Bid Expression Network Controls Neuronal Cell Fate During Avian Ciliary Ganglion Development

Avian ciliary ganglion (CG) development involves a transient execution phase of apoptosis controlling the final number of neurons, but the time-dependent molecular mechanisms for neuronal cell fate are largely unknown. To elucidate the molecular networks regulating important aspects of parasympathet...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Sophie Koszinowski [verfasserIn] Veronica La Padula [verfasserIn] Frank Edlich [verfasserIn] Kerstin Krieglstein [verfasserIn] Hauke Busch [verfasserIn] Melanie Boerries [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	network inference protein interaction network ontogenetic cell death neuronal development BID time series analysis

Übergeordnetes Werk:	In: Frontiers in Physiology - Frontiers Media S.A., 2011, 9(2018)
Übergeordnetes Werk:	volume:9 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphys.2018.00797

Katalog-ID:	DOAJ006177948

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520			\|a Avian ciliary ganglion (CG) development involves a transient execution phase of apoptosis controlling the final number of neurons, but the time-dependent molecular mechanisms for neuronal cell fate are largely unknown. To elucidate the molecular networks regulating important aspects of parasympathetic neuronal development, a genome-wide expression analysis was performed during multiple stages of avian CG development between embryonic days E6 and E14. The transcriptome data showed a well-defined sequence of events, starting from neuronal migration via neuronal fate cell determination, synaptic transmission, and regulation of synaptic plasticity to growth factor associated signaling. In particular, we extracted a neuronal apoptosis network that characterized the cell death execution phase at E8/E9 and apoptotic cell clearance at E14 by combining the gene time series analysis with network synthesis from the chicken interactome. Network analysis identified TP53 as key regulator and predicted involvement of the BH3 interacting domain death agonist (BID). A virus-based RNAi knockdown approach in vivo showed a crucial impact of BID expression on the execution of ontogenetic programmed cell death (PCD). In contrast, Bcl-XL expression did not impact PCD. Therefore, BID-mediated apoptosis represents a novel cue essential for timing within CG maturation.
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allfieldsSound	10.3389/fphys.2018.00797 doi (DE-627)DOAJ006177948 (DE-599)DOAJ3ea2526f7d52483fa371f8ac55dc799e DE-627 ger DE-627 rakwb eng QP1-981 Sophie Koszinowski verfasserin aut Bid Expression Network Controls Neuronal Cell Fate During Avian Ciliary Ganglion Development 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Avian ciliary ganglion (CG) development involves a transient execution phase of apoptosis controlling the final number of neurons, but the time-dependent molecular mechanisms for neuronal cell fate are largely unknown. To elucidate the molecular networks regulating important aspects of parasympathetic neuronal development, a genome-wide expression analysis was performed during multiple stages of avian CG development between embryonic days E6 and E14. The transcriptome data showed a well-defined sequence of events, starting from neuronal migration via neuronal fate cell determination, synaptic transmission, and regulation of synaptic plasticity to growth factor associated signaling. In particular, we extracted a neuronal apoptosis network that characterized the cell death execution phase at E8/E9 and apoptotic cell clearance at E14 by combining the gene time series analysis with network synthesis from the chicken interactome. Network analysis identified TP53 as key regulator and predicted involvement of the BH3 interacting domain death agonist (BID). A virus-based RNAi knockdown approach in vivo showed a crucial impact of BID expression on the execution of ontogenetic programmed cell death (PCD). In contrast, Bcl-XL expression did not impact PCD. Therefore, BID-mediated apoptosis represents a novel cue essential for timing within CG maturation. network inference protein interaction network ontogenetic cell death neuronal development BID time series analysis Physiology Sophie Koszinowski verfasserin aut Veronica La Padula verfasserin aut Veronica La Padula verfasserin aut Frank Edlich verfasserin aut Kerstin Krieglstein verfasserin aut Hauke Busch verfasserin aut Hauke Busch verfasserin aut Hauke Busch verfasserin aut Melanie Boerries verfasserin aut Melanie Boerries verfasserin aut Melanie Boerries verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 9(2018) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:9 year:2018 https://doi.org/10.3389/fphys.2018.00797 kostenfrei https://doaj.org/article/3ea2526f7d52483fa371f8ac55dc799e kostenfrei https://www.frontiersin.org/article/10.3389/fphys.2018.00797/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
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authorswithroles_txt_mv	Sophie Koszinowski @@aut@@ Veronica La Padula @@aut@@ Frank Edlich @@aut@@ Kerstin Krieglstein @@aut@@ Hauke Busch @@aut@@ Melanie Boerries @@aut@@
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author	Sophie Koszinowski
spellingShingle	Sophie Koszinowski misc QP1-981 misc network inference misc protein interaction network misc ontogenetic cell death misc neuronal development misc BID misc time series analysis misc Physiology Bid Expression Network Controls Neuronal Cell Fate During Avian Ciliary Ganglion Development
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topic_title	QP1-981 Bid Expression Network Controls Neuronal Cell Fate During Avian Ciliary Ganglion Development network inference protein interaction network ontogenetic cell death neuronal development BID time series analysis
topic	misc QP1-981 misc network inference misc protein interaction network misc ontogenetic cell death misc neuronal development misc BID misc time series analysis misc Physiology
topic_unstemmed	misc QP1-981 misc network inference misc protein interaction network misc ontogenetic cell death misc neuronal development misc BID misc time series analysis misc Physiology
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title	Bid Expression Network Controls Neuronal Cell Fate During Avian Ciliary Ganglion Development
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title_full	Bid Expression Network Controls Neuronal Cell Fate During Avian Ciliary Ganglion Development
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title_sort	bid expression network controls neuronal cell fate during avian ciliary ganglion development
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title_auth	Bid Expression Network Controls Neuronal Cell Fate During Avian Ciliary Ganglion Development
abstract	Avian ciliary ganglion (CG) development involves a transient execution phase of apoptosis controlling the final number of neurons, but the time-dependent molecular mechanisms for neuronal cell fate are largely unknown. To elucidate the molecular networks regulating important aspects of parasympathetic neuronal development, a genome-wide expression analysis was performed during multiple stages of avian CG development between embryonic days E6 and E14. The transcriptome data showed a well-defined sequence of events, starting from neuronal migration via neuronal fate cell determination, synaptic transmission, and regulation of synaptic plasticity to growth factor associated signaling. In particular, we extracted a neuronal apoptosis network that characterized the cell death execution phase at E8/E9 and apoptotic cell clearance at E14 by combining the gene time series analysis with network synthesis from the chicken interactome. Network analysis identified TP53 as key regulator and predicted involvement of the BH3 interacting domain death agonist (BID). A virus-based RNAi knockdown approach in vivo showed a crucial impact of BID expression on the execution of ontogenetic programmed cell death (PCD). In contrast, Bcl-XL expression did not impact PCD. Therefore, BID-mediated apoptosis represents a novel cue essential for timing within CG maturation.
abstractGer	Avian ciliary ganglion (CG) development involves a transient execution phase of apoptosis controlling the final number of neurons, but the time-dependent molecular mechanisms for neuronal cell fate are largely unknown. To elucidate the molecular networks regulating important aspects of parasympathetic neuronal development, a genome-wide expression analysis was performed during multiple stages of avian CG development between embryonic days E6 and E14. The transcriptome data showed a well-defined sequence of events, starting from neuronal migration via neuronal fate cell determination, synaptic transmission, and regulation of synaptic plasticity to growth factor associated signaling. In particular, we extracted a neuronal apoptosis network that characterized the cell death execution phase at E8/E9 and apoptotic cell clearance at E14 by combining the gene time series analysis with network synthesis from the chicken interactome. Network analysis identified TP53 as key regulator and predicted involvement of the BH3 interacting domain death agonist (BID). A virus-based RNAi knockdown approach in vivo showed a crucial impact of BID expression on the execution of ontogenetic programmed cell death (PCD). In contrast, Bcl-XL expression did not impact PCD. Therefore, BID-mediated apoptosis represents a novel cue essential for timing within CG maturation.
abstract_unstemmed	Avian ciliary ganglion (CG) development involves a transient execution phase of apoptosis controlling the final number of neurons, but the time-dependent molecular mechanisms for neuronal cell fate are largely unknown. To elucidate the molecular networks regulating important aspects of parasympathetic neuronal development, a genome-wide expression analysis was performed during multiple stages of avian CG development between embryonic days E6 and E14. The transcriptome data showed a well-defined sequence of events, starting from neuronal migration via neuronal fate cell determination, synaptic transmission, and regulation of synaptic plasticity to growth factor associated signaling. In particular, we extracted a neuronal apoptosis network that characterized the cell death execution phase at E8/E9 and apoptotic cell clearance at E14 by combining the gene time series analysis with network synthesis from the chicken interactome. Network analysis identified TP53 as key regulator and predicted involvement of the BH3 interacting domain death agonist (BID). A virus-based RNAi knockdown approach in vivo showed a crucial impact of BID expression on the execution of ontogenetic programmed cell death (PCD). In contrast, Bcl-XL expression did not impact PCD. Therefore, BID-mediated apoptosis represents a novel cue essential for timing within CG maturation.
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title_short	Bid Expression Network Controls Neuronal Cell Fate During Avian Ciliary Ganglion Development
url	https://doi.org/10.3389/fphys.2018.00797 https://doaj.org/article/3ea2526f7d52483fa371f8ac55dc799e https://www.frontiersin.org/article/10.3389/fphys.2018.00797/full https://doaj.org/toc/1664-042X
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Bid Expression Network Controls Neuronal Cell Fate During Avian Ciliary Ganglion Development

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