Effect of NTSR1 Gene on Proliferation and Invasion of Gastric Adenocarcinoma and Its Mechanism

Objective To investigate the role of NTSR1 gene in the proliferation and invasion of gastric cancer cells and its possible mechanism. Methods The relationship between expression of NTSR1 protein and EGFR, HER2 in 233 cases of gastric cancer was analyzed by Envision two-step immunohistochemistry. The...
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Autor*in:	YANG Shudong [verfasserIn] CAI Ying [verfasserIn] LIANG Jiabei [verfasserIn] ZHOU Jing [verfasserIn] GUO Qing [verfasserIn] YANG Lihua [verfasserIn] SUN Rongchao [verfasserIn] WU Haorong [verfasserIn] ZHOU Zhiyi [verfasserIn]

Format:	E-Artikel
Sprache:	Chinesisch

Erschienen:	2018

Schlagwörter:	gastric cancer ntsr1 proliferation metastasis

Übergeordnetes Werk:	In: Zhongliu Fangzhi Yanjiu - Magazine House of Cancer Research on Prevention and Treatment, 2019, 45(2018), 1, Seite 9-14
Übergeordnetes Werk:	volume:45 ; year:2018 ; number:1 ; pages:9-14

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3971/j.issn.1000-8578.2018.17.0658

Katalog-ID:	DOAJ006816584

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520			\|a Objective To investigate the role of NTSR1 gene in the proliferation and invasion of gastric cancer cells and its possible mechanism. Methods The relationship between expression of NTSR1 protein and EGFR, HER2 in 233 cases of gastric cancer was analyzed by Envision two-step immunohistochemistry. The expression of NTSR1 mRNA in gastric cancer cell line was detected, and the cell line with high abundance was selected as the experimental object. MKN-45 cells with the highest interference efficiency of shNTSR1 were constructed. MTT and cell invasion assay were used to detect the effect of NTSR1 gene silencing on the proliferation and invasion of gastric cancer cells. The effect of shNTSR1 on the expression of 19 related genes in the Cancer Phenotype signaling pathway, including EGFR and HER2, was investigated. Results (1) There was a significant positive correlation between the positive expression of NTSR1 and the expression of EGFR and HER2 in 233 cases of gastric cancer(P < 0.05), and there was a significantly positive correlation between EGFR and HER2 expression(P < 0.05). (2) The expression abundance of NTSR1 in MKN-45 cells was high. (3) The NTSR1 shRNA expression vector was successfully constructed to construct stable cell lines. (4) The proliferation of MKN-45 cells was significantly down-regulated by NTSR1 shRNA interference (P < 0.05). (5) The invasion and metastasis rates of MKN-45 were significantly decreased by NTSR1 shRNA interference(P < 0.05). (6) The expression of p27Kip1 protein in Cancer Phenotype signaling pathway of MKN-45 cells was significantly up-regulated, meanwhile, EGFR, HER2, EpCAM and Met also showed a significant downward trend by NTSR1 shRNA interference(P < 0.05). Conclusion NTSR1 plays an important role in the occurrence, invasion and metastasis of gastric cancer by regulating EGFR/HER2 signaling pathway and P27 Kip1, EpCAM, Met and other Cancer Phenotype signaling pathways.
650		4	\|a gastric cancer
650		4	\|a ntsr1
650		4	\|a proliferation
650		4	\|a metastasis
653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
700	0		\|a CAI Ying \|e verfasserin \|4 aut
700	0		\|a LIANG Jiabei \|e verfasserin \|4 aut
700	0		\|a ZHOU Jing \|e verfasserin \|4 aut
700	0		\|a GUO Qing \|e verfasserin \|4 aut
700	0		\|a YANG Lihua \|e verfasserin \|4 aut
700	0		\|a SUN Rongchao \|e verfasserin \|4 aut
700	0		\|a WU Haorong \|e verfasserin \|4 aut
700	0		\|a ZHOU Zhiyi \|e verfasserin \|4 aut
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allfields	10.3971/j.issn.1000-8578.2018.17.0658 doi (DE-627)DOAJ006816584 (DE-599)DOAJb8db302a97974d54a9e9d4fc2e326614 DE-627 ger DE-627 rakwb chi RC254-282 YANG Shudong verfasserin aut Effect of NTSR1 Gene on Proliferation and Invasion of Gastric Adenocarcinoma and Its Mechanism 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To investigate the role of NTSR1 gene in the proliferation and invasion of gastric cancer cells and its possible mechanism. Methods The relationship between expression of NTSR1 protein and EGFR, HER2 in 233 cases of gastric cancer was analyzed by Envision two-step immunohistochemistry. The expression of NTSR1 mRNA in gastric cancer cell line was detected, and the cell line with high abundance was selected as the experimental object. MKN-45 cells with the highest interference efficiency of shNTSR1 were constructed. MTT and cell invasion assay were used to detect the effect of NTSR1 gene silencing on the proliferation and invasion of gastric cancer cells. The effect of shNTSR1 on the expression of 19 related genes in the Cancer Phenotype signaling pathway, including EGFR and HER2, was investigated. Results (1) There was a significant positive correlation between the positive expression of NTSR1 and the expression of EGFR and HER2 in 233 cases of gastric cancer(P < 0.05), and there was a significantly positive correlation between EGFR and HER2 expression(P < 0.05). (2) The expression abundance of NTSR1 in MKN-45 cells was high. (3) The NTSR1 shRNA expression vector was successfully constructed to construct stable cell lines. (4) The proliferation of MKN-45 cells was significantly down-regulated by NTSR1 shRNA interference (P < 0.05). (5) The invasion and metastasis rates of MKN-45 were significantly decreased by NTSR1 shRNA interference(P < 0.05). (6) The expression of p27Kip1 protein in Cancer Phenotype signaling pathway of MKN-45 cells was significantly up-regulated, meanwhile, EGFR, HER2, EpCAM and Met also showed a significant downward trend by NTSR1 shRNA interference(P < 0.05). Conclusion NTSR1 plays an important role in the occurrence, invasion and metastasis of gastric cancer by regulating EGFR/HER2 signaling pathway and P27 Kip1, EpCAM, Met and other Cancer Phenotype signaling pathways. gastric cancer ntsr1 proliferation metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens CAI Ying verfasserin aut LIANG Jiabei verfasserin aut ZHOU Jing verfasserin aut GUO Qing verfasserin aut YANG Lihua verfasserin aut SUN Rongchao verfasserin aut WU Haorong verfasserin aut ZHOU Zhiyi verfasserin aut In Zhongliu Fangzhi Yanjiu Magazine House of Cancer Research on Prevention and Treatment, 2019 45(2018), 1, Seite 9-14 (DE-627)176063638X 10008578 nnns volume:45 year:2018 number:1 pages:9-14 https://doi.org/10.3971/j.issn.1000-8578.2018.17.0658 kostenfrei https://doaj.org/article/b8db302a97974d54a9e9d4fc2e326614 kostenfrei http://html.rhhz.net/ZLFZYJ/html/8578.2018.17.0658.htm kostenfrei https://doaj.org/toc/1000-8578 Journal toc kostenfrei https://doaj.org/toc/1000-8578 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 45 2018 1 9-14
spelling	10.3971/j.issn.1000-8578.2018.17.0658 doi (DE-627)DOAJ006816584 (DE-599)DOAJb8db302a97974d54a9e9d4fc2e326614 DE-627 ger DE-627 rakwb chi RC254-282 YANG Shudong verfasserin aut Effect of NTSR1 Gene on Proliferation and Invasion of Gastric Adenocarcinoma and Its Mechanism 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To investigate the role of NTSR1 gene in the proliferation and invasion of gastric cancer cells and its possible mechanism. Methods The relationship between expression of NTSR1 protein and EGFR, HER2 in 233 cases of gastric cancer was analyzed by Envision two-step immunohistochemistry. The expression of NTSR1 mRNA in gastric cancer cell line was detected, and the cell line with high abundance was selected as the experimental object. MKN-45 cells with the highest interference efficiency of shNTSR1 were constructed. MTT and cell invasion assay were used to detect the effect of NTSR1 gene silencing on the proliferation and invasion of gastric cancer cells. The effect of shNTSR1 on the expression of 19 related genes in the Cancer Phenotype signaling pathway, including EGFR and HER2, was investigated. Results (1) There was a significant positive correlation between the positive expression of NTSR1 and the expression of EGFR and HER2 in 233 cases of gastric cancer(P < 0.05), and there was a significantly positive correlation between EGFR and HER2 expression(P < 0.05). (2) The expression abundance of NTSR1 in MKN-45 cells was high. (3) The NTSR1 shRNA expression vector was successfully constructed to construct stable cell lines. (4) The proliferation of MKN-45 cells was significantly down-regulated by NTSR1 shRNA interference (P < 0.05). (5) The invasion and metastasis rates of MKN-45 were significantly decreased by NTSR1 shRNA interference(P < 0.05). (6) The expression of p27Kip1 protein in Cancer Phenotype signaling pathway of MKN-45 cells was significantly up-regulated, meanwhile, EGFR, HER2, EpCAM and Met also showed a significant downward trend by NTSR1 shRNA interference(P < 0.05). Conclusion NTSR1 plays an important role in the occurrence, invasion and metastasis of gastric cancer by regulating EGFR/HER2 signaling pathway and P27 Kip1, EpCAM, Met and other Cancer Phenotype signaling pathways. gastric cancer ntsr1 proliferation metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens CAI Ying verfasserin aut LIANG Jiabei verfasserin aut ZHOU Jing verfasserin aut GUO Qing verfasserin aut YANG Lihua verfasserin aut SUN Rongchao verfasserin aut WU Haorong verfasserin aut ZHOU Zhiyi verfasserin aut In Zhongliu Fangzhi Yanjiu Magazine House of Cancer Research on Prevention and Treatment, 2019 45(2018), 1, Seite 9-14 (DE-627)176063638X 10008578 nnns volume:45 year:2018 number:1 pages:9-14 https://doi.org/10.3971/j.issn.1000-8578.2018.17.0658 kostenfrei https://doaj.org/article/b8db302a97974d54a9e9d4fc2e326614 kostenfrei http://html.rhhz.net/ZLFZYJ/html/8578.2018.17.0658.htm kostenfrei https://doaj.org/toc/1000-8578 Journal toc kostenfrei https://doaj.org/toc/1000-8578 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 45 2018 1 9-14
allfields_unstemmed	10.3971/j.issn.1000-8578.2018.17.0658 doi (DE-627)DOAJ006816584 (DE-599)DOAJb8db302a97974d54a9e9d4fc2e326614 DE-627 ger DE-627 rakwb chi RC254-282 YANG Shudong verfasserin aut Effect of NTSR1 Gene on Proliferation and Invasion of Gastric Adenocarcinoma and Its Mechanism 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To investigate the role of NTSR1 gene in the proliferation and invasion of gastric cancer cells and its possible mechanism. Methods The relationship between expression of NTSR1 protein and EGFR, HER2 in 233 cases of gastric cancer was analyzed by Envision two-step immunohistochemistry. The expression of NTSR1 mRNA in gastric cancer cell line was detected, and the cell line with high abundance was selected as the experimental object. MKN-45 cells with the highest interference efficiency of shNTSR1 were constructed. MTT and cell invasion assay were used to detect the effect of NTSR1 gene silencing on the proliferation and invasion of gastric cancer cells. The effect of shNTSR1 on the expression of 19 related genes in the Cancer Phenotype signaling pathway, including EGFR and HER2, was investigated. Results (1) There was a significant positive correlation between the positive expression of NTSR1 and the expression of EGFR and HER2 in 233 cases of gastric cancer(P < 0.05), and there was a significantly positive correlation between EGFR and HER2 expression(P < 0.05). (2) The expression abundance of NTSR1 in MKN-45 cells was high. (3) The NTSR1 shRNA expression vector was successfully constructed to construct stable cell lines. (4) The proliferation of MKN-45 cells was significantly down-regulated by NTSR1 shRNA interference (P < 0.05). (5) The invasion and metastasis rates of MKN-45 were significantly decreased by NTSR1 shRNA interference(P < 0.05). (6) The expression of p27Kip1 protein in Cancer Phenotype signaling pathway of MKN-45 cells was significantly up-regulated, meanwhile, EGFR, HER2, EpCAM and Met also showed a significant downward trend by NTSR1 shRNA interference(P < 0.05). Conclusion NTSR1 plays an important role in the occurrence, invasion and metastasis of gastric cancer by regulating EGFR/HER2 signaling pathway and P27 Kip1, EpCAM, Met and other Cancer Phenotype signaling pathways. gastric cancer ntsr1 proliferation metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens CAI Ying verfasserin aut LIANG Jiabei verfasserin aut ZHOU Jing verfasserin aut GUO Qing verfasserin aut YANG Lihua verfasserin aut SUN Rongchao verfasserin aut WU Haorong verfasserin aut ZHOU Zhiyi verfasserin aut In Zhongliu Fangzhi Yanjiu Magazine House of Cancer Research on Prevention and Treatment, 2019 45(2018), 1, Seite 9-14 (DE-627)176063638X 10008578 nnns volume:45 year:2018 number:1 pages:9-14 https://doi.org/10.3971/j.issn.1000-8578.2018.17.0658 kostenfrei https://doaj.org/article/b8db302a97974d54a9e9d4fc2e326614 kostenfrei http://html.rhhz.net/ZLFZYJ/html/8578.2018.17.0658.htm kostenfrei https://doaj.org/toc/1000-8578 Journal toc kostenfrei https://doaj.org/toc/1000-8578 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 45 2018 1 9-14
allfieldsGer	10.3971/j.issn.1000-8578.2018.17.0658 doi (DE-627)DOAJ006816584 (DE-599)DOAJb8db302a97974d54a9e9d4fc2e326614 DE-627 ger DE-627 rakwb chi RC254-282 YANG Shudong verfasserin aut Effect of NTSR1 Gene on Proliferation and Invasion of Gastric Adenocarcinoma and Its Mechanism 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To investigate the role of NTSR1 gene in the proliferation and invasion of gastric cancer cells and its possible mechanism. Methods The relationship between expression of NTSR1 protein and EGFR, HER2 in 233 cases of gastric cancer was analyzed by Envision two-step immunohistochemistry. The expression of NTSR1 mRNA in gastric cancer cell line was detected, and the cell line with high abundance was selected as the experimental object. MKN-45 cells with the highest interference efficiency of shNTSR1 were constructed. MTT and cell invasion assay were used to detect the effect of NTSR1 gene silencing on the proliferation and invasion of gastric cancer cells. The effect of shNTSR1 on the expression of 19 related genes in the Cancer Phenotype signaling pathway, including EGFR and HER2, was investigated. Results (1) There was a significant positive correlation between the positive expression of NTSR1 and the expression of EGFR and HER2 in 233 cases of gastric cancer(P < 0.05), and there was a significantly positive correlation between EGFR and HER2 expression(P < 0.05). (2) The expression abundance of NTSR1 in MKN-45 cells was high. (3) The NTSR1 shRNA expression vector was successfully constructed to construct stable cell lines. (4) The proliferation of MKN-45 cells was significantly down-regulated by NTSR1 shRNA interference (P < 0.05). (5) The invasion and metastasis rates of MKN-45 were significantly decreased by NTSR1 shRNA interference(P < 0.05). (6) The expression of p27Kip1 protein in Cancer Phenotype signaling pathway of MKN-45 cells was significantly up-regulated, meanwhile, EGFR, HER2, EpCAM and Met also showed a significant downward trend by NTSR1 shRNA interference(P < 0.05). Conclusion NTSR1 plays an important role in the occurrence, invasion and metastasis of gastric cancer by regulating EGFR/HER2 signaling pathway and P27 Kip1, EpCAM, Met and other Cancer Phenotype signaling pathways. gastric cancer ntsr1 proliferation metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens CAI Ying verfasserin aut LIANG Jiabei verfasserin aut ZHOU Jing verfasserin aut GUO Qing verfasserin aut YANG Lihua verfasserin aut SUN Rongchao verfasserin aut WU Haorong verfasserin aut ZHOU Zhiyi verfasserin aut In Zhongliu Fangzhi Yanjiu Magazine House of Cancer Research on Prevention and Treatment, 2019 45(2018), 1, Seite 9-14 (DE-627)176063638X 10008578 nnns volume:45 year:2018 number:1 pages:9-14 https://doi.org/10.3971/j.issn.1000-8578.2018.17.0658 kostenfrei https://doaj.org/article/b8db302a97974d54a9e9d4fc2e326614 kostenfrei http://html.rhhz.net/ZLFZYJ/html/8578.2018.17.0658.htm kostenfrei https://doaj.org/toc/1000-8578 Journal toc kostenfrei https://doaj.org/toc/1000-8578 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 45 2018 1 9-14
allfieldsSound	10.3971/j.issn.1000-8578.2018.17.0658 doi (DE-627)DOAJ006816584 (DE-599)DOAJb8db302a97974d54a9e9d4fc2e326614 DE-627 ger DE-627 rakwb chi RC254-282 YANG Shudong verfasserin aut Effect of NTSR1 Gene on Proliferation and Invasion of Gastric Adenocarcinoma and Its Mechanism 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To investigate the role of NTSR1 gene in the proliferation and invasion of gastric cancer cells and its possible mechanism. Methods The relationship between expression of NTSR1 protein and EGFR, HER2 in 233 cases of gastric cancer was analyzed by Envision two-step immunohistochemistry. The expression of NTSR1 mRNA in gastric cancer cell line was detected, and the cell line with high abundance was selected as the experimental object. MKN-45 cells with the highest interference efficiency of shNTSR1 were constructed. MTT and cell invasion assay were used to detect the effect of NTSR1 gene silencing on the proliferation and invasion of gastric cancer cells. The effect of shNTSR1 on the expression of 19 related genes in the Cancer Phenotype signaling pathway, including EGFR and HER2, was investigated. Results (1) There was a significant positive correlation between the positive expression of NTSR1 and the expression of EGFR and HER2 in 233 cases of gastric cancer(P < 0.05), and there was a significantly positive correlation between EGFR and HER2 expression(P < 0.05). (2) The expression abundance of NTSR1 in MKN-45 cells was high. (3) The NTSR1 shRNA expression vector was successfully constructed to construct stable cell lines. (4) The proliferation of MKN-45 cells was significantly down-regulated by NTSR1 shRNA interference (P < 0.05). (5) The invasion and metastasis rates of MKN-45 were significantly decreased by NTSR1 shRNA interference(P < 0.05). (6) The expression of p27Kip1 protein in Cancer Phenotype signaling pathway of MKN-45 cells was significantly up-regulated, meanwhile, EGFR, HER2, EpCAM and Met also showed a significant downward trend by NTSR1 shRNA interference(P < 0.05). Conclusion NTSR1 plays an important role in the occurrence, invasion and metastasis of gastric cancer by regulating EGFR/HER2 signaling pathway and P27 Kip1, EpCAM, Met and other Cancer Phenotype signaling pathways. gastric cancer ntsr1 proliferation metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens CAI Ying verfasserin aut LIANG Jiabei verfasserin aut ZHOU Jing verfasserin aut GUO Qing verfasserin aut YANG Lihua verfasserin aut SUN Rongchao verfasserin aut WU Haorong verfasserin aut ZHOU Zhiyi verfasserin aut In Zhongliu Fangzhi Yanjiu Magazine House of Cancer Research on Prevention and Treatment, 2019 45(2018), 1, Seite 9-14 (DE-627)176063638X 10008578 nnns volume:45 year:2018 number:1 pages:9-14 https://doi.org/10.3971/j.issn.1000-8578.2018.17.0658 kostenfrei https://doaj.org/article/b8db302a97974d54a9e9d4fc2e326614 kostenfrei http://html.rhhz.net/ZLFZYJ/html/8578.2018.17.0658.htm kostenfrei https://doaj.org/toc/1000-8578 Journal toc kostenfrei https://doaj.org/toc/1000-8578 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 45 2018 1 9-14
language	Chinese
source	In Zhongliu Fangzhi Yanjiu 45(2018), 1, Seite 9-14 volume:45 year:2018 number:1 pages:9-14
sourceStr	In Zhongliu Fangzhi Yanjiu 45(2018), 1, Seite 9-14 volume:45 year:2018 number:1 pages:9-14
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	gastric cancer ntsr1 proliferation metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Zhongliu Fangzhi Yanjiu
authorswithroles_txt_mv	YANG Shudong @@aut@@ CAI Ying @@aut@@ LIANG Jiabei @@aut@@ ZHOU Jing @@aut@@ GUO Qing @@aut@@ YANG Lihua @@aut@@ SUN Rongchao @@aut@@ WU Haorong @@aut@@ ZHOU Zhiyi @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	176063638X
id	DOAJ006816584
language_de	chinesisch
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Methods The relationship between expression of NTSR1 protein and EGFR, HER2 in 233 cases of gastric cancer was analyzed by Envision two-step immunohistochemistry. The expression of NTSR1 mRNA in gastric cancer cell line was detected, and the cell line with high abundance was selected as the experimental object. MKN-45 cells with the highest interference efficiency of shNTSR1 were constructed. MTT and cell invasion assay were used to detect the effect of NTSR1 gene silencing on the proliferation and invasion of gastric cancer cells. The effect of shNTSR1 on the expression of 19 related genes in the Cancer Phenotype signaling pathway, including EGFR and HER2, was investigated. Results (1) There was a significant positive correlation between the positive expression of NTSR1 and the expression of EGFR and HER2 in 233 cases of gastric cancer(P < 0.05), and there was a significantly positive correlation between EGFR and HER2 expression(P < 0.05). (2) The expression abundance of NTSR1 in MKN-45 cells was high. (3) The NTSR1 shRNA expression vector was successfully constructed to construct stable cell lines. (4) The proliferation of MKN-45 cells was significantly down-regulated by NTSR1 shRNA interference (P < 0.05). (5) The invasion and metastasis rates of MKN-45 were significantly decreased by NTSR1 shRNA interference(P < 0.05). (6) The expression of p27Kip1 protein in Cancer Phenotype signaling pathway of MKN-45 cells was significantly up-regulated, meanwhile, EGFR, HER2, EpCAM and Met also showed a significant downward trend by NTSR1 shRNA interference(P < 0.05). Conclusion NTSR1 plays an important role in the occurrence, invasion and metastasis of gastric cancer by regulating EGFR/HER2 signaling pathway and P27 Kip1, EpCAM, Met and other Cancer Phenotype signaling pathways.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">gastric cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ntsr1</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">proliferation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">metastasis</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neoplasms. Tumors. Oncology. 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callnumber-first	R - Medicine
author	YANG Shudong
spellingShingle	YANG Shudong misc RC254-282 misc gastric cancer misc ntsr1 misc proliferation misc metastasis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Effect of NTSR1 Gene on Proliferation and Invasion of Gastric Adenocarcinoma and Its Mechanism
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topic_title	RC254-282 Effect of NTSR1 Gene on Proliferation and Invasion of Gastric Adenocarcinoma and Its Mechanism gastric cancer ntsr1 proliferation metastasis
topic	misc RC254-282 misc gastric cancer misc ntsr1 misc proliferation misc metastasis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc gastric cancer misc ntsr1 misc proliferation misc metastasis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc gastric cancer misc ntsr1 misc proliferation misc metastasis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Effect of NTSR1 Gene on Proliferation and Invasion of Gastric Adenocarcinoma and Its Mechanism
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title_full	Effect of NTSR1 Gene on Proliferation and Invasion of Gastric Adenocarcinoma and Its Mechanism
author_sort	YANG Shudong
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author_browse	YANG Shudong CAI Ying LIANG Jiabei ZHOU Jing GUO Qing YANG Lihua SUN Rongchao WU Haorong ZHOU Zhiyi
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title_sort	effect of ntsr1 gene on proliferation and invasion of gastric adenocarcinoma and its mechanism
callnumber	RC254-282
title_auth	Effect of NTSR1 Gene on Proliferation and Invasion of Gastric Adenocarcinoma and Its Mechanism
abstract	Objective To investigate the role of NTSR1 gene in the proliferation and invasion of gastric cancer cells and its possible mechanism. Methods The relationship between expression of NTSR1 protein and EGFR, HER2 in 233 cases of gastric cancer was analyzed by Envision two-step immunohistochemistry. The expression of NTSR1 mRNA in gastric cancer cell line was detected, and the cell line with high abundance was selected as the experimental object. MKN-45 cells with the highest interference efficiency of shNTSR1 were constructed. MTT and cell invasion assay were used to detect the effect of NTSR1 gene silencing on the proliferation and invasion of gastric cancer cells. The effect of shNTSR1 on the expression of 19 related genes in the Cancer Phenotype signaling pathway, including EGFR and HER2, was investigated. Results (1) There was a significant positive correlation between the positive expression of NTSR1 and the expression of EGFR and HER2 in 233 cases of gastric cancer(P < 0.05), and there was a significantly positive correlation between EGFR and HER2 expression(P < 0.05). (2) The expression abundance of NTSR1 in MKN-45 cells was high. (3) The NTSR1 shRNA expression vector was successfully constructed to construct stable cell lines. (4) The proliferation of MKN-45 cells was significantly down-regulated by NTSR1 shRNA interference (P < 0.05). (5) The invasion and metastasis rates of MKN-45 were significantly decreased by NTSR1 shRNA interference(P < 0.05). (6) The expression of p27Kip1 protein in Cancer Phenotype signaling pathway of MKN-45 cells was significantly up-regulated, meanwhile, EGFR, HER2, EpCAM and Met also showed a significant downward trend by NTSR1 shRNA interference(P < 0.05). Conclusion NTSR1 plays an important role in the occurrence, invasion and metastasis of gastric cancer by regulating EGFR/HER2 signaling pathway and P27 Kip1, EpCAM, Met and other Cancer Phenotype signaling pathways.
abstractGer	Objective To investigate the role of NTSR1 gene in the proliferation and invasion of gastric cancer cells and its possible mechanism. Methods The relationship between expression of NTSR1 protein and EGFR, HER2 in 233 cases of gastric cancer was analyzed by Envision two-step immunohistochemistry. The expression of NTSR1 mRNA in gastric cancer cell line was detected, and the cell line with high abundance was selected as the experimental object. MKN-45 cells with the highest interference efficiency of shNTSR1 were constructed. MTT and cell invasion assay were used to detect the effect of NTSR1 gene silencing on the proliferation and invasion of gastric cancer cells. The effect of shNTSR1 on the expression of 19 related genes in the Cancer Phenotype signaling pathway, including EGFR and HER2, was investigated. Results (1) There was a significant positive correlation between the positive expression of NTSR1 and the expression of EGFR and HER2 in 233 cases of gastric cancer(P < 0.05), and there was a significantly positive correlation between EGFR and HER2 expression(P < 0.05). (2) The expression abundance of NTSR1 in MKN-45 cells was high. (3) The NTSR1 shRNA expression vector was successfully constructed to construct stable cell lines. (4) The proliferation of MKN-45 cells was significantly down-regulated by NTSR1 shRNA interference (P < 0.05). (5) The invasion and metastasis rates of MKN-45 were significantly decreased by NTSR1 shRNA interference(P < 0.05). (6) The expression of p27Kip1 protein in Cancer Phenotype signaling pathway of MKN-45 cells was significantly up-regulated, meanwhile, EGFR, HER2, EpCAM and Met also showed a significant downward trend by NTSR1 shRNA interference(P < 0.05). Conclusion NTSR1 plays an important role in the occurrence, invasion and metastasis of gastric cancer by regulating EGFR/HER2 signaling pathway and P27 Kip1, EpCAM, Met and other Cancer Phenotype signaling pathways.
abstract_unstemmed	Objective To investigate the role of NTSR1 gene in the proliferation and invasion of gastric cancer cells and its possible mechanism. Methods The relationship between expression of NTSR1 protein and EGFR, HER2 in 233 cases of gastric cancer was analyzed by Envision two-step immunohistochemistry. The expression of NTSR1 mRNA in gastric cancer cell line was detected, and the cell line with high abundance was selected as the experimental object. MKN-45 cells with the highest interference efficiency of shNTSR1 were constructed. MTT and cell invasion assay were used to detect the effect of NTSR1 gene silencing on the proliferation and invasion of gastric cancer cells. The effect of shNTSR1 on the expression of 19 related genes in the Cancer Phenotype signaling pathway, including EGFR and HER2, was investigated. Results (1) There was a significant positive correlation between the positive expression of NTSR1 and the expression of EGFR and HER2 in 233 cases of gastric cancer(P < 0.05), and there was a significantly positive correlation between EGFR and HER2 expression(P < 0.05). (2) The expression abundance of NTSR1 in MKN-45 cells was high. (3) The NTSR1 shRNA expression vector was successfully constructed to construct stable cell lines. (4) The proliferation of MKN-45 cells was significantly down-regulated by NTSR1 shRNA interference (P < 0.05). (5) The invasion and metastasis rates of MKN-45 were significantly decreased by NTSR1 shRNA interference(P < 0.05). (6) The expression of p27Kip1 protein in Cancer Phenotype signaling pathway of MKN-45 cells was significantly up-regulated, meanwhile, EGFR, HER2, EpCAM and Met also showed a significant downward trend by NTSR1 shRNA interference(P < 0.05). Conclusion NTSR1 plays an important role in the occurrence, invasion and metastasis of gastric cancer by regulating EGFR/HER2 signaling pathway and P27 Kip1, EpCAM, Met and other Cancer Phenotype signaling pathways.
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title_short	Effect of NTSR1 Gene on Proliferation and Invasion of Gastric Adenocarcinoma and Its Mechanism
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