Pharmacological In vivo test to evaluate the antidepressant activity of polyherbal formulation

The antidepressant effects of the polyherbal formulation (PF) (contain four extracts of medicinal plants namely: Nyctanthes arbortristis, Hippophae salcifolia, Ocimum tenuiflorum and Withania somnifera ) was examined by evaluating the extent of reduction of behavioural alterations and neurotransmitt...
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Autor*in:	Rinki Kumari [verfasserIn] K. Ilango [verfasserIn] G.P.I. Singh [verfasserIn] G.P. Dubey [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	depression antidepressant nyctanthes arbortristis hippophae salcifolia ocimum tenuiflorum withania somnifera forced swim test

Übergeordnetes Werk:	In: Nepal Journal of Biotechnology - Biotechnology Society of Nepal, 2020, 7(2019), 1, Seite 63-73
Übergeordnetes Werk:	volume:7 ; year:2019 ; number:1 ; pages:63-73

Links:	Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3126/njb.v7i1.26952

Katalog-ID:	DOAJ005720559

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allfields	10.3126/njb.v7i1.26952 doi (DE-627)DOAJ005720559 (DE-599)DOAJaf86eab69cff4769b985d00da579fe91 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QD415-436 Rinki Kumari verfasserin aut Pharmacological In vivo test to evaluate the antidepressant activity of polyherbal formulation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The antidepressant effects of the polyherbal formulation (PF) (contain four extracts of medicinal plants namely: Nyctanthes arbortristis, Hippophae salcifolia, Ocimum tenuiflorum and Withania somnifera ) was examined by evaluating the extent of reduction of behavioural alterations and neurotransmitter in the rats stressed by forced swim test (FST). In the present study, compared with the model control group (FST), the altered behavioural parameters were attenuated significantly (P < 0.05) in the group treated with the PF (100, 200 and 400 mg•kg−1), comparable with the standard drug treated group, Sertraline (10mg•kg−1). The PF and Sertraline significantly (P < 0.05) increased the level of the neurotransmitter such as serotonin, dopamine, acetylcholine and noradrenalin whereas decreased the level of monoamine oxidase along with oxidant in the brain of the stressed rats. PF and Sertraline were also involved in the reduced oxidant and generated antioxidant in the stressed rats. The results indicated that polyherbal formulation exhibited significant antidepressant activity, as indicated by its ability to decrease force swim stress, induced immobility time in rats as well as restoring the biogenic amines to normal level that were altered by the swim induced stress in whole rat brain. Therefore, PF can be a potential candidate for treatment of depression as well as a potent antidepressant. However, further studies are required to substantiate the same. depression antidepressant nyctanthes arbortristis hippophae salcifolia ocimum tenuiflorum withania somnifera forced swim test Biotechnology Biochemistry K. Ilango verfasserin aut G.P.I. Singh verfasserin aut G.P. Dubey verfasserin aut In Nepal Journal of Biotechnology Biotechnology Society of Nepal, 2020 7(2019), 1, Seite 63-73 (DE-627)739217054 (DE-600)2708349-4 24679313 nnns volume:7 year:2019 number:1 pages:63-73 https://doi.org/10.3126/njb.v7i1.26952 kostenfrei https://doaj.org/article/af86eab69cff4769b985d00da579fe91 kostenfrei https://doaj.org/toc/2091-1130 Journal toc kostenfrei https://doaj.org/toc/2467-9313 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 1 63-73
spelling	10.3126/njb.v7i1.26952 doi (DE-627)DOAJ005720559 (DE-599)DOAJaf86eab69cff4769b985d00da579fe91 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QD415-436 Rinki Kumari verfasserin aut Pharmacological In vivo test to evaluate the antidepressant activity of polyherbal formulation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The antidepressant effects of the polyherbal formulation (PF) (contain four extracts of medicinal plants namely: Nyctanthes arbortristis, Hippophae salcifolia, Ocimum tenuiflorum and Withania somnifera ) was examined by evaluating the extent of reduction of behavioural alterations and neurotransmitter in the rats stressed by forced swim test (FST). In the present study, compared with the model control group (FST), the altered behavioural parameters were attenuated significantly (P < 0.05) in the group treated with the PF (100, 200 and 400 mg•kg−1), comparable with the standard drug treated group, Sertraline (10mg•kg−1). The PF and Sertraline significantly (P < 0.05) increased the level of the neurotransmitter such as serotonin, dopamine, acetylcholine and noradrenalin whereas decreased the level of monoamine oxidase along with oxidant in the brain of the stressed rats. PF and Sertraline were also involved in the reduced oxidant and generated antioxidant in the stressed rats. The results indicated that polyherbal formulation exhibited significant antidepressant activity, as indicated by its ability to decrease force swim stress, induced immobility time in rats as well as restoring the biogenic amines to normal level that were altered by the swim induced stress in whole rat brain. Therefore, PF can be a potential candidate for treatment of depression as well as a potent antidepressant. However, further studies are required to substantiate the same. depression antidepressant nyctanthes arbortristis hippophae salcifolia ocimum tenuiflorum withania somnifera forced swim test Biotechnology Biochemistry K. Ilango verfasserin aut G.P.I. Singh verfasserin aut G.P. Dubey verfasserin aut In Nepal Journal of Biotechnology Biotechnology Society of Nepal, 2020 7(2019), 1, Seite 63-73 (DE-627)739217054 (DE-600)2708349-4 24679313 nnns volume:7 year:2019 number:1 pages:63-73 https://doi.org/10.3126/njb.v7i1.26952 kostenfrei https://doaj.org/article/af86eab69cff4769b985d00da579fe91 kostenfrei https://doaj.org/toc/2091-1130 Journal toc kostenfrei https://doaj.org/toc/2467-9313 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 1 63-73
allfields_unstemmed	10.3126/njb.v7i1.26952 doi (DE-627)DOAJ005720559 (DE-599)DOAJaf86eab69cff4769b985d00da579fe91 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QD415-436 Rinki Kumari verfasserin aut Pharmacological In vivo test to evaluate the antidepressant activity of polyherbal formulation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The antidepressant effects of the polyherbal formulation (PF) (contain four extracts of medicinal plants namely: Nyctanthes arbortristis, Hippophae salcifolia, Ocimum tenuiflorum and Withania somnifera ) was examined by evaluating the extent of reduction of behavioural alterations and neurotransmitter in the rats stressed by forced swim test (FST). In the present study, compared with the model control group (FST), the altered behavioural parameters were attenuated significantly (P < 0.05) in the group treated with the PF (100, 200 and 400 mg•kg−1), comparable with the standard drug treated group, Sertraline (10mg•kg−1). The PF and Sertraline significantly (P < 0.05) increased the level of the neurotransmitter such as serotonin, dopamine, acetylcholine and noradrenalin whereas decreased the level of monoamine oxidase along with oxidant in the brain of the stressed rats. PF and Sertraline were also involved in the reduced oxidant and generated antioxidant in the stressed rats. The results indicated that polyherbal formulation exhibited significant antidepressant activity, as indicated by its ability to decrease force swim stress, induced immobility time in rats as well as restoring the biogenic amines to normal level that were altered by the swim induced stress in whole rat brain. Therefore, PF can be a potential candidate for treatment of depression as well as a potent antidepressant. However, further studies are required to substantiate the same. depression antidepressant nyctanthes arbortristis hippophae salcifolia ocimum tenuiflorum withania somnifera forced swim test Biotechnology Biochemistry K. Ilango verfasserin aut G.P.I. Singh verfasserin aut G.P. Dubey verfasserin aut In Nepal Journal of Biotechnology Biotechnology Society of Nepal, 2020 7(2019), 1, Seite 63-73 (DE-627)739217054 (DE-600)2708349-4 24679313 nnns volume:7 year:2019 number:1 pages:63-73 https://doi.org/10.3126/njb.v7i1.26952 kostenfrei https://doaj.org/article/af86eab69cff4769b985d00da579fe91 kostenfrei https://doaj.org/toc/2091-1130 Journal toc kostenfrei https://doaj.org/toc/2467-9313 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 1 63-73
allfieldsGer	10.3126/njb.v7i1.26952 doi (DE-627)DOAJ005720559 (DE-599)DOAJaf86eab69cff4769b985d00da579fe91 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QD415-436 Rinki Kumari verfasserin aut Pharmacological In vivo test to evaluate the antidepressant activity of polyherbal formulation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The antidepressant effects of the polyherbal formulation (PF) (contain four extracts of medicinal plants namely: Nyctanthes arbortristis, Hippophae salcifolia, Ocimum tenuiflorum and Withania somnifera ) was examined by evaluating the extent of reduction of behavioural alterations and neurotransmitter in the rats stressed by forced swim test (FST). In the present study, compared with the model control group (FST), the altered behavioural parameters were attenuated significantly (P < 0.05) in the group treated with the PF (100, 200 and 400 mg•kg−1), comparable with the standard drug treated group, Sertraline (10mg•kg−1). The PF and Sertraline significantly (P < 0.05) increased the level of the neurotransmitter such as serotonin, dopamine, acetylcholine and noradrenalin whereas decreased the level of monoamine oxidase along with oxidant in the brain of the stressed rats. PF and Sertraline were also involved in the reduced oxidant and generated antioxidant in the stressed rats. The results indicated that polyherbal formulation exhibited significant antidepressant activity, as indicated by its ability to decrease force swim stress, induced immobility time in rats as well as restoring the biogenic amines to normal level that were altered by the swim induced stress in whole rat brain. Therefore, PF can be a potential candidate for treatment of depression as well as a potent antidepressant. However, further studies are required to substantiate the same. depression antidepressant nyctanthes arbortristis hippophae salcifolia ocimum tenuiflorum withania somnifera forced swim test Biotechnology Biochemistry K. Ilango verfasserin aut G.P.I. Singh verfasserin aut G.P. Dubey verfasserin aut In Nepal Journal of Biotechnology Biotechnology Society of Nepal, 2020 7(2019), 1, Seite 63-73 (DE-627)739217054 (DE-600)2708349-4 24679313 nnns volume:7 year:2019 number:1 pages:63-73 https://doi.org/10.3126/njb.v7i1.26952 kostenfrei https://doaj.org/article/af86eab69cff4769b985d00da579fe91 kostenfrei https://doaj.org/toc/2091-1130 Journal toc kostenfrei https://doaj.org/toc/2467-9313 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 1 63-73
allfieldsSound	10.3126/njb.v7i1.26952 doi (DE-627)DOAJ005720559 (DE-599)DOAJaf86eab69cff4769b985d00da579fe91 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QD415-436 Rinki Kumari verfasserin aut Pharmacological In vivo test to evaluate the antidepressant activity of polyherbal formulation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The antidepressant effects of the polyherbal formulation (PF) (contain four extracts of medicinal plants namely: Nyctanthes arbortristis, Hippophae salcifolia, Ocimum tenuiflorum and Withania somnifera ) was examined by evaluating the extent of reduction of behavioural alterations and neurotransmitter in the rats stressed by forced swim test (FST). In the present study, compared with the model control group (FST), the altered behavioural parameters were attenuated significantly (P < 0.05) in the group treated with the PF (100, 200 and 400 mg•kg−1), comparable with the standard drug treated group, Sertraline (10mg•kg−1). The PF and Sertraline significantly (P < 0.05) increased the level of the neurotransmitter such as serotonin, dopamine, acetylcholine and noradrenalin whereas decreased the level of monoamine oxidase along with oxidant in the brain of the stressed rats. PF and Sertraline were also involved in the reduced oxidant and generated antioxidant in the stressed rats. The results indicated that polyherbal formulation exhibited significant antidepressant activity, as indicated by its ability to decrease force swim stress, induced immobility time in rats as well as restoring the biogenic amines to normal level that were altered by the swim induced stress in whole rat brain. Therefore, PF can be a potential candidate for treatment of depression as well as a potent antidepressant. However, further studies are required to substantiate the same. depression antidepressant nyctanthes arbortristis hippophae salcifolia ocimum tenuiflorum withania somnifera forced swim test Biotechnology Biochemistry K. Ilango verfasserin aut G.P.I. Singh verfasserin aut G.P. Dubey verfasserin aut In Nepal Journal of Biotechnology Biotechnology Society of Nepal, 2020 7(2019), 1, Seite 63-73 (DE-627)739217054 (DE-600)2708349-4 24679313 nnns volume:7 year:2019 number:1 pages:63-73 https://doi.org/10.3126/njb.v7i1.26952 kostenfrei https://doaj.org/article/af86eab69cff4769b985d00da579fe91 kostenfrei https://doaj.org/toc/2091-1130 Journal toc kostenfrei https://doaj.org/toc/2467-9313 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 1 63-73
language	English
source	In Nepal Journal of Biotechnology 7(2019), 1, Seite 63-73 volume:7 year:2019 number:1 pages:63-73
sourceStr	In Nepal Journal of Biotechnology 7(2019), 1, Seite 63-73 volume:7 year:2019 number:1 pages:63-73
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	depression antidepressant nyctanthes arbortristis hippophae salcifolia ocimum tenuiflorum withania somnifera forced swim test Biotechnology Biochemistry
isfreeaccess_bool	true
container_title	Nepal Journal of Biotechnology
authorswithroles_txt_mv	Rinki Kumari @@aut@@ K. Ilango @@aut@@ G.P.I. Singh @@aut@@ G.P. Dubey @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	739217054
id	DOAJ005720559
language_de	englisch
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callnumber-first	T - Technology
author	Rinki Kumari
spellingShingle	Rinki Kumari misc TP248.13-248.65 misc QD415-436 misc depression misc antidepressant misc nyctanthes arbortristis misc hippophae salcifolia misc ocimum tenuiflorum misc withania somnifera misc forced swim test misc Biotechnology misc Biochemistry Pharmacological In vivo test to evaluate the antidepressant activity of polyherbal formulation
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topic_title	TP248.13-248.65 QD415-436 Pharmacological In vivo test to evaluate the antidepressant activity of polyherbal formulation depression antidepressant nyctanthes arbortristis hippophae salcifolia ocimum tenuiflorum withania somnifera forced swim test
topic	misc TP248.13-248.65 misc QD415-436 misc depression misc antidepressant misc nyctanthes arbortristis misc hippophae salcifolia misc ocimum tenuiflorum misc withania somnifera misc forced swim test misc Biotechnology misc Biochemistry
topic_unstemmed	misc TP248.13-248.65 misc QD415-436 misc depression misc antidepressant misc nyctanthes arbortristis misc hippophae salcifolia misc ocimum tenuiflorum misc withania somnifera misc forced swim test misc Biotechnology misc Biochemistry
topic_browse	misc TP248.13-248.65 misc QD415-436 misc depression misc antidepressant misc nyctanthes arbortristis misc hippophae salcifolia misc ocimum tenuiflorum misc withania somnifera misc forced swim test misc Biotechnology misc Biochemistry
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title	Pharmacological In vivo test to evaluate the antidepressant activity of polyherbal formulation
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title_full	Pharmacological In vivo test to evaluate the antidepressant activity of polyherbal formulation
author_sort	Rinki Kumari
journal	Nepal Journal of Biotechnology
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author_browse	Rinki Kumari K. Ilango G.P.I. Singh G.P. Dubey
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title_sort	pharmacological in vivo test to evaluate the antidepressant activity of polyherbal formulation
callnumber	TP248.13-248.65
title_auth	Pharmacological In vivo test to evaluate the antidepressant activity of polyherbal formulation
abstract	The antidepressant effects of the polyherbal formulation (PF) (contain four extracts of medicinal plants namely: Nyctanthes arbortristis, Hippophae salcifolia, Ocimum tenuiflorum and Withania somnifera ) was examined by evaluating the extent of reduction of behavioural alterations and neurotransmitter in the rats stressed by forced swim test (FST). In the present study, compared with the model control group (FST), the altered behavioural parameters were attenuated significantly (P < 0.05) in the group treated with the PF (100, 200 and 400 mg•kg−1), comparable with the standard drug treated group, Sertraline (10mg•kg−1). The PF and Sertraline significantly (P < 0.05) increased the level of the neurotransmitter such as serotonin, dopamine, acetylcholine and noradrenalin whereas decreased the level of monoamine oxidase along with oxidant in the brain of the stressed rats. PF and Sertraline were also involved in the reduced oxidant and generated antioxidant in the stressed rats. The results indicated that polyherbal formulation exhibited significant antidepressant activity, as indicated by its ability to decrease force swim stress, induced immobility time in rats as well as restoring the biogenic amines to normal level that were altered by the swim induced stress in whole rat brain. Therefore, PF can be a potential candidate for treatment of depression as well as a potent antidepressant. However, further studies are required to substantiate the same.
abstractGer	The antidepressant effects of the polyherbal formulation (PF) (contain four extracts of medicinal plants namely: Nyctanthes arbortristis, Hippophae salcifolia, Ocimum tenuiflorum and Withania somnifera ) was examined by evaluating the extent of reduction of behavioural alterations and neurotransmitter in the rats stressed by forced swim test (FST). In the present study, compared with the model control group (FST), the altered behavioural parameters were attenuated significantly (P < 0.05) in the group treated with the PF (100, 200 and 400 mg•kg−1), comparable with the standard drug treated group, Sertraline (10mg•kg−1). The PF and Sertraline significantly (P < 0.05) increased the level of the neurotransmitter such as serotonin, dopamine, acetylcholine and noradrenalin whereas decreased the level of monoamine oxidase along with oxidant in the brain of the stressed rats. PF and Sertraline were also involved in the reduced oxidant and generated antioxidant in the stressed rats. The results indicated that polyherbal formulation exhibited significant antidepressant activity, as indicated by its ability to decrease force swim stress, induced immobility time in rats as well as restoring the biogenic amines to normal level that were altered by the swim induced stress in whole rat brain. Therefore, PF can be a potential candidate for treatment of depression as well as a potent antidepressant. However, further studies are required to substantiate the same.
abstract_unstemmed	The antidepressant effects of the polyherbal formulation (PF) (contain four extracts of medicinal plants namely: Nyctanthes arbortristis, Hippophae salcifolia, Ocimum tenuiflorum and Withania somnifera ) was examined by evaluating the extent of reduction of behavioural alterations and neurotransmitter in the rats stressed by forced swim test (FST). In the present study, compared with the model control group (FST), the altered behavioural parameters were attenuated significantly (P < 0.05) in the group treated with the PF (100, 200 and 400 mg•kg−1), comparable with the standard drug treated group, Sertraline (10mg•kg−1). The PF and Sertraline significantly (P < 0.05) increased the level of the neurotransmitter such as serotonin, dopamine, acetylcholine and noradrenalin whereas decreased the level of monoamine oxidase along with oxidant in the brain of the stressed rats. PF and Sertraline were also involved in the reduced oxidant and generated antioxidant in the stressed rats. The results indicated that polyherbal formulation exhibited significant antidepressant activity, as indicated by its ability to decrease force swim stress, induced immobility time in rats as well as restoring the biogenic amines to normal level that were altered by the swim induced stress in whole rat brain. Therefore, PF can be a potential candidate for treatment of depression as well as a potent antidepressant. However, further studies are required to substantiate the same.
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title_short	Pharmacological In vivo test to evaluate the antidepressant activity of polyherbal formulation
url	https://doi.org/10.3126/njb.v7i1.26952 https://doaj.org/article/af86eab69cff4769b985d00da579fe91 https://doaj.org/toc/2091-1130 https://doaj.org/toc/2467-9313
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up_date	2024-07-03T16:43:27.632Z
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Pharmacological In vivo test to evaluate the antidepressant activity of polyherbal formulation

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