Brain Structures Associated With Individual Differences in Somatic Symptoms and Emotional Distress in a Healthy Sample
Stress-related psychosomatic responses are viewed as important risks to our physical health. Growing evidence from structural imaging studies has implicated that stress and trauma exposures have negative effects on brain structural alterations. However, whether stress-related emotional distress and...
Ausführliche Beschreibung
Autor*in: |
Dongtao Wei [verfasserIn] Yu Liu [verfasserIn] Kaixiang Zhuang [verfasserIn] Jieyu Lv [verfasserIn] Jie Meng [verfasserIn] Jiangzhou Sun [verfasserIn] Qunlin Chen [verfasserIn] Wenjing Yang [verfasserIn] Jiang Qiu [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2020 |
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Übergeordnetes Werk: |
In: Frontiers in Human Neuroscience - Frontiers Media S.A., 2008, 14(2020) |
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Übergeordnetes Werk: |
volume:14 ; year:2020 |
Links: |
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DOI / URN: |
10.3389/fnhum.2020.492990 |
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Katalog-ID: |
DOAJ006512305 |
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10.3389/fnhum.2020.492990 doi (DE-627)DOAJ006512305 (DE-599)DOAJ8b27326c30f245d889b8dacd1f2e892f DE-627 ger DE-627 rakwb eng RC321-571 Dongtao Wei verfasserin aut Brain Structures Associated With Individual Differences in Somatic Symptoms and Emotional Distress in a Healthy Sample 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Stress-related psychosomatic responses are viewed as important risks to our physical health. Growing evidence from structural imaging studies has implicated that stress and trauma exposures have negative effects on brain structural alterations. However, whether stress-related emotional distress and somatic symptoms are related to the structure of brain systems remains unclear. Also, stress-related somatic symptoms have adverse effects on emotional distress. In turn, emotional distress may influence somatic symptom reports via negative cognitive bias. However, whether this relationship is mediated by specific brain morphology remains poorly understood. First, we used voxel-based morphometric approaches to investigate the neuroanatomical basis underlying somatic symptoms and emotional distress in a large sample of healthy subjects (ages 18–27 years). We found that relatively high stress-related somatic symptoms were associated with reduced gray matter volumes (GMVs) in the ventral medial prefrontal cortex (vmPFC), anterior insula, somatosensory cortex, hippocampus, and amygdala. Furthermore, a moderator analysis was performed to investigate the impact of recent stressful life events (moderators) on the association between specific GMVs (independent variables) and emotional distress (dependent variables). Interestingly, high levels of emotional distress were associated with small volumes of the vmPFC, anterior insula, hippocampus, and amygdala in participants with experience with more recent stressful life events. Finally, we performed mediation analyses to investigate the specific brain areas that mediate the association between emotional distress and somatic symptoms. The results showed that the effect of emotional distress on somatic symptoms is mediated by reductions in the volume of the hippocampus, the impact of somatic symptoms on emotional distress is mediated by the volume of the vmPFC. These results provided evidence that higher stress-related somatic symptoms are associated with smaller volume in prefrontal, insula, and limbic regions involved in emotion, interoception, and memory processing. The vmPFC and hippocampus play different roles in the relationship between emotional distress and somatic symptoms. stress psychosomatic voxel-based morphometry (VBM) cortical-limbic system individual differences Neurosciences. Biological psychiatry. Neuropsychiatry Dongtao Wei verfasserin aut Yu Liu verfasserin aut Yu Liu verfasserin aut Kaixiang Zhuang verfasserin aut Kaixiang Zhuang verfasserin aut Jieyu Lv verfasserin aut Jie Meng verfasserin aut Jie Meng verfasserin aut Jiangzhou Sun verfasserin aut Jiangzhou Sun verfasserin aut Qunlin Chen verfasserin aut Qunlin Chen verfasserin aut Wenjing Yang verfasserin aut Wenjing Yang verfasserin aut Jiang Qiu verfasserin aut Jiang Qiu verfasserin aut In Frontiers in Human Neuroscience Frontiers Media S.A., 2008 14(2020) (DE-627)56601243X (DE-600)2425477-0 16625161 nnns volume:14 year:2020 https://doi.org/10.3389/fnhum.2020.492990 kostenfrei https://doaj.org/article/8b27326c30f245d889b8dacd1f2e892f kostenfrei https://www.frontiersin.org/articles/10.3389/fnhum.2020.492990/full kostenfrei https://doaj.org/toc/1662-5161 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2020 |
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10.3389/fnhum.2020.492990 doi (DE-627)DOAJ006512305 (DE-599)DOAJ8b27326c30f245d889b8dacd1f2e892f DE-627 ger DE-627 rakwb eng RC321-571 Dongtao Wei verfasserin aut Brain Structures Associated With Individual Differences in Somatic Symptoms and Emotional Distress in a Healthy Sample 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Stress-related psychosomatic responses are viewed as important risks to our physical health. Growing evidence from structural imaging studies has implicated that stress and trauma exposures have negative effects on brain structural alterations. However, whether stress-related emotional distress and somatic symptoms are related to the structure of brain systems remains unclear. Also, stress-related somatic symptoms have adverse effects on emotional distress. In turn, emotional distress may influence somatic symptom reports via negative cognitive bias. However, whether this relationship is mediated by specific brain morphology remains poorly understood. First, we used voxel-based morphometric approaches to investigate the neuroanatomical basis underlying somatic symptoms and emotional distress in a large sample of healthy subjects (ages 18–27 years). We found that relatively high stress-related somatic symptoms were associated with reduced gray matter volumes (GMVs) in the ventral medial prefrontal cortex (vmPFC), anterior insula, somatosensory cortex, hippocampus, and amygdala. Furthermore, a moderator analysis was performed to investigate the impact of recent stressful life events (moderators) on the association between specific GMVs (independent variables) and emotional distress (dependent variables). Interestingly, high levels of emotional distress were associated with small volumes of the vmPFC, anterior insula, hippocampus, and amygdala in participants with experience with more recent stressful life events. Finally, we performed mediation analyses to investigate the specific brain areas that mediate the association between emotional distress and somatic symptoms. The results showed that the effect of emotional distress on somatic symptoms is mediated by reductions in the volume of the hippocampus, the impact of somatic symptoms on emotional distress is mediated by the volume of the vmPFC. These results provided evidence that higher stress-related somatic symptoms are associated with smaller volume in prefrontal, insula, and limbic regions involved in emotion, interoception, and memory processing. The vmPFC and hippocampus play different roles in the relationship between emotional distress and somatic symptoms. stress psychosomatic voxel-based morphometry (VBM) cortical-limbic system individual differences Neurosciences. Biological psychiatry. Neuropsychiatry Dongtao Wei verfasserin aut Yu Liu verfasserin aut Yu Liu verfasserin aut Kaixiang Zhuang verfasserin aut Kaixiang Zhuang verfasserin aut Jieyu Lv verfasserin aut Jie Meng verfasserin aut Jie Meng verfasserin aut Jiangzhou Sun verfasserin aut Jiangzhou Sun verfasserin aut Qunlin Chen verfasserin aut Qunlin Chen verfasserin aut Wenjing Yang verfasserin aut Wenjing Yang verfasserin aut Jiang Qiu verfasserin aut Jiang Qiu verfasserin aut In Frontiers in Human Neuroscience Frontiers Media S.A., 2008 14(2020) (DE-627)56601243X (DE-600)2425477-0 16625161 nnns volume:14 year:2020 https://doi.org/10.3389/fnhum.2020.492990 kostenfrei https://doaj.org/article/8b27326c30f245d889b8dacd1f2e892f kostenfrei https://www.frontiersin.org/articles/10.3389/fnhum.2020.492990/full kostenfrei https://doaj.org/toc/1662-5161 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2020 |
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10.3389/fnhum.2020.492990 doi (DE-627)DOAJ006512305 (DE-599)DOAJ8b27326c30f245d889b8dacd1f2e892f DE-627 ger DE-627 rakwb eng RC321-571 Dongtao Wei verfasserin aut Brain Structures Associated With Individual Differences in Somatic Symptoms and Emotional Distress in a Healthy Sample 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Stress-related psychosomatic responses are viewed as important risks to our physical health. Growing evidence from structural imaging studies has implicated that stress and trauma exposures have negative effects on brain structural alterations. However, whether stress-related emotional distress and somatic symptoms are related to the structure of brain systems remains unclear. Also, stress-related somatic symptoms have adverse effects on emotional distress. In turn, emotional distress may influence somatic symptom reports via negative cognitive bias. However, whether this relationship is mediated by specific brain morphology remains poorly understood. First, we used voxel-based morphometric approaches to investigate the neuroanatomical basis underlying somatic symptoms and emotional distress in a large sample of healthy subjects (ages 18–27 years). We found that relatively high stress-related somatic symptoms were associated with reduced gray matter volumes (GMVs) in the ventral medial prefrontal cortex (vmPFC), anterior insula, somatosensory cortex, hippocampus, and amygdala. Furthermore, a moderator analysis was performed to investigate the impact of recent stressful life events (moderators) on the association between specific GMVs (independent variables) and emotional distress (dependent variables). Interestingly, high levels of emotional distress were associated with small volumes of the vmPFC, anterior insula, hippocampus, and amygdala in participants with experience with more recent stressful life events. Finally, we performed mediation analyses to investigate the specific brain areas that mediate the association between emotional distress and somatic symptoms. The results showed that the effect of emotional distress on somatic symptoms is mediated by reductions in the volume of the hippocampus, the impact of somatic symptoms on emotional distress is mediated by the volume of the vmPFC. These results provided evidence that higher stress-related somatic symptoms are associated with smaller volume in prefrontal, insula, and limbic regions involved in emotion, interoception, and memory processing. The vmPFC and hippocampus play different roles in the relationship between emotional distress and somatic symptoms. stress psychosomatic voxel-based morphometry (VBM) cortical-limbic system individual differences Neurosciences. Biological psychiatry. Neuropsychiatry Dongtao Wei verfasserin aut Yu Liu verfasserin aut Yu Liu verfasserin aut Kaixiang Zhuang verfasserin aut Kaixiang Zhuang verfasserin aut Jieyu Lv verfasserin aut Jie Meng verfasserin aut Jie Meng verfasserin aut Jiangzhou Sun verfasserin aut Jiangzhou Sun verfasserin aut Qunlin Chen verfasserin aut Qunlin Chen verfasserin aut Wenjing Yang verfasserin aut Wenjing Yang verfasserin aut Jiang Qiu verfasserin aut Jiang Qiu verfasserin aut In Frontiers in Human Neuroscience Frontiers Media S.A., 2008 14(2020) (DE-627)56601243X (DE-600)2425477-0 16625161 nnns volume:14 year:2020 https://doi.org/10.3389/fnhum.2020.492990 kostenfrei https://doaj.org/article/8b27326c30f245d889b8dacd1f2e892f kostenfrei https://www.frontiersin.org/articles/10.3389/fnhum.2020.492990/full kostenfrei https://doaj.org/toc/1662-5161 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2020 |
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Brain Structures Associated With Individual Differences in Somatic Symptoms and Emotional Distress in a Healthy Sample |
abstract |
Stress-related psychosomatic responses are viewed as important risks to our physical health. Growing evidence from structural imaging studies has implicated that stress and trauma exposures have negative effects on brain structural alterations. However, whether stress-related emotional distress and somatic symptoms are related to the structure of brain systems remains unclear. Also, stress-related somatic symptoms have adverse effects on emotional distress. In turn, emotional distress may influence somatic symptom reports via negative cognitive bias. However, whether this relationship is mediated by specific brain morphology remains poorly understood. First, we used voxel-based morphometric approaches to investigate the neuroanatomical basis underlying somatic symptoms and emotional distress in a large sample of healthy subjects (ages 18–27 years). We found that relatively high stress-related somatic symptoms were associated with reduced gray matter volumes (GMVs) in the ventral medial prefrontal cortex (vmPFC), anterior insula, somatosensory cortex, hippocampus, and amygdala. Furthermore, a moderator analysis was performed to investigate the impact of recent stressful life events (moderators) on the association between specific GMVs (independent variables) and emotional distress (dependent variables). Interestingly, high levels of emotional distress were associated with small volumes of the vmPFC, anterior insula, hippocampus, and amygdala in participants with experience with more recent stressful life events. Finally, we performed mediation analyses to investigate the specific brain areas that mediate the association between emotional distress and somatic symptoms. The results showed that the effect of emotional distress on somatic symptoms is mediated by reductions in the volume of the hippocampus, the impact of somatic symptoms on emotional distress is mediated by the volume of the vmPFC. These results provided evidence that higher stress-related somatic symptoms are associated with smaller volume in prefrontal, insula, and limbic regions involved in emotion, interoception, and memory processing. The vmPFC and hippocampus play different roles in the relationship between emotional distress and somatic symptoms. |
abstractGer |
Stress-related psychosomatic responses are viewed as important risks to our physical health. Growing evidence from structural imaging studies has implicated that stress and trauma exposures have negative effects on brain structural alterations. However, whether stress-related emotional distress and somatic symptoms are related to the structure of brain systems remains unclear. Also, stress-related somatic symptoms have adverse effects on emotional distress. In turn, emotional distress may influence somatic symptom reports via negative cognitive bias. However, whether this relationship is mediated by specific brain morphology remains poorly understood. First, we used voxel-based morphometric approaches to investigate the neuroanatomical basis underlying somatic symptoms and emotional distress in a large sample of healthy subjects (ages 18–27 years). We found that relatively high stress-related somatic symptoms were associated with reduced gray matter volumes (GMVs) in the ventral medial prefrontal cortex (vmPFC), anterior insula, somatosensory cortex, hippocampus, and amygdala. Furthermore, a moderator analysis was performed to investigate the impact of recent stressful life events (moderators) on the association between specific GMVs (independent variables) and emotional distress (dependent variables). Interestingly, high levels of emotional distress were associated with small volumes of the vmPFC, anterior insula, hippocampus, and amygdala in participants with experience with more recent stressful life events. Finally, we performed mediation analyses to investigate the specific brain areas that mediate the association between emotional distress and somatic symptoms. The results showed that the effect of emotional distress on somatic symptoms is mediated by reductions in the volume of the hippocampus, the impact of somatic symptoms on emotional distress is mediated by the volume of the vmPFC. These results provided evidence that higher stress-related somatic symptoms are associated with smaller volume in prefrontal, insula, and limbic regions involved in emotion, interoception, and memory processing. The vmPFC and hippocampus play different roles in the relationship between emotional distress and somatic symptoms. |
abstract_unstemmed |
Stress-related psychosomatic responses are viewed as important risks to our physical health. Growing evidence from structural imaging studies has implicated that stress and trauma exposures have negative effects on brain structural alterations. However, whether stress-related emotional distress and somatic symptoms are related to the structure of brain systems remains unclear. Also, stress-related somatic symptoms have adverse effects on emotional distress. In turn, emotional distress may influence somatic symptom reports via negative cognitive bias. However, whether this relationship is mediated by specific brain morphology remains poorly understood. First, we used voxel-based morphometric approaches to investigate the neuroanatomical basis underlying somatic symptoms and emotional distress in a large sample of healthy subjects (ages 18–27 years). We found that relatively high stress-related somatic symptoms were associated with reduced gray matter volumes (GMVs) in the ventral medial prefrontal cortex (vmPFC), anterior insula, somatosensory cortex, hippocampus, and amygdala. Furthermore, a moderator analysis was performed to investigate the impact of recent stressful life events (moderators) on the association between specific GMVs (independent variables) and emotional distress (dependent variables). Interestingly, high levels of emotional distress were associated with small volumes of the vmPFC, anterior insula, hippocampus, and amygdala in participants with experience with more recent stressful life events. Finally, we performed mediation analyses to investigate the specific brain areas that mediate the association between emotional distress and somatic symptoms. The results showed that the effect of emotional distress on somatic symptoms is mediated by reductions in the volume of the hippocampus, the impact of somatic symptoms on emotional distress is mediated by the volume of the vmPFC. These results provided evidence that higher stress-related somatic symptoms are associated with smaller volume in prefrontal, insula, and limbic regions involved in emotion, interoception, and memory processing. The vmPFC and hippocampus play different roles in the relationship between emotional distress and somatic symptoms. |
collection_details |
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title_short |
Brain Structures Associated With Individual Differences in Somatic Symptoms and Emotional Distress in a Healthy Sample |
url |
https://doi.org/10.3389/fnhum.2020.492990 https://doaj.org/article/8b27326c30f245d889b8dacd1f2e892f https://www.frontiersin.org/articles/10.3389/fnhum.2020.492990/full https://doaj.org/toc/1662-5161 |
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author2 |
Dongtao Wei Yu Liu Kaixiang Zhuang Jieyu Lv Jie Meng Jiangzhou Sun Qunlin Chen Wenjing Yang Jiang Qiu |
author2Str |
Dongtao Wei Yu Liu Kaixiang Zhuang Jieyu Lv Jie Meng Jiangzhou Sun Qunlin Chen Wenjing Yang Jiang Qiu |
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callnumber-subject |
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doi_str |
10.3389/fnhum.2020.492990 |
callnumber-a |
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up_date |
2024-07-03T21:22:14.127Z |
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