Virgin Olive Oil Extracts Reduce Oxidative Stress and Modulate Cholesterol Metabolism: Comparison between Oils Obtained with Traditional and Innovative Processes

This study was aimed at demonstrating the substantial equivalence of two extra virgin olive oil samples extracted from the same batch of Coratina olives with (OMU) or without (OMN) using ultrasound technology, by performing chemical, biochemical, and cellular investigations. The volatile organic com...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Carmen Lammi [verfasserIn] Nadia Mulinacci [verfasserIn] Lorenzo Cecchi [verfasserIn] Maria Bellumori [verfasserIn] Carlotta Bollati [verfasserIn] Martina Bartolomei [verfasserIn] Carlo Franchini [verfasserIn] Maria Lisa Clodoveo [verfasserIn] Filomena Corbo [verfasserIn] Anna Arnoldi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	antioxidant HepG2 cells EVOO extract IOC methods LDLR PCSK9

Übergeordnetes Werk:	In: Antioxidants - MDPI AG, 2013, 9(2020), 9, p 798
Übergeordnetes Werk:	volume:9 ; year:2020 ; number:9, p 798

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antiox9090798

Katalog-ID:	DOAJ00577683X

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callnumber-first	R - Medicine
author	Carmen Lammi
spellingShingle	Carmen Lammi misc RM1-950 misc antioxidant misc HepG2 cells misc EVOO extract misc IOC methods misc LDLR misc PCSK9 misc Therapeutics. Pharmacology Virgin Olive Oil Extracts Reduce Oxidative Stress and Modulate Cholesterol Metabolism: Comparison between Oils Obtained with Traditional and Innovative Processes
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topic_title	RM1-950 Virgin Olive Oil Extracts Reduce Oxidative Stress and Modulate Cholesterol Metabolism: Comparison between Oils Obtained with Traditional and Innovative Processes antioxidant HepG2 cells EVOO extract IOC methods LDLR PCSK9
topic	misc RM1-950 misc antioxidant misc HepG2 cells misc EVOO extract misc IOC methods misc LDLR misc PCSK9 misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc antioxidant misc HepG2 cells misc EVOO extract misc IOC methods misc LDLR misc PCSK9 misc Therapeutics. Pharmacology
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title	Virgin Olive Oil Extracts Reduce Oxidative Stress and Modulate Cholesterol Metabolism: Comparison between Oils Obtained with Traditional and Innovative Processes
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title_full	Virgin Olive Oil Extracts Reduce Oxidative Stress and Modulate Cholesterol Metabolism: Comparison between Oils Obtained with Traditional and Innovative Processes
author_sort	Carmen Lammi
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author_browse	Carmen Lammi Nadia Mulinacci Lorenzo Cecchi Maria Bellumori Carlotta Bollati Martina Bartolomei Carlo Franchini Maria Lisa Clodoveo Filomena Corbo Anna Arnoldi
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title_sort	virgin olive oil extracts reduce oxidative stress and modulate cholesterol metabolism: comparison between oils obtained with traditional and innovative processes
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title_auth	Virgin Olive Oil Extracts Reduce Oxidative Stress and Modulate Cholesterol Metabolism: Comparison between Oils Obtained with Traditional and Innovative Processes
abstract	This study was aimed at demonstrating the substantial equivalence of two extra virgin olive oil samples extracted from the same batch of Coratina olives with (OMU) or without (OMN) using ultrasound technology, by performing chemical, biochemical, and cellular investigations. The volatile organic compounds compositions and phenolic profiles were very similar, showing that, while increasing the extraction yields, the innovative process does not change these features. The antioxidant and hypocholesterolemic activities of the extra virgin olive oil (EVOO) phenol extracts were also preserved, since OMU and OMN had equivalent abilities to scavenge the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radicals in vitro and to protect HepG2 cells from oxidative stress induced by H<sub<2</sub<O<sub<2</sub<, reducing intracellular reactive oxygen species (ROS) and lipid peroxidation levels. In addition, by inhibiting 3-hydroxy-3-methylglutarylcoenzyme a reductase, both samples modulated the low-density lipoprotein receptor (LDLR) pathway leading to increased LDLR protein levels and activity.
abstractGer	This study was aimed at demonstrating the substantial equivalence of two extra virgin olive oil samples extracted from the same batch of Coratina olives with (OMU) or without (OMN) using ultrasound technology, by performing chemical, biochemical, and cellular investigations. The volatile organic compounds compositions and phenolic profiles were very similar, showing that, while increasing the extraction yields, the innovative process does not change these features. The antioxidant and hypocholesterolemic activities of the extra virgin olive oil (EVOO) phenol extracts were also preserved, since OMU and OMN had equivalent abilities to scavenge the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radicals in vitro and to protect HepG2 cells from oxidative stress induced by H<sub<2</sub<O<sub<2</sub<, reducing intracellular reactive oxygen species (ROS) and lipid peroxidation levels. In addition, by inhibiting 3-hydroxy-3-methylglutarylcoenzyme a reductase, both samples modulated the low-density lipoprotein receptor (LDLR) pathway leading to increased LDLR protein levels and activity.
abstract_unstemmed	This study was aimed at demonstrating the substantial equivalence of two extra virgin olive oil samples extracted from the same batch of Coratina olives with (OMU) or without (OMN) using ultrasound technology, by performing chemical, biochemical, and cellular investigations. The volatile organic compounds compositions and phenolic profiles were very similar, showing that, while increasing the extraction yields, the innovative process does not change these features. The antioxidant and hypocholesterolemic activities of the extra virgin olive oil (EVOO) phenol extracts were also preserved, since OMU and OMN had equivalent abilities to scavenge the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radicals in vitro and to protect HepG2 cells from oxidative stress induced by H<sub<2</sub<O<sub<2</sub<, reducing intracellular reactive oxygen species (ROS) and lipid peroxidation levels. In addition, by inhibiting 3-hydroxy-3-methylglutarylcoenzyme a reductase, both samples modulated the low-density lipoprotein receptor (LDLR) pathway leading to increased LDLR protein levels and activity.
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container_issue	9, p 798
title_short	Virgin Olive Oil Extracts Reduce Oxidative Stress and Modulate Cholesterol Metabolism: Comparison between Oils Obtained with Traditional and Innovative Processes
url	https://doi.org/10.3390/antiox9090798 https://doaj.org/article/5b21df1895f44419a9f1b964b61f8233 https://www.mdpi.com/2076-3921/9/9/798 https://doaj.org/toc/2076-3921
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up_date	2024-07-03T17:03:01.015Z
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