Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions?

Dopamine and noradrenaline are crucial neuromodulators controlling brain states, vigilance, action, reward, learning, and memory processes. Ventral tegmental area (VTA) and Locus Coeruleus (LC) are canonically described as the main sources of dopamine (DA) and noradrenaline (NA) with dissociate func...
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Gespeichert in:

Autor*in:	Yadollah Ranjbar-Slamloo [verfasserIn] Zeinab Fazlali [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	dopamine noradrenaline ventral tegmental area Locus Coeruleus co-transmission neuromodulator

Übergeordnetes Werk:	In: Frontiers in Molecular Neuroscience - Frontiers Media S.A., 2008, 12(2020)
Übergeordnetes Werk:	volume:12 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnmol.2019.00334

Katalog-ID:	DOAJ006554210

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spelling	10.3389/fnmol.2019.00334 doi (DE-627)DOAJ006554210 (DE-599)DOAJ7a264a9be4bf42afa35c3468e7e7694b DE-627 ger DE-627 rakwb eng RC321-571 Yadollah Ranjbar-Slamloo verfasserin aut Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions? 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dopamine and noradrenaline are crucial neuromodulators controlling brain states, vigilance, action, reward, learning, and memory processes. Ventral tegmental area (VTA) and Locus Coeruleus (LC) are canonically described as the main sources of dopamine (DA) and noradrenaline (NA) with dissociate functions. A comparison of diverse studies shows that these neuromodulators largely overlap in multiple domains such as shared biosynthetic pathway and co-release from the LC terminals, convergent innervations, non-specificity of receptors and transporters, and shared intracellular signaling pathways. DA–NA interactions are mainly studied in prefrontal cortex and hippocampus, yet it can be extended to the whole brain given the diversity of catecholamine innervations. LC can simultaneously broadcast both dopamine and noradrenaline across the brain. Here, we briefly review the molecular, cellular, and physiological overlaps between DA and NA systems and point to their functional implications. We suggest that DA and NA may function in parallel to facilitate learning and maintain the states required for normal cognitive processes. Various signaling modules of NA and DA have been targeted for developing of therapeutics. Understanding overlaps of the two systems is crucial for more effective interventions in a range of neuropsychiatric conditions. dopamine noradrenaline ventral tegmental area Locus Coeruleus co-transmission neuromodulator Neurosciences. Biological psychiatry. Neuropsychiatry Zeinab Fazlali verfasserin aut In Frontiers in Molecular Neuroscience Frontiers Media S.A., 2008 12(2020) (DE-627)579826449 (DE-600)2452967-9 16625099 nnns volume:12 year:2020 https://doi.org/10.3389/fnmol.2019.00334 kostenfrei https://doaj.org/article/7a264a9be4bf42afa35c3468e7e7694b kostenfrei https://www.frontiersin.org/article/10.3389/fnmol.2019.00334/full kostenfrei https://doaj.org/toc/1662-5099 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020
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allfieldsSound	10.3389/fnmol.2019.00334 doi (DE-627)DOAJ006554210 (DE-599)DOAJ7a264a9be4bf42afa35c3468e7e7694b DE-627 ger DE-627 rakwb eng RC321-571 Yadollah Ranjbar-Slamloo verfasserin aut Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions? 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dopamine and noradrenaline are crucial neuromodulators controlling brain states, vigilance, action, reward, learning, and memory processes. Ventral tegmental area (VTA) and Locus Coeruleus (LC) are canonically described as the main sources of dopamine (DA) and noradrenaline (NA) with dissociate functions. A comparison of diverse studies shows that these neuromodulators largely overlap in multiple domains such as shared biosynthetic pathway and co-release from the LC terminals, convergent innervations, non-specificity of receptors and transporters, and shared intracellular signaling pathways. DA–NA interactions are mainly studied in prefrontal cortex and hippocampus, yet it can be extended to the whole brain given the diversity of catecholamine innervations. LC can simultaneously broadcast both dopamine and noradrenaline across the brain. Here, we briefly review the molecular, cellular, and physiological overlaps between DA and NA systems and point to their functional implications. We suggest that DA and NA may function in parallel to facilitate learning and maintain the states required for normal cognitive processes. Various signaling modules of NA and DA have been targeted for developing of therapeutics. Understanding overlaps of the two systems is crucial for more effective interventions in a range of neuropsychiatric conditions. dopamine noradrenaline ventral tegmental area Locus Coeruleus co-transmission neuromodulator Neurosciences. Biological psychiatry. Neuropsychiatry Zeinab Fazlali verfasserin aut In Frontiers in Molecular Neuroscience Frontiers Media S.A., 2008 12(2020) (DE-627)579826449 (DE-600)2452967-9 16625099 nnns volume:12 year:2020 https://doi.org/10.3389/fnmol.2019.00334 kostenfrei https://doaj.org/article/7a264a9be4bf42afa35c3468e7e7694b kostenfrei https://www.frontiersin.org/article/10.3389/fnmol.2019.00334/full kostenfrei https://doaj.org/toc/1662-5099 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020
language	English
source	In Frontiers in Molecular Neuroscience 12(2020) volume:12 year:2020
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container_title	Frontiers in Molecular Neuroscience
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callnumber-first	R - Medicine
author	Yadollah Ranjbar-Slamloo
spellingShingle	Yadollah Ranjbar-Slamloo misc RC321-571 misc dopamine misc noradrenaline misc ventral tegmental area misc Locus Coeruleus misc co-transmission misc neuromodulator misc Neurosciences. Biological psychiatry. Neuropsychiatry Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions?
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topic_title	RC321-571 Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions? dopamine noradrenaline ventral tegmental area Locus Coeruleus co-transmission neuromodulator
topic	misc RC321-571 misc dopamine misc noradrenaline misc ventral tegmental area misc Locus Coeruleus misc co-transmission misc neuromodulator misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc dopamine misc noradrenaline misc ventral tegmental area misc Locus Coeruleus misc co-transmission misc neuromodulator misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions?
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title_full	Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions?
author_sort	Yadollah Ranjbar-Slamloo
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title_sort	dopamine and noradrenaline in the brain; overlapping or dissociate functions?
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title_auth	Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions?
abstract	Dopamine and noradrenaline are crucial neuromodulators controlling brain states, vigilance, action, reward, learning, and memory processes. Ventral tegmental area (VTA) and Locus Coeruleus (LC) are canonically described as the main sources of dopamine (DA) and noradrenaline (NA) with dissociate functions. A comparison of diverse studies shows that these neuromodulators largely overlap in multiple domains such as shared biosynthetic pathway and co-release from the LC terminals, convergent innervations, non-specificity of receptors and transporters, and shared intracellular signaling pathways. DA–NA interactions are mainly studied in prefrontal cortex and hippocampus, yet it can be extended to the whole brain given the diversity of catecholamine innervations. LC can simultaneously broadcast both dopamine and noradrenaline across the brain. Here, we briefly review the molecular, cellular, and physiological overlaps between DA and NA systems and point to their functional implications. We suggest that DA and NA may function in parallel to facilitate learning and maintain the states required for normal cognitive processes. Various signaling modules of NA and DA have been targeted for developing of therapeutics. Understanding overlaps of the two systems is crucial for more effective interventions in a range of neuropsychiatric conditions.
abstractGer	Dopamine and noradrenaline are crucial neuromodulators controlling brain states, vigilance, action, reward, learning, and memory processes. Ventral tegmental area (VTA) and Locus Coeruleus (LC) are canonically described as the main sources of dopamine (DA) and noradrenaline (NA) with dissociate functions. A comparison of diverse studies shows that these neuromodulators largely overlap in multiple domains such as shared biosynthetic pathway and co-release from the LC terminals, convergent innervations, non-specificity of receptors and transporters, and shared intracellular signaling pathways. DA–NA interactions are mainly studied in prefrontal cortex and hippocampus, yet it can be extended to the whole brain given the diversity of catecholamine innervations. LC can simultaneously broadcast both dopamine and noradrenaline across the brain. Here, we briefly review the molecular, cellular, and physiological overlaps between DA and NA systems and point to their functional implications. We suggest that DA and NA may function in parallel to facilitate learning and maintain the states required for normal cognitive processes. Various signaling modules of NA and DA have been targeted for developing of therapeutics. Understanding overlaps of the two systems is crucial for more effective interventions in a range of neuropsychiatric conditions.
abstract_unstemmed	Dopamine and noradrenaline are crucial neuromodulators controlling brain states, vigilance, action, reward, learning, and memory processes. Ventral tegmental area (VTA) and Locus Coeruleus (LC) are canonically described as the main sources of dopamine (DA) and noradrenaline (NA) with dissociate functions. A comparison of diverse studies shows that these neuromodulators largely overlap in multiple domains such as shared biosynthetic pathway and co-release from the LC terminals, convergent innervations, non-specificity of receptors and transporters, and shared intracellular signaling pathways. DA–NA interactions are mainly studied in prefrontal cortex and hippocampus, yet it can be extended to the whole brain given the diversity of catecholamine innervations. LC can simultaneously broadcast both dopamine and noradrenaline across the brain. Here, we briefly review the molecular, cellular, and physiological overlaps between DA and NA systems and point to their functional implications. We suggest that DA and NA may function in parallel to facilitate learning and maintain the states required for normal cognitive processes. Various signaling modules of NA and DA have been targeted for developing of therapeutics. Understanding overlaps of the two systems is crucial for more effective interventions in a range of neuropsychiatric conditions.
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title_short	Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions?
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