Ovarian Cancer Metastasis to the Breast: A Case Report and Review of the Literature

Although ovarian cancer often presents as a widespread disease, metastases to the breast and/or axillary lymph nodes are a very rare event, accounting for only 0.03–0.6% of all breast cancers. Its early recognition and accurate distinction from primary breast cancer are of crucial importance to choo...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Giuseppe Caruso [verfasserIn] Lucia Musacchio [verfasserIn] Giusi Santangelo [verfasserIn] Innocenza Palaia [verfasserIn] Federica Tomao [verfasserIn] Violante Di Donato [verfasserIn] Giorgia Perniola [verfasserIn] Vanda Salutari [verfasserIn] Pierluigi Benedetti Panici [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	ovarian cancer breast metastasis breast cancer chemotherapy

Übergeordnetes Werk:	In: Case Reports in Oncology - Karger Publishers, 2009, 13(2020), 3, Seite 1317-1324
Übergeordnetes Werk:	volume:13 ; year:2020 ; number:3 ; pages:1317-1324

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1159/000509770

Katalog-ID:	DOAJ006476791

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authorswithroles_txt_mv	Giuseppe Caruso @@aut@@ Lucia Musacchio @@aut@@ Giusi Santangelo @@aut@@ Innocenza Palaia @@aut@@ Federica Tomao @@aut@@ Violante Di Donato @@aut@@ Giorgia Perniola @@aut@@ Vanda Salutari @@aut@@ Pierluigi Benedetti Panici @@aut@@
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callnumber-first	R - Medicine
author	Giuseppe Caruso
spellingShingle	Giuseppe Caruso misc RC254-282 misc ovarian cancer misc breast metastasis misc breast cancer misc chemotherapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ovarian Cancer Metastasis to the Breast: A Case Report and Review of the Literature
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topic_title	RC254-282 Ovarian Cancer Metastasis to the Breast: A Case Report and Review of the Literature ovarian cancer breast metastasis breast cancer chemotherapy
topic	misc RC254-282 misc ovarian cancer misc breast metastasis misc breast cancer misc chemotherapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc ovarian cancer misc breast metastasis misc breast cancer misc chemotherapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Ovarian Cancer Metastasis to the Breast: A Case Report and Review of the Literature
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title_sort	ovarian cancer metastasis to the breast: a case report and review of the literature
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title_auth	Ovarian Cancer Metastasis to the Breast: A Case Report and Review of the Literature
abstract	Although ovarian cancer often presents as a widespread disease, metastases to the breast and/or axillary lymph nodes are a very rare event, accounting for only 0.03–0.6% of all breast cancers. Its early recognition and accurate distinction from primary breast cancer are of crucial importance to choose an adequate systemic therapy over unnecessary surgeries. We presented the case of a 53-year-old woman who was diagnosed with breast metastases 2 years after the diagnosis of advanced primary serous ovarian cancer. The patient underwent primary cytoreductive surgery and platinum-based chemotherapy in combination with bevacizumab, followed by bevacizumab maintenance for 18 months. After 2 years of negative follow-ups, the disease unexpectedly spread to the left breast and axillary lymph nodes. No axillary lymph node dissection or breast surgery was performed. The patient received axillary radiotherapy and multiple chemotherapy lines: gemcitabine/cisplatin, liposomal doxorubicin, topotecan, olaparib/cediranib, paclitaxel, and cisplatin. Unfortunately, none of these treatments improved her prognosis and she died 3 years after the disease recurrence. Ovarian cancer metastasis to the breast reveals a disseminated disease with a poor prognosis. Currently, no valid treatment options are available as the disease shows multidrug chemoresistance. In the era of precision medicine, the characterization of genetic and molecular markers may play a role in offering new promising targeted therapies.
abstractGer	Although ovarian cancer often presents as a widespread disease, metastases to the breast and/or axillary lymph nodes are a very rare event, accounting for only 0.03–0.6% of all breast cancers. Its early recognition and accurate distinction from primary breast cancer are of crucial importance to choose an adequate systemic therapy over unnecessary surgeries. We presented the case of a 53-year-old woman who was diagnosed with breast metastases 2 years after the diagnosis of advanced primary serous ovarian cancer. The patient underwent primary cytoreductive surgery and platinum-based chemotherapy in combination with bevacizumab, followed by bevacizumab maintenance for 18 months. After 2 years of negative follow-ups, the disease unexpectedly spread to the left breast and axillary lymph nodes. No axillary lymph node dissection or breast surgery was performed. The patient received axillary radiotherapy and multiple chemotherapy lines: gemcitabine/cisplatin, liposomal doxorubicin, topotecan, olaparib/cediranib, paclitaxel, and cisplatin. Unfortunately, none of these treatments improved her prognosis and she died 3 years after the disease recurrence. Ovarian cancer metastasis to the breast reveals a disseminated disease with a poor prognosis. Currently, no valid treatment options are available as the disease shows multidrug chemoresistance. In the era of precision medicine, the characterization of genetic and molecular markers may play a role in offering new promising targeted therapies.
abstract_unstemmed	Although ovarian cancer often presents as a widespread disease, metastases to the breast and/or axillary lymph nodes are a very rare event, accounting for only 0.03–0.6% of all breast cancers. Its early recognition and accurate distinction from primary breast cancer are of crucial importance to choose an adequate systemic therapy over unnecessary surgeries. We presented the case of a 53-year-old woman who was diagnosed with breast metastases 2 years after the diagnosis of advanced primary serous ovarian cancer. The patient underwent primary cytoreductive surgery and platinum-based chemotherapy in combination with bevacizumab, followed by bevacizumab maintenance for 18 months. After 2 years of negative follow-ups, the disease unexpectedly spread to the left breast and axillary lymph nodes. No axillary lymph node dissection or breast surgery was performed. The patient received axillary radiotherapy and multiple chemotherapy lines: gemcitabine/cisplatin, liposomal doxorubicin, topotecan, olaparib/cediranib, paclitaxel, and cisplatin. Unfortunately, none of these treatments improved her prognosis and she died 3 years after the disease recurrence. Ovarian cancer metastasis to the breast reveals a disseminated disease with a poor prognosis. Currently, no valid treatment options are available as the disease shows multidrug chemoresistance. In the era of precision medicine, the characterization of genetic and molecular markers may play a role in offering new promising targeted therapies.
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title_short	Ovarian Cancer Metastasis to the Breast: A Case Report and Review of the Literature
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Ovarian Cancer Metastasis to the Breast: A Case Report and Review of the Literature

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