.sciencedirect.com/science/article/pii/S0264127522010887 kostenfrei https://doaj.org/toc/0264-1275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 225 2023 111465-
allfieldsSound	10.1016/j.matdes.2022.111465 doi (DE-627)DOAJ005569451 (DE-599)DOAJac6ab6d0cbd042eeae939abf1bdb7294 DE-627 ger DE-627 rakwb eng TA401-492 Sen Lin verfasserin aut Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inflammatory bowel disease (IBD) is a life-threatening organ dysfunction amplified by complex interactions between genetic, environmental, and immune factors. Sulfasalazine (Sul), an immunosuppressant, can potentially treat autoinflammation-induced disorders; however, clinical application of Sul is hindered by its inability to be directly taken up by cells. To address this challenge, we developed Mn doped prussian blue nanozymes (MPBs) to directly deliver Sul for targeting reactive oxygen species (ROS)-enriched microenvironment. The artificial nanozyme (Sul-MPBs) exhibits reactive oxygen species (ROS)-scavenging properties against hydrogen peroxide (H2O2)-mediated mitochondrial dysfunction and possesses both catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)-like properties in vitro. Furthermore, it significantly enhances therapeutic effects in treating dextran sulfate sodium salt (DSS)-induced IBD via alleviating ROS-mediated inflammatory responses. This study demonstrates good biocompatibility and protective properties of this artificial nanozyme, thus potentially leading to a highly innovative and translational approach to treat IBD efficiently and safely. Inflammatory bowel disease Sulfasalazine Mn doped prussian blue nanoparticles ROS Inflammation Materials of engineering and construction. Mechanics of materials Haosen Zhao verfasserin aut Chang Xu verfasserin aut Peng Zhang verfasserin aut Xifan Mei verfasserin aut Dingwen Jiang verfasserin aut In Materials & Design Elsevier, 2019 225(2023), Seite 111465- (DE-627)32052857X (DE-600)2015480-X 18734197 nnns volume:225 year:2023 pages:111465- https://doi.org/10.1016/j.matdes.2022.111465 kostenfrei https://doaj.org/article/ac6ab6d0cbd042eeae939abf1bdb7294 kostenfrei http://www.sciencedirect.com/science/article/pii/S0264127522010887 kostenfrei https://doaj.org/toc/0264-1275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 225 2023 111465-
language	English
source	In Materials & Design 225(2023), Seite 111465- volume:225 year:2023 pages:111465-
sourceStr	In Materials & Design 225(2023), Seite 111465- volume:225 year:2023 pages:111465-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Inflammatory bowel disease Sulfasalazine Mn doped prussian blue nanoparticles ROS Inflammation Materials of engineering and construction. Mechanics of materials
isfreeaccess_bool	true
container_title	Materials & Design
authorswithroles_txt_mv	Sen Lin @@aut@@ Haosen Zhao @@aut@@ Chang Xu @@aut@@ Peng Zhang @@aut@@ Xifan Mei @@aut@@ Dingwen Jiang @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	32052857X
id	DOAJ005569451
language_de	englisch
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callnumber-first	T - Technology
author	Sen Lin
spellingShingle	Sen Lin misc TA401-492 misc Inflammatory bowel disease misc Sulfasalazine misc Mn doped prussian blue nanoparticles misc ROS misc Inflammation misc Materials of engineering and construction. Mechanics of materials Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy
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topic_title	TA401-492 Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy Inflammatory bowel disease Sulfasalazine Mn doped prussian blue nanoparticles ROS Inflammation
topic	misc TA401-492 misc Inflammatory bowel disease misc Sulfasalazine misc Mn doped prussian blue nanoparticles misc ROS misc Inflammation misc Materials of engineering and construction. Mechanics of materials
topic_unstemmed	misc TA401-492 misc Inflammatory bowel disease misc Sulfasalazine misc Mn doped prussian blue nanoparticles misc ROS misc Inflammation misc Materials of engineering and construction. Mechanics of materials
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title	Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy
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title_full	Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy
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title_sort	sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ros-scavenging strategy
callnumber	TA401-492
title_auth	Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy
abstract	Inflammatory bowel disease (IBD) is a life-threatening organ dysfunction amplified by complex interactions between genetic, environmental, and immune factors. Sulfasalazine (Sul), an immunosuppressant, can potentially treat autoinflammation-induced disorders; however, clinical application of Sul is hindered by its inability to be directly taken up by cells. To address this challenge, we developed Mn doped prussian blue nanozymes (MPBs) to directly deliver Sul for targeting reactive oxygen species (ROS)-enriched microenvironment. The artificial nanozyme (Sul-MPBs) exhibits reactive oxygen species (ROS)-scavenging properties against hydrogen peroxide (H2O2)-mediated mitochondrial dysfunction and possesses both catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)-like properties in vitro. Furthermore, it significantly enhances therapeutic effects in treating dextran sulfate sodium salt (DSS)-induced IBD via alleviating ROS-mediated inflammatory responses. This study demonstrates good biocompatibility and protective properties of this artificial nanozyme, thus potentially leading to a highly innovative and translational approach to treat IBD efficiently and safely.
abstractGer	Inflammatory bowel disease (IBD) is a life-threatening organ dysfunction amplified by complex interactions between genetic, environmental, and immune factors. Sulfasalazine (Sul), an immunosuppressant, can potentially treat autoinflammation-induced disorders; however, clinical application of Sul is hindered by its inability to be directly taken up by cells. To address this challenge, we developed Mn doped prussian blue nanozymes (MPBs) to directly deliver Sul for targeting reactive oxygen species (ROS)-enriched microenvironment. The artificial nanozyme (Sul-MPBs) exhibits reactive oxygen species (ROS)-scavenging properties against hydrogen peroxide (H2O2)-mediated mitochondrial dysfunction and possesses both catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)-like properties in vitro. Furthermore, it significantly enhances therapeutic effects in treating dextran sulfate sodium salt (DSS)-induced IBD via alleviating ROS-mediated inflammatory responses. This study demonstrates good biocompatibility and protective properties of this artificial nanozyme, thus potentially leading to a highly innovative and translational approach to treat IBD efficiently and safely.
abstract_unstemmed	Inflammatory bowel disease (IBD) is a life-threatening organ dysfunction amplified by complex interactions between genetic, environmental, and immune factors. Sulfasalazine (Sul), an immunosuppressant, can potentially treat autoinflammation-induced disorders; however, clinical application of Sul is hindered by its inability to be directly taken up by cells. To address this challenge, we developed Mn doped prussian blue nanozymes (MPBs) to directly deliver Sul for targeting reactive oxygen species (ROS)-enriched microenvironment. The artificial nanozyme (Sul-MPBs) exhibits reactive oxygen species (ROS)-scavenging properties against hydrogen peroxide (H2O2)-mediated mitochondrial dysfunction and possesses both catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)-like properties in vitro. Furthermore, it significantly enhances therapeutic effects in treating dextran sulfate sodium salt (DSS)-induced IBD via alleviating ROS-mediated inflammatory responses. This study demonstrates good biocompatibility and protective properties of this artificial nanozyme, thus potentially leading to a highly innovative and translational approach to treat IBD efficiently and safely.
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title_short	Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy
url	https://doi.org/10.1016/j.matdes.2022.111465 https://doaj.org/article/ac6ab6d0cbd042eeae939abf1bdb7294 http://www.sciencedirect.com/science/article/pii/S0264127522010887 https://doaj.org/toc/0264-1275
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up_date	2024-07-03T15:49:07.172Z
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Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy

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