Rapid reinfection with SARS-CoV-2 variant-of-concern Alpha detected in a nurse during an outbreak at a non-covid inpatient ward: lessons learned

Abstract We describe the lessons learned during a SARS-CoV-2 variant-of-concern Alpha outbreak investigation at a normal care unit in a university hospital in Amsterdam in December 2020. The outbreak consisted of nine nurses and two roomed-in patient family members. (attack rate 18%). One nurse test...
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Autor*in:	Jelle Koopsen [verfasserIn] Mireille Dekker [verfasserIn] Philip Thung [verfasserIn] Marcel Jonges [verfasserIn] Harry Vennema [verfasserIn] Tjalling Leenstra [verfasserIn] Dirk Eggink [verfasserIn] Matthijs R. A. Welkers [verfasserIn] Peter A. A. Struijs [verfasserIn] Chantal Reusken [verfasserIn] Rosa van Mansfeld [verfasserIn] Menno D. de Jong [verfasserIn] Janke Schinkel [verfasserIn] Ingrid J. B. Spijkerman [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Nosocomial transmission Outbreak investigation Infection prevention and control Infection control guidelines

Übergeordnetes Werk:	In: Antimicrobial Resistance and Infection Control - BMC, 2012, 10(2021), 1, Seite 6
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:1 ; pages:6

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s13756-021-01008-4

Katalog-ID:	DOAJ006143148

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allfields	10.1186/s13756-021-01008-4 doi (DE-627)DOAJ006143148 (DE-599)DOAJ09d130a38b4940abada68fcc46630fbe DE-627 ger DE-627 rakwb eng RC109-216 Jelle Koopsen verfasserin aut Rapid reinfection with SARS-CoV-2 variant-of-concern Alpha detected in a nurse during an outbreak at a non-covid inpatient ward: lessons learned 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract We describe the lessons learned during a SARS-CoV-2 variant-of-concern Alpha outbreak investigation at a normal care unit in a university hospital in Amsterdam in December 2020. The outbreak consisted of nine nurses and two roomed-in patient family members. (attack rate 18%). One nurse tested positive with a phylogenetically distinct variant, after a documented infection 83 days prior. Three key points were taken from this investigation. First, it was controlled by adherence to existing guidelines, despite increased transmissibility of the variant. Second, viral sequencing can inform transmission cluster inference, but the epidemiological context is essential to draw appropriate conclusions. Third, reinfections with Alpha variants can occur rapidly after primary infection. Nosocomial transmission Outbreak investigation Infection prevention and control Infection control guidelines Infectious and parasitic diseases Mireille Dekker verfasserin aut Philip Thung verfasserin aut Marcel Jonges verfasserin aut Harry Vennema verfasserin aut Tjalling Leenstra verfasserin aut Dirk Eggink verfasserin aut Matthijs R. A. Welkers verfasserin aut Peter A. A. Struijs verfasserin aut Chantal Reusken verfasserin aut Rosa van Mansfeld verfasserin aut Menno D. de Jong verfasserin aut Janke Schinkel verfasserin aut Ingrid J. B. Spijkerman verfasserin aut In Antimicrobial Resistance and Infection Control BMC, 2012 10(2021), 1, Seite 6 (DE-627)718716140 (DE-600)2666706-X 20472994 nnns volume:10 year:2021 number:1 pages:6 https://doi.org/10.1186/s13756-021-01008-4 kostenfrei https://doaj.org/article/09d130a38b4940abada68fcc46630fbe kostenfrei https://doi.org/10.1186/s13756-021-01008-4 kostenfrei https://doaj.org/toc/2047-2994 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 1 6
spelling	10.1186/s13756-021-01008-4 doi (DE-627)DOAJ006143148 (DE-599)DOAJ09d130a38b4940abada68fcc46630fbe DE-627 ger DE-627 rakwb eng RC109-216 Jelle Koopsen verfasserin aut Rapid reinfection with SARS-CoV-2 variant-of-concern Alpha detected in a nurse during an outbreak at a non-covid inpatient ward: lessons learned 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract We describe the lessons learned during a SARS-CoV-2 variant-of-concern Alpha outbreak investigation at a normal care unit in a university hospital in Amsterdam in December 2020. The outbreak consisted of nine nurses and two roomed-in patient family members. (attack rate 18%). One nurse tested positive with a phylogenetically distinct variant, after a documented infection 83 days prior. Three key points were taken from this investigation. First, it was controlled by adherence to existing guidelines, despite increased transmissibility of the variant. Second, viral sequencing can inform transmission cluster inference, but the epidemiological context is essential to draw appropriate conclusions. Third, reinfections with Alpha variants can occur rapidly after primary infection. Nosocomial transmission Outbreak investigation Infection prevention and control Infection control guidelines Infectious and parasitic diseases Mireille Dekker verfasserin aut Philip Thung verfasserin aut Marcel Jonges verfasserin aut Harry Vennema verfasserin aut Tjalling Leenstra verfasserin aut Dirk Eggink verfasserin aut Matthijs R. A. Welkers verfasserin aut Peter A. A. Struijs verfasserin aut Chantal Reusken verfasserin aut Rosa van Mansfeld verfasserin aut Menno D. de Jong verfasserin aut Janke Schinkel verfasserin aut Ingrid J. B. Spijkerman verfasserin aut In Antimicrobial Resistance and Infection Control BMC, 2012 10(2021), 1, Seite 6 (DE-627)718716140 (DE-600)2666706-X 20472994 nnns volume:10 year:2021 number:1 pages:6 https://doi.org/10.1186/s13756-021-01008-4 kostenfrei https://doaj.org/article/09d130a38b4940abada68fcc46630fbe kostenfrei https://doi.org/10.1186/s13756-021-01008-4 kostenfrei https://doaj.org/toc/2047-2994 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 1 6
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allfieldsSound	10.1186/s13756-021-01008-4 doi (DE-627)DOAJ006143148 (DE-599)DOAJ09d130a38b4940abada68fcc46630fbe DE-627 ger DE-627 rakwb eng RC109-216 Jelle Koopsen verfasserin aut Rapid reinfection with SARS-CoV-2 variant-of-concern Alpha detected in a nurse during an outbreak at a non-covid inpatient ward: lessons learned 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract We describe the lessons learned during a SARS-CoV-2 variant-of-concern Alpha outbreak investigation at a normal care unit in a university hospital in Amsterdam in December 2020. The outbreak consisted of nine nurses and two roomed-in patient family members. (attack rate 18%). One nurse tested positive with a phylogenetically distinct variant, after a documented infection 83 days prior. Three key points were taken from this investigation. First, it was controlled by adherence to existing guidelines, despite increased transmissibility of the variant. Second, viral sequencing can inform transmission cluster inference, but the epidemiological context is essential to draw appropriate conclusions. Third, reinfections with Alpha variants can occur rapidly after primary infection. Nosocomial transmission Outbreak investigation Infection prevention and control Infection control guidelines Infectious and parasitic diseases Mireille Dekker verfasserin aut Philip Thung verfasserin aut Marcel Jonges verfasserin aut Harry Vennema verfasserin aut Tjalling Leenstra verfasserin aut Dirk Eggink verfasserin aut Matthijs R. A. Welkers verfasserin aut Peter A. A. Struijs verfasserin aut Chantal Reusken verfasserin aut Rosa van Mansfeld verfasserin aut Menno D. de Jong verfasserin aut Janke Schinkel verfasserin aut Ingrid J. B. Spijkerman verfasserin aut In Antimicrobial Resistance and Infection Control BMC, 2012 10(2021), 1, Seite 6 (DE-627)718716140 (DE-600)2666706-X 20472994 nnns volume:10 year:2021 number:1 pages:6 https://doi.org/10.1186/s13756-021-01008-4 kostenfrei https://doaj.org/article/09d130a38b4940abada68fcc46630fbe kostenfrei https://doi.org/10.1186/s13756-021-01008-4 kostenfrei https://doaj.org/toc/2047-2994 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 1 6
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source	In Antimicrobial Resistance and Infection Control 10(2021), 1, Seite 6 volume:10 year:2021 number:1 pages:6
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authorswithroles_txt_mv	Jelle Koopsen @@aut@@ Mireille Dekker @@aut@@ Philip Thung @@aut@@ Marcel Jonges @@aut@@ Harry Vennema @@aut@@ Tjalling Leenstra @@aut@@ Dirk Eggink @@aut@@ Matthijs R. A. Welkers @@aut@@ Peter A. A. Struijs @@aut@@ Chantal Reusken @@aut@@ Rosa van Mansfeld @@aut@@ Menno D. de Jong @@aut@@ Janke Schinkel @@aut@@ Ingrid J. B. Spijkerman @@aut@@
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author	Jelle Koopsen
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topic_title	RC109-216 Rapid reinfection with SARS-CoV-2 variant-of-concern Alpha detected in a nurse during an outbreak at a non-covid inpatient ward: lessons learned Nosocomial transmission Outbreak investigation Infection prevention and control Infection control guidelines
topic	misc RC109-216 misc Nosocomial transmission misc Outbreak investigation misc Infection prevention and control misc Infection control guidelines misc Infectious and parasitic diseases
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title	Rapid reinfection with SARS-CoV-2 variant-of-concern Alpha detected in a nurse during an outbreak at a non-covid inpatient ward: lessons learned
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title_full	Rapid reinfection with SARS-CoV-2 variant-of-concern Alpha detected in a nurse during an outbreak at a non-covid inpatient ward: lessons learned
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title_sort	rapid reinfection with sars-cov-2 variant-of-concern alpha detected in a nurse during an outbreak at a non-covid inpatient ward: lessons learned
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title_auth	Rapid reinfection with SARS-CoV-2 variant-of-concern Alpha detected in a nurse during an outbreak at a non-covid inpatient ward: lessons learned
abstract	Abstract We describe the lessons learned during a SARS-CoV-2 variant-of-concern Alpha outbreak investigation at a normal care unit in a university hospital in Amsterdam in December 2020. The outbreak consisted of nine nurses and two roomed-in patient family members. (attack rate 18%). One nurse tested positive with a phylogenetically distinct variant, after a documented infection 83 days prior. Three key points were taken from this investigation. First, it was controlled by adherence to existing guidelines, despite increased transmissibility of the variant. Second, viral sequencing can inform transmission cluster inference, but the epidemiological context is essential to draw appropriate conclusions. Third, reinfections with Alpha variants can occur rapidly after primary infection.
abstractGer	Abstract We describe the lessons learned during a SARS-CoV-2 variant-of-concern Alpha outbreak investigation at a normal care unit in a university hospital in Amsterdam in December 2020. The outbreak consisted of nine nurses and two roomed-in patient family members. (attack rate 18%). One nurse tested positive with a phylogenetically distinct variant, after a documented infection 83 days prior. Three key points were taken from this investigation. First, it was controlled by adherence to existing guidelines, despite increased transmissibility of the variant. Second, viral sequencing can inform transmission cluster inference, but the epidemiological context is essential to draw appropriate conclusions. Third, reinfections with Alpha variants can occur rapidly after primary infection.
abstract_unstemmed	Abstract We describe the lessons learned during a SARS-CoV-2 variant-of-concern Alpha outbreak investigation at a normal care unit in a university hospital in Amsterdam in December 2020. The outbreak consisted of nine nurses and two roomed-in patient family members. (attack rate 18%). One nurse tested positive with a phylogenetically distinct variant, after a documented infection 83 days prior. Three key points were taken from this investigation. First, it was controlled by adherence to existing guidelines, despite increased transmissibility of the variant. Second, viral sequencing can inform transmission cluster inference, but the epidemiological context is essential to draw appropriate conclusions. Third, reinfections with Alpha variants can occur rapidly after primary infection.
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title_short	Rapid reinfection with SARS-CoV-2 variant-of-concern Alpha detected in a nurse during an outbreak at a non-covid inpatient ward: lessons learned
url	https://doi.org/10.1186/s13756-021-01008-4 https://doaj.org/article/09d130a38b4940abada68fcc46630fbe https://doaj.org/toc/2047-2994
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Rapid reinfection with SARS-CoV-2 variant-of-concern Alpha detected in a nurse during an outbreak at a non-covid inpatient ward: lessons learned

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