Feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model

Purpose: To evaluate the feasibility and assess safety parameters of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated hyperthermia (HT; heating to 40–45 °C) in various pelvic targets in a porcine model in vivo. Methods: Thirteen HT treatments were performed in six pigs...
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Autor*in:	Lifei Zhu [verfasserIn] Ari Partanen [verfasserIn] Michael R. Talcott [verfasserIn] H. Michael Gach [verfasserIn] Suellen C. Greco [verfasserIn] Lauren E. Henke [verfasserIn] Jessika A. Contreras [verfasserIn] Imran Zoberi [verfasserIn] Dennis E. Hallahan [verfasserIn] Hong Chen [verfasserIn] Michael B. Altman [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	hifu hyperthermia mr thermometry mr-guided hifu image-guided therapy

Übergeordnetes Werk:	In: International Journal of Hyperthermia - Taylor & Francis Group, 2019, 36(2019), 1, Seite 1146-1158
Übergeordnetes Werk:	volume:36 ; year:2019 ; number:1 ; pages:1146-1158

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/02656736.2019.1685684

Katalog-ID:	DOAJ006262058

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520			\|a Purpose: To evaluate the feasibility and assess safety parameters of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated hyperthermia (HT; heating to 40–45 °C) in various pelvic targets in a porcine model in vivo. Methods: Thirteen HT treatments were performed in six pigs with a commercial MRgHIFU system (Sonalleve V2, Profound Medical Inc., Mississauga, Canada) to muscle adjacent to the ventral/dorsal bladder wall and uterus to administer 42 °C (±1°) for 30 min (±5%) using an 18-mm target diameter and 100 W power. Feasibility was assessed using accuracy, uniformity, and MR-thermometry performance-based metrics. Safety parameters were assessed for tissues in the targets and beam-path by contrast-enhanced MRI, gross-pathology and histopathology. Results: Across all HT sessions, the mean difference between average temperature (Tavg) and the target temperature within the target region-of-interest (tROI, the cross-section of the heated volume at focal depth) was 0.51 ± 0.33 °C. Within the tROI, the temperature standard deviation averaged 1.55 ± 0.31 °C, the average 30-min Tavg variation was 0.80 ± 0.17 °C, and the maximum difference between Tavg and the 10th- or 90th-percentile temperature averaged 2.01 ± 0.44 °C. The average time to reach ≥41 °C and cool to ≤40 °C within the tROI at the beginning and end of treatment was 47.25 ± 27.47 s and 66.37 ± 62.68 s, respectively. Compared to unheated controls, no abnormally-perfused tissue or permanent damage was evident in the MR images, gross pathology or histological analysis. Conclusions: MRgHIFU-mediated HT is feasible and safety assessment is satisfactory for treating an array of clinically-mimicking pelvic geometries in a porcine model in vivo, implying the technique may have utility in treating pelvic targets in human patients.
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allfields	10.1080/02656736.2019.1685684 doi (DE-627)DOAJ006262058 (DE-599)DOAJd514533e02ca49e18c61f02e7aa54e4e DE-627 ger DE-627 rakwb eng R855-855.5 Lifei Zhu verfasserin aut Feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: To evaluate the feasibility and assess safety parameters of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated hyperthermia (HT; heating to 40–45 °C) in various pelvic targets in a porcine model in vivo. Methods: Thirteen HT treatments were performed in six pigs with a commercial MRgHIFU system (Sonalleve V2, Profound Medical Inc., Mississauga, Canada) to muscle adjacent to the ventral/dorsal bladder wall and uterus to administer 42 °C (±1°) for 30 min (±5%) using an 18-mm target diameter and 100 W power. Feasibility was assessed using accuracy, uniformity, and MR-thermometry performance-based metrics. Safety parameters were assessed for tissues in the targets and beam-path by contrast-enhanced MRI, gross-pathology and histopathology. Results: Across all HT sessions, the mean difference between average temperature (Tavg) and the target temperature within the target region-of-interest (tROI, the cross-section of the heated volume at focal depth) was 0.51 ± 0.33 °C. Within the tROI, the temperature standard deviation averaged 1.55 ± 0.31 °C, the average 30-min Tavg variation was 0.80 ± 0.17 °C, and the maximum difference between Tavg and the 10th- or 90th-percentile temperature averaged 2.01 ± 0.44 °C. The average time to reach ≥41 °C and cool to ≤40 °C within the tROI at the beginning and end of treatment was 47.25 ± 27.47 s and 66.37 ± 62.68 s, respectively. Compared to unheated controls, no abnormally-perfused tissue or permanent damage was evident in the MR images, gross pathology or histological analysis. Conclusions: MRgHIFU-mediated HT is feasible and safety assessment is satisfactory for treating an array of clinically-mimicking pelvic geometries in a porcine model in vivo, implying the technique may have utility in treating pelvic targets in human patients. hifu hyperthermia mr thermometry mr-guided hifu image-guided therapy Medical technology Ari Partanen verfasserin aut Michael R. Talcott verfasserin aut H. Michael Gach verfasserin aut Suellen C. Greco verfasserin aut Lauren E. Henke verfasserin aut Jessika A. Contreras verfasserin aut Imran Zoberi verfasserin aut Dennis E. Hallahan verfasserin aut Hong Chen verfasserin aut Michael B. Altman verfasserin aut In International Journal of Hyperthermia Taylor & Francis Group, 2019 36(2019), 1, Seite 1146-1158 (DE-627)899027342 (DE-600)2907482-4 14645157 nnns volume:36 year:2019 number:1 pages:1146-1158 https://doi.org/10.1080/02656736.2019.1685684 kostenfrei https://doaj.org/article/d514533e02ca49e18c61f02e7aa54e4e kostenfrei http://dx.doi.org/10.1080/02656736.2019.1685684 kostenfrei https://doaj.org/toc/0265-6736 Journal toc kostenfrei https://doaj.org/toc/1464-5157 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 36 2019 1 1146-1158
spelling	10.1080/02656736.2019.1685684 doi (DE-627)DOAJ006262058 (DE-599)DOAJd514533e02ca49e18c61f02e7aa54e4e DE-627 ger DE-627 rakwb eng R855-855.5 Lifei Zhu verfasserin aut Feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: To evaluate the feasibility and assess safety parameters of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated hyperthermia (HT; heating to 40–45 °C) in various pelvic targets in a porcine model in vivo. Methods: Thirteen HT treatments were performed in six pigs with a commercial MRgHIFU system (Sonalleve V2, Profound Medical Inc., Mississauga, Canada) to muscle adjacent to the ventral/dorsal bladder wall and uterus to administer 42 °C (±1°) for 30 min (±5%) using an 18-mm target diameter and 100 W power. Feasibility was assessed using accuracy, uniformity, and MR-thermometry performance-based metrics. Safety parameters were assessed for tissues in the targets and beam-path by contrast-enhanced MRI, gross-pathology and histopathology. Results: Across all HT sessions, the mean difference between average temperature (Tavg) and the target temperature within the target region-of-interest (tROI, the cross-section of the heated volume at focal depth) was 0.51 ± 0.33 °C. Within the tROI, the temperature standard deviation averaged 1.55 ± 0.31 °C, the average 30-min Tavg variation was 0.80 ± 0.17 °C, and the maximum difference between Tavg and the 10th- or 90th-percentile temperature averaged 2.01 ± 0.44 °C. The average time to reach ≥41 °C and cool to ≤40 °C within the tROI at the beginning and end of treatment was 47.25 ± 27.47 s and 66.37 ± 62.68 s, respectively. Compared to unheated controls, no abnormally-perfused tissue or permanent damage was evident in the MR images, gross pathology or histological analysis. Conclusions: MRgHIFU-mediated HT is feasible and safety assessment is satisfactory for treating an array of clinically-mimicking pelvic geometries in a porcine model in vivo, implying the technique may have utility in treating pelvic targets in human patients. hifu hyperthermia mr thermometry mr-guided hifu image-guided therapy Medical technology Ari Partanen verfasserin aut Michael R. Talcott verfasserin aut H. Michael Gach verfasserin aut Suellen C. Greco verfasserin aut Lauren E. Henke verfasserin aut Jessika A. Contreras verfasserin aut Imran Zoberi verfasserin aut Dennis E. Hallahan verfasserin aut Hong Chen verfasserin aut Michael B. Altman verfasserin aut In International Journal of Hyperthermia Taylor & Francis Group, 2019 36(2019), 1, Seite 1146-1158 (DE-627)899027342 (DE-600)2907482-4 14645157 nnns volume:36 year:2019 number:1 pages:1146-1158 https://doi.org/10.1080/02656736.2019.1685684 kostenfrei https://doaj.org/article/d514533e02ca49e18c61f02e7aa54e4e kostenfrei http://dx.doi.org/10.1080/02656736.2019.1685684 kostenfrei https://doaj.org/toc/0265-6736 Journal toc kostenfrei https://doaj.org/toc/1464-5157 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 36 2019 1 1146-1158
allfields_unstemmed	10.1080/02656736.2019.1685684 doi (DE-627)DOAJ006262058 (DE-599)DOAJd514533e02ca49e18c61f02e7aa54e4e DE-627 ger DE-627 rakwb eng R855-855.5 Lifei Zhu verfasserin aut Feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: To evaluate the feasibility and assess safety parameters of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated hyperthermia (HT; heating to 40–45 °C) in various pelvic targets in a porcine model in vivo. Methods: Thirteen HT treatments were performed in six pigs with a commercial MRgHIFU system (Sonalleve V2, Profound Medical Inc., Mississauga, Canada) to muscle adjacent to the ventral/dorsal bladder wall and uterus to administer 42 °C (±1°) for 30 min (±5%) using an 18-mm target diameter and 100 W power. Feasibility was assessed using accuracy, uniformity, and MR-thermometry performance-based metrics. Safety parameters were assessed for tissues in the targets and beam-path by contrast-enhanced MRI, gross-pathology and histopathology. Results: Across all HT sessions, the mean difference between average temperature (Tavg) and the target temperature within the target region-of-interest (tROI, the cross-section of the heated volume at focal depth) was 0.51 ± 0.33 °C. Within the tROI, the temperature standard deviation averaged 1.55 ± 0.31 °C, the average 30-min Tavg variation was 0.80 ± 0.17 °C, and the maximum difference between Tavg and the 10th- or 90th-percentile temperature averaged 2.01 ± 0.44 °C. The average time to reach ≥41 °C and cool to ≤40 °C within the tROI at the beginning and end of treatment was 47.25 ± 27.47 s and 66.37 ± 62.68 s, respectively. Compared to unheated controls, no abnormally-perfused tissue or permanent damage was evident in the MR images, gross pathology or histological analysis. Conclusions: MRgHIFU-mediated HT is feasible and safety assessment is satisfactory for treating an array of clinically-mimicking pelvic geometries in a porcine model in vivo, implying the technique may have utility in treating pelvic targets in human patients. hifu hyperthermia mr thermometry mr-guided hifu image-guided therapy Medical technology Ari Partanen verfasserin aut Michael R. Talcott verfasserin aut H. Michael Gach verfasserin aut Suellen C. Greco verfasserin aut Lauren E. Henke verfasserin aut Jessika A. Contreras verfasserin aut Imran Zoberi verfasserin aut Dennis E. Hallahan verfasserin aut Hong Chen verfasserin aut Michael B. Altman verfasserin aut In International Journal of Hyperthermia Taylor & Francis Group, 2019 36(2019), 1, Seite 1146-1158 (DE-627)899027342 (DE-600)2907482-4 14645157 nnns volume:36 year:2019 number:1 pages:1146-1158 https://doi.org/10.1080/02656736.2019.1685684 kostenfrei https://doaj.org/article/d514533e02ca49e18c61f02e7aa54e4e kostenfrei http://dx.doi.org/10.1080/02656736.2019.1685684 kostenfrei https://doaj.org/toc/0265-6736 Journal toc kostenfrei https://doaj.org/toc/1464-5157 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 36 2019 1 1146-1158
allfieldsGer	10.1080/02656736.2019.1685684 doi (DE-627)DOAJ006262058 (DE-599)DOAJd514533e02ca49e18c61f02e7aa54e4e DE-627 ger DE-627 rakwb eng R855-855.5 Lifei Zhu verfasserin aut Feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: To evaluate the feasibility and assess safety parameters of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated hyperthermia (HT; heating to 40–45 °C) in various pelvic targets in a porcine model in vivo. Methods: Thirteen HT treatments were performed in six pigs with a commercial MRgHIFU system (Sonalleve V2, Profound Medical Inc., Mississauga, Canada) to muscle adjacent to the ventral/dorsal bladder wall and uterus to administer 42 °C (±1°) for 30 min (±5%) using an 18-mm target diameter and 100 W power. Feasibility was assessed using accuracy, uniformity, and MR-thermometry performance-based metrics. Safety parameters were assessed for tissues in the targets and beam-path by contrast-enhanced MRI, gross-pathology and histopathology. Results: Across all HT sessions, the mean difference between average temperature (Tavg) and the target temperature within the target region-of-interest (tROI, the cross-section of the heated volume at focal depth) was 0.51 ± 0.33 °C. Within the tROI, the temperature standard deviation averaged 1.55 ± 0.31 °C, the average 30-min Tavg variation was 0.80 ± 0.17 °C, and the maximum difference between Tavg and the 10th- or 90th-percentile temperature averaged 2.01 ± 0.44 °C. The average time to reach ≥41 °C and cool to ≤40 °C within the tROI at the beginning and end of treatment was 47.25 ± 27.47 s and 66.37 ± 62.68 s, respectively. Compared to unheated controls, no abnormally-perfused tissue or permanent damage was evident in the MR images, gross pathology or histological analysis. Conclusions: MRgHIFU-mediated HT is feasible and safety assessment is satisfactory for treating an array of clinically-mimicking pelvic geometries in a porcine model in vivo, implying the technique may have utility in treating pelvic targets in human patients. hifu hyperthermia mr thermometry mr-guided hifu image-guided therapy Medical technology Ari Partanen verfasserin aut Michael R. Talcott verfasserin aut H. Michael Gach verfasserin aut Suellen C. Greco verfasserin aut Lauren E. Henke verfasserin aut Jessika A. Contreras verfasserin aut Imran Zoberi verfasserin aut Dennis E. Hallahan verfasserin aut Hong Chen verfasserin aut Michael B. Altman verfasserin aut In International Journal of Hyperthermia Taylor & Francis Group, 2019 36(2019), 1, Seite 1146-1158 (DE-627)899027342 (DE-600)2907482-4 14645157 nnns volume:36 year:2019 number:1 pages:1146-1158 https://doi.org/10.1080/02656736.2019.1685684 kostenfrei https://doaj.org/article/d514533e02ca49e18c61f02e7aa54e4e kostenfrei http://dx.doi.org/10.1080/02656736.2019.1685684 kostenfrei https://doaj.org/toc/0265-6736 Journal toc kostenfrei https://doaj.org/toc/1464-5157 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 36 2019 1 1146-1158
allfieldsSound	10.1080/02656736.2019.1685684 doi (DE-627)DOAJ006262058 (DE-599)DOAJd514533e02ca49e18c61f02e7aa54e4e DE-627 ger DE-627 rakwb eng R855-855.5 Lifei Zhu verfasserin aut Feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: To evaluate the feasibility and assess safety parameters of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated hyperthermia (HT; heating to 40–45 °C) in various pelvic targets in a porcine model in vivo. Methods: Thirteen HT treatments were performed in six pigs with a commercial MRgHIFU system (Sonalleve V2, Profound Medical Inc., Mississauga, Canada) to muscle adjacent to the ventral/dorsal bladder wall and uterus to administer 42 °C (±1°) for 30 min (±5%) using an 18-mm target diameter and 100 W power. Feasibility was assessed using accuracy, uniformity, and MR-thermometry performance-based metrics. Safety parameters were assessed for tissues in the targets and beam-path by contrast-enhanced MRI, gross-pathology and histopathology. Results: Across all HT sessions, the mean difference between average temperature (Tavg) and the target temperature within the target region-of-interest (tROI, the cross-section of the heated volume at focal depth) was 0.51 ± 0.33 °C. Within the tROI, the temperature standard deviation averaged 1.55 ± 0.31 °C, the average 30-min Tavg variation was 0.80 ± 0.17 °C, and the maximum difference between Tavg and the 10th- or 90th-percentile temperature averaged 2.01 ± 0.44 °C. The average time to reach ≥41 °C and cool to ≤40 °C within the tROI at the beginning and end of treatment was 47.25 ± 27.47 s and 66.37 ± 62.68 s, respectively. Compared to unheated controls, no abnormally-perfused tissue or permanent damage was evident in the MR images, gross pathology or histological analysis. Conclusions: MRgHIFU-mediated HT is feasible and safety assessment is satisfactory for treating an array of clinically-mimicking pelvic geometries in a porcine model in vivo, implying the technique may have utility in treating pelvic targets in human patients. hifu hyperthermia mr thermometry mr-guided hifu image-guided therapy Medical technology Ari Partanen verfasserin aut Michael R. Talcott verfasserin aut H. Michael Gach verfasserin aut Suellen C. Greco verfasserin aut Lauren E. Henke verfasserin aut Jessika A. Contreras verfasserin aut Imran Zoberi verfasserin aut Dennis E. Hallahan verfasserin aut Hong Chen verfasserin aut Michael B. Altman verfasserin aut In International Journal of Hyperthermia Taylor & Francis Group, 2019 36(2019), 1, Seite 1146-1158 (DE-627)899027342 (DE-600)2907482-4 14645157 nnns volume:36 year:2019 number:1 pages:1146-1158 https://doi.org/10.1080/02656736.2019.1685684 kostenfrei https://doaj.org/article/d514533e02ca49e18c61f02e7aa54e4e kostenfrei http://dx.doi.org/10.1080/02656736.2019.1685684 kostenfrei https://doaj.org/toc/0265-6736 Journal toc kostenfrei https://doaj.org/toc/1464-5157 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 36 2019 1 1146-1158
language	English
source	In International Journal of Hyperthermia 36(2019), 1, Seite 1146-1158 volume:36 year:2019 number:1 pages:1146-1158
sourceStr	In International Journal of Hyperthermia 36(2019), 1, Seite 1146-1158 volume:36 year:2019 number:1 pages:1146-1158
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	hifu hyperthermia mr thermometry mr-guided hifu image-guided therapy Medical technology
isfreeaccess_bool	true
container_title	International Journal of Hyperthermia
authorswithroles_txt_mv	Lifei Zhu @@aut@@ Ari Partanen @@aut@@ Michael R. Talcott @@aut@@ H. Michael Gach @@aut@@ Suellen C. Greco @@aut@@ Lauren E. Henke @@aut@@ Jessika A. Contreras @@aut@@ Imran Zoberi @@aut@@ Dennis E. Hallahan @@aut@@ Hong Chen @@aut@@ Michael B. Altman @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	899027342
id	DOAJ006262058
language_de	englisch
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Methods: Thirteen HT treatments were performed in six pigs with a commercial MRgHIFU system (Sonalleve V2, Profound Medical Inc., Mississauga, Canada) to muscle adjacent to the ventral/dorsal bladder wall and uterus to administer 42 °C (±1°) for 30 min (±5%) using an 18-mm target diameter and 100 W power. Feasibility was assessed using accuracy, uniformity, and MR-thermometry performance-based metrics. Safety parameters were assessed for tissues in the targets and beam-path by contrast-enhanced MRI, gross-pathology and histopathology. Results: Across all HT sessions, the mean difference between average temperature (Tavg) and the target temperature within the target region-of-interest (tROI, the cross-section of the heated volume at focal depth) was 0.51 ± 0.33 °C. Within the tROI, the temperature standard deviation averaged 1.55 ± 0.31 °C, the average 30-min Tavg variation was 0.80 ± 0.17 °C, and the maximum difference between Tavg and the 10th- or 90th-percentile temperature averaged 2.01 ± 0.44 °C. The average time to reach ≥41 °C and cool to ≤40 °C within the tROI at the beginning and end of treatment was 47.25 ± 27.47 s and 66.37 ± 62.68 s, respectively. Compared to unheated controls, no abnormally-perfused tissue or permanent damage was evident in the MR images, gross pathology or histological analysis. 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callnumber-first	R - Medicine
author	Lifei Zhu
spellingShingle	Lifei Zhu misc R855-855.5 misc hifu misc hyperthermia misc mr thermometry misc mr-guided hifu misc image-guided therapy misc Medical technology Feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model
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topic_title	R855-855.5 Feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model hifu hyperthermia mr thermometry mr-guided hifu image-guided therapy
topic	misc R855-855.5 misc hifu misc hyperthermia misc mr thermometry misc mr-guided hifu misc image-guided therapy misc Medical technology
topic_unstemmed	misc R855-855.5 misc hifu misc hyperthermia misc mr thermometry misc mr-guided hifu misc image-guided therapy misc Medical technology
topic_browse	misc R855-855.5 misc hifu misc hyperthermia misc mr thermometry misc mr-guided hifu misc image-guided therapy misc Medical technology
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title	Feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model
ctrlnum	(DE-627)DOAJ006262058 (DE-599)DOAJd514533e02ca49e18c61f02e7aa54e4e
title_full	Feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model
author_sort	Lifei Zhu
journal	International Journal of Hyperthermia
journalStr	International Journal of Hyperthermia
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lang_code	eng
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author_browse	Lifei Zhu Ari Partanen Michael R. Talcott H. Michael Gach Suellen C. Greco Lauren E. Henke Jessika A. Contreras Imran Zoberi Dennis E. Hallahan Hong Chen Michael B. Altman
container_volume	36
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author-letter	Lifei Zhu
doi_str_mv	10.1080/02656736.2019.1685684
author2-role	verfasserin
title_sort	feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (mrghifu)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model
callnumber	R855-855.5
title_auth	Feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model
abstract	Purpose: To evaluate the feasibility and assess safety parameters of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated hyperthermia (HT; heating to 40–45 °C) in various pelvic targets in a porcine model in vivo. Methods: Thirteen HT treatments were performed in six pigs with a commercial MRgHIFU system (Sonalleve V2, Profound Medical Inc., Mississauga, Canada) to muscle adjacent to the ventral/dorsal bladder wall and uterus to administer 42 °C (±1°) for 30 min (±5%) using an 18-mm target diameter and 100 W power. Feasibility was assessed using accuracy, uniformity, and MR-thermometry performance-based metrics. Safety parameters were assessed for tissues in the targets and beam-path by contrast-enhanced MRI, gross-pathology and histopathology. Results: Across all HT sessions, the mean difference between average temperature (Tavg) and the target temperature within the target region-of-interest (tROI, the cross-section of the heated volume at focal depth) was 0.51 ± 0.33 °C. Within the tROI, the temperature standard deviation averaged 1.55 ± 0.31 °C, the average 30-min Tavg variation was 0.80 ± 0.17 °C, and the maximum difference between Tavg and the 10th- or 90th-percentile temperature averaged 2.01 ± 0.44 °C. The average time to reach ≥41 °C and cool to ≤40 °C within the tROI at the beginning and end of treatment was 47.25 ± 27.47 s and 66.37 ± 62.68 s, respectively. Compared to unheated controls, no abnormally-perfused tissue or permanent damage was evident in the MR images, gross pathology or histological analysis. Conclusions: MRgHIFU-mediated HT is feasible and safety assessment is satisfactory for treating an array of clinically-mimicking pelvic geometries in a porcine model in vivo, implying the technique may have utility in treating pelvic targets in human patients.
abstractGer	Purpose: To evaluate the feasibility and assess safety parameters of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated hyperthermia (HT; heating to 40–45 °C) in various pelvic targets in a porcine model in vivo. Methods: Thirteen HT treatments were performed in six pigs with a commercial MRgHIFU system (Sonalleve V2, Profound Medical Inc., Mississauga, Canada) to muscle adjacent to the ventral/dorsal bladder wall and uterus to administer 42 °C (±1°) for 30 min (±5%) using an 18-mm target diameter and 100 W power. Feasibility was assessed using accuracy, uniformity, and MR-thermometry performance-based metrics. Safety parameters were assessed for tissues in the targets and beam-path by contrast-enhanced MRI, gross-pathology and histopathology. Results: Across all HT sessions, the mean difference between average temperature (Tavg) and the target temperature within the target region-of-interest (tROI, the cross-section of the heated volume at focal depth) was 0.51 ± 0.33 °C. Within the tROI, the temperature standard deviation averaged 1.55 ± 0.31 °C, the average 30-min Tavg variation was 0.80 ± 0.17 °C, and the maximum difference between Tavg and the 10th- or 90th-percentile temperature averaged 2.01 ± 0.44 °C. The average time to reach ≥41 °C and cool to ≤40 °C within the tROI at the beginning and end of treatment was 47.25 ± 27.47 s and 66.37 ± 62.68 s, respectively. Compared to unheated controls, no abnormally-perfused tissue or permanent damage was evident in the MR images, gross pathology or histological analysis. Conclusions: MRgHIFU-mediated HT is feasible and safety assessment is satisfactory for treating an array of clinically-mimicking pelvic geometries in a porcine model in vivo, implying the technique may have utility in treating pelvic targets in human patients.
abstract_unstemmed	Purpose: To evaluate the feasibility and assess safety parameters of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated hyperthermia (HT; heating to 40–45 °C) in various pelvic targets in a porcine model in vivo. Methods: Thirteen HT treatments were performed in six pigs with a commercial MRgHIFU system (Sonalleve V2, Profound Medical Inc., Mississauga, Canada) to muscle adjacent to the ventral/dorsal bladder wall and uterus to administer 42 °C (±1°) for 30 min (±5%) using an 18-mm target diameter and 100 W power. Feasibility was assessed using accuracy, uniformity, and MR-thermometry performance-based metrics. Safety parameters were assessed for tissues in the targets and beam-path by contrast-enhanced MRI, gross-pathology and histopathology. Results: Across all HT sessions, the mean difference between average temperature (Tavg) and the target temperature within the target region-of-interest (tROI, the cross-section of the heated volume at focal depth) was 0.51 ± 0.33 °C. Within the tROI, the temperature standard deviation averaged 1.55 ± 0.31 °C, the average 30-min Tavg variation was 0.80 ± 0.17 °C, and the maximum difference between Tavg and the 10th- or 90th-percentile temperature averaged 2.01 ± 0.44 °C. The average time to reach ≥41 °C and cool to ≤40 °C within the tROI at the beginning and end of treatment was 47.25 ± 27.47 s and 66.37 ± 62.68 s, respectively. Compared to unheated controls, no abnormally-perfused tissue or permanent damage was evident in the MR images, gross pathology or histological analysis. Conclusions: MRgHIFU-mediated HT is feasible and safety assessment is satisfactory for treating an array of clinically-mimicking pelvic geometries in a porcine model in vivo, implying the technique may have utility in treating pelvic targets in human patients.
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title_short	Feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model
url	https://doi.org/10.1080/02656736.2019.1685684 https://doaj.org/article/d514533e02ca49e18c61f02e7aa54e4e http://dx.doi.org/10.1080/02656736.2019.1685684 https://doaj.org/toc/0265-6736 https://doaj.org/toc/1464-5157
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author2	Ari Partanen Michael R. Talcott H. Michael Gach Suellen C. Greco Lauren E. Henke Jessika A. Contreras Imran Zoberi Dennis E. Hallahan Hong Chen Michael B. Altman
author2Str	Ari Partanen Michael R. Talcott H. Michael Gach Suellen C. Greco Lauren E. Henke Jessika A. Contreras Imran Zoberi Dennis E. Hallahan Hong Chen Michael B. Altman
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up_date	2024-07-03T19:55:20.112Z
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Feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model

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