Inflammation from an immunologic perspective: a challenge to medicine in the 21st century
<p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and...
Ausführliche Beschreibung
Autor*in: |
Maricarmen González Costa [verfasserIn] Alexander Ariel Padrón González [verfasserIn] |
---|
Format: |
E-Artikel |
---|---|
Sprache: |
Englisch ; Spanisch |
Erschienen: |
2019 |
---|
Schlagwörter: |
---|
Übergeordnetes Werk: |
In: Revista Habanera de Ciencias Médicas - Universidad de Ciencias Médicas de La Habana, 2018, 18(2019), 1, Seite 30-44 |
---|---|
Übergeordnetes Werk: |
volume:18 ; year:2019 ; number:1 ; pages:30-44 |
Links: |
---|
Katalog-ID: |
DOAJ006511287 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | DOAJ006511287 | ||
003 | DE-627 | ||
005 | 20230309204135.0 | ||
007 | cr uuu---uuuuu | ||
008 | 230225s2019 xx |||||o 00| ||eng c | ||
035 | |a (DE-627)DOAJ006511287 | ||
035 | |a (DE-599)DOAJebb5224448d44b45915c2e2b59360e7b | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng |a spa | ||
050 | 0 | |a R5-920 | |
050 | 0 | |a RA1-1270 | |
100 | 0 | |a Maricarmen González Costa |e verfasserin |4 aut | |
245 | 1 | 0 | |a Inflammation from an immunologic perspective: a challenge to medicine in the 21st century |
264 | 1 | |c 2019 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
520 | |a <p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and multifactorial process. Therefore, it is a challenge to elucidate the elements and the tissue changes that it causes to establish the best way to improve the clinical practice related to an inflammatory process.</p<<p<<strong<Objective:</strong< To describe inflammation, its classification, elements involved, and systemic changes from an immunological perspective.</p<<p<<strong<Material and Methods:</strong< A review of the topic was made using the updated bibliography. Free-access articles were consulted in <em<Pubmed</em< and <em<Scielo</em< databases in the period from January 2013 to December 2018.</p<<p<<strong<Development:</strong< Inflammation can be classified according to the damage, time or effectors involved. The main molecules are the cytokines like TNF-α, IFN-γ, IL-1β, IL-10, IL-6, TGF-β. Some cells participate such as neutrophils, mastocytes, macrophages, T-lymphocyes, and the vascular endothelium. During the inflammatory process, the functions of almost all organ systems are modified. It produces systemic changes that are observed in physiological processes such as pregnancy or aging. Sometimes inflammation triggers diseases such as cardiovascular and neurological ones, and cancer. The pathophysiological mechanisms have not been clarified.</p<<p<<strong<Conclusions:</strong< Currently, the events that trigger chronic inflammation and how tissue damage occurs are unknown. The biggest challenge is to elucidate the causes and immunological mechanisms that lead to inflammatory manifestations that are expressed as systemic neurological, cardiovascular and autoimmune diseases, among others.</p<<p class="Textopreformateado"<<strong<Keywords:</strong< Acute inflammation, chronic inflammation, proinflammatory mediators, sepsis.</p< | ||
650 | 4 | |a inflamación aguda | |
650 | 4 | |a inflamación crónica | |
650 | 4 | |a mediadores proinflamatorios | |
650 | 4 | |a sepsis. acute inflammation | |
650 | 4 | |a chronic inflammation | |
650 | 4 | |a proinflammatory mediators | |
650 | 4 | |a sepsis. | |
653 | 0 | |a Medicine (General) | |
653 | 0 | |a Public aspects of medicine | |
700 | 0 | |a Alexander Ariel Padrón González |e verfasserin |4 aut | |
773 | 0 | 8 | |i In |t Revista Habanera de Ciencias Médicas |d Universidad de Ciencias Médicas de La Habana, 2018 |g 18(2019), 1, Seite 30-44 |w (DE-627)1760627410 |x 1729519X |7 nnns |
773 | 1 | 8 | |g volume:18 |g year:2019 |g number:1 |g pages:30-44 |
856 | 4 | 0 | |u https://doaj.org/article/ebb5224448d44b45915c2e2b59360e7b |z kostenfrei |
856 | 4 | 0 | |u http://www.revhabanera.sld.cu/index.php/rhab/article/view/2445 |z kostenfrei |
856 | 4 | 2 | |u https://doaj.org/toc/1729-519X |y Journal toc |z kostenfrei |
912 | |a GBV_USEFLAG_A | ||
912 | |a SYSFLAG_A | ||
912 | |a GBV_DOAJ | ||
951 | |a AR | ||
952 | |d 18 |j 2019 |e 1 |h 30-44 |
author_variant |
m g c mgc a a p g aapg |
---|---|
matchkey_str |
article:1729519X:2019----::nlmainrmnmuooiprpciecalneoei |
hierarchy_sort_str |
2019 |
callnumber-subject-code |
R |
publishDate |
2019 |
allfields |
(DE-627)DOAJ006511287 (DE-599)DOAJebb5224448d44b45915c2e2b59360e7b DE-627 ger DE-627 rakwb eng spa R5-920 RA1-1270 Maricarmen González Costa verfasserin aut Inflammation from an immunologic perspective: a challenge to medicine in the 21st century 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and multifactorial process. Therefore, it is a challenge to elucidate the elements and the tissue changes that it causes to establish the best way to improve the clinical practice related to an inflammatory process.</p<<p<<strong<Objective:</strong< To describe inflammation, its classification, elements involved, and systemic changes from an immunological perspective.</p<<p<<strong<Material and Methods:</strong< A review of the topic was made using the updated bibliography. Free-access articles were consulted in <em<Pubmed</em< and <em<Scielo</em< databases in the period from January 2013 to December 2018.</p<<p<<strong<Development:</strong< Inflammation can be classified according to the damage, time or effectors involved. The main molecules are the cytokines like TNF-α, IFN-γ, IL-1β, IL-10, IL-6, TGF-β. Some cells participate such as neutrophils, mastocytes, macrophages, T-lymphocyes, and the vascular endothelium. During the inflammatory process, the functions of almost all organ systems are modified. It produces systemic changes that are observed in physiological processes such as pregnancy or aging. Sometimes inflammation triggers diseases such as cardiovascular and neurological ones, and cancer. The pathophysiological mechanisms have not been clarified.</p<<p<<strong<Conclusions:</strong< Currently, the events that trigger chronic inflammation and how tissue damage occurs are unknown. The biggest challenge is to elucidate the causes and immunological mechanisms that lead to inflammatory manifestations that are expressed as systemic neurological, cardiovascular and autoimmune diseases, among others.</p<<p class="Textopreformateado"<<strong<Keywords:</strong< Acute inflammation, chronic inflammation, proinflammatory mediators, sepsis.</p< inflamación aguda inflamación crónica mediadores proinflamatorios sepsis. acute inflammation chronic inflammation proinflammatory mediators sepsis. Medicine (General) Public aspects of medicine Alexander Ariel Padrón González verfasserin aut In Revista Habanera de Ciencias Médicas Universidad de Ciencias Médicas de La Habana, 2018 18(2019), 1, Seite 30-44 (DE-627)1760627410 1729519X nnns volume:18 year:2019 number:1 pages:30-44 https://doaj.org/article/ebb5224448d44b45915c2e2b59360e7b kostenfrei http://www.revhabanera.sld.cu/index.php/rhab/article/view/2445 kostenfrei https://doaj.org/toc/1729-519X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 18 2019 1 30-44 |
spelling |
(DE-627)DOAJ006511287 (DE-599)DOAJebb5224448d44b45915c2e2b59360e7b DE-627 ger DE-627 rakwb eng spa R5-920 RA1-1270 Maricarmen González Costa verfasserin aut Inflammation from an immunologic perspective: a challenge to medicine in the 21st century 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and multifactorial process. Therefore, it is a challenge to elucidate the elements and the tissue changes that it causes to establish the best way to improve the clinical practice related to an inflammatory process.</p<<p<<strong<Objective:</strong< To describe inflammation, its classification, elements involved, and systemic changes from an immunological perspective.</p<<p<<strong<Material and Methods:</strong< A review of the topic was made using the updated bibliography. Free-access articles were consulted in <em<Pubmed</em< and <em<Scielo</em< databases in the period from January 2013 to December 2018.</p<<p<<strong<Development:</strong< Inflammation can be classified according to the damage, time or effectors involved. The main molecules are the cytokines like TNF-α, IFN-γ, IL-1β, IL-10, IL-6, TGF-β. Some cells participate such as neutrophils, mastocytes, macrophages, T-lymphocyes, and the vascular endothelium. During the inflammatory process, the functions of almost all organ systems are modified. It produces systemic changes that are observed in physiological processes such as pregnancy or aging. Sometimes inflammation triggers diseases such as cardiovascular and neurological ones, and cancer. The pathophysiological mechanisms have not been clarified.</p<<p<<strong<Conclusions:</strong< Currently, the events that trigger chronic inflammation and how tissue damage occurs are unknown. The biggest challenge is to elucidate the causes and immunological mechanisms that lead to inflammatory manifestations that are expressed as systemic neurological, cardiovascular and autoimmune diseases, among others.</p<<p class="Textopreformateado"<<strong<Keywords:</strong< Acute inflammation, chronic inflammation, proinflammatory mediators, sepsis.</p< inflamación aguda inflamación crónica mediadores proinflamatorios sepsis. acute inflammation chronic inflammation proinflammatory mediators sepsis. Medicine (General) Public aspects of medicine Alexander Ariel Padrón González verfasserin aut In Revista Habanera de Ciencias Médicas Universidad de Ciencias Médicas de La Habana, 2018 18(2019), 1, Seite 30-44 (DE-627)1760627410 1729519X nnns volume:18 year:2019 number:1 pages:30-44 https://doaj.org/article/ebb5224448d44b45915c2e2b59360e7b kostenfrei http://www.revhabanera.sld.cu/index.php/rhab/article/view/2445 kostenfrei https://doaj.org/toc/1729-519X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 18 2019 1 30-44 |
allfields_unstemmed |
(DE-627)DOAJ006511287 (DE-599)DOAJebb5224448d44b45915c2e2b59360e7b DE-627 ger DE-627 rakwb eng spa R5-920 RA1-1270 Maricarmen González Costa verfasserin aut Inflammation from an immunologic perspective: a challenge to medicine in the 21st century 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and multifactorial process. Therefore, it is a challenge to elucidate the elements and the tissue changes that it causes to establish the best way to improve the clinical practice related to an inflammatory process.</p<<p<<strong<Objective:</strong< To describe inflammation, its classification, elements involved, and systemic changes from an immunological perspective.</p<<p<<strong<Material and Methods:</strong< A review of the topic was made using the updated bibliography. Free-access articles were consulted in <em<Pubmed</em< and <em<Scielo</em< databases in the period from January 2013 to December 2018.</p<<p<<strong<Development:</strong< Inflammation can be classified according to the damage, time or effectors involved. The main molecules are the cytokines like TNF-α, IFN-γ, IL-1β, IL-10, IL-6, TGF-β. Some cells participate such as neutrophils, mastocytes, macrophages, T-lymphocyes, and the vascular endothelium. During the inflammatory process, the functions of almost all organ systems are modified. It produces systemic changes that are observed in physiological processes such as pregnancy or aging. Sometimes inflammation triggers diseases such as cardiovascular and neurological ones, and cancer. The pathophysiological mechanisms have not been clarified.</p<<p<<strong<Conclusions:</strong< Currently, the events that trigger chronic inflammation and how tissue damage occurs are unknown. The biggest challenge is to elucidate the causes and immunological mechanisms that lead to inflammatory manifestations that are expressed as systemic neurological, cardiovascular and autoimmune diseases, among others.</p<<p class="Textopreformateado"<<strong<Keywords:</strong< Acute inflammation, chronic inflammation, proinflammatory mediators, sepsis.</p< inflamación aguda inflamación crónica mediadores proinflamatorios sepsis. acute inflammation chronic inflammation proinflammatory mediators sepsis. Medicine (General) Public aspects of medicine Alexander Ariel Padrón González verfasserin aut In Revista Habanera de Ciencias Médicas Universidad de Ciencias Médicas de La Habana, 2018 18(2019), 1, Seite 30-44 (DE-627)1760627410 1729519X nnns volume:18 year:2019 number:1 pages:30-44 https://doaj.org/article/ebb5224448d44b45915c2e2b59360e7b kostenfrei http://www.revhabanera.sld.cu/index.php/rhab/article/view/2445 kostenfrei https://doaj.org/toc/1729-519X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 18 2019 1 30-44 |
allfieldsGer |
(DE-627)DOAJ006511287 (DE-599)DOAJebb5224448d44b45915c2e2b59360e7b DE-627 ger DE-627 rakwb eng spa R5-920 RA1-1270 Maricarmen González Costa verfasserin aut Inflammation from an immunologic perspective: a challenge to medicine in the 21st century 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and multifactorial process. Therefore, it is a challenge to elucidate the elements and the tissue changes that it causes to establish the best way to improve the clinical practice related to an inflammatory process.</p<<p<<strong<Objective:</strong< To describe inflammation, its classification, elements involved, and systemic changes from an immunological perspective.</p<<p<<strong<Material and Methods:</strong< A review of the topic was made using the updated bibliography. Free-access articles were consulted in <em<Pubmed</em< and <em<Scielo</em< databases in the period from January 2013 to December 2018.</p<<p<<strong<Development:</strong< Inflammation can be classified according to the damage, time or effectors involved. The main molecules are the cytokines like TNF-α, IFN-γ, IL-1β, IL-10, IL-6, TGF-β. Some cells participate such as neutrophils, mastocytes, macrophages, T-lymphocyes, and the vascular endothelium. During the inflammatory process, the functions of almost all organ systems are modified. It produces systemic changes that are observed in physiological processes such as pregnancy or aging. Sometimes inflammation triggers diseases such as cardiovascular and neurological ones, and cancer. The pathophysiological mechanisms have not been clarified.</p<<p<<strong<Conclusions:</strong< Currently, the events that trigger chronic inflammation and how tissue damage occurs are unknown. The biggest challenge is to elucidate the causes and immunological mechanisms that lead to inflammatory manifestations that are expressed as systemic neurological, cardiovascular and autoimmune diseases, among others.</p<<p class="Textopreformateado"<<strong<Keywords:</strong< Acute inflammation, chronic inflammation, proinflammatory mediators, sepsis.</p< inflamación aguda inflamación crónica mediadores proinflamatorios sepsis. acute inflammation chronic inflammation proinflammatory mediators sepsis. Medicine (General) Public aspects of medicine Alexander Ariel Padrón González verfasserin aut In Revista Habanera de Ciencias Médicas Universidad de Ciencias Médicas de La Habana, 2018 18(2019), 1, Seite 30-44 (DE-627)1760627410 1729519X nnns volume:18 year:2019 number:1 pages:30-44 https://doaj.org/article/ebb5224448d44b45915c2e2b59360e7b kostenfrei http://www.revhabanera.sld.cu/index.php/rhab/article/view/2445 kostenfrei https://doaj.org/toc/1729-519X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 18 2019 1 30-44 |
allfieldsSound |
(DE-627)DOAJ006511287 (DE-599)DOAJebb5224448d44b45915c2e2b59360e7b DE-627 ger DE-627 rakwb eng spa R5-920 RA1-1270 Maricarmen González Costa verfasserin aut Inflammation from an immunologic perspective: a challenge to medicine in the 21st century 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and multifactorial process. Therefore, it is a challenge to elucidate the elements and the tissue changes that it causes to establish the best way to improve the clinical practice related to an inflammatory process.</p<<p<<strong<Objective:</strong< To describe inflammation, its classification, elements involved, and systemic changes from an immunological perspective.</p<<p<<strong<Material and Methods:</strong< A review of the topic was made using the updated bibliography. Free-access articles were consulted in <em<Pubmed</em< and <em<Scielo</em< databases in the period from January 2013 to December 2018.</p<<p<<strong<Development:</strong< Inflammation can be classified according to the damage, time or effectors involved. The main molecules are the cytokines like TNF-α, IFN-γ, IL-1β, IL-10, IL-6, TGF-β. Some cells participate such as neutrophils, mastocytes, macrophages, T-lymphocyes, and the vascular endothelium. During the inflammatory process, the functions of almost all organ systems are modified. It produces systemic changes that are observed in physiological processes such as pregnancy or aging. Sometimes inflammation triggers diseases such as cardiovascular and neurological ones, and cancer. The pathophysiological mechanisms have not been clarified.</p<<p<<strong<Conclusions:</strong< Currently, the events that trigger chronic inflammation and how tissue damage occurs are unknown. The biggest challenge is to elucidate the causes and immunological mechanisms that lead to inflammatory manifestations that are expressed as systemic neurological, cardiovascular and autoimmune diseases, among others.</p<<p class="Textopreformateado"<<strong<Keywords:</strong< Acute inflammation, chronic inflammation, proinflammatory mediators, sepsis.</p< inflamación aguda inflamación crónica mediadores proinflamatorios sepsis. acute inflammation chronic inflammation proinflammatory mediators sepsis. Medicine (General) Public aspects of medicine Alexander Ariel Padrón González verfasserin aut In Revista Habanera de Ciencias Médicas Universidad de Ciencias Médicas de La Habana, 2018 18(2019), 1, Seite 30-44 (DE-627)1760627410 1729519X nnns volume:18 year:2019 number:1 pages:30-44 https://doaj.org/article/ebb5224448d44b45915c2e2b59360e7b kostenfrei http://www.revhabanera.sld.cu/index.php/rhab/article/view/2445 kostenfrei https://doaj.org/toc/1729-519X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 18 2019 1 30-44 |
language |
English Spanish |
source |
In Revista Habanera de Ciencias Médicas 18(2019), 1, Seite 30-44 volume:18 year:2019 number:1 pages:30-44 |
sourceStr |
In Revista Habanera de Ciencias Médicas 18(2019), 1, Seite 30-44 volume:18 year:2019 number:1 pages:30-44 |
format_phy_str_mv |
Article |
institution |
findex.gbv.de |
topic_facet |
inflamación aguda inflamación crónica mediadores proinflamatorios sepsis. acute inflammation chronic inflammation proinflammatory mediators sepsis. Medicine (General) Public aspects of medicine |
isfreeaccess_bool |
true |
container_title |
Revista Habanera de Ciencias Médicas |
authorswithroles_txt_mv |
Maricarmen González Costa @@aut@@ Alexander Ariel Padrón González @@aut@@ |
publishDateDaySort_date |
2019-01-01T00:00:00Z |
hierarchy_top_id |
1760627410 |
id |
DOAJ006511287 |
language_de |
englisch spanisch |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ006511287</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309204135.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230225s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ006511287</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJebb5224448d44b45915c2e2b59360e7b</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield><subfield code="a">spa</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">R5-920</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RA1-1270</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Maricarmen González Costa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Inflammation from an immunologic perspective: a challenge to medicine in the 21st century</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a"><p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and multifactorial process. Therefore, it is a challenge to elucidate the elements and the tissue changes that it causes to establish the best way to improve the clinical practice related to an inflammatory process.</p<<p<<strong<Objective:</strong< To describe inflammation, its classification, elements involved, and systemic changes from an immunological perspective.</p<<p<<strong<Material and Methods:</strong< A review of the topic was made using the updated bibliography. Free-access articles were consulted in <em<Pubmed</em< and <em<Scielo</em< databases in the period from January 2013 to December 2018.</p<<p<<strong<Development:</strong< Inflammation can be classified according to the damage, time or effectors involved. The main molecules are the cytokines like TNF-α, IFN-γ, IL-1β, IL-10, IL-6, TGF-β. Some cells participate such as neutrophils, mastocytes, macrophages, T-lymphocyes, and the vascular endothelium. During the inflammatory process, the functions of almost all organ systems are modified. It produces systemic changes that are observed in physiological processes such as pregnancy or aging. Sometimes inflammation triggers diseases such as cardiovascular and neurological ones, and cancer. The pathophysiological mechanisms have not been clarified.</p<<p<<strong<Conclusions:</strong< Currently, the events that trigger chronic inflammation and how tissue damage occurs are unknown. The biggest challenge is to elucidate the causes and immunological mechanisms that lead to inflammatory manifestations that are expressed as systemic neurological, cardiovascular and autoimmune diseases, among others.</p<<p class="Textopreformateado"<<strong<Keywords:</strong< Acute inflammation, chronic inflammation, proinflammatory mediators, sepsis.</p<</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">inflamación aguda</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">inflamación crónica</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">mediadores proinflamatorios</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">sepsis. acute inflammation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">chronic inflammation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">proinflammatory mediators</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">sepsis.</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine (General)</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Public aspects of medicine</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alexander Ariel Padrón González</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Revista Habanera de Ciencias Médicas</subfield><subfield code="d">Universidad de Ciencias Médicas de La Habana, 2018</subfield><subfield code="g">18(2019), 1, Seite 30-44</subfield><subfield code="w">(DE-627)1760627410</subfield><subfield code="x">1729519X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:18</subfield><subfield code="g">year:2019</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:30-44</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/ebb5224448d44b45915c2e2b59360e7b</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.revhabanera.sld.cu/index.php/rhab/article/view/2445</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1729-519X</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">18</subfield><subfield code="j">2019</subfield><subfield code="e">1</subfield><subfield code="h">30-44</subfield></datafield></record></collection>
|
callnumber-first |
R - Medicine |
author |
Maricarmen González Costa |
spellingShingle |
Maricarmen González Costa misc R5-920 misc RA1-1270 misc inflamación aguda misc inflamación crónica misc mediadores proinflamatorios misc sepsis. acute inflammation misc chronic inflammation misc proinflammatory mediators misc sepsis. misc Medicine (General) misc Public aspects of medicine Inflammation from an immunologic perspective: a challenge to medicine in the 21st century |
authorStr |
Maricarmen González Costa |
ppnlink_with_tag_str_mv |
@@773@@(DE-627)1760627410 |
format |
electronic Article |
delete_txt_mv |
keep |
author_role |
aut aut |
collection |
DOAJ |
remote_str |
true |
callnumber-label |
R5-920 |
illustrated |
Not Illustrated |
issn |
1729519X |
topic_title |
R5-920 RA1-1270 Inflammation from an immunologic perspective: a challenge to medicine in the 21st century inflamación aguda inflamación crónica mediadores proinflamatorios sepsis. acute inflammation chronic inflammation proinflammatory mediators sepsis |
topic |
misc R5-920 misc RA1-1270 misc inflamación aguda misc inflamación crónica misc mediadores proinflamatorios misc sepsis. acute inflammation misc chronic inflammation misc proinflammatory mediators misc sepsis. misc Medicine (General) misc Public aspects of medicine |
topic_unstemmed |
misc R5-920 misc RA1-1270 misc inflamación aguda misc inflamación crónica misc mediadores proinflamatorios misc sepsis. acute inflammation misc chronic inflammation misc proinflammatory mediators misc sepsis. misc Medicine (General) misc Public aspects of medicine |
topic_browse |
misc R5-920 misc RA1-1270 misc inflamación aguda misc inflamación crónica misc mediadores proinflamatorios misc sepsis. acute inflammation misc chronic inflammation misc proinflammatory mediators misc sepsis. misc Medicine (General) misc Public aspects of medicine |
format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
format_main_str_mv |
Text Zeitschrift/Artikel |
carriertype_str_mv |
cr |
hierarchy_parent_title |
Revista Habanera de Ciencias Médicas |
hierarchy_parent_id |
1760627410 |
hierarchy_top_title |
Revista Habanera de Ciencias Médicas |
isfreeaccess_txt |
true |
familylinks_str_mv |
(DE-627)1760627410 |
title |
Inflammation from an immunologic perspective: a challenge to medicine in the 21st century |
ctrlnum |
(DE-627)DOAJ006511287 (DE-599)DOAJebb5224448d44b45915c2e2b59360e7b |
title_full |
Inflammation from an immunologic perspective: a challenge to medicine in the 21st century |
author_sort |
Maricarmen González Costa |
journal |
Revista Habanera de Ciencias Médicas |
journalStr |
Revista Habanera de Ciencias Médicas |
callnumber-first-code |
R |
lang_code |
eng spa |
isOA_bool |
true |
recordtype |
marc |
publishDateSort |
2019 |
contenttype_str_mv |
txt |
container_start_page |
30 |
author_browse |
Maricarmen González Costa Alexander Ariel Padrón González |
container_volume |
18 |
class |
R5-920 RA1-1270 |
format_se |
Elektronische Aufsätze |
author-letter |
Maricarmen González Costa |
author2-role |
verfasserin |
title_sort |
inflammation from an immunologic perspective: a challenge to medicine in the 21st century |
callnumber |
R5-920 |
title_auth |
Inflammation from an immunologic perspective: a challenge to medicine in the 21st century |
abstract |
<p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and multifactorial process. Therefore, it is a challenge to elucidate the elements and the tissue changes that it causes to establish the best way to improve the clinical practice related to an inflammatory process.</p<<p<<strong<Objective:</strong< To describe inflammation, its classification, elements involved, and systemic changes from an immunological perspective.</p<<p<<strong<Material and Methods:</strong< A review of the topic was made using the updated bibliography. Free-access articles were consulted in <em<Pubmed</em< and <em<Scielo</em< databases in the period from January 2013 to December 2018.</p<<p<<strong<Development:</strong< Inflammation can be classified according to the damage, time or effectors involved. The main molecules are the cytokines like TNF-α, IFN-γ, IL-1β, IL-10, IL-6, TGF-β. Some cells participate such as neutrophils, mastocytes, macrophages, T-lymphocyes, and the vascular endothelium. During the inflammatory process, the functions of almost all organ systems are modified. It produces systemic changes that are observed in physiological processes such as pregnancy or aging. Sometimes inflammation triggers diseases such as cardiovascular and neurological ones, and cancer. The pathophysiological mechanisms have not been clarified.</p<<p<<strong<Conclusions:</strong< Currently, the events that trigger chronic inflammation and how tissue damage occurs are unknown. The biggest challenge is to elucidate the causes and immunological mechanisms that lead to inflammatory manifestations that are expressed as systemic neurological, cardiovascular and autoimmune diseases, among others.</p<<p class="Textopreformateado"<<strong<Keywords:</strong< Acute inflammation, chronic inflammation, proinflammatory mediators, sepsis.</p< |
abstractGer |
<p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and multifactorial process. Therefore, it is a challenge to elucidate the elements and the tissue changes that it causes to establish the best way to improve the clinical practice related to an inflammatory process.</p<<p<<strong<Objective:</strong< To describe inflammation, its classification, elements involved, and systemic changes from an immunological perspective.</p<<p<<strong<Material and Methods:</strong< A review of the topic was made using the updated bibliography. Free-access articles were consulted in <em<Pubmed</em< and <em<Scielo</em< databases in the period from January 2013 to December 2018.</p<<p<<strong<Development:</strong< Inflammation can be classified according to the damage, time or effectors involved. The main molecules are the cytokines like TNF-α, IFN-γ, IL-1β, IL-10, IL-6, TGF-β. Some cells participate such as neutrophils, mastocytes, macrophages, T-lymphocyes, and the vascular endothelium. During the inflammatory process, the functions of almost all organ systems are modified. It produces systemic changes that are observed in physiological processes such as pregnancy or aging. Sometimes inflammation triggers diseases such as cardiovascular and neurological ones, and cancer. The pathophysiological mechanisms have not been clarified.</p<<p<<strong<Conclusions:</strong< Currently, the events that trigger chronic inflammation and how tissue damage occurs are unknown. The biggest challenge is to elucidate the causes and immunological mechanisms that lead to inflammatory manifestations that are expressed as systemic neurological, cardiovascular and autoimmune diseases, among others.</p<<p class="Textopreformateado"<<strong<Keywords:</strong< Acute inflammation, chronic inflammation, proinflammatory mediators, sepsis.</p< |
abstract_unstemmed |
<p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and multifactorial process. Therefore, it is a challenge to elucidate the elements and the tissue changes that it causes to establish the best way to improve the clinical practice related to an inflammatory process.</p<<p<<strong<Objective:</strong< To describe inflammation, its classification, elements involved, and systemic changes from an immunological perspective.</p<<p<<strong<Material and Methods:</strong< A review of the topic was made using the updated bibliography. Free-access articles were consulted in <em<Pubmed</em< and <em<Scielo</em< databases in the period from January 2013 to December 2018.</p<<p<<strong<Development:</strong< Inflammation can be classified according to the damage, time or effectors involved. The main molecules are the cytokines like TNF-α, IFN-γ, IL-1β, IL-10, IL-6, TGF-β. Some cells participate such as neutrophils, mastocytes, macrophages, T-lymphocyes, and the vascular endothelium. During the inflammatory process, the functions of almost all organ systems are modified. It produces systemic changes that are observed in physiological processes such as pregnancy or aging. Sometimes inflammation triggers diseases such as cardiovascular and neurological ones, and cancer. The pathophysiological mechanisms have not been clarified.</p<<p<<strong<Conclusions:</strong< Currently, the events that trigger chronic inflammation and how tissue damage occurs are unknown. The biggest challenge is to elucidate the causes and immunological mechanisms that lead to inflammatory manifestations that are expressed as systemic neurological, cardiovascular and autoimmune diseases, among others.</p<<p class="Textopreformateado"<<strong<Keywords:</strong< Acute inflammation, chronic inflammation, proinflammatory mediators, sepsis.</p< |
collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ |
container_issue |
1 |
title_short |
Inflammation from an immunologic perspective: a challenge to medicine in the 21st century |
url |
https://doaj.org/article/ebb5224448d44b45915c2e2b59360e7b http://www.revhabanera.sld.cu/index.php/rhab/article/view/2445 https://doaj.org/toc/1729-519X |
remote_bool |
true |
author2 |
Alexander Ariel Padrón González |
author2Str |
Alexander Ariel Padrón González |
ppnlink |
1760627410 |
callnumber-subject |
R - General Medicine |
mediatype_str_mv |
c |
isOA_txt |
true |
hochschulschrift_bool |
false |
callnumber-a |
R5-920 |
up_date |
2024-07-03T21:21:52.315Z |
_version_ |
1803594458534510592 |
fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ006511287</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230309204135.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230225s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ006511287</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJebb5224448d44b45915c2e2b59360e7b</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield><subfield code="a">spa</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">R5-920</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RA1-1270</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Maricarmen González Costa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Inflammation from an immunologic perspective: a challenge to medicine in the 21st century</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a"><p<<strong<Introduction:</strong< Inflammation is a homeostatic response of the body. It is one of the main reasons for consultation in Cuba and throughout world. There is a misperception that it is an isolated and always pathological entity. It is a dynamic, complex, systemic, and multifactorial process. Therefore, it is a challenge to elucidate the elements and the tissue changes that it causes to establish the best way to improve the clinical practice related to an inflammatory process.</p<<p<<strong<Objective:</strong< To describe inflammation, its classification, elements involved, and systemic changes from an immunological perspective.</p<<p<<strong<Material and Methods:</strong< A review of the topic was made using the updated bibliography. Free-access articles were consulted in <em<Pubmed</em< and <em<Scielo</em< databases in the period from January 2013 to December 2018.</p<<p<<strong<Development:</strong< Inflammation can be classified according to the damage, time or effectors involved. The main molecules are the cytokines like TNF-α, IFN-γ, IL-1β, IL-10, IL-6, TGF-β. Some cells participate such as neutrophils, mastocytes, macrophages, T-lymphocyes, and the vascular endothelium. During the inflammatory process, the functions of almost all organ systems are modified. It produces systemic changes that are observed in physiological processes such as pregnancy or aging. Sometimes inflammation triggers diseases such as cardiovascular and neurological ones, and cancer. The pathophysiological mechanisms have not been clarified.</p<<p<<strong<Conclusions:</strong< Currently, the events that trigger chronic inflammation and how tissue damage occurs are unknown. The biggest challenge is to elucidate the causes and immunological mechanisms that lead to inflammatory manifestations that are expressed as systemic neurological, cardiovascular and autoimmune diseases, among others.</p<<p class="Textopreformateado"<<strong<Keywords:</strong< Acute inflammation, chronic inflammation, proinflammatory mediators, sepsis.</p<</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">inflamación aguda</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">inflamación crónica</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">mediadores proinflamatorios</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">sepsis. acute inflammation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">chronic inflammation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">proinflammatory mediators</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">sepsis.</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine (General)</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Public aspects of medicine</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alexander Ariel Padrón González</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Revista Habanera de Ciencias Médicas</subfield><subfield code="d">Universidad de Ciencias Médicas de La Habana, 2018</subfield><subfield code="g">18(2019), 1, Seite 30-44</subfield><subfield code="w">(DE-627)1760627410</subfield><subfield code="x">1729519X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:18</subfield><subfield code="g">year:2019</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:30-44</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/ebb5224448d44b45915c2e2b59360e7b</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.revhabanera.sld.cu/index.php/rhab/article/view/2445</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1729-519X</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">18</subfield><subfield code="j">2019</subfield><subfield code="e">1</subfield><subfield code="h">30-44</subfield></datafield></record></collection>
|
score |
7.3993244 |