Inflammation from an immunologic perspective: a challenge to medicine in the 21st century
<p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Maricarmen González Costa [verfasserIn] Alexander Ariel Padrón González [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch ; Spanisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Revista Habanera de Ciencias Médicas - Universidad de Ciencias Médicas de La Habana, 2018, 18(2019), 1, Seite 30-44 |
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| Übergeordnetes Werk: |
volume:18 ; year:2019 ; number:1 ; pages:30-44 |
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DOAJ006511287 |
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| 520 | |a <p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and multifactorial process. Therefore, it is a challenge to elucidate the elements and the tissue changes that it causes to establish the best way to improve the clinical practice related to an inflammatory process.</p<<p<<strong<Objective:</strong< To describe inflammation, its classification, elements involved, and systemic changes from an immunological perspective.</p<<p<<strong<Material and Methods:</strong< A review of the topic was made using the updated bibliography. Free-access articles were consulted in <em<Pubmed</em< and <em<Scielo</em< databases in the period from January 2013 to December 2018.</p<<p<<strong<Development:</strong< Inflammation can be classified according to the damage, time or effectors involved. The main molecules are the cytokines like TNF-α, IFN-γ, IL-1β, IL-10, IL-6, TGF-β. Some cells participate such as neutrophils, mastocytes, macrophages, T-lymphocyes, and the vascular endothelium. During the inflammatory process, the functions of almost all organ systems are modified. It produces systemic changes that are observed in physiological processes such as pregnancy or aging. Sometimes inflammation triggers diseases such as cardiovascular and neurological ones, and cancer. The pathophysiological mechanisms have not been clarified.</p<<p<<strong<Conclusions:</strong< Currently, the events that trigger chronic inflammation and how tissue damage occurs are unknown. The biggest challenge is to elucidate the causes and immunological mechanisms that lead to inflammatory manifestations that are expressed as systemic neurological, cardiovascular and autoimmune diseases, among others.</p<<p class="Textopreformateado"<<strong<Keywords:</strong< Acute inflammation, chronic inflammation, proinflammatory mediators, sepsis.</p< | ||
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(DE-627)DOAJ006511287 (DE-599)DOAJebb5224448d44b45915c2e2b59360e7b DE-627 ger DE-627 rakwb eng spa R5-920 RA1-1270 Maricarmen González Costa verfasserin aut Inflammation from an immunologic perspective: a challenge to medicine in the 21st century 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and multifactorial process. Therefore, it is a challenge to elucidate the elements and the tissue changes that it causes to establish the best way to improve the clinical practice related to an inflammatory process.</p<<p<<strong<Objective:</strong< To describe inflammation, its classification, elements involved, and systemic changes from an immunological perspective.</p<<p<<strong<Material and Methods:</strong< A review of the topic was made using the updated bibliography. Free-access articles were consulted in <em<Pubmed</em< and <em<Scielo</em< databases in the period from January 2013 to December 2018.</p<<p<<strong<Development:</strong< Inflammation can be classified according to the damage, time or effectors involved. The main molecules are the cytokines like TNF-α, IFN-γ, IL-1β, IL-10, IL-6, TGF-β. Some cells participate such as neutrophils, mastocytes, macrophages, T-lymphocyes, and the vascular endothelium. During the inflammatory process, the functions of almost all organ systems are modified. It produces systemic changes that are observed in physiological processes such as pregnancy or aging. Sometimes inflammation triggers diseases such as cardiovascular and neurological ones, and cancer. The pathophysiological mechanisms have not been clarified.</p<<p<<strong<Conclusions:</strong< Currently, the events that trigger chronic inflammation and how tissue damage occurs are unknown. The biggest challenge is to elucidate the causes and immunological mechanisms that lead to inflammatory manifestations that are expressed as systemic neurological, cardiovascular and autoimmune diseases, among others.</p<<p class="Textopreformateado"<<strong<Keywords:</strong< Acute inflammation, chronic inflammation, proinflammatory mediators, sepsis.</p< inflamación aguda inflamación crónica mediadores proinflamatorios sepsis. acute inflammation chronic inflammation proinflammatory mediators sepsis. Medicine (General) Public aspects of medicine Alexander Ariel Padrón González verfasserin aut In Revista Habanera de Ciencias Médicas Universidad de Ciencias Médicas de La Habana, 2018 18(2019), 1, Seite 30-44 (DE-627)1760627410 1729519X nnns volume:18 year:2019 number:1 pages:30-44 https://doaj.org/article/ebb5224448d44b45915c2e2b59360e7b kostenfrei http://www.revhabanera.sld.cu/index.php/rhab/article/view/2445 kostenfrei https://doaj.org/toc/1729-519X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 18 2019 1 30-44 |
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(DE-627)DOAJ006511287 (DE-599)DOAJebb5224448d44b45915c2e2b59360e7b DE-627 ger DE-627 rakwb eng spa R5-920 RA1-1270 Maricarmen González Costa verfasserin aut Inflammation from an immunologic perspective: a challenge to medicine in the 21st century 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and multifactorial process. Therefore, it is a challenge to elucidate the elements and the tissue changes that it causes to establish the best way to improve the clinical practice related to an inflammatory process.</p<<p<<strong<Objective:</strong< To describe inflammation, its classification, elements involved, and systemic changes from an immunological perspective.</p<<p<<strong<Material and Methods:</strong< A review of the topic was made using the updated bibliography. Free-access articles were consulted in <em<Pubmed</em< and <em<Scielo</em< databases in the period from January 2013 to December 2018.</p<<p<<strong<Development:</strong< Inflammation can be classified according to the damage, time or effectors involved. The main molecules are the cytokines like TNF-α, IFN-γ, IL-1β, IL-10, IL-6, TGF-β. Some cells participate such as neutrophils, mastocytes, macrophages, T-lymphocyes, and the vascular endothelium. During the inflammatory process, the functions of almost all organ systems are modified. It produces systemic changes that are observed in physiological processes such as pregnancy or aging. Sometimes inflammation triggers diseases such as cardiovascular and neurological ones, and cancer. The pathophysiological mechanisms have not been clarified.</p<<p<<strong<Conclusions:</strong< Currently, the events that trigger chronic inflammation and how tissue damage occurs are unknown. The biggest challenge is to elucidate the causes and immunological mechanisms that lead to inflammatory manifestations that are expressed as systemic neurological, cardiovascular and autoimmune diseases, among others.</p<<p class="Textopreformateado"<<strong<Keywords:</strong< Acute inflammation, chronic inflammation, proinflammatory mediators, sepsis.</p< inflamación aguda inflamación crónica mediadores proinflamatorios sepsis. acute inflammation chronic inflammation proinflammatory mediators sepsis. Medicine (General) Public aspects of medicine Alexander Ariel Padrón González verfasserin aut In Revista Habanera de Ciencias Médicas Universidad de Ciencias Médicas de La Habana, 2018 18(2019), 1, Seite 30-44 (DE-627)1760627410 1729519X nnns volume:18 year:2019 number:1 pages:30-44 https://doaj.org/article/ebb5224448d44b45915c2e2b59360e7b kostenfrei http://www.revhabanera.sld.cu/index.php/rhab/article/view/2445 kostenfrei https://doaj.org/toc/1729-519X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 18 2019 1 30-44 |
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(DE-627)DOAJ006511287 (DE-599)DOAJebb5224448d44b45915c2e2b59360e7b DE-627 ger DE-627 rakwb eng spa R5-920 RA1-1270 Maricarmen González Costa verfasserin aut Inflammation from an immunologic perspective: a challenge to medicine in the 21st century 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and multifactorial process. Therefore, it is a challenge to elucidate the elements and the tissue changes that it causes to establish the best way to improve the clinical practice related to an inflammatory process.</p<<p<<strong<Objective:</strong< To describe inflammation, its classification, elements involved, and systemic changes from an immunological perspective.</p<<p<<strong<Material and Methods:</strong< A review of the topic was made using the updated bibliography. Free-access articles were consulted in <em<Pubmed</em< and <em<Scielo</em< databases in the period from January 2013 to December 2018.</p<<p<<strong<Development:</strong< Inflammation can be classified according to the damage, time or effectors involved. The main molecules are the cytokines like TNF-α, IFN-γ, IL-1β, IL-10, IL-6, TGF-β. Some cells participate such as neutrophils, mastocytes, macrophages, T-lymphocyes, and the vascular endothelium. During the inflammatory process, the functions of almost all organ systems are modified. It produces systemic changes that are observed in physiological processes such as pregnancy or aging. Sometimes inflammation triggers diseases such as cardiovascular and neurological ones, and cancer. The pathophysiological mechanisms have not been clarified.</p<<p<<strong<Conclusions:</strong< Currently, the events that trigger chronic inflammation and how tissue damage occurs are unknown. The biggest challenge is to elucidate the causes and immunological mechanisms that lead to inflammatory manifestations that are expressed as systemic neurological, cardiovascular and autoimmune diseases, among others.</p<<p class="Textopreformateado"<<strong<Keywords:</strong< Acute inflammation, chronic inflammation, proinflammatory mediators, sepsis.</p< inflamación aguda inflamación crónica mediadores proinflamatorios sepsis. acute inflammation chronic inflammation proinflammatory mediators sepsis. Medicine (General) Public aspects of medicine Alexander Ariel Padrón González verfasserin aut In Revista Habanera de Ciencias Médicas Universidad de Ciencias Médicas de La Habana, 2018 18(2019), 1, Seite 30-44 (DE-627)1760627410 1729519X nnns volume:18 year:2019 number:1 pages:30-44 https://doaj.org/article/ebb5224448d44b45915c2e2b59360e7b kostenfrei http://www.revhabanera.sld.cu/index.php/rhab/article/view/2445 kostenfrei https://doaj.org/toc/1729-519X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 18 2019 1 30-44 |
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(DE-627)DOAJ006511287 (DE-599)DOAJebb5224448d44b45915c2e2b59360e7b DE-627 ger DE-627 rakwb eng spa R5-920 RA1-1270 Maricarmen González Costa verfasserin aut Inflammation from an immunologic perspective: a challenge to medicine in the 21st century 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and multifactorial process. Therefore, it is a challenge to elucidate the elements and the tissue changes that it causes to establish the best way to improve the clinical practice related to an inflammatory process.</p<<p<<strong<Objective:</strong< To describe inflammation, its classification, elements involved, and systemic changes from an immunological perspective.</p<<p<<strong<Material and Methods:</strong< A review of the topic was made using the updated bibliography. Free-access articles were consulted in <em<Pubmed</em< and <em<Scielo</em< databases in the period from January 2013 to December 2018.</p<<p<<strong<Development:</strong< Inflammation can be classified according to the damage, time or effectors involved. The main molecules are the cytokines like TNF-α, IFN-γ, IL-1β, IL-10, IL-6, TGF-β. Some cells participate such as neutrophils, mastocytes, macrophages, T-lymphocyes, and the vascular endothelium. During the inflammatory process, the functions of almost all organ systems are modified. It produces systemic changes that are observed in physiological processes such as pregnancy or aging. Sometimes inflammation triggers diseases such as cardiovascular and neurological ones, and cancer. The pathophysiological mechanisms have not been clarified.</p<<p<<strong<Conclusions:</strong< Currently, the events that trigger chronic inflammation and how tissue damage occurs are unknown. The biggest challenge is to elucidate the causes and immunological mechanisms that lead to inflammatory manifestations that are expressed as systemic neurological, cardiovascular and autoimmune diseases, among others.</p<<p class="Textopreformateado"<<strong<Keywords:</strong< Acute inflammation, chronic inflammation, proinflammatory mediators, sepsis.</p< inflamación aguda inflamación crónica mediadores proinflamatorios sepsis. acute inflammation chronic inflammation proinflammatory mediators sepsis. Medicine (General) Public aspects of medicine Alexander Ariel Padrón González verfasserin aut In Revista Habanera de Ciencias Médicas Universidad de Ciencias Médicas de La Habana, 2018 18(2019), 1, Seite 30-44 (DE-627)1760627410 1729519X nnns volume:18 year:2019 number:1 pages:30-44 https://doaj.org/article/ebb5224448d44b45915c2e2b59360e7b kostenfrei http://www.revhabanera.sld.cu/index.php/rhab/article/view/2445 kostenfrei https://doaj.org/toc/1729-519X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 18 2019 1 30-44 |
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(DE-627)DOAJ006511287 (DE-599)DOAJebb5224448d44b45915c2e2b59360e7b DE-627 ger DE-627 rakwb eng spa R5-920 RA1-1270 Maricarmen González Costa verfasserin aut Inflammation from an immunologic perspective: a challenge to medicine in the 21st century 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and multifactorial process. Therefore, it is a challenge to elucidate the elements and the tissue changes that it causes to establish the best way to improve the clinical practice related to an inflammatory process.</p<<p<<strong<Objective:</strong< To describe inflammation, its classification, elements involved, and systemic changes from an immunological perspective.</p<<p<<strong<Material and Methods:</strong< A review of the topic was made using the updated bibliography. Free-access articles were consulted in <em<Pubmed</em< and <em<Scielo</em< databases in the period from January 2013 to December 2018.</p<<p<<strong<Development:</strong< Inflammation can be classified according to the damage, time or effectors involved. The main molecules are the cytokines like TNF-α, IFN-γ, IL-1β, IL-10, IL-6, TGF-β. Some cells participate such as neutrophils, mastocytes, macrophages, T-lymphocyes, and the vascular endothelium. During the inflammatory process, the functions of almost all organ systems are modified. It produces systemic changes that are observed in physiological processes such as pregnancy or aging. Sometimes inflammation triggers diseases such as cardiovascular and neurological ones, and cancer. The pathophysiological mechanisms have not been clarified.</p<<p<<strong<Conclusions:</strong< Currently, the events that trigger chronic inflammation and how tissue damage occurs are unknown. The biggest challenge is to elucidate the causes and immunological mechanisms that lead to inflammatory manifestations that are expressed as systemic neurological, cardiovascular and autoimmune diseases, among others.</p<<p class="Textopreformateado"<<strong<Keywords:</strong< Acute inflammation, chronic inflammation, proinflammatory mediators, sepsis.</p< inflamación aguda inflamación crónica mediadores proinflamatorios sepsis. acute inflammation chronic inflammation proinflammatory mediators sepsis. Medicine (General) Public aspects of medicine Alexander Ariel Padrón González verfasserin aut In Revista Habanera de Ciencias Médicas Universidad de Ciencias Médicas de La Habana, 2018 18(2019), 1, Seite 30-44 (DE-627)1760627410 1729519X nnns volume:18 year:2019 number:1 pages:30-44 https://doaj.org/article/ebb5224448d44b45915c2e2b59360e7b kostenfrei http://www.revhabanera.sld.cu/index.php/rhab/article/view/2445 kostenfrei https://doaj.org/toc/1729-519X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 18 2019 1 30-44 |
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R5-920 RA1-1270 Inflammation from an immunologic perspective: a challenge to medicine in the 21st century inflamación aguda inflamación crónica mediadores proinflamatorios sepsis. acute inflammation chronic inflammation proinflammatory mediators sepsis |
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Maricarmen González Costa |
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Maricarmen González Costa Alexander Ariel Padrón González |
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Inflammation from an immunologic perspective: a challenge to medicine in the 21st century |
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<p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and multifactorial process. Therefore, it is a challenge to elucidate the elements and the tissue changes that it causes to establish the best way to improve the clinical practice related to an inflammatory process.</p<<p<<strong<Objective:</strong< To describe inflammation, its classification, elements involved, and systemic changes from an immunological perspective.</p<<p<<strong<Material and Methods:</strong< A review of the topic was made using the updated bibliography. Free-access articles were consulted in <em<Pubmed</em< and <em<Scielo</em< databases in the period from January 2013 to December 2018.</p<<p<<strong<Development:</strong< Inflammation can be classified according to the damage, time or effectors involved. The main molecules are the cytokines like TNF-α, IFN-γ, IL-1β, IL-10, IL-6, TGF-β. Some cells participate such as neutrophils, mastocytes, macrophages, T-lymphocyes, and the vascular endothelium. During the inflammatory process, the functions of almost all organ systems are modified. It produces systemic changes that are observed in physiological processes such as pregnancy or aging. Sometimes inflammation triggers diseases such as cardiovascular and neurological ones, and cancer. The pathophysiological mechanisms have not been clarified.</p<<p<<strong<Conclusions:</strong< Currently, the events that trigger chronic inflammation and how tissue damage occurs are unknown. The biggest challenge is to elucidate the causes and immunological mechanisms that lead to inflammatory manifestations that are expressed as systemic neurological, cardiovascular and autoimmune diseases, among others.</p<<p class="Textopreformateado"<<strong<Keywords:</strong< Acute inflammation, chronic inflammation, proinflammatory mediators, sepsis.</p< |
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<p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and multifactorial process. Therefore, it is a challenge to elucidate the elements and the tissue changes that it causes to establish the best way to improve the clinical practice related to an inflammatory process.</p<<p<<strong<Objective:</strong< To describe inflammation, its classification, elements involved, and systemic changes from an immunological perspective.</p<<p<<strong<Material and Methods:</strong< A review of the topic was made using the updated bibliography. Free-access articles were consulted in <em<Pubmed</em< and <em<Scielo</em< databases in the period from January 2013 to December 2018.</p<<p<<strong<Development:</strong< Inflammation can be classified according to the damage, time or effectors involved. The main molecules are the cytokines like TNF-α, IFN-γ, IL-1β, IL-10, IL-6, TGF-β. Some cells participate such as neutrophils, mastocytes, macrophages, T-lymphocyes, and the vascular endothelium. During the inflammatory process, the functions of almost all organ systems are modified. It produces systemic changes that are observed in physiological processes such as pregnancy or aging. Sometimes inflammation triggers diseases such as cardiovascular and neurological ones, and cancer. The pathophysiological mechanisms have not been clarified.</p<<p<<strong<Conclusions:</strong< Currently, the events that trigger chronic inflammation and how tissue damage occurs are unknown. The biggest challenge is to elucidate the causes and immunological mechanisms that lead to inflammatory manifestations that are expressed as systemic neurological, cardiovascular and autoimmune diseases, among others.</p<<p class="Textopreformateado"<<strong<Keywords:</strong< Acute inflammation, chronic inflammation, proinflammatory mediators, sepsis.</p< |
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<p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and multifactorial process. Therefore, it is a challenge to elucidate the elements and the tissue changes that it causes to establish the best way to improve the clinical practice related to an inflammatory process.</p<<p<<strong<Objective:</strong< To describe inflammation, its classification, elements involved, and systemic changes from an immunological perspective.</p<<p<<strong<Material and Methods:</strong< A review of the topic was made using the updated bibliography. Free-access articles were consulted in <em<Pubmed</em< and <em<Scielo</em< databases in the period from January 2013 to December 2018.</p<<p<<strong<Development:</strong< Inflammation can be classified according to the damage, time or effectors involved. The main molecules are the cytokines like TNF-α, IFN-γ, IL-1β, IL-10, IL-6, TGF-β. Some cells participate such as neutrophils, mastocytes, macrophages, T-lymphocyes, and the vascular endothelium. During the inflammatory process, the functions of almost all organ systems are modified. It produces systemic changes that are observed in physiological processes such as pregnancy or aging. Sometimes inflammation triggers diseases such as cardiovascular and neurological ones, and cancer. The pathophysiological mechanisms have not been clarified.</p<<p<<strong<Conclusions:</strong< Currently, the events that trigger chronic inflammation and how tissue damage occurs are unknown. The biggest challenge is to elucidate the causes and immunological mechanisms that lead to inflammatory manifestations that are expressed as systemic neurological, cardiovascular and autoimmune diseases, among others.</p<<p class="Textopreformateado"<<strong<Keywords:</strong< Acute inflammation, chronic inflammation, proinflammatory mediators, sepsis.</p< |
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