NK Cells as Potential Targets for Immunotherapy in Endometriosis

Endometriosis is a common gynecological disease defined by the presence of endometrial-like tissue outside the uterus, most frequently on the pelvic viscera and ovaries, which is associated with pelvic pains and infertility. It is an inflammatory disorder with some features of autoimmunity. It is ac...
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Autor*in:	Aneta Ścieżyńska [verfasserIn] Michał Komorowski [verfasserIn] Marta Soszyńska [verfasserIn] Jacek Malejczyk [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	endometriotic cells endometriosis immune checkpoint immunotherapy major histocompatibility complex class I natural killer (NK) cells NK cell receptors

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 8(2019), 9, p 1468
Übergeordnetes Werk:	volume:8 ; year:2019 ; number:9, p 1468

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm8091468

Katalog-ID:	DOAJ00589882X

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allfields	10.3390/jcm8091468 doi (DE-627)DOAJ00589882X (DE-599)DOAJ3f0b9164ab6a4d0e85818eb116243bf5 DE-627 ger DE-627 rakwb eng Aneta Ścieżyńska verfasserin aut NK Cells as Potential Targets for Immunotherapy in Endometriosis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Endometriosis is a common gynecological disease defined by the presence of endometrial-like tissue outside the uterus, most frequently on the pelvic viscera and ovaries, which is associated with pelvic pains and infertility. It is an inflammatory disorder with some features of autoimmunity. It is accepted that ectopic endometriotic tissue originates from endometrial cells exfoliated during menstruation and disseminating into the peritoneum by retrograde menstrual blood flow. It is assumed that the survival of endometriotic cells in the peritoneal cavity may be partially due to their abrogated elimination by natural killer (NK) cells. The decrease of NK cell cytotoxic activity in endometriosis is associated with an increased expression of some inhibitory NK cell receptors. It may be also related to the expression of human leukocyte antigen G (HLA-G), a ligand for inhibitory leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1) receptors. The downregulated cytotoxic activity of NK cells may be due to inhibitory cytokines present in the peritoneal milieu of patients with endometriosis. The role of NK cell receptors and their ligands in endometriosis is also confirmed by genetic association studies. Thus, endometriosis may be a subject of immunotherapy by blocking NK cell negative control checkpoints including inhibitory NK cell receptors. Immunotherapies with genetically modified NK cells also cannot be excluded. endometriotic cells endometriosis immune checkpoint immunotherapy major histocompatibility complex class I natural killer (NK) cells NK cell receptors Medicine R Michał Komorowski verfasserin aut Marta Soszyńska verfasserin aut Jacek Malejczyk verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 8(2019), 9, p 1468 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:8 year:2019 number:9, p 1468 https://doi.org/10.3390/jcm8091468 kostenfrei https://doaj.org/article/3f0b9164ab6a4d0e85818eb116243bf5 kostenfrei https://www.mdpi.com/2077-0383/8/9/1468 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 9, p 1468
spelling	10.3390/jcm8091468 doi (DE-627)DOAJ00589882X (DE-599)DOAJ3f0b9164ab6a4d0e85818eb116243bf5 DE-627 ger DE-627 rakwb eng Aneta Ścieżyńska verfasserin aut NK Cells as Potential Targets for Immunotherapy in Endometriosis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Endometriosis is a common gynecological disease defined by the presence of endometrial-like tissue outside the uterus, most frequently on the pelvic viscera and ovaries, which is associated with pelvic pains and infertility. It is an inflammatory disorder with some features of autoimmunity. It is accepted that ectopic endometriotic tissue originates from endometrial cells exfoliated during menstruation and disseminating into the peritoneum by retrograde menstrual blood flow. It is assumed that the survival of endometriotic cells in the peritoneal cavity may be partially due to their abrogated elimination by natural killer (NK) cells. The decrease of NK cell cytotoxic activity in endometriosis is associated with an increased expression of some inhibitory NK cell receptors. It may be also related to the expression of human leukocyte antigen G (HLA-G), a ligand for inhibitory leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1) receptors. The downregulated cytotoxic activity of NK cells may be due to inhibitory cytokines present in the peritoneal milieu of patients with endometriosis. The role of NK cell receptors and their ligands in endometriosis is also confirmed by genetic association studies. Thus, endometriosis may be a subject of immunotherapy by blocking NK cell negative control checkpoints including inhibitory NK cell receptors. Immunotherapies with genetically modified NK cells also cannot be excluded. endometriotic cells endometriosis immune checkpoint immunotherapy major histocompatibility complex class I natural killer (NK) cells NK cell receptors Medicine R Michał Komorowski verfasserin aut Marta Soszyńska verfasserin aut Jacek Malejczyk verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 8(2019), 9, p 1468 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:8 year:2019 number:9, p 1468 https://doi.org/10.3390/jcm8091468 kostenfrei https://doaj.org/article/3f0b9164ab6a4d0e85818eb116243bf5 kostenfrei https://www.mdpi.com/2077-0383/8/9/1468 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 9, p 1468
allfields_unstemmed	10.3390/jcm8091468 doi (DE-627)DOAJ00589882X (DE-599)DOAJ3f0b9164ab6a4d0e85818eb116243bf5 DE-627 ger DE-627 rakwb eng Aneta Ścieżyńska verfasserin aut NK Cells as Potential Targets for Immunotherapy in Endometriosis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Endometriosis is a common gynecological disease defined by the presence of endometrial-like tissue outside the uterus, most frequently on the pelvic viscera and ovaries, which is associated with pelvic pains and infertility. It is an inflammatory disorder with some features of autoimmunity. It is accepted that ectopic endometriotic tissue originates from endometrial cells exfoliated during menstruation and disseminating into the peritoneum by retrograde menstrual blood flow. It is assumed that the survival of endometriotic cells in the peritoneal cavity may be partially due to their abrogated elimination by natural killer (NK) cells. The decrease of NK cell cytotoxic activity in endometriosis is associated with an increased expression of some inhibitory NK cell receptors. It may be also related to the expression of human leukocyte antigen G (HLA-G), a ligand for inhibitory leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1) receptors. The downregulated cytotoxic activity of NK cells may be due to inhibitory cytokines present in the peritoneal milieu of patients with endometriosis. The role of NK cell receptors and their ligands in endometriosis is also confirmed by genetic association studies. Thus, endometriosis may be a subject of immunotherapy by blocking NK cell negative control checkpoints including inhibitory NK cell receptors. Immunotherapies with genetically modified NK cells also cannot be excluded. endometriotic cells endometriosis immune checkpoint immunotherapy major histocompatibility complex class I natural killer (NK) cells NK cell receptors Medicine R Michał Komorowski verfasserin aut Marta Soszyńska verfasserin aut Jacek Malejczyk verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 8(2019), 9, p 1468 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:8 year:2019 number:9, p 1468 https://doi.org/10.3390/jcm8091468 kostenfrei https://doaj.org/article/3f0b9164ab6a4d0e85818eb116243bf5 kostenfrei https://www.mdpi.com/2077-0383/8/9/1468 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 9, p 1468
allfieldsGer	10.3390/jcm8091468 doi (DE-627)DOAJ00589882X (DE-599)DOAJ3f0b9164ab6a4d0e85818eb116243bf5 DE-627 ger DE-627 rakwb eng Aneta Ścieżyńska verfasserin aut NK Cells as Potential Targets for Immunotherapy in Endometriosis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Endometriosis is a common gynecological disease defined by the presence of endometrial-like tissue outside the uterus, most frequently on the pelvic viscera and ovaries, which is associated with pelvic pains and infertility. It is an inflammatory disorder with some features of autoimmunity. It is accepted that ectopic endometriotic tissue originates from endometrial cells exfoliated during menstruation and disseminating into the peritoneum by retrograde menstrual blood flow. It is assumed that the survival of endometriotic cells in the peritoneal cavity may be partially due to their abrogated elimination by natural killer (NK) cells. The decrease of NK cell cytotoxic activity in endometriosis is associated with an increased expression of some inhibitory NK cell receptors. It may be also related to the expression of human leukocyte antigen G (HLA-G), a ligand for inhibitory leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1) receptors. The downregulated cytotoxic activity of NK cells may be due to inhibitory cytokines present in the peritoneal milieu of patients with endometriosis. The role of NK cell receptors and their ligands in endometriosis is also confirmed by genetic association studies. Thus, endometriosis may be a subject of immunotherapy by blocking NK cell negative control checkpoints including inhibitory NK cell receptors. Immunotherapies with genetically modified NK cells also cannot be excluded. endometriotic cells endometriosis immune checkpoint immunotherapy major histocompatibility complex class I natural killer (NK) cells NK cell receptors Medicine R Michał Komorowski verfasserin aut Marta Soszyńska verfasserin aut Jacek Malejczyk verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 8(2019), 9, p 1468 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:8 year:2019 number:9, p 1468 https://doi.org/10.3390/jcm8091468 kostenfrei https://doaj.org/article/3f0b9164ab6a4d0e85818eb116243bf5 kostenfrei https://www.mdpi.com/2077-0383/8/9/1468 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 9, p 1468
allfieldsSound	10.3390/jcm8091468 doi (DE-627)DOAJ00589882X (DE-599)DOAJ3f0b9164ab6a4d0e85818eb116243bf5 DE-627 ger DE-627 rakwb eng Aneta Ścieżyńska verfasserin aut NK Cells as Potential Targets for Immunotherapy in Endometriosis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Endometriosis is a common gynecological disease defined by the presence of endometrial-like tissue outside the uterus, most frequently on the pelvic viscera and ovaries, which is associated with pelvic pains and infertility. It is an inflammatory disorder with some features of autoimmunity. It is accepted that ectopic endometriotic tissue originates from endometrial cells exfoliated during menstruation and disseminating into the peritoneum by retrograde menstrual blood flow. It is assumed that the survival of endometriotic cells in the peritoneal cavity may be partially due to their abrogated elimination by natural killer (NK) cells. The decrease of NK cell cytotoxic activity in endometriosis is associated with an increased expression of some inhibitory NK cell receptors. It may be also related to the expression of human leukocyte antigen G (HLA-G), a ligand for inhibitory leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1) receptors. The downregulated cytotoxic activity of NK cells may be due to inhibitory cytokines present in the peritoneal milieu of patients with endometriosis. The role of NK cell receptors and their ligands in endometriosis is also confirmed by genetic association studies. Thus, endometriosis may be a subject of immunotherapy by blocking NK cell negative control checkpoints including inhibitory NK cell receptors. Immunotherapies with genetically modified NK cells also cannot be excluded. endometriotic cells endometriosis immune checkpoint immunotherapy major histocompatibility complex class I natural killer (NK) cells NK cell receptors Medicine R Michał Komorowski verfasserin aut Marta Soszyńska verfasserin aut Jacek Malejczyk verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 8(2019), 9, p 1468 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:8 year:2019 number:9, p 1468 https://doi.org/10.3390/jcm8091468 kostenfrei https://doaj.org/article/3f0b9164ab6a4d0e85818eb116243bf5 kostenfrei https://www.mdpi.com/2077-0383/8/9/1468 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 9, p 1468
language	English
source	In Journal of Clinical Medicine 8(2019), 9, p 1468 volume:8 year:2019 number:9, p 1468
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topic_facet	endometriotic cells endometriosis immune checkpoint immunotherapy major histocompatibility complex class I natural killer (NK) cells NK cell receptors Medicine R
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container_title	Journal of Clinical Medicine
authorswithroles_txt_mv	Aneta Ścieżyńska @@aut@@ Michał Komorowski @@aut@@ Marta Soszyńska @@aut@@ Jacek Malejczyk @@aut@@
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author	Aneta Ścieżyńska
spellingShingle	Aneta Ścieżyńska misc endometriotic cells misc endometriosis misc immune checkpoint misc immunotherapy misc major histocompatibility complex class I misc natural killer (NK) cells misc NK cell receptors misc Medicine misc R NK Cells as Potential Targets for Immunotherapy in Endometriosis
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topic_title	NK Cells as Potential Targets for Immunotherapy in Endometriosis endometriotic cells endometriosis immune checkpoint immunotherapy major histocompatibility complex class I natural killer (NK) cells NK cell receptors
topic	misc endometriotic cells misc endometriosis misc immune checkpoint misc immunotherapy misc major histocompatibility complex class I misc natural killer (NK) cells misc NK cell receptors misc Medicine misc R
topic_unstemmed	misc endometriotic cells misc endometriosis misc immune checkpoint misc immunotherapy misc major histocompatibility complex class I misc natural killer (NK) cells misc NK cell receptors misc Medicine misc R
topic_browse	misc endometriotic cells misc endometriosis misc immune checkpoint misc immunotherapy misc major histocompatibility complex class I misc natural killer (NK) cells misc NK cell receptors misc Medicine misc R
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title	NK Cells as Potential Targets for Immunotherapy in Endometriosis
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title_full	NK Cells as Potential Targets for Immunotherapy in Endometriosis
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author_browse	Aneta Ścieżyńska Michał Komorowski Marta Soszyńska Jacek Malejczyk
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title_sort	nk cells as potential targets for immunotherapy in endometriosis
title_auth	NK Cells as Potential Targets for Immunotherapy in Endometriosis
abstract	Endometriosis is a common gynecological disease defined by the presence of endometrial-like tissue outside the uterus, most frequently on the pelvic viscera and ovaries, which is associated with pelvic pains and infertility. It is an inflammatory disorder with some features of autoimmunity. It is accepted that ectopic endometriotic tissue originates from endometrial cells exfoliated during menstruation and disseminating into the peritoneum by retrograde menstrual blood flow. It is assumed that the survival of endometriotic cells in the peritoneal cavity may be partially due to their abrogated elimination by natural killer (NK) cells. The decrease of NK cell cytotoxic activity in endometriosis is associated with an increased expression of some inhibitory NK cell receptors. It may be also related to the expression of human leukocyte antigen G (HLA-G), a ligand for inhibitory leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1) receptors. The downregulated cytotoxic activity of NK cells may be due to inhibitory cytokines present in the peritoneal milieu of patients with endometriosis. The role of NK cell receptors and their ligands in endometriosis is also confirmed by genetic association studies. Thus, endometriosis may be a subject of immunotherapy by blocking NK cell negative control checkpoints including inhibitory NK cell receptors. Immunotherapies with genetically modified NK cells also cannot be excluded.
abstractGer	Endometriosis is a common gynecological disease defined by the presence of endometrial-like tissue outside the uterus, most frequently on the pelvic viscera and ovaries, which is associated with pelvic pains and infertility. It is an inflammatory disorder with some features of autoimmunity. It is accepted that ectopic endometriotic tissue originates from endometrial cells exfoliated during menstruation and disseminating into the peritoneum by retrograde menstrual blood flow. It is assumed that the survival of endometriotic cells in the peritoneal cavity may be partially due to their abrogated elimination by natural killer (NK) cells. The decrease of NK cell cytotoxic activity in endometriosis is associated with an increased expression of some inhibitory NK cell receptors. It may be also related to the expression of human leukocyte antigen G (HLA-G), a ligand for inhibitory leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1) receptors. The downregulated cytotoxic activity of NK cells may be due to inhibitory cytokines present in the peritoneal milieu of patients with endometriosis. The role of NK cell receptors and their ligands in endometriosis is also confirmed by genetic association studies. Thus, endometriosis may be a subject of immunotherapy by blocking NK cell negative control checkpoints including inhibitory NK cell receptors. Immunotherapies with genetically modified NK cells also cannot be excluded.
abstract_unstemmed	Endometriosis is a common gynecological disease defined by the presence of endometrial-like tissue outside the uterus, most frequently on the pelvic viscera and ovaries, which is associated with pelvic pains and infertility. It is an inflammatory disorder with some features of autoimmunity. It is accepted that ectopic endometriotic tissue originates from endometrial cells exfoliated during menstruation and disseminating into the peritoneum by retrograde menstrual blood flow. It is assumed that the survival of endometriotic cells in the peritoneal cavity may be partially due to their abrogated elimination by natural killer (NK) cells. The decrease of NK cell cytotoxic activity in endometriosis is associated with an increased expression of some inhibitory NK cell receptors. It may be also related to the expression of human leukocyte antigen G (HLA-G), a ligand for inhibitory leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1) receptors. The downregulated cytotoxic activity of NK cells may be due to inhibitory cytokines present in the peritoneal milieu of patients with endometriosis. The role of NK cell receptors and their ligands in endometriosis is also confirmed by genetic association studies. Thus, endometriosis may be a subject of immunotherapy by blocking NK cell negative control checkpoints including inhibitory NK cell receptors. Immunotherapies with genetically modified NK cells also cannot be excluded.
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title_short	NK Cells as Potential Targets for Immunotherapy in Endometriosis
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up_date	2024-07-03T17:46:57.516Z
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