The Influence of Transcranial Magnetoacoustic Stimulation Parameters on the Basal Ganglia-Thalamus Neural Network in Parkinson’s Disease

Objective: Parkinson’s disease (PD) is a degenerative disease of the nervous system that frequently occurs in the aged. Transcranial magnetoacoustic stimulation (TMAS) is a neuronal adjustment method that combines sound fields and magnetic fields. It has the characteristics of high spatial resolutio...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Yanqiu Zhang [verfasserIn] Mohan Zhang [verfasserIn] Zichao Ling [verfasserIn] Peiguo Wang [verfasserIn] Xiqi Jian [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	transcranial magnetoacoustic stimulation Parkinson’s disease neural network Hodgkin-Huxley model numerical simulation

Übergeordnetes Werk:	In: Frontiers in Neuroscience - Frontiers Media S.A., 2008, 15(2021)
Übergeordnetes Werk:	volume:15 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnins.2021.761720

Katalog-ID:	DOAJ00618359X

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520			\|a Objective: Parkinson’s disease (PD) is a degenerative disease of the nervous system that frequently occurs in the aged. Transcranial magnetoacoustic stimulation (TMAS) is a neuronal adjustment method that combines sound fields and magnetic fields. It has the characteristics of high spatial resolution and noninvasive deep brain focusing.Methods: This paper constructed a simulation model of TMAS based on volunteer’s skull computer tomography, phased controlled transducer and permanent magnet. It simulates a transcranial focused sound pressure field with the Westervelt equation and builds a basal ganglia and thalamus neural network model in the PD state based on the Hodgkin-Huxley model.Results: A biased sinusoidal pulsed ultrasonic TMAS induced current with 0.3 T static magnetic field induction and 0.2 W⋅cm–2 sound intensity can effectively modulate PD states with RI ≥ 0.633. The magnitude of magnetic induction strength was changed to 0.2 and 0.4 T. The induced current was the same when the sound intensity was 0.4 and 0.1 W⋅cm–2. And the sound pressure level is in the range of −1 dB (the induced current difference is less than or equal to 0.019 μA⋅cm–2). TMAS with a duty cycle of approximately 50% can effectively modulates the error firings in the PD neural network with a relay reliability not less than 0.633.Conclusion: TMAS can modulates the state of PD.
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allfields	10.3389/fnins.2021.761720 doi (DE-627)DOAJ00618359X (DE-599)DOAJae00acec38134c3ba70bcd61e049b3fe DE-627 ger DE-627 rakwb eng RC321-571 Yanqiu Zhang verfasserin aut The Influence of Transcranial Magnetoacoustic Stimulation Parameters on the Basal Ganglia-Thalamus Neural Network in Parkinson’s Disease 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Parkinson’s disease (PD) is a degenerative disease of the nervous system that frequently occurs in the aged. Transcranial magnetoacoustic stimulation (TMAS) is a neuronal adjustment method that combines sound fields and magnetic fields. It has the characteristics of high spatial resolution and noninvasive deep brain focusing.Methods: This paper constructed a simulation model of TMAS based on volunteer’s skull computer tomography, phased controlled transducer and permanent magnet. It simulates a transcranial focused sound pressure field with the Westervelt equation and builds a basal ganglia and thalamus neural network model in the PD state based on the Hodgkin-Huxley model.Results: A biased sinusoidal pulsed ultrasonic TMAS induced current with 0.3 T static magnetic field induction and 0.2 W⋅cm–2 sound intensity can effectively modulate PD states with RI ≥ 0.633. The magnitude of magnetic induction strength was changed to 0.2 and 0.4 T. The induced current was the same when the sound intensity was 0.4 and 0.1 W⋅cm–2. And the sound pressure level is in the range of −1 dB (the induced current difference is less than or equal to 0.019 μA⋅cm–2). TMAS with a duty cycle of approximately 50% can effectively modulates the error firings in the PD neural network with a relay reliability not less than 0.633.Conclusion: TMAS can modulates the state of PD. transcranial magnetoacoustic stimulation Parkinson’s disease neural network Hodgkin-Huxley model numerical simulation Neurosciences. Biological psychiatry. Neuropsychiatry Mohan Zhang verfasserin aut Zichao Ling verfasserin aut Peiguo Wang verfasserin aut Xiqi Jian verfasserin aut In Frontiers in Neuroscience Frontiers Media S.A., 2008 15(2021) (DE-627)55908109X (DE-600)2411902-7 1662453X nnns volume:15 year:2021 https://doi.org/10.3389/fnins.2021.761720 kostenfrei https://doaj.org/article/ae00acec38134c3ba70bcd61e049b3fe kostenfrei https://www.frontiersin.org/articles/10.3389/fnins.2021.761720/full kostenfrei https://doaj.org/toc/1662-453X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2021
spelling	10.3389/fnins.2021.761720 doi (DE-627)DOAJ00618359X (DE-599)DOAJae00acec38134c3ba70bcd61e049b3fe DE-627 ger DE-627 rakwb eng RC321-571 Yanqiu Zhang verfasserin aut The Influence of Transcranial Magnetoacoustic Stimulation Parameters on the Basal Ganglia-Thalamus Neural Network in Parkinson’s Disease 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Parkinson’s disease (PD) is a degenerative disease of the nervous system that frequently occurs in the aged. Transcranial magnetoacoustic stimulation (TMAS) is a neuronal adjustment method that combines sound fields and magnetic fields. It has the characteristics of high spatial resolution and noninvasive deep brain focusing.Methods: This paper constructed a simulation model of TMAS based on volunteer’s skull computer tomography, phased controlled transducer and permanent magnet. It simulates a transcranial focused sound pressure field with the Westervelt equation and builds a basal ganglia and thalamus neural network model in the PD state based on the Hodgkin-Huxley model.Results: A biased sinusoidal pulsed ultrasonic TMAS induced current with 0.3 T static magnetic field induction and 0.2 W⋅cm–2 sound intensity can effectively modulate PD states with RI ≥ 0.633. The magnitude of magnetic induction strength was changed to 0.2 and 0.4 T. The induced current was the same when the sound intensity was 0.4 and 0.1 W⋅cm–2. And the sound pressure level is in the range of −1 dB (the induced current difference is less than or equal to 0.019 μA⋅cm–2). TMAS with a duty cycle of approximately 50% can effectively modulates the error firings in the PD neural network with a relay reliability not less than 0.633.Conclusion: TMAS can modulates the state of PD. transcranial magnetoacoustic stimulation Parkinson’s disease neural network Hodgkin-Huxley model numerical simulation Neurosciences. Biological psychiatry. Neuropsychiatry Mohan Zhang verfasserin aut Zichao Ling verfasserin aut Peiguo Wang verfasserin aut Xiqi Jian verfasserin aut In Frontiers in Neuroscience Frontiers Media S.A., 2008 15(2021) (DE-627)55908109X (DE-600)2411902-7 1662453X nnns volume:15 year:2021 https://doi.org/10.3389/fnins.2021.761720 kostenfrei https://doaj.org/article/ae00acec38134c3ba70bcd61e049b3fe kostenfrei https://www.frontiersin.org/articles/10.3389/fnins.2021.761720/full kostenfrei https://doaj.org/toc/1662-453X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2021
allfields_unstemmed	10.3389/fnins.2021.761720 doi (DE-627)DOAJ00618359X (DE-599)DOAJae00acec38134c3ba70bcd61e049b3fe DE-627 ger DE-627 rakwb eng RC321-571 Yanqiu Zhang verfasserin aut The Influence of Transcranial Magnetoacoustic Stimulation Parameters on the Basal Ganglia-Thalamus Neural Network in Parkinson’s Disease 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Parkinson’s disease (PD) is a degenerative disease of the nervous system that frequently occurs in the aged. Transcranial magnetoacoustic stimulation (TMAS) is a neuronal adjustment method that combines sound fields and magnetic fields. It has the characteristics of high spatial resolution and noninvasive deep brain focusing.Methods: This paper constructed a simulation model of TMAS based on volunteer’s skull computer tomography, phased controlled transducer and permanent magnet. It simulates a transcranial focused sound pressure field with the Westervelt equation and builds a basal ganglia and thalamus neural network model in the PD state based on the Hodgkin-Huxley model.Results: A biased sinusoidal pulsed ultrasonic TMAS induced current with 0.3 T static magnetic field induction and 0.2 W⋅cm–2 sound intensity can effectively modulate PD states with RI ≥ 0.633. The magnitude of magnetic induction strength was changed to 0.2 and 0.4 T. The induced current was the same when the sound intensity was 0.4 and 0.1 W⋅cm–2. And the sound pressure level is in the range of −1 dB (the induced current difference is less than or equal to 0.019 μA⋅cm–2). TMAS with a duty cycle of approximately 50% can effectively modulates the error firings in the PD neural network with a relay reliability not less than 0.633.Conclusion: TMAS can modulates the state of PD. transcranial magnetoacoustic stimulation Parkinson’s disease neural network Hodgkin-Huxley model numerical simulation Neurosciences. Biological psychiatry. Neuropsychiatry Mohan Zhang verfasserin aut Zichao Ling verfasserin aut Peiguo Wang verfasserin aut Xiqi Jian verfasserin aut In Frontiers in Neuroscience Frontiers Media S.A., 2008 15(2021) (DE-627)55908109X (DE-600)2411902-7 1662453X nnns volume:15 year:2021 https://doi.org/10.3389/fnins.2021.761720 kostenfrei https://doaj.org/article/ae00acec38134c3ba70bcd61e049b3fe kostenfrei https://www.frontiersin.org/articles/10.3389/fnins.2021.761720/full kostenfrei https://doaj.org/toc/1662-453X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2021
allfieldsGer	10.3389/fnins.2021.761720 doi (DE-627)DOAJ00618359X (DE-599)DOAJae00acec38134c3ba70bcd61e049b3fe DE-627 ger DE-627 rakwb eng RC321-571 Yanqiu Zhang verfasserin aut The Influence of Transcranial Magnetoacoustic Stimulation Parameters on the Basal Ganglia-Thalamus Neural Network in Parkinson’s Disease 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Parkinson’s disease (PD) is a degenerative disease of the nervous system that frequently occurs in the aged. Transcranial magnetoacoustic stimulation (TMAS) is a neuronal adjustment method that combines sound fields and magnetic fields. It has the characteristics of high spatial resolution and noninvasive deep brain focusing.Methods: This paper constructed a simulation model of TMAS based on volunteer’s skull computer tomography, phased controlled transducer and permanent magnet. It simulates a transcranial focused sound pressure field with the Westervelt equation and builds a basal ganglia and thalamus neural network model in the PD state based on the Hodgkin-Huxley model.Results: A biased sinusoidal pulsed ultrasonic TMAS induced current with 0.3 T static magnetic field induction and 0.2 W⋅cm–2 sound intensity can effectively modulate PD states with RI ≥ 0.633. The magnitude of magnetic induction strength was changed to 0.2 and 0.4 T. The induced current was the same when the sound intensity was 0.4 and 0.1 W⋅cm–2. And the sound pressure level is in the range of −1 dB (the induced current difference is less than or equal to 0.019 μA⋅cm–2). TMAS with a duty cycle of approximately 50% can effectively modulates the error firings in the PD neural network with a relay reliability not less than 0.633.Conclusion: TMAS can modulates the state of PD. transcranial magnetoacoustic stimulation Parkinson’s disease neural network Hodgkin-Huxley model numerical simulation Neurosciences. Biological psychiatry. Neuropsychiatry Mohan Zhang verfasserin aut Zichao Ling verfasserin aut Peiguo Wang verfasserin aut Xiqi Jian verfasserin aut In Frontiers in Neuroscience Frontiers Media S.A., 2008 15(2021) (DE-627)55908109X (DE-600)2411902-7 1662453X nnns volume:15 year:2021 https://doi.org/10.3389/fnins.2021.761720 kostenfrei https://doaj.org/article/ae00acec38134c3ba70bcd61e049b3fe kostenfrei https://www.frontiersin.org/articles/10.3389/fnins.2021.761720/full kostenfrei https://doaj.org/toc/1662-453X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2021
allfieldsSound	10.3389/fnins.2021.761720 doi (DE-627)DOAJ00618359X (DE-599)DOAJae00acec38134c3ba70bcd61e049b3fe DE-627 ger DE-627 rakwb eng RC321-571 Yanqiu Zhang verfasserin aut The Influence of Transcranial Magnetoacoustic Stimulation Parameters on the Basal Ganglia-Thalamus Neural Network in Parkinson’s Disease 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Parkinson’s disease (PD) is a degenerative disease of the nervous system that frequently occurs in the aged. Transcranial magnetoacoustic stimulation (TMAS) is a neuronal adjustment method that combines sound fields and magnetic fields. It has the characteristics of high spatial resolution and noninvasive deep brain focusing.Methods: This paper constructed a simulation model of TMAS based on volunteer’s skull computer tomography, phased controlled transducer and permanent magnet. It simulates a transcranial focused sound pressure field with the Westervelt equation and builds a basal ganglia and thalamus neural network model in the PD state based on the Hodgkin-Huxley model.Results: A biased sinusoidal pulsed ultrasonic TMAS induced current with 0.3 T static magnetic field induction and 0.2 W⋅cm–2 sound intensity can effectively modulate PD states with RI ≥ 0.633. The magnitude of magnetic induction strength was changed to 0.2 and 0.4 T. The induced current was the same when the sound intensity was 0.4 and 0.1 W⋅cm–2. And the sound pressure level is in the range of −1 dB (the induced current difference is less than or equal to 0.019 μA⋅cm–2). TMAS with a duty cycle of approximately 50% can effectively modulates the error firings in the PD neural network with a relay reliability not less than 0.633.Conclusion: TMAS can modulates the state of PD. transcranial magnetoacoustic stimulation Parkinson’s disease neural network Hodgkin-Huxley model numerical simulation Neurosciences. Biological psychiatry. Neuropsychiatry Mohan Zhang verfasserin aut Zichao Ling verfasserin aut Peiguo Wang verfasserin aut Xiqi Jian verfasserin aut In Frontiers in Neuroscience Frontiers Media S.A., 2008 15(2021) (DE-627)55908109X (DE-600)2411902-7 1662453X nnns volume:15 year:2021 https://doi.org/10.3389/fnins.2021.761720 kostenfrei https://doaj.org/article/ae00acec38134c3ba70bcd61e049b3fe kostenfrei https://www.frontiersin.org/articles/10.3389/fnins.2021.761720/full kostenfrei https://doaj.org/toc/1662-453X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2021
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source	In Frontiers in Neuroscience 15(2021) volume:15 year:2021
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topic_facet	transcranial magnetoacoustic stimulation Parkinson’s disease neural network Hodgkin-Huxley model numerical simulation Neurosciences. Biological psychiatry. Neuropsychiatry
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authorswithroles_txt_mv	Yanqiu Zhang @@aut@@ Mohan Zhang @@aut@@ Zichao Ling @@aut@@ Peiguo Wang @@aut@@ Xiqi Jian @@aut@@
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callnumber-first	R - Medicine
author	Yanqiu Zhang
spellingShingle	Yanqiu Zhang misc RC321-571 misc transcranial magnetoacoustic stimulation misc Parkinson’s disease misc neural network misc Hodgkin-Huxley model misc numerical simulation misc Neurosciences. Biological psychiatry. Neuropsychiatry The Influence of Transcranial Magnetoacoustic Stimulation Parameters on the Basal Ganglia-Thalamus Neural Network in Parkinson’s Disease
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topic_title	RC321-571 The Influence of Transcranial Magnetoacoustic Stimulation Parameters on the Basal Ganglia-Thalamus Neural Network in Parkinson’s Disease transcranial magnetoacoustic stimulation Parkinson’s disease neural network Hodgkin-Huxley model numerical simulation
topic	misc RC321-571 misc transcranial magnetoacoustic stimulation misc Parkinson’s disease misc neural network misc Hodgkin-Huxley model misc numerical simulation misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc transcranial magnetoacoustic stimulation misc Parkinson’s disease misc neural network misc Hodgkin-Huxley model misc numerical simulation misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_browse	misc RC321-571 misc transcranial magnetoacoustic stimulation misc Parkinson’s disease misc neural network misc Hodgkin-Huxley model misc numerical simulation misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	The Influence of Transcranial Magnetoacoustic Stimulation Parameters on the Basal Ganglia-Thalamus Neural Network in Parkinson’s Disease
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title_full	The Influence of Transcranial Magnetoacoustic Stimulation Parameters on the Basal Ganglia-Thalamus Neural Network in Parkinson’s Disease
author_sort	Yanqiu Zhang
journal	Frontiers in Neuroscience
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author_browse	Yanqiu Zhang Mohan Zhang Zichao Ling Peiguo Wang Xiqi Jian
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doi_str_mv	10.3389/fnins.2021.761720
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title_sort	influence of transcranial magnetoacoustic stimulation parameters on the basal ganglia-thalamus neural network in parkinson’s disease
callnumber	RC321-571
title_auth	The Influence of Transcranial Magnetoacoustic Stimulation Parameters on the Basal Ganglia-Thalamus Neural Network in Parkinson’s Disease
abstract	Objective: Parkinson’s disease (PD) is a degenerative disease of the nervous system that frequently occurs in the aged. Transcranial magnetoacoustic stimulation (TMAS) is a neuronal adjustment method that combines sound fields and magnetic fields. It has the characteristics of high spatial resolution and noninvasive deep brain focusing.Methods: This paper constructed a simulation model of TMAS based on volunteer’s skull computer tomography, phased controlled transducer and permanent magnet. It simulates a transcranial focused sound pressure field with the Westervelt equation and builds a basal ganglia and thalamus neural network model in the PD state based on the Hodgkin-Huxley model.Results: A biased sinusoidal pulsed ultrasonic TMAS induced current with 0.3 T static magnetic field induction and 0.2 W⋅cm–2 sound intensity can effectively modulate PD states with RI ≥ 0.633. The magnitude of magnetic induction strength was changed to 0.2 and 0.4 T. The induced current was the same when the sound intensity was 0.4 and 0.1 W⋅cm–2. And the sound pressure level is in the range of −1 dB (the induced current difference is less than or equal to 0.019 μA⋅cm–2). TMAS with a duty cycle of approximately 50% can effectively modulates the error firings in the PD neural network with a relay reliability not less than 0.633.Conclusion: TMAS can modulates the state of PD.
abstractGer	Objective: Parkinson’s disease (PD) is a degenerative disease of the nervous system that frequently occurs in the aged. Transcranial magnetoacoustic stimulation (TMAS) is a neuronal adjustment method that combines sound fields and magnetic fields. It has the characteristics of high spatial resolution and noninvasive deep brain focusing.Methods: This paper constructed a simulation model of TMAS based on volunteer’s skull computer tomography, phased controlled transducer and permanent magnet. It simulates a transcranial focused sound pressure field with the Westervelt equation and builds a basal ganglia and thalamus neural network model in the PD state based on the Hodgkin-Huxley model.Results: A biased sinusoidal pulsed ultrasonic TMAS induced current with 0.3 T static magnetic field induction and 0.2 W⋅cm–2 sound intensity can effectively modulate PD states with RI ≥ 0.633. The magnitude of magnetic induction strength was changed to 0.2 and 0.4 T. The induced current was the same when the sound intensity was 0.4 and 0.1 W⋅cm–2. And the sound pressure level is in the range of −1 dB (the induced current difference is less than or equal to 0.019 μA⋅cm–2). TMAS with a duty cycle of approximately 50% can effectively modulates the error firings in the PD neural network with a relay reliability not less than 0.633.Conclusion: TMAS can modulates the state of PD.
abstract_unstemmed	Objective: Parkinson’s disease (PD) is a degenerative disease of the nervous system that frequently occurs in the aged. Transcranial magnetoacoustic stimulation (TMAS) is a neuronal adjustment method that combines sound fields and magnetic fields. It has the characteristics of high spatial resolution and noninvasive deep brain focusing.Methods: This paper constructed a simulation model of TMAS based on volunteer’s skull computer tomography, phased controlled transducer and permanent magnet. It simulates a transcranial focused sound pressure field with the Westervelt equation and builds a basal ganglia and thalamus neural network model in the PD state based on the Hodgkin-Huxley model.Results: A biased sinusoidal pulsed ultrasonic TMAS induced current with 0.3 T static magnetic field induction and 0.2 W⋅cm–2 sound intensity can effectively modulate PD states with RI ≥ 0.633. The magnitude of magnetic induction strength was changed to 0.2 and 0.4 T. The induced current was the same when the sound intensity was 0.4 and 0.1 W⋅cm–2. And the sound pressure level is in the range of −1 dB (the induced current difference is less than or equal to 0.019 μA⋅cm–2). TMAS with a duty cycle of approximately 50% can effectively modulates the error firings in the PD neural network with a relay reliability not less than 0.633.Conclusion: TMAS can modulates the state of PD.
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title_short	The Influence of Transcranial Magnetoacoustic Stimulation Parameters on the Basal Ganglia-Thalamus Neural Network in Parkinson’s Disease
url	https://doi.org/10.3389/fnins.2021.761720 https://doaj.org/article/ae00acec38134c3ba70bcd61e049b3fe https://www.frontiersin.org/articles/10.3389/fnins.2021.761720/full https://doaj.org/toc/1662-453X
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author2	Mohan Zhang Zichao Ling Peiguo Wang Xiqi Jian
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up_date	2024-07-03T19:27:47.491Z
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The Influence of Transcranial Magnetoacoustic Stimulation Parameters on the Basal Ganglia-Thalamus Neural Network in Parkinson’s Disease

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