The Genetics of Sleep Disorders in Children: A Narrative Review

Sleep is a universal, highly preserved process, essential for human and animal life, whose complete functions are yet to be unravelled. Familial recurrence is acknowledged for some sleep disorders, but definite data are lacking for many of them. Genetic studies on sleep disorders have progressed fro...
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Gespeichert in:

Autor*in:	Greta Mainieri [verfasserIn] Angelica Montini [verfasserIn] Antonio Nicotera [verfasserIn] Gabriella Di Rosa [verfasserIn] Federica Provini [verfasserIn] Giuseppe Loddo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	insomnia sleep-related breathing disorders hypersomnolence circadian rhythm sleep-wake disorders parasomnias sleep-related movement disorders

Übergeordnetes Werk:	In: Brain Sciences - MDPI AG, 2012, 11(2021), 10, p 1259
Übergeordnetes Werk:	volume:11 ; year:2021 ; number:10, p 1259

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/brainsci11101259

Katalog-ID:	DOAJ006019412

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language	English
source	In Brain Sciences 11(2021), 10, p 1259 volume:11 year:2021 number:10, p 1259
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topic_facet	insomnia sleep-related breathing disorders hypersomnolence circadian rhythm sleep-wake disorders parasomnias sleep-related movement disorders Neurosciences. Biological psychiatry. Neuropsychiatry
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container_title	Brain Sciences
authorswithroles_txt_mv	Greta Mainieri @@aut@@ Angelica Montini @@aut@@ Antonio Nicotera @@aut@@ Gabriella Di Rosa @@aut@@ Federica Provini @@aut@@ Giuseppe Loddo @@aut@@
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callnumber-first	R - Medicine
author	Greta Mainieri
spellingShingle	Greta Mainieri misc RC321-571 misc insomnia misc sleep-related breathing disorders misc hypersomnolence misc circadian rhythm sleep-wake disorders misc parasomnias misc sleep-related movement disorders misc Neurosciences. Biological psychiatry. Neuropsychiatry The Genetics of Sleep Disorders in Children: A Narrative Review
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topic_title	RC321-571 The Genetics of Sleep Disorders in Children: A Narrative Review insomnia sleep-related breathing disorders hypersomnolence circadian rhythm sleep-wake disorders parasomnias sleep-related movement disorders
topic	misc RC321-571 misc insomnia misc sleep-related breathing disorders misc hypersomnolence misc circadian rhythm sleep-wake disorders misc parasomnias misc sleep-related movement disorders misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	The Genetics of Sleep Disorders in Children: A Narrative Review
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title_sort	genetics of sleep disorders in children: a narrative review
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title_auth	The Genetics of Sleep Disorders in Children: A Narrative Review
abstract	Sleep is a universal, highly preserved process, essential for human and animal life, whose complete functions are yet to be unravelled. Familial recurrence is acknowledged for some sleep disorders, but definite data are lacking for many of them. Genetic studies on sleep disorders have progressed from twin and family studies to candidate gene approaches to culminate in genome-wide association studies (GWAS). Several works disclosed that sleep-wake characteristics, in addition to electroencephalographic (EEG) sleep patterns, have a certain degree of heritability. Notwithstanding, it is rare for sleep disorders to be attributed to single gene defects because of the complexity of the brain network/pathways involved. Besides, the advancing insights in epigenetic gene-environment interactions add further complexity to understanding the genetic control of sleep and its disorders. This narrative review explores the current genetic knowledge in sleep disorders in children, following the International Classification of Sleep Disorders—Third Edition (ICSD-3) categorisation.
abstractGer	Sleep is a universal, highly preserved process, essential for human and animal life, whose complete functions are yet to be unravelled. Familial recurrence is acknowledged for some sleep disorders, but definite data are lacking for many of them. Genetic studies on sleep disorders have progressed from twin and family studies to candidate gene approaches to culminate in genome-wide association studies (GWAS). Several works disclosed that sleep-wake characteristics, in addition to electroencephalographic (EEG) sleep patterns, have a certain degree of heritability. Notwithstanding, it is rare for sleep disorders to be attributed to single gene defects because of the complexity of the brain network/pathways involved. Besides, the advancing insights in epigenetic gene-environment interactions add further complexity to understanding the genetic control of sleep and its disorders. This narrative review explores the current genetic knowledge in sleep disorders in children, following the International Classification of Sleep Disorders—Third Edition (ICSD-3) categorisation.
abstract_unstemmed	Sleep is a universal, highly preserved process, essential for human and animal life, whose complete functions are yet to be unravelled. Familial recurrence is acknowledged for some sleep disorders, but definite data are lacking for many of them. Genetic studies on sleep disorders have progressed from twin and family studies to candidate gene approaches to culminate in genome-wide association studies (GWAS). Several works disclosed that sleep-wake characteristics, in addition to electroencephalographic (EEG) sleep patterns, have a certain degree of heritability. Notwithstanding, it is rare for sleep disorders to be attributed to single gene defects because of the complexity of the brain network/pathways involved. Besides, the advancing insights in epigenetic gene-environment interactions add further complexity to understanding the genetic control of sleep and its disorders. This narrative review explores the current genetic knowledge in sleep disorders in children, following the International Classification of Sleep Disorders—Third Edition (ICSD-3) categorisation.
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