A Hybrid RSM-ANN-GA Approach on Optimization of Ultrasound-Assisted Extraction Conditions for Bioactive Component-Rich <i<Stevia rebaudiana</i< (Bertoni) Leaves Extract

<i<Stevia rebaudiana</i< (Bertoni) leaves consist of dietetically important diterpene steviol glycosides (SGs): stevioside (ST) and rebaudioside-A (Reb-A). ST and Reb-A are key sweetening compounds exhibiting a sweetening potential of 100 to 300 times more intense than that of table sucr...
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Autor*in:	Kashif Ameer [verfasserIn] Saqib Ameer [verfasserIn] Young-Min Kim [verfasserIn] Muhammad Nadeem [verfasserIn] Mi-Kyung Park [verfasserIn] Mian Anjum Murtaza [verfasserIn] Muhammad Asif Khan [verfasserIn] Muhammad Adnan Nasir [verfasserIn] Ghulam Mueen-ud-Din [verfasserIn] Shahid Mahmood [verfasserIn] Tusneem Kausar [verfasserIn] Muhammad Abubakar [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	ultrasound-assisted extraction stevioside rebaudioside-A optimization

Übergeordnetes Werk:	In: Foods - MDPI AG, 2013, 11(2022), 6, p 883
Übergeordnetes Werk:	volume:11 ; year:2022 ; number:6, p 883

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/foods11060883

Katalog-ID:	DOAJ006431011

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spelling	10.3390/foods11060883 doi (DE-627)DOAJ006431011 (DE-599)DOAJd1a765c4f0d64fa59af9a6634b2b859d DE-627 ger DE-627 rakwb eng TP1-1185 Kashif Ameer verfasserin aut A Hybrid RSM-ANN-GA Approach on Optimization of Ultrasound-Assisted Extraction Conditions for Bioactive Component-Rich <i<Stevia rebaudiana</i< (Bertoni) Leaves Extract 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Stevia rebaudiana</i< (Bertoni) leaves consist of dietetically important diterpene steviol glycosides (SGs): stevioside (ST) and rebaudioside-A (Reb-A). ST and Reb-A are key sweetening compounds exhibiting a sweetening potential of 100 to 300 times more intense than that of table sucrose. Ultrasound-assisted extraction (UAE) of SGs was optimized by effective process optimization techniques, such as response surface methodology (RSM) and artificial neural network (ANN) modeling coupled with genetic algorithm (GA) as a function of ethanol concentration (<i<X</i<<sub<1</sub<: 0–100%), sonication time (<i<X</i<<sub<2</sub<: 10–54 min), and leaf–solvent ratio (<i<X</i<<sub<3</sub<: 0.148–0.313 g·mL<sup<−1</sup<). The maximum target responses were obtained at optimum UAE conditions of 75% (<i<X</i<<sub<1</sub<), 43 min (<i<X</i<<sub<2</sub<), and 0.28 g·mL<sup<−1</sup< (<i<X</i<<sub<3</sub<). ANN-GA as a potential alternative indicated superiority to RSM. UAE as a green technology proved superior to conventional maceration extraction (CME) with reduced resource consumption. Moreover, UAE resulted in a higher total extract yield (TEY) and SGs including Reb-A and ST yields as compared to those that were obtained by CME with a marked reduction in resource consumption and CO<sub<2</sub< emission. The findings of the present study evidenced the significance of UAE as an ecofriendly extraction method for extracting SGs, and UAE scale-up could be employed for effectiveness on an industrial scale. These findings evidenced that the UAE is a high-efficiency extraction method with an improved statistical approach. <i<Stevia rebaudiana</i< ultrasound-assisted extraction stevioside rebaudioside-A optimization Chemical technology Saqib Ameer verfasserin aut Young-Min Kim verfasserin aut Muhammad Nadeem verfasserin aut Mi-Kyung Park verfasserin aut Mian Anjum Murtaza verfasserin aut Muhammad Asif Khan verfasserin aut Muhammad Adnan Nasir verfasserin aut Ghulam Mueen-ud-Din verfasserin aut Shahid Mahmood verfasserin aut Tusneem Kausar verfasserin aut Muhammad Abubakar verfasserin aut In Foods MDPI AG, 2013 11(2022), 6, p 883 (DE-627)737287632 (DE-600)2704223-6 23048158 nnns volume:11 year:2022 number:6, p 883 https://doi.org/10.3390/foods11060883 kostenfrei https://doaj.org/article/d1a765c4f0d64fa59af9a6634b2b859d kostenfrei https://www.mdpi.com/2304-8158/11/6/883 kostenfrei https://doaj.org/toc/2304-8158 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 6, p 883
allfields_unstemmed	10.3390/foods11060883 doi (DE-627)DOAJ006431011 (DE-599)DOAJd1a765c4f0d64fa59af9a6634b2b859d DE-627 ger DE-627 rakwb eng TP1-1185 Kashif Ameer verfasserin aut A Hybrid RSM-ANN-GA Approach on Optimization of Ultrasound-Assisted Extraction Conditions for Bioactive Component-Rich <i<Stevia rebaudiana</i< (Bertoni) Leaves Extract 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Stevia rebaudiana</i< (Bertoni) leaves consist of dietetically important diterpene steviol glycosides (SGs): stevioside (ST) and rebaudioside-A (Reb-A). ST and Reb-A are key sweetening compounds exhibiting a sweetening potential of 100 to 300 times more intense than that of table sucrose. Ultrasound-assisted extraction (UAE) of SGs was optimized by effective process optimization techniques, such as response surface methodology (RSM) and artificial neural network (ANN) modeling coupled with genetic algorithm (GA) as a function of ethanol concentration (<i<X</i<<sub<1</sub<: 0–100%), sonication time (<i<X</i<<sub<2</sub<: 10–54 min), and leaf–solvent ratio (<i<X</i<<sub<3</sub<: 0.148–0.313 g·mL<sup<−1</sup<). The maximum target responses were obtained at optimum UAE conditions of 75% (<i<X</i<<sub<1</sub<), 43 min (<i<X</i<<sub<2</sub<), and 0.28 g·mL<sup<−1</sup< (<i<X</i<<sub<3</sub<). ANN-GA as a potential alternative indicated superiority to RSM. UAE as a green technology proved superior to conventional maceration extraction (CME) with reduced resource consumption. Moreover, UAE resulted in a higher total extract yield (TEY) and SGs including Reb-A and ST yields as compared to those that were obtained by CME with a marked reduction in resource consumption and CO<sub<2</sub< emission. The findings of the present study evidenced the significance of UAE as an ecofriendly extraction method for extracting SGs, and UAE scale-up could be employed for effectiveness on an industrial scale. These findings evidenced that the UAE is a high-efficiency extraction method with an improved statistical approach. <i<Stevia rebaudiana</i< ultrasound-assisted extraction stevioside rebaudioside-A optimization Chemical technology Saqib Ameer verfasserin aut Young-Min Kim verfasserin aut Muhammad Nadeem verfasserin aut Mi-Kyung Park verfasserin aut Mian Anjum Murtaza verfasserin aut Muhammad Asif Khan verfasserin aut Muhammad Adnan Nasir verfasserin aut Ghulam Mueen-ud-Din verfasserin aut Shahid Mahmood verfasserin aut Tusneem Kausar verfasserin aut Muhammad Abubakar verfasserin aut In Foods MDPI AG, 2013 11(2022), 6, p 883 (DE-627)737287632 (DE-600)2704223-6 23048158 nnns volume:11 year:2022 number:6, p 883 https://doi.org/10.3390/foods11060883 kostenfrei https://doaj.org/article/d1a765c4f0d64fa59af9a6634b2b859d kostenfrei https://www.mdpi.com/2304-8158/11/6/883 kostenfrei https://doaj.org/toc/2304-8158 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 6, p 883
allfieldsGer	10.3390/foods11060883 doi (DE-627)DOAJ006431011 (DE-599)DOAJd1a765c4f0d64fa59af9a6634b2b859d DE-627 ger DE-627 rakwb eng TP1-1185 Kashif Ameer verfasserin aut A Hybrid RSM-ANN-GA Approach on Optimization of Ultrasound-Assisted Extraction Conditions for Bioactive Component-Rich <i<Stevia rebaudiana</i< (Bertoni) Leaves Extract 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Stevia rebaudiana</i< (Bertoni) leaves consist of dietetically important diterpene steviol glycosides (SGs): stevioside (ST) and rebaudioside-A (Reb-A). ST and Reb-A are key sweetening compounds exhibiting a sweetening potential of 100 to 300 times more intense than that of table sucrose. Ultrasound-assisted extraction (UAE) of SGs was optimized by effective process optimization techniques, such as response surface methodology (RSM) and artificial neural network (ANN) modeling coupled with genetic algorithm (GA) as a function of ethanol concentration (<i<X</i<<sub<1</sub<: 0–100%), sonication time (<i<X</i<<sub<2</sub<: 10–54 min), and leaf–solvent ratio (<i<X</i<<sub<3</sub<: 0.148–0.313 g·mL<sup<−1</sup<). The maximum target responses were obtained at optimum UAE conditions of 75% (<i<X</i<<sub<1</sub<), 43 min (<i<X</i<<sub<2</sub<), and 0.28 g·mL<sup<−1</sup< (<i<X</i<<sub<3</sub<). ANN-GA as a potential alternative indicated superiority to RSM. UAE as a green technology proved superior to conventional maceration extraction (CME) with reduced resource consumption. Moreover, UAE resulted in a higher total extract yield (TEY) and SGs including Reb-A and ST yields as compared to those that were obtained by CME with a marked reduction in resource consumption and CO<sub<2</sub< emission. The findings of the present study evidenced the significance of UAE as an ecofriendly extraction method for extracting SGs, and UAE scale-up could be employed for effectiveness on an industrial scale. These findings evidenced that the UAE is a high-efficiency extraction method with an improved statistical approach. <i<Stevia rebaudiana</i< ultrasound-assisted extraction stevioside rebaudioside-A optimization Chemical technology Saqib Ameer verfasserin aut Young-Min Kim verfasserin aut Muhammad Nadeem verfasserin aut Mi-Kyung Park verfasserin aut Mian Anjum Murtaza verfasserin aut Muhammad Asif Khan verfasserin aut Muhammad Adnan Nasir verfasserin aut Ghulam Mueen-ud-Din verfasserin aut Shahid Mahmood verfasserin aut Tusneem Kausar verfasserin aut Muhammad Abubakar verfasserin aut In Foods MDPI AG, 2013 11(2022), 6, p 883 (DE-627)737287632 (DE-600)2704223-6 23048158 nnns volume:11 year:2022 number:6, p 883 https://doi.org/10.3390/foods11060883 kostenfrei https://doaj.org/article/d1a765c4f0d64fa59af9a6634b2b859d kostenfrei https://www.mdpi.com/2304-8158/11/6/883 kostenfrei https://doaj.org/toc/2304-8158 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 6, p 883
allfieldsSound	10.3390/foods11060883 doi (DE-627)DOAJ006431011 (DE-599)DOAJd1a765c4f0d64fa59af9a6634b2b859d DE-627 ger DE-627 rakwb eng TP1-1185 Kashif Ameer verfasserin aut A Hybrid RSM-ANN-GA Approach on Optimization of Ultrasound-Assisted Extraction Conditions for Bioactive Component-Rich <i<Stevia rebaudiana</i< (Bertoni) Leaves Extract 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Stevia rebaudiana</i< (Bertoni) leaves consist of dietetically important diterpene steviol glycosides (SGs): stevioside (ST) and rebaudioside-A (Reb-A). ST and Reb-A are key sweetening compounds exhibiting a sweetening potential of 100 to 300 times more intense than that of table sucrose. Ultrasound-assisted extraction (UAE) of SGs was optimized by effective process optimization techniques, such as response surface methodology (RSM) and artificial neural network (ANN) modeling coupled with genetic algorithm (GA) as a function of ethanol concentration (<i<X</i<<sub<1</sub<: 0–100%), sonication time (<i<X</i<<sub<2</sub<: 10–54 min), and leaf–solvent ratio (<i<X</i<<sub<3</sub<: 0.148–0.313 g·mL<sup<−1</sup<). The maximum target responses were obtained at optimum UAE conditions of 75% (<i<X</i<<sub<1</sub<), 43 min (<i<X</i<<sub<2</sub<), and 0.28 g·mL<sup<−1</sup< (<i<X</i<<sub<3</sub<). ANN-GA as a potential alternative indicated superiority to RSM. UAE as a green technology proved superior to conventional maceration extraction (CME) with reduced resource consumption. Moreover, UAE resulted in a higher total extract yield (TEY) and SGs including Reb-A and ST yields as compared to those that were obtained by CME with a marked reduction in resource consumption and CO<sub<2</sub< emission. The findings of the present study evidenced the significance of UAE as an ecofriendly extraction method for extracting SGs, and UAE scale-up could be employed for effectiveness on an industrial scale. These findings evidenced that the UAE is a high-efficiency extraction method with an improved statistical approach. <i<Stevia rebaudiana</i< ultrasound-assisted extraction stevioside rebaudioside-A optimization Chemical technology Saqib Ameer verfasserin aut Young-Min Kim verfasserin aut Muhammad Nadeem verfasserin aut Mi-Kyung Park verfasserin aut Mian Anjum Murtaza verfasserin aut Muhammad Asif Khan verfasserin aut Muhammad Adnan Nasir verfasserin aut Ghulam Mueen-ud-Din verfasserin aut Shahid Mahmood verfasserin aut Tusneem Kausar verfasserin aut Muhammad Abubakar verfasserin aut In Foods MDPI AG, 2013 11(2022), 6, p 883 (DE-627)737287632 (DE-600)2704223-6 23048158 nnns volume:11 year:2022 number:6, p 883 https://doi.org/10.3390/foods11060883 kostenfrei https://doaj.org/article/d1a765c4f0d64fa59af9a6634b2b859d kostenfrei https://www.mdpi.com/2304-8158/11/6/883 kostenfrei https://doaj.org/toc/2304-8158 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 6, p 883
language	English
source	In Foods 11(2022), 6, p 883 volume:11 year:2022 number:6, p 883
sourceStr	In Foods 11(2022), 6, p 883 volume:11 year:2022 number:6, p 883
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	<i<Stevia rebaudiana</i< ultrasound-assisted extraction stevioside rebaudioside-A optimization Chemical technology
isfreeaccess_bool	true
container_title	Foods
authorswithroles_txt_mv	Kashif Ameer @@aut@@ Saqib Ameer @@aut@@ Young-Min Kim @@aut@@ Muhammad Nadeem @@aut@@ Mi-Kyung Park @@aut@@ Mian Anjum Murtaza @@aut@@ Muhammad Asif Khan @@aut@@ Muhammad Adnan Nasir @@aut@@ Ghulam Mueen-ud-Din @@aut@@ Shahid Mahmood @@aut@@ Tusneem Kausar @@aut@@ Muhammad Abubakar @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	737287632
id	DOAJ006431011
language_de	englisch
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callnumber-first	T - Technology
author	Kashif Ameer
spellingShingle	Kashif Ameer misc TP1-1185 misc <i<Stevia rebaudiana</i< misc ultrasound-assisted extraction misc stevioside misc rebaudioside-A misc optimization misc Chemical technology A Hybrid RSM-ANN-GA Approach on Optimization of Ultrasound-Assisted Extraction Conditions for Bioactive Component-Rich <i<Stevia rebaudiana</i< (Bertoni) Leaves Extract
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topic_title	TP1-1185 A Hybrid RSM-ANN-GA Approach on Optimization of Ultrasound-Assisted Extraction Conditions for Bioactive Component-Rich <i<Stevia rebaudiana</i< (Bertoni) Leaves Extract <i<Stevia rebaudiana</i< ultrasound-assisted extraction stevioside rebaudioside-A optimization
topic	misc TP1-1185 misc <i<Stevia rebaudiana</i< misc ultrasound-assisted extraction misc stevioside misc rebaudioside-A misc optimization misc Chemical technology
topic_unstemmed	misc TP1-1185 misc <i<Stevia rebaudiana</i< misc ultrasound-assisted extraction misc stevioside misc rebaudioside-A misc optimization misc Chemical technology
topic_browse	misc TP1-1185 misc <i<Stevia rebaudiana</i< misc ultrasound-assisted extraction misc stevioside misc rebaudioside-A misc optimization misc Chemical technology
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title	A Hybrid RSM-ANN-GA Approach on Optimization of Ultrasound-Assisted Extraction Conditions for Bioactive Component-Rich <i<Stevia rebaudiana</i< (Bertoni) Leaves Extract
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title_full	A Hybrid RSM-ANN-GA Approach on Optimization of Ultrasound-Assisted Extraction Conditions for Bioactive Component-Rich <i<Stevia rebaudiana</i< (Bertoni) Leaves Extract
author_sort	Kashif Ameer
journal	Foods
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author_browse	Kashif Ameer Saqib Ameer Young-Min Kim Muhammad Nadeem Mi-Kyung Park Mian Anjum Murtaza Muhammad Asif Khan Muhammad Adnan Nasir Ghulam Mueen-ud-Din Shahid Mahmood Tusneem Kausar Muhammad Abubakar
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author-letter	Kashif Ameer
doi_str_mv	10.3390/foods11060883
author2-role	verfasserin
title_sort	hybrid rsm-ann-ga approach on optimization of ultrasound-assisted extraction conditions for bioactive component-rich <i<stevia rebaudiana</i< (bertoni) leaves extract
callnumber	TP1-1185
title_auth	A Hybrid RSM-ANN-GA Approach on Optimization of Ultrasound-Assisted Extraction Conditions for Bioactive Component-Rich <i<Stevia rebaudiana</i< (Bertoni) Leaves Extract
abstract	<i<Stevia rebaudiana</i< (Bertoni) leaves consist of dietetically important diterpene steviol glycosides (SGs): stevioside (ST) and rebaudioside-A (Reb-A). ST and Reb-A are key sweetening compounds exhibiting a sweetening potential of 100 to 300 times more intense than that of table sucrose. Ultrasound-assisted extraction (UAE) of SGs was optimized by effective process optimization techniques, such as response surface methodology (RSM) and artificial neural network (ANN) modeling coupled with genetic algorithm (GA) as a function of ethanol concentration (<i<X</i<<sub<1</sub<: 0–100%), sonication time (<i<X</i<<sub<2</sub<: 10–54 min), and leaf–solvent ratio (<i<X</i<<sub<3</sub<: 0.148–0.313 g·mL<sup<−1</sup<). The maximum target responses were obtained at optimum UAE conditions of 75% (<i<X</i<<sub<1</sub<), 43 min (<i<X</i<<sub<2</sub<), and 0.28 g·mL<sup<−1</sup< (<i<X</i<<sub<3</sub<). ANN-GA as a potential alternative indicated superiority to RSM. UAE as a green technology proved superior to conventional maceration extraction (CME) with reduced resource consumption. Moreover, UAE resulted in a higher total extract yield (TEY) and SGs including Reb-A and ST yields as compared to those that were obtained by CME with a marked reduction in resource consumption and CO<sub<2</sub< emission. The findings of the present study evidenced the significance of UAE as an ecofriendly extraction method for extracting SGs, and UAE scale-up could be employed for effectiveness on an industrial scale. These findings evidenced that the UAE is a high-efficiency extraction method with an improved statistical approach.
abstractGer	<i<Stevia rebaudiana</i< (Bertoni) leaves consist of dietetically important diterpene steviol glycosides (SGs): stevioside (ST) and rebaudioside-A (Reb-A). ST and Reb-A are key sweetening compounds exhibiting a sweetening potential of 100 to 300 times more intense than that of table sucrose. Ultrasound-assisted extraction (UAE) of SGs was optimized by effective process optimization techniques, such as response surface methodology (RSM) and artificial neural network (ANN) modeling coupled with genetic algorithm (GA) as a function of ethanol concentration (<i<X</i<<sub<1</sub<: 0–100%), sonication time (<i<X</i<<sub<2</sub<: 10–54 min), and leaf–solvent ratio (<i<X</i<<sub<3</sub<: 0.148–0.313 g·mL<sup<−1</sup<). The maximum target responses were obtained at optimum UAE conditions of 75% (<i<X</i<<sub<1</sub<), 43 min (<i<X</i<<sub<2</sub<), and 0.28 g·mL<sup<−1</sup< (<i<X</i<<sub<3</sub<). ANN-GA as a potential alternative indicated superiority to RSM. UAE as a green technology proved superior to conventional maceration extraction (CME) with reduced resource consumption. Moreover, UAE resulted in a higher total extract yield (TEY) and SGs including Reb-A and ST yields as compared to those that were obtained by CME with a marked reduction in resource consumption and CO<sub<2</sub< emission. The findings of the present study evidenced the significance of UAE as an ecofriendly extraction method for extracting SGs, and UAE scale-up could be employed for effectiveness on an industrial scale. These findings evidenced that the UAE is a high-efficiency extraction method with an improved statistical approach.
abstract_unstemmed	<i<Stevia rebaudiana</i< (Bertoni) leaves consist of dietetically important diterpene steviol glycosides (SGs): stevioside (ST) and rebaudioside-A (Reb-A). ST and Reb-A are key sweetening compounds exhibiting a sweetening potential of 100 to 300 times more intense than that of table sucrose. Ultrasound-assisted extraction (UAE) of SGs was optimized by effective process optimization techniques, such as response surface methodology (RSM) and artificial neural network (ANN) modeling coupled with genetic algorithm (GA) as a function of ethanol concentration (<i<X</i<<sub<1</sub<: 0–100%), sonication time (<i<X</i<<sub<2</sub<: 10–54 min), and leaf–solvent ratio (<i<X</i<<sub<3</sub<: 0.148–0.313 g·mL<sup<−1</sup<). The maximum target responses were obtained at optimum UAE conditions of 75% (<i<X</i<<sub<1</sub<), 43 min (<i<X</i<<sub<2</sub<), and 0.28 g·mL<sup<−1</sup< (<i<X</i<<sub<3</sub<). ANN-GA as a potential alternative indicated superiority to RSM. UAE as a green technology proved superior to conventional maceration extraction (CME) with reduced resource consumption. Moreover, UAE resulted in a higher total extract yield (TEY) and SGs including Reb-A and ST yields as compared to those that were obtained by CME with a marked reduction in resource consumption and CO<sub<2</sub< emission. The findings of the present study evidenced the significance of UAE as an ecofriendly extraction method for extracting SGs, and UAE scale-up could be employed for effectiveness on an industrial scale. These findings evidenced that the UAE is a high-efficiency extraction method with an improved statistical approach.
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title_short	A Hybrid RSM-ANN-GA Approach on Optimization of Ultrasound-Assisted Extraction Conditions for Bioactive Component-Rich <i<Stevia rebaudiana</i< (Bertoni) Leaves Extract
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