An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5

The Nucleosome Remodeling and Deacetylase (NuRD) complex is a chromatin regulatory complex that functions as a transcriptional co-repressor in metazoans. The NuRD subunit MBD3 is essential for targeting and assembly of a functional NuRD complex as well as embryonic stem cell (ESC) pluripotency. Thre...
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Autor*in:	Ly-Sha Ee [verfasserIn] Kurtis N. McCannell [verfasserIn] Yang Tang [verfasserIn] Nancy Fernandes [verfasserIn] W. Rod Hardy [verfasserIn] Michael R. Green [verfasserIn] Feixia Chu [verfasserIn] Thomas G. Fazzio [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	NuRD Mbd3 Wdr5 chromatin differentiation

Übergeordnetes Werk:	In: Stem Cell Reports - Elsevier, 2015, 8(2017), 6, Seite 1488-1496
Übergeordnetes Werk:	volume:8 ; year:2017 ; number:6 ; pages:1488-1496

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.stemcr.2017.04.020

Katalog-ID:	DOAJ006404200

Internformat


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520			\|a The Nucleosome Remodeling and Deacetylase (NuRD) complex is a chromatin regulatory complex that functions as a transcriptional co-repressor in metazoans. The NuRD subunit MBD3 is essential for targeting and assembly of a functional NuRD complex as well as embryonic stem cell (ESC) pluripotency. Three MBD3 isoforms (MBD3A, MBD3B, and MBD3C) are expressed in mouse. Here, we find that the MBD3C isoform contains a unique 50-amino-acid N-terminal region that is necessary for MBD3C to specifically interact with the histone H3 binding protein WDR5. Domain analyses of WDR5 reveal that the H3 binding pocket is required for interaction with MBD3C. We find that while Mbd3c knockout ESCs differentiate normally, MBD3C is redundant with the MBD3A and MBD3B isoforms in regulation of gene expression, with the unique MBD3C N terminus required for this redundancy. Together, our data characterize a unique NuRD complex variant that functions specifically in ESCs.
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allfields	10.1016/j.stemcr.2017.04.020 doi (DE-627)DOAJ006404200 (DE-599)DOAJf8e6ef562d6546779d980cf547c22c37 DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 Ly-Sha Ee verfasserin aut An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Nucleosome Remodeling and Deacetylase (NuRD) complex is a chromatin regulatory complex that functions as a transcriptional co-repressor in metazoans. The NuRD subunit MBD3 is essential for targeting and assembly of a functional NuRD complex as well as embryonic stem cell (ESC) pluripotency. Three MBD3 isoforms (MBD3A, MBD3B, and MBD3C) are expressed in mouse. Here, we find that the MBD3C isoform contains a unique 50-amino-acid N-terminal region that is necessary for MBD3C to specifically interact with the histone H3 binding protein WDR5. Domain analyses of WDR5 reveal that the H3 binding pocket is required for interaction with MBD3C. We find that while Mbd3c knockout ESCs differentiate normally, MBD3C is redundant with the MBD3A and MBD3B isoforms in regulation of gene expression, with the unique MBD3C N terminus required for this redundancy. Together, our data characterize a unique NuRD complex variant that functions specifically in ESCs. NuRD Mbd3 Wdr5 chromatin differentiation Medicine (General) Biology (General) Kurtis N. McCannell verfasserin aut Yang Tang verfasserin aut Nancy Fernandes verfasserin aut W. Rod Hardy verfasserin aut Michael R. Green verfasserin aut Feixia Chu verfasserin aut Thomas G. Fazzio verfasserin aut In Stem Cell Reports Elsevier, 2015 8(2017), 6, Seite 1488-1496 (DE-627)749730862 (DE-600)2720528-9 22136711 nnns volume:8 year:2017 number:6 pages:1488-1496 https://doi.org/10.1016/j.stemcr.2017.04.020 kostenfrei https://doaj.org/article/f8e6ef562d6546779d980cf547c22c37 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213671117301741 kostenfrei https://doaj.org/toc/2213-6711 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 8 2017 6 1488-1496
spelling	10.1016/j.stemcr.2017.04.020 doi (DE-627)DOAJ006404200 (DE-599)DOAJf8e6ef562d6546779d980cf547c22c37 DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 Ly-Sha Ee verfasserin aut An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Nucleosome Remodeling and Deacetylase (NuRD) complex is a chromatin regulatory complex that functions as a transcriptional co-repressor in metazoans. The NuRD subunit MBD3 is essential for targeting and assembly of a functional NuRD complex as well as embryonic stem cell (ESC) pluripotency. Three MBD3 isoforms (MBD3A, MBD3B, and MBD3C) are expressed in mouse. Here, we find that the MBD3C isoform contains a unique 50-amino-acid N-terminal region that is necessary for MBD3C to specifically interact with the histone H3 binding protein WDR5. Domain analyses of WDR5 reveal that the H3 binding pocket is required for interaction with MBD3C. We find that while Mbd3c knockout ESCs differentiate normally, MBD3C is redundant with the MBD3A and MBD3B isoforms in regulation of gene expression, with the unique MBD3C N terminus required for this redundancy. Together, our data characterize a unique NuRD complex variant that functions specifically in ESCs. NuRD Mbd3 Wdr5 chromatin differentiation Medicine (General) Biology (General) Kurtis N. McCannell verfasserin aut Yang Tang verfasserin aut Nancy Fernandes verfasserin aut W. Rod Hardy verfasserin aut Michael R. Green verfasserin aut Feixia Chu verfasserin aut Thomas G. Fazzio verfasserin aut In Stem Cell Reports Elsevier, 2015 8(2017), 6, Seite 1488-1496 (DE-627)749730862 (DE-600)2720528-9 22136711 nnns volume:8 year:2017 number:6 pages:1488-1496 https://doi.org/10.1016/j.stemcr.2017.04.020 kostenfrei https://doaj.org/article/f8e6ef562d6546779d980cf547c22c37 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213671117301741 kostenfrei https://doaj.org/toc/2213-6711 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 8 2017 6 1488-1496
allfields_unstemmed	10.1016/j.stemcr.2017.04.020 doi (DE-627)DOAJ006404200 (DE-599)DOAJf8e6ef562d6546779d980cf547c22c37 DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 Ly-Sha Ee verfasserin aut An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Nucleosome Remodeling and Deacetylase (NuRD) complex is a chromatin regulatory complex that functions as a transcriptional co-repressor in metazoans. The NuRD subunit MBD3 is essential for targeting and assembly of a functional NuRD complex as well as embryonic stem cell (ESC) pluripotency. Three MBD3 isoforms (MBD3A, MBD3B, and MBD3C) are expressed in mouse. Here, we find that the MBD3C isoform contains a unique 50-amino-acid N-terminal region that is necessary for MBD3C to specifically interact with the histone H3 binding protein WDR5. Domain analyses of WDR5 reveal that the H3 binding pocket is required for interaction with MBD3C. We find that while Mbd3c knockout ESCs differentiate normally, MBD3C is redundant with the MBD3A and MBD3B isoforms in regulation of gene expression, with the unique MBD3C N terminus required for this redundancy. Together, our data characterize a unique NuRD complex variant that functions specifically in ESCs. NuRD Mbd3 Wdr5 chromatin differentiation Medicine (General) Biology (General) Kurtis N. McCannell verfasserin aut Yang Tang verfasserin aut Nancy Fernandes verfasserin aut W. Rod Hardy verfasserin aut Michael R. Green verfasserin aut Feixia Chu verfasserin aut Thomas G. Fazzio verfasserin aut In Stem Cell Reports Elsevier, 2015 8(2017), 6, Seite 1488-1496 (DE-627)749730862 (DE-600)2720528-9 22136711 nnns volume:8 year:2017 number:6 pages:1488-1496 https://doi.org/10.1016/j.stemcr.2017.04.020 kostenfrei https://doaj.org/article/f8e6ef562d6546779d980cf547c22c37 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213671117301741 kostenfrei https://doaj.org/toc/2213-6711 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 8 2017 6 1488-1496
allfieldsGer	10.1016/j.stemcr.2017.04.020 doi (DE-627)DOAJ006404200 (DE-599)DOAJf8e6ef562d6546779d980cf547c22c37 DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 Ly-Sha Ee verfasserin aut An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Nucleosome Remodeling and Deacetylase (NuRD) complex is a chromatin regulatory complex that functions as a transcriptional co-repressor in metazoans. The NuRD subunit MBD3 is essential for targeting and assembly of a functional NuRD complex as well as embryonic stem cell (ESC) pluripotency. Three MBD3 isoforms (MBD3A, MBD3B, and MBD3C) are expressed in mouse. Here, we find that the MBD3C isoform contains a unique 50-amino-acid N-terminal region that is necessary for MBD3C to specifically interact with the histone H3 binding protein WDR5. Domain analyses of WDR5 reveal that the H3 binding pocket is required for interaction with MBD3C. We find that while Mbd3c knockout ESCs differentiate normally, MBD3C is redundant with the MBD3A and MBD3B isoforms in regulation of gene expression, with the unique MBD3C N terminus required for this redundancy. Together, our data characterize a unique NuRD complex variant that functions specifically in ESCs. NuRD Mbd3 Wdr5 chromatin differentiation Medicine (General) Biology (General) Kurtis N. McCannell verfasserin aut Yang Tang verfasserin aut Nancy Fernandes verfasserin aut W. Rod Hardy verfasserin aut Michael R. Green verfasserin aut Feixia Chu verfasserin aut Thomas G. Fazzio verfasserin aut In Stem Cell Reports Elsevier, 2015 8(2017), 6, Seite 1488-1496 (DE-627)749730862 (DE-600)2720528-9 22136711 nnns volume:8 year:2017 number:6 pages:1488-1496 https://doi.org/10.1016/j.stemcr.2017.04.020 kostenfrei https://doaj.org/article/f8e6ef562d6546779d980cf547c22c37 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213671117301741 kostenfrei https://doaj.org/toc/2213-6711 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 8 2017 6 1488-1496
allfieldsSound	10.1016/j.stemcr.2017.04.020 doi (DE-627)DOAJ006404200 (DE-599)DOAJf8e6ef562d6546779d980cf547c22c37 DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 Ly-Sha Ee verfasserin aut An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Nucleosome Remodeling and Deacetylase (NuRD) complex is a chromatin regulatory complex that functions as a transcriptional co-repressor in metazoans. The NuRD subunit MBD3 is essential for targeting and assembly of a functional NuRD complex as well as embryonic stem cell (ESC) pluripotency. Three MBD3 isoforms (MBD3A, MBD3B, and MBD3C) are expressed in mouse. Here, we find that the MBD3C isoform contains a unique 50-amino-acid N-terminal region that is necessary for MBD3C to specifically interact with the histone H3 binding protein WDR5. Domain analyses of WDR5 reveal that the H3 binding pocket is required for interaction with MBD3C. We find that while Mbd3c knockout ESCs differentiate normally, MBD3C is redundant with the MBD3A and MBD3B isoforms in regulation of gene expression, with the unique MBD3C N terminus required for this redundancy. Together, our data characterize a unique NuRD complex variant that functions specifically in ESCs. NuRD Mbd3 Wdr5 chromatin differentiation Medicine (General) Biology (General) Kurtis N. McCannell verfasserin aut Yang Tang verfasserin aut Nancy Fernandes verfasserin aut W. Rod Hardy verfasserin aut Michael R. Green verfasserin aut Feixia Chu verfasserin aut Thomas G. Fazzio verfasserin aut In Stem Cell Reports Elsevier, 2015 8(2017), 6, Seite 1488-1496 (DE-627)749730862 (DE-600)2720528-9 22136711 nnns volume:8 year:2017 number:6 pages:1488-1496 https://doi.org/10.1016/j.stemcr.2017.04.020 kostenfrei https://doaj.org/article/f8e6ef562d6546779d980cf547c22c37 kostenfrei http://www.sciencedirect.com/science/article/pii/S2213671117301741 kostenfrei https://doaj.org/toc/2213-6711 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 8 2017 6 1488-1496
language	English
source	In Stem Cell Reports 8(2017), 6, Seite 1488-1496 volume:8 year:2017 number:6 pages:1488-1496
sourceStr	In Stem Cell Reports 8(2017), 6, Seite 1488-1496 volume:8 year:2017 number:6 pages:1488-1496
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	NuRD Mbd3 Wdr5 chromatin differentiation Medicine (General) Biology (General)
isfreeaccess_bool	true
container_title	Stem Cell Reports
authorswithroles_txt_mv	Ly-Sha Ee @@aut@@ Kurtis N. McCannell @@aut@@ Yang Tang @@aut@@ Nancy Fernandes @@aut@@ W. Rod Hardy @@aut@@ Michael R. Green @@aut@@ Feixia Chu @@aut@@ Thomas G. Fazzio @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
hierarchy_top_id	749730862
id	DOAJ006404200
language_de	englisch
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callnumber-first	R - Medicine
author	Ly-Sha Ee
spellingShingle	Ly-Sha Ee misc R5-920 misc QH301-705.5 misc NuRD misc Mbd3 misc Wdr5 misc chromatin misc differentiation misc Medicine (General) misc Biology (General) An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5
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topic_title	R5-920 QH301-705.5 An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5 NuRD Mbd3 Wdr5 chromatin differentiation
topic	misc R5-920 misc QH301-705.5 misc NuRD misc Mbd3 misc Wdr5 misc chromatin misc differentiation misc Medicine (General) misc Biology (General)
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title	An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5
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title_full	An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5
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author_browse	Ly-Sha Ee Kurtis N. McCannell Yang Tang Nancy Fernandes W. Rod Hardy Michael R. Green Feixia Chu Thomas G. Fazzio
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title_sort	embryonic stem cell-specific nurd complex functions through interaction with wdr5
callnumber	R5-920
title_auth	An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5
abstract	The Nucleosome Remodeling and Deacetylase (NuRD) complex is a chromatin regulatory complex that functions as a transcriptional co-repressor in metazoans. The NuRD subunit MBD3 is essential for targeting and assembly of a functional NuRD complex as well as embryonic stem cell (ESC) pluripotency. Three MBD3 isoforms (MBD3A, MBD3B, and MBD3C) are expressed in mouse. Here, we find that the MBD3C isoform contains a unique 50-amino-acid N-terminal region that is necessary for MBD3C to specifically interact with the histone H3 binding protein WDR5. Domain analyses of WDR5 reveal that the H3 binding pocket is required for interaction with MBD3C. We find that while Mbd3c knockout ESCs differentiate normally, MBD3C is redundant with the MBD3A and MBD3B isoforms in regulation of gene expression, with the unique MBD3C N terminus required for this redundancy. Together, our data characterize a unique NuRD complex variant that functions specifically in ESCs.
abstractGer	The Nucleosome Remodeling and Deacetylase (NuRD) complex is a chromatin regulatory complex that functions as a transcriptional co-repressor in metazoans. The NuRD subunit MBD3 is essential for targeting and assembly of a functional NuRD complex as well as embryonic stem cell (ESC) pluripotency. Three MBD3 isoforms (MBD3A, MBD3B, and MBD3C) are expressed in mouse. Here, we find that the MBD3C isoform contains a unique 50-amino-acid N-terminal region that is necessary for MBD3C to specifically interact with the histone H3 binding protein WDR5. Domain analyses of WDR5 reveal that the H3 binding pocket is required for interaction with MBD3C. We find that while Mbd3c knockout ESCs differentiate normally, MBD3C is redundant with the MBD3A and MBD3B isoforms in regulation of gene expression, with the unique MBD3C N terminus required for this redundancy. Together, our data characterize a unique NuRD complex variant that functions specifically in ESCs.
abstract_unstemmed	The Nucleosome Remodeling and Deacetylase (NuRD) complex is a chromatin regulatory complex that functions as a transcriptional co-repressor in metazoans. The NuRD subunit MBD3 is essential for targeting and assembly of a functional NuRD complex as well as embryonic stem cell (ESC) pluripotency. Three MBD3 isoforms (MBD3A, MBD3B, and MBD3C) are expressed in mouse. Here, we find that the MBD3C isoform contains a unique 50-amino-acid N-terminal region that is necessary for MBD3C to specifically interact with the histone H3 binding protein WDR5. Domain analyses of WDR5 reveal that the H3 binding pocket is required for interaction with MBD3C. We find that while Mbd3c knockout ESCs differentiate normally, MBD3C is redundant with the MBD3A and MBD3B isoforms in regulation of gene expression, with the unique MBD3C N terminus required for this redundancy. Together, our data characterize a unique NuRD complex variant that functions specifically in ESCs.
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title_short	An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5
url	https://doi.org/10.1016/j.stemcr.2017.04.020 https://doaj.org/article/f8e6ef562d6546779d980cf547c22c37 http://www.sciencedirect.com/science/article/pii/S2213671117301741 https://doaj.org/toc/2213-6711
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