Impact of antigen avoidance test for fibrotic hypersensitivity pneumonitis in stable phase
Abstract Background The antigen avoidance has been used in the diagnosis and treatment of hypersensitivity pneumonitis (HP); however, its usefulness in stable fibrotic HP is controversial. Objective To investigate the usefulness of the antigen avoidance test in patients with fibrotic HP in stable ph...
Ausführliche Beschreibung
Autor*in: |
Ryo Okuda [verfasserIn] Tamiko Takemura [verfasserIn] Tae Iwasawa [verfasserIn] Shota Kaburaki [verfasserIn] Tomohisa Baba [verfasserIn] Eri Hagiwara [verfasserIn] Takashi Ogura [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Übergeordnetes Werk: |
In: Allergy, Asthma & Clinical Immunology - BMC, 2011, 18(2022), 1, Seite 8 |
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Übergeordnetes Werk: |
volume:18 ; year:2022 ; number:1 ; pages:8 |
Links: |
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DOI / URN: |
10.1186/s13223-022-00748-1 |
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Katalog-ID: |
DOAJ006739407 |
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520 | |a Abstract Background The antigen avoidance has been used in the diagnosis and treatment of hypersensitivity pneumonitis (HP); however, its usefulness in stable fibrotic HP is controversial. Objective To investigate the usefulness of the antigen avoidance test in patients with fibrotic HP in stable phase. Methods The antigen avoidance test was conducted during a 2-week hospitalization comparing clinical parameters at admission and before discharge. A retrospective review of patients who underwent surgical lung biopsy or transbronchial lung cryobiopsy, who were diagnosed with fibrotic HP by multi-disciplinary discussion, and whose disease progression was stable for more than two months before the antigen avoidance test was done. Results Between 2016 and 2021, 40 patients met the criteria, and 17 (43%) patients had a positive antigen avoidance test. The patients with positive in the antigen avoidance test had significantly greater annual forced vital capacity (FVC) decline than those with negative before the test (− 6.5% vs. − 0.3%, p = 0.045). The patients with positive antigen avoidance test had less annual FVC decline than those with negative in the year following the test (0.8% vs. − 5.0%, p = 0.048). The differences in annual improvement were found for serum Krebs von den Lungen-6 between the positive and negative patients in the year following the test (− 27% vs. − 5%, p = 0.049). In multivariate Cox hazard regression analysis, a negative result of the antigen avoidance test was a risk factor for death or acute exacerbation of fibrotic HP (HR = 0.26 [95% CI: 0.07–0.90], p = 0.034). Conclusions In fibrotic HP patients in stable phase, the antigen avoidance test under a 2-week hospitalization was valuable in predicting prognosis. | ||
650 | 4 | |a Acute exacerbation | |
650 | 4 | |a Bird fancier's lung | |
650 | 4 | |a Causative antigen | |
650 | 4 | |a Chronic hypersensitivity pneumonitis | |
650 | 4 | |a Home-related hypersensitivity pneumonitis | |
653 | 0 | |a Immunologic diseases. Allergy | |
700 | 0 | |a Tamiko Takemura |e verfasserin |4 aut | |
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700 | 0 | |a Shota Kaburaki |e verfasserin |4 aut | |
700 | 0 | |a Tomohisa Baba |e verfasserin |4 aut | |
700 | 0 | |a Eri Hagiwara |e verfasserin |4 aut | |
700 | 0 | |a Takashi Ogura |e verfasserin |4 aut | |
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10.1186/s13223-022-00748-1 doi (DE-627)DOAJ006739407 (DE-599)DOAJ2f6325e4d80b45c18c56a648e28714fa DE-627 ger DE-627 rakwb eng RC581-607 Ryo Okuda verfasserin aut Impact of antigen avoidance test for fibrotic hypersensitivity pneumonitis in stable phase 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The antigen avoidance has been used in the diagnosis and treatment of hypersensitivity pneumonitis (HP); however, its usefulness in stable fibrotic HP is controversial. Objective To investigate the usefulness of the antigen avoidance test in patients with fibrotic HP in stable phase. Methods The antigen avoidance test was conducted during a 2-week hospitalization comparing clinical parameters at admission and before discharge. A retrospective review of patients who underwent surgical lung biopsy or transbronchial lung cryobiopsy, who were diagnosed with fibrotic HP by multi-disciplinary discussion, and whose disease progression was stable for more than two months before the antigen avoidance test was done. Results Between 2016 and 2021, 40 patients met the criteria, and 17 (43%) patients had a positive antigen avoidance test. The patients with positive in the antigen avoidance test had significantly greater annual forced vital capacity (FVC) decline than those with negative before the test (− 6.5% vs. − 0.3%, p = 0.045). The patients with positive antigen avoidance test had less annual FVC decline than those with negative in the year following the test (0.8% vs. − 5.0%, p = 0.048). The differences in annual improvement were found for serum Krebs von den Lungen-6 between the positive and negative patients in the year following the test (− 27% vs. − 5%, p = 0.049). In multivariate Cox hazard regression analysis, a negative result of the antigen avoidance test was a risk factor for death or acute exacerbation of fibrotic HP (HR = 0.26 [95% CI: 0.07–0.90], p = 0.034). Conclusions In fibrotic HP patients in stable phase, the antigen avoidance test under a 2-week hospitalization was valuable in predicting prognosis. Acute exacerbation Bird fancier's lung Causative antigen Chronic hypersensitivity pneumonitis Home-related hypersensitivity pneumonitis Immunologic diseases. Allergy Tamiko Takemura verfasserin aut Tae Iwasawa verfasserin aut Shota Kaburaki verfasserin aut Tomohisa Baba verfasserin aut Eri Hagiwara verfasserin aut Takashi Ogura verfasserin aut In Allergy, Asthma & Clinical Immunology BMC, 2011 18(2022), 1, Seite 8 (DE-627)512662487 (DE-600)2236671-4 17101492 nnns volume:18 year:2022 number:1 pages:8 https://doi.org/10.1186/s13223-022-00748-1 kostenfrei https://doaj.org/article/2f6325e4d80b45c18c56a648e28714fa kostenfrei https://doi.org/10.1186/s13223-022-00748-1 kostenfrei https://doaj.org/toc/1710-1492 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2022 1 8 |
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10.1186/s13223-022-00748-1 doi (DE-627)DOAJ006739407 (DE-599)DOAJ2f6325e4d80b45c18c56a648e28714fa DE-627 ger DE-627 rakwb eng RC581-607 Ryo Okuda verfasserin aut Impact of antigen avoidance test for fibrotic hypersensitivity pneumonitis in stable phase 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The antigen avoidance has been used in the diagnosis and treatment of hypersensitivity pneumonitis (HP); however, its usefulness in stable fibrotic HP is controversial. Objective To investigate the usefulness of the antigen avoidance test in patients with fibrotic HP in stable phase. Methods The antigen avoidance test was conducted during a 2-week hospitalization comparing clinical parameters at admission and before discharge. A retrospective review of patients who underwent surgical lung biopsy or transbronchial lung cryobiopsy, who were diagnosed with fibrotic HP by multi-disciplinary discussion, and whose disease progression was stable for more than two months before the antigen avoidance test was done. Results Between 2016 and 2021, 40 patients met the criteria, and 17 (43%) patients had a positive antigen avoidance test. The patients with positive in the antigen avoidance test had significantly greater annual forced vital capacity (FVC) decline than those with negative before the test (− 6.5% vs. − 0.3%, p = 0.045). The patients with positive antigen avoidance test had less annual FVC decline than those with negative in the year following the test (0.8% vs. − 5.0%, p = 0.048). The differences in annual improvement were found for serum Krebs von den Lungen-6 between the positive and negative patients in the year following the test (− 27% vs. − 5%, p = 0.049). In multivariate Cox hazard regression analysis, a negative result of the antigen avoidance test was a risk factor for death or acute exacerbation of fibrotic HP (HR = 0.26 [95% CI: 0.07–0.90], p = 0.034). Conclusions In fibrotic HP patients in stable phase, the antigen avoidance test under a 2-week hospitalization was valuable in predicting prognosis. Acute exacerbation Bird fancier's lung Causative antigen Chronic hypersensitivity pneumonitis Home-related hypersensitivity pneumonitis Immunologic diseases. Allergy Tamiko Takemura verfasserin aut Tae Iwasawa verfasserin aut Shota Kaburaki verfasserin aut Tomohisa Baba verfasserin aut Eri Hagiwara verfasserin aut Takashi Ogura verfasserin aut In Allergy, Asthma & Clinical Immunology BMC, 2011 18(2022), 1, Seite 8 (DE-627)512662487 (DE-600)2236671-4 17101492 nnns volume:18 year:2022 number:1 pages:8 https://doi.org/10.1186/s13223-022-00748-1 kostenfrei https://doaj.org/article/2f6325e4d80b45c18c56a648e28714fa kostenfrei https://doi.org/10.1186/s13223-022-00748-1 kostenfrei https://doaj.org/toc/1710-1492 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2022 1 8 |
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10.1186/s13223-022-00748-1 doi (DE-627)DOAJ006739407 (DE-599)DOAJ2f6325e4d80b45c18c56a648e28714fa DE-627 ger DE-627 rakwb eng RC581-607 Ryo Okuda verfasserin aut Impact of antigen avoidance test for fibrotic hypersensitivity pneumonitis in stable phase 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The antigen avoidance has been used in the diagnosis and treatment of hypersensitivity pneumonitis (HP); however, its usefulness in stable fibrotic HP is controversial. Objective To investigate the usefulness of the antigen avoidance test in patients with fibrotic HP in stable phase. Methods The antigen avoidance test was conducted during a 2-week hospitalization comparing clinical parameters at admission and before discharge. A retrospective review of patients who underwent surgical lung biopsy or transbronchial lung cryobiopsy, who were diagnosed with fibrotic HP by multi-disciplinary discussion, and whose disease progression was stable for more than two months before the antigen avoidance test was done. Results Between 2016 and 2021, 40 patients met the criteria, and 17 (43%) patients had a positive antigen avoidance test. The patients with positive in the antigen avoidance test had significantly greater annual forced vital capacity (FVC) decline than those with negative before the test (− 6.5% vs. − 0.3%, p = 0.045). The patients with positive antigen avoidance test had less annual FVC decline than those with negative in the year following the test (0.8% vs. − 5.0%, p = 0.048). The differences in annual improvement were found for serum Krebs von den Lungen-6 between the positive and negative patients in the year following the test (− 27% vs. − 5%, p = 0.049). In multivariate Cox hazard regression analysis, a negative result of the antigen avoidance test was a risk factor for death or acute exacerbation of fibrotic HP (HR = 0.26 [95% CI: 0.07–0.90], p = 0.034). Conclusions In fibrotic HP patients in stable phase, the antigen avoidance test under a 2-week hospitalization was valuable in predicting prognosis. Acute exacerbation Bird fancier's lung Causative antigen Chronic hypersensitivity pneumonitis Home-related hypersensitivity pneumonitis Immunologic diseases. Allergy Tamiko Takemura verfasserin aut Tae Iwasawa verfasserin aut Shota Kaburaki verfasserin aut Tomohisa Baba verfasserin aut Eri Hagiwara verfasserin aut Takashi Ogura verfasserin aut In Allergy, Asthma & Clinical Immunology BMC, 2011 18(2022), 1, Seite 8 (DE-627)512662487 (DE-600)2236671-4 17101492 nnns volume:18 year:2022 number:1 pages:8 https://doi.org/10.1186/s13223-022-00748-1 kostenfrei https://doaj.org/article/2f6325e4d80b45c18c56a648e28714fa kostenfrei https://doi.org/10.1186/s13223-022-00748-1 kostenfrei https://doaj.org/toc/1710-1492 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2022 1 8 |
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10.1186/s13223-022-00748-1 doi (DE-627)DOAJ006739407 (DE-599)DOAJ2f6325e4d80b45c18c56a648e28714fa DE-627 ger DE-627 rakwb eng RC581-607 Ryo Okuda verfasserin aut Impact of antigen avoidance test for fibrotic hypersensitivity pneumonitis in stable phase 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The antigen avoidance has been used in the diagnosis and treatment of hypersensitivity pneumonitis (HP); however, its usefulness in stable fibrotic HP is controversial. Objective To investigate the usefulness of the antigen avoidance test in patients with fibrotic HP in stable phase. Methods The antigen avoidance test was conducted during a 2-week hospitalization comparing clinical parameters at admission and before discharge. A retrospective review of patients who underwent surgical lung biopsy or transbronchial lung cryobiopsy, who were diagnosed with fibrotic HP by multi-disciplinary discussion, and whose disease progression was stable for more than two months before the antigen avoidance test was done. Results Between 2016 and 2021, 40 patients met the criteria, and 17 (43%) patients had a positive antigen avoidance test. The patients with positive in the antigen avoidance test had significantly greater annual forced vital capacity (FVC) decline than those with negative before the test (− 6.5% vs. − 0.3%, p = 0.045). The patients with positive antigen avoidance test had less annual FVC decline than those with negative in the year following the test (0.8% vs. − 5.0%, p = 0.048). The differences in annual improvement were found for serum Krebs von den Lungen-6 between the positive and negative patients in the year following the test (− 27% vs. − 5%, p = 0.049). In multivariate Cox hazard regression analysis, a negative result of the antigen avoidance test was a risk factor for death or acute exacerbation of fibrotic HP (HR = 0.26 [95% CI: 0.07–0.90], p = 0.034). Conclusions In fibrotic HP patients in stable phase, the antigen avoidance test under a 2-week hospitalization was valuable in predicting prognosis. Acute exacerbation Bird fancier's lung Causative antigen Chronic hypersensitivity pneumonitis Home-related hypersensitivity pneumonitis Immunologic diseases. Allergy Tamiko Takemura verfasserin aut Tae Iwasawa verfasserin aut Shota Kaburaki verfasserin aut Tomohisa Baba verfasserin aut Eri Hagiwara verfasserin aut Takashi Ogura verfasserin aut In Allergy, Asthma & Clinical Immunology BMC, 2011 18(2022), 1, Seite 8 (DE-627)512662487 (DE-600)2236671-4 17101492 nnns volume:18 year:2022 number:1 pages:8 https://doi.org/10.1186/s13223-022-00748-1 kostenfrei https://doaj.org/article/2f6325e4d80b45c18c56a648e28714fa kostenfrei https://doi.org/10.1186/s13223-022-00748-1 kostenfrei https://doaj.org/toc/1710-1492 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2022 1 8 |
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10.1186/s13223-022-00748-1 doi (DE-627)DOAJ006739407 (DE-599)DOAJ2f6325e4d80b45c18c56a648e28714fa DE-627 ger DE-627 rakwb eng RC581-607 Ryo Okuda verfasserin aut Impact of antigen avoidance test for fibrotic hypersensitivity pneumonitis in stable phase 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The antigen avoidance has been used in the diagnosis and treatment of hypersensitivity pneumonitis (HP); however, its usefulness in stable fibrotic HP is controversial. Objective To investigate the usefulness of the antigen avoidance test in patients with fibrotic HP in stable phase. Methods The antigen avoidance test was conducted during a 2-week hospitalization comparing clinical parameters at admission and before discharge. A retrospective review of patients who underwent surgical lung biopsy or transbronchial lung cryobiopsy, who were diagnosed with fibrotic HP by multi-disciplinary discussion, and whose disease progression was stable for more than two months before the antigen avoidance test was done. Results Between 2016 and 2021, 40 patients met the criteria, and 17 (43%) patients had a positive antigen avoidance test. The patients with positive in the antigen avoidance test had significantly greater annual forced vital capacity (FVC) decline than those with negative before the test (− 6.5% vs. − 0.3%, p = 0.045). The patients with positive antigen avoidance test had less annual FVC decline than those with negative in the year following the test (0.8% vs. − 5.0%, p = 0.048). The differences in annual improvement were found for serum Krebs von den Lungen-6 between the positive and negative patients in the year following the test (− 27% vs. − 5%, p = 0.049). In multivariate Cox hazard regression analysis, a negative result of the antigen avoidance test was a risk factor for death or acute exacerbation of fibrotic HP (HR = 0.26 [95% CI: 0.07–0.90], p = 0.034). Conclusions In fibrotic HP patients in stable phase, the antigen avoidance test under a 2-week hospitalization was valuable in predicting prognosis. Acute exacerbation Bird fancier's lung Causative antigen Chronic hypersensitivity pneumonitis Home-related hypersensitivity pneumonitis Immunologic diseases. Allergy Tamiko Takemura verfasserin aut Tae Iwasawa verfasserin aut Shota Kaburaki verfasserin aut Tomohisa Baba verfasserin aut Eri Hagiwara verfasserin aut Takashi Ogura verfasserin aut In Allergy, Asthma & Clinical Immunology BMC, 2011 18(2022), 1, Seite 8 (DE-627)512662487 (DE-600)2236671-4 17101492 nnns volume:18 year:2022 number:1 pages:8 https://doi.org/10.1186/s13223-022-00748-1 kostenfrei https://doaj.org/article/2f6325e4d80b45c18c56a648e28714fa kostenfrei https://doi.org/10.1186/s13223-022-00748-1 kostenfrei https://doaj.org/toc/1710-1492 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2022 1 8 |
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Impact of antigen avoidance test for fibrotic hypersensitivity pneumonitis in stable phase |
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Abstract Background The antigen avoidance has been used in the diagnosis and treatment of hypersensitivity pneumonitis (HP); however, its usefulness in stable fibrotic HP is controversial. Objective To investigate the usefulness of the antigen avoidance test in patients with fibrotic HP in stable phase. Methods The antigen avoidance test was conducted during a 2-week hospitalization comparing clinical parameters at admission and before discharge. A retrospective review of patients who underwent surgical lung biopsy or transbronchial lung cryobiopsy, who were diagnosed with fibrotic HP by multi-disciplinary discussion, and whose disease progression was stable for more than two months before the antigen avoidance test was done. Results Between 2016 and 2021, 40 patients met the criteria, and 17 (43%) patients had a positive antigen avoidance test. The patients with positive in the antigen avoidance test had significantly greater annual forced vital capacity (FVC) decline than those with negative before the test (− 6.5% vs. − 0.3%, p = 0.045). The patients with positive antigen avoidance test had less annual FVC decline than those with negative in the year following the test (0.8% vs. − 5.0%, p = 0.048). The differences in annual improvement were found for serum Krebs von den Lungen-6 between the positive and negative patients in the year following the test (− 27% vs. − 5%, p = 0.049). In multivariate Cox hazard regression analysis, a negative result of the antigen avoidance test was a risk factor for death or acute exacerbation of fibrotic HP (HR = 0.26 [95% CI: 0.07–0.90], p = 0.034). Conclusions In fibrotic HP patients in stable phase, the antigen avoidance test under a 2-week hospitalization was valuable in predicting prognosis. |
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Abstract Background The antigen avoidance has been used in the diagnosis and treatment of hypersensitivity pneumonitis (HP); however, its usefulness in stable fibrotic HP is controversial. Objective To investigate the usefulness of the antigen avoidance test in patients with fibrotic HP in stable phase. Methods The antigen avoidance test was conducted during a 2-week hospitalization comparing clinical parameters at admission and before discharge. A retrospective review of patients who underwent surgical lung biopsy or transbronchial lung cryobiopsy, who were diagnosed with fibrotic HP by multi-disciplinary discussion, and whose disease progression was stable for more than two months before the antigen avoidance test was done. Results Between 2016 and 2021, 40 patients met the criteria, and 17 (43%) patients had a positive antigen avoidance test. The patients with positive in the antigen avoidance test had significantly greater annual forced vital capacity (FVC) decline than those with negative before the test (− 6.5% vs. − 0.3%, p = 0.045). The patients with positive antigen avoidance test had less annual FVC decline than those with negative in the year following the test (0.8% vs. − 5.0%, p = 0.048). The differences in annual improvement were found for serum Krebs von den Lungen-6 between the positive and negative patients in the year following the test (− 27% vs. − 5%, p = 0.049). In multivariate Cox hazard regression analysis, a negative result of the antigen avoidance test was a risk factor for death or acute exacerbation of fibrotic HP (HR = 0.26 [95% CI: 0.07–0.90], p = 0.034). Conclusions In fibrotic HP patients in stable phase, the antigen avoidance test under a 2-week hospitalization was valuable in predicting prognosis. |
abstract_unstemmed |
Abstract Background The antigen avoidance has been used in the diagnosis and treatment of hypersensitivity pneumonitis (HP); however, its usefulness in stable fibrotic HP is controversial. Objective To investigate the usefulness of the antigen avoidance test in patients with fibrotic HP in stable phase. Methods The antigen avoidance test was conducted during a 2-week hospitalization comparing clinical parameters at admission and before discharge. A retrospective review of patients who underwent surgical lung biopsy or transbronchial lung cryobiopsy, who were diagnosed with fibrotic HP by multi-disciplinary discussion, and whose disease progression was stable for more than two months before the antigen avoidance test was done. Results Between 2016 and 2021, 40 patients met the criteria, and 17 (43%) patients had a positive antigen avoidance test. The patients with positive in the antigen avoidance test had significantly greater annual forced vital capacity (FVC) decline than those with negative before the test (− 6.5% vs. − 0.3%, p = 0.045). The patients with positive antigen avoidance test had less annual FVC decline than those with negative in the year following the test (0.8% vs. − 5.0%, p = 0.048). The differences in annual improvement were found for serum Krebs von den Lungen-6 between the positive and negative patients in the year following the test (− 27% vs. − 5%, p = 0.049). In multivariate Cox hazard regression analysis, a negative result of the antigen avoidance test was a risk factor for death or acute exacerbation of fibrotic HP (HR = 0.26 [95% CI: 0.07–0.90], p = 0.034). Conclusions In fibrotic HP patients in stable phase, the antigen avoidance test under a 2-week hospitalization was valuable in predicting prognosis. |
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Impact of antigen avoidance test for fibrotic hypersensitivity pneumonitis in stable phase |
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https://doi.org/10.1186/s13223-022-00748-1 https://doaj.org/article/2f6325e4d80b45c18c56a648e28714fa https://doaj.org/toc/1710-1492 |
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Tamiko Takemura Tae Iwasawa Shota Kaburaki Tomohisa Baba Eri Hagiwara Takashi Ogura |
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Tamiko Takemura Tae Iwasawa Shota Kaburaki Tomohisa Baba Eri Hagiwara Takashi Ogura |
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Objective To investigate the usefulness of the antigen avoidance test in patients with fibrotic HP in stable phase. Methods The antigen avoidance test was conducted during a 2-week hospitalization comparing clinical parameters at admission and before discharge. A retrospective review of patients who underwent surgical lung biopsy or transbronchial lung cryobiopsy, who were diagnosed with fibrotic HP by multi-disciplinary discussion, and whose disease progression was stable for more than two months before the antigen avoidance test was done. Results Between 2016 and 2021, 40 patients met the criteria, and 17 (43%) patients had a positive antigen avoidance test. The patients with positive in the antigen avoidance test had significantly greater annual forced vital capacity (FVC) decline than those with negative before the test (− 6.5% vs. − 0.3%, p = 0.045). The patients with positive antigen avoidance test had less annual FVC decline than those with negative in the year following the test (0.8% vs. − 5.0%, p = 0.048). The differences in annual improvement were found for serum Krebs von den Lungen-6 between the positive and negative patients in the year following the test (− 27% vs. − 5%, p = 0.049). In multivariate Cox hazard regression analysis, a negative result of the antigen avoidance test was a risk factor for death or acute exacerbation of fibrotic HP (HR = 0.26 [95% CI: 0.07–0.90], p = 0.034). 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