Biochemical parameters of rickets in Iranian children: A systematic review and meta-analysis

Background: Many causes can lead to childhood rickets. We aimed to investigate the biochemical symptoms of childhood rickets with systematic review and meta-analysis. Materials and Methods: Seven articles published from 1975 to 2018 were recruited. The literature search was performed in the Scientif...
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Gespeichert in:

Autor*in:	Kourosh Sayehmiri [verfasserIn] Masoumeh Shohani [verfasserIn] Gholamreza Kalvandi [verfasserIn] Reza Najafi [verfasserIn] Hamed Tavan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	biochemical symptoms childhood meta-analysis rickets systematic review

Übergeordnetes Werk:	In: Journal of Research in Medical Sciences - Wolters Kluwer Medknow Publications, 2005, 24(2019), 1, Seite 76-76
Übergeordnetes Werk:	volume:24 ; year:2019 ; number:1 ; pages:76-76

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.4103/jrms.JRMS_354_18

Katalog-ID:	DOAJ006932983

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520			\|a Background: Many causes can lead to childhood rickets. We aimed to investigate the biochemical symptoms of childhood rickets with systematic review and meta-analysis. Materials and Methods: Seven articles published from 1975 to 2018 were recruited. The literature search was performed in the Scientific Information Database, Google Scholar, PubMed, and Elsevier databases using related keywords. For meta-analysis, the results of the studies were pooled using the random-effects model. The heterogeneity between the studies was checked using Q test and I2 index. Results: The total sample population consisted of 933 children with biochemical symptoms of rickets (133 participants per article). According to our findings, the mean serum levels of PO4, Ca, and alkaline phosphatase in children with rickets were 4.18 (95% confidence interval [CI]: 3.75–4.61, I2 = 98.3%,P <0.001), 9.23 (95% CI: 8.78–9.68, I2 = 99.6%,P < 0.001), and 1.33 (95% CI: 1.23–1.44, I2 = 95.6%,P < 0.001), respectively. Conclusion: Characterizing the biochemical symptoms of rickets in children can help to early diagnose and prevent the disease in children. Furthermore, educating parents about biochemical symptoms can lead to early diagnosis and successful treatment of rickets in children.
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allfields	10.4103/jrms.JRMS_354_18 doi (DE-627)DOAJ006932983 (DE-599)DOAJ038a5d9a9efb46a4bd6416644180f811 DE-627 ger DE-627 rakwb eng Kourosh Sayehmiri verfasserin aut Biochemical parameters of rickets in Iranian children: A systematic review and meta-analysis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Many causes can lead to childhood rickets. We aimed to investigate the biochemical symptoms of childhood rickets with systematic review and meta-analysis. Materials and Methods: Seven articles published from 1975 to 2018 were recruited. The literature search was performed in the Scientific Information Database, Google Scholar, PubMed, and Elsevier databases using related keywords. For meta-analysis, the results of the studies were pooled using the random-effects model. The heterogeneity between the studies was checked using Q test and I2 index. Results: The total sample population consisted of 933 children with biochemical symptoms of rickets (133 participants per article). According to our findings, the mean serum levels of PO4, Ca, and alkaline phosphatase in children with rickets were 4.18 (95% confidence interval [CI]: 3.75–4.61, I2 = 98.3%,P <0.001), 9.23 (95% CI: 8.78–9.68, I2 = 99.6%,P < 0.001), and 1.33 (95% CI: 1.23–1.44, I2 = 95.6%,P < 0.001), respectively. Conclusion: Characterizing the biochemical symptoms of rickets in children can help to early diagnose and prevent the disease in children. Furthermore, educating parents about biochemical symptoms can lead to early diagnosis and successful treatment of rickets in children. biochemical symptoms childhood meta-analysis rickets systematic review Medicine R Masoumeh Shohani verfasserin aut Gholamreza Kalvandi verfasserin aut Reza Najafi verfasserin aut Hamed Tavan verfasserin aut In Journal of Research in Medical Sciences Wolters Kluwer Medknow Publications, 2005 24(2019), 1, Seite 76-76 (DE-627)608492930 (DE-600)2513075-4 17357136 nnns volume:24 year:2019 number:1 pages:76-76 https://doi.org/10.4103/jrms.JRMS_354_18 kostenfrei https://doaj.org/article/038a5d9a9efb46a4bd6416644180f811 kostenfrei http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2019;volume=24;issue=1;spage=76;epage=76;aulast=Sayehmiri kostenfrei https://doaj.org/toc/1735-1995 Journal toc kostenfrei https://doaj.org/toc/1735-7136 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2019 1 76-76
spelling	10.4103/jrms.JRMS_354_18 doi (DE-627)DOAJ006932983 (DE-599)DOAJ038a5d9a9efb46a4bd6416644180f811 DE-627 ger DE-627 rakwb eng Kourosh Sayehmiri verfasserin aut Biochemical parameters of rickets in Iranian children: A systematic review and meta-analysis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Many causes can lead to childhood rickets. We aimed to investigate the biochemical symptoms of childhood rickets with systematic review and meta-analysis. Materials and Methods: Seven articles published from 1975 to 2018 were recruited. The literature search was performed in the Scientific Information Database, Google Scholar, PubMed, and Elsevier databases using related keywords. For meta-analysis, the results of the studies were pooled using the random-effects model. The heterogeneity between the studies was checked using Q test and I2 index. Results: The total sample population consisted of 933 children with biochemical symptoms of rickets (133 participants per article). According to our findings, the mean serum levels of PO4, Ca, and alkaline phosphatase in children with rickets were 4.18 (95% confidence interval [CI]: 3.75–4.61, I2 = 98.3%,P <0.001), 9.23 (95% CI: 8.78–9.68, I2 = 99.6%,P < 0.001), and 1.33 (95% CI: 1.23–1.44, I2 = 95.6%,P < 0.001), respectively. Conclusion: Characterizing the biochemical symptoms of rickets in children can help to early diagnose and prevent the disease in children. Furthermore, educating parents about biochemical symptoms can lead to early diagnosis and successful treatment of rickets in children. biochemical symptoms childhood meta-analysis rickets systematic review Medicine R Masoumeh Shohani verfasserin aut Gholamreza Kalvandi verfasserin aut Reza Najafi verfasserin aut Hamed Tavan verfasserin aut In Journal of Research in Medical Sciences Wolters Kluwer Medknow Publications, 2005 24(2019), 1, Seite 76-76 (DE-627)608492930 (DE-600)2513075-4 17357136 nnns volume:24 year:2019 number:1 pages:76-76 https://doi.org/10.4103/jrms.JRMS_354_18 kostenfrei https://doaj.org/article/038a5d9a9efb46a4bd6416644180f811 kostenfrei http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2019;volume=24;issue=1;spage=76;epage=76;aulast=Sayehmiri kostenfrei https://doaj.org/toc/1735-1995 Journal toc kostenfrei https://doaj.org/toc/1735-7136 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2019 1 76-76
allfields_unstemmed	10.4103/jrms.JRMS_354_18 doi (DE-627)DOAJ006932983 (DE-599)DOAJ038a5d9a9efb46a4bd6416644180f811 DE-627 ger DE-627 rakwb eng Kourosh Sayehmiri verfasserin aut Biochemical parameters of rickets in Iranian children: A systematic review and meta-analysis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Many causes can lead to childhood rickets. We aimed to investigate the biochemical symptoms of childhood rickets with systematic review and meta-analysis. Materials and Methods: Seven articles published from 1975 to 2018 were recruited. The literature search was performed in the Scientific Information Database, Google Scholar, PubMed, and Elsevier databases using related keywords. For meta-analysis, the results of the studies were pooled using the random-effects model. The heterogeneity between the studies was checked using Q test and I2 index. Results: The total sample population consisted of 933 children with biochemical symptoms of rickets (133 participants per article). According to our findings, the mean serum levels of PO4, Ca, and alkaline phosphatase in children with rickets were 4.18 (95% confidence interval [CI]: 3.75–4.61, I2 = 98.3%,P <0.001), 9.23 (95% CI: 8.78–9.68, I2 = 99.6%,P < 0.001), and 1.33 (95% CI: 1.23–1.44, I2 = 95.6%,P < 0.001), respectively. Conclusion: Characterizing the biochemical symptoms of rickets in children can help to early diagnose and prevent the disease in children. Furthermore, educating parents about biochemical symptoms can lead to early diagnosis and successful treatment of rickets in children. biochemical symptoms childhood meta-analysis rickets systematic review Medicine R Masoumeh Shohani verfasserin aut Gholamreza Kalvandi verfasserin aut Reza Najafi verfasserin aut Hamed Tavan verfasserin aut In Journal of Research in Medical Sciences Wolters Kluwer Medknow Publications, 2005 24(2019), 1, Seite 76-76 (DE-627)608492930 (DE-600)2513075-4 17357136 nnns volume:24 year:2019 number:1 pages:76-76 https://doi.org/10.4103/jrms.JRMS_354_18 kostenfrei https://doaj.org/article/038a5d9a9efb46a4bd6416644180f811 kostenfrei http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2019;volume=24;issue=1;spage=76;epage=76;aulast=Sayehmiri kostenfrei https://doaj.org/toc/1735-1995 Journal toc kostenfrei https://doaj.org/toc/1735-7136 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2019 1 76-76
allfieldsGer	10.4103/jrms.JRMS_354_18 doi (DE-627)DOAJ006932983 (DE-599)DOAJ038a5d9a9efb46a4bd6416644180f811 DE-627 ger DE-627 rakwb eng Kourosh Sayehmiri verfasserin aut Biochemical parameters of rickets in Iranian children: A systematic review and meta-analysis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Many causes can lead to childhood rickets. We aimed to investigate the biochemical symptoms of childhood rickets with systematic review and meta-analysis. Materials and Methods: Seven articles published from 1975 to 2018 were recruited. The literature search was performed in the Scientific Information Database, Google Scholar, PubMed, and Elsevier databases using related keywords. For meta-analysis, the results of the studies were pooled using the random-effects model. The heterogeneity between the studies was checked using Q test and I2 index. Results: The total sample population consisted of 933 children with biochemical symptoms of rickets (133 participants per article). According to our findings, the mean serum levels of PO4, Ca, and alkaline phosphatase in children with rickets were 4.18 (95% confidence interval [CI]: 3.75–4.61, I2 = 98.3%,P <0.001), 9.23 (95% CI: 8.78–9.68, I2 = 99.6%,P < 0.001), and 1.33 (95% CI: 1.23–1.44, I2 = 95.6%,P < 0.001), respectively. Conclusion: Characterizing the biochemical symptoms of rickets in children can help to early diagnose and prevent the disease in children. Furthermore, educating parents about biochemical symptoms can lead to early diagnosis and successful treatment of rickets in children. biochemical symptoms childhood meta-analysis rickets systematic review Medicine R Masoumeh Shohani verfasserin aut Gholamreza Kalvandi verfasserin aut Reza Najafi verfasserin aut Hamed Tavan verfasserin aut In Journal of Research in Medical Sciences Wolters Kluwer Medknow Publications, 2005 24(2019), 1, Seite 76-76 (DE-627)608492930 (DE-600)2513075-4 17357136 nnns volume:24 year:2019 number:1 pages:76-76 https://doi.org/10.4103/jrms.JRMS_354_18 kostenfrei https://doaj.org/article/038a5d9a9efb46a4bd6416644180f811 kostenfrei http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2019;volume=24;issue=1;spage=76;epage=76;aulast=Sayehmiri kostenfrei https://doaj.org/toc/1735-1995 Journal toc kostenfrei https://doaj.org/toc/1735-7136 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2019 1 76-76
allfieldsSound	10.4103/jrms.JRMS_354_18 doi (DE-627)DOAJ006932983 (DE-599)DOAJ038a5d9a9efb46a4bd6416644180f811 DE-627 ger DE-627 rakwb eng Kourosh Sayehmiri verfasserin aut Biochemical parameters of rickets in Iranian children: A systematic review and meta-analysis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Many causes can lead to childhood rickets. We aimed to investigate the biochemical symptoms of childhood rickets with systematic review and meta-analysis. Materials and Methods: Seven articles published from 1975 to 2018 were recruited. The literature search was performed in the Scientific Information Database, Google Scholar, PubMed, and Elsevier databases using related keywords. For meta-analysis, the results of the studies were pooled using the random-effects model. The heterogeneity between the studies was checked using Q test and I2 index. Results: The total sample population consisted of 933 children with biochemical symptoms of rickets (133 participants per article). According to our findings, the mean serum levels of PO4, Ca, and alkaline phosphatase in children with rickets were 4.18 (95% confidence interval [CI]: 3.75–4.61, I2 = 98.3%,P <0.001), 9.23 (95% CI: 8.78–9.68, I2 = 99.6%,P < 0.001), and 1.33 (95% CI: 1.23–1.44, I2 = 95.6%,P < 0.001), respectively. Conclusion: Characterizing the biochemical symptoms of rickets in children can help to early diagnose and prevent the disease in children. Furthermore, educating parents about biochemical symptoms can lead to early diagnosis and successful treatment of rickets in children. biochemical symptoms childhood meta-analysis rickets systematic review Medicine R Masoumeh Shohani verfasserin aut Gholamreza Kalvandi verfasserin aut Reza Najafi verfasserin aut Hamed Tavan verfasserin aut In Journal of Research in Medical Sciences Wolters Kluwer Medknow Publications, 2005 24(2019), 1, Seite 76-76 (DE-627)608492930 (DE-600)2513075-4 17357136 nnns volume:24 year:2019 number:1 pages:76-76 https://doi.org/10.4103/jrms.JRMS_354_18 kostenfrei https://doaj.org/article/038a5d9a9efb46a4bd6416644180f811 kostenfrei http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2019;volume=24;issue=1;spage=76;epage=76;aulast=Sayehmiri kostenfrei https://doaj.org/toc/1735-1995 Journal toc kostenfrei https://doaj.org/toc/1735-7136 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2019 1 76-76
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author	Kourosh Sayehmiri
spellingShingle	Kourosh Sayehmiri misc biochemical symptoms misc childhood misc meta-analysis misc rickets misc systematic review misc Medicine misc R Biochemical parameters of rickets in Iranian children: A systematic review and meta-analysis
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topic_title	Biochemical parameters of rickets in Iranian children: A systematic review and meta-analysis biochemical symptoms childhood meta-analysis rickets systematic review
topic	misc biochemical symptoms misc childhood misc meta-analysis misc rickets misc systematic review misc Medicine misc R
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title	Biochemical parameters of rickets in Iranian children: A systematic review and meta-analysis
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title_full	Biochemical parameters of rickets in Iranian children: A systematic review and meta-analysis
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author_browse	Kourosh Sayehmiri Masoumeh Shohani Gholamreza Kalvandi Reza Najafi Hamed Tavan
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title_sort	biochemical parameters of rickets in iranian children: a systematic review and meta-analysis
title_auth	Biochemical parameters of rickets in Iranian children: A systematic review and meta-analysis
abstract	Background: Many causes can lead to childhood rickets. We aimed to investigate the biochemical symptoms of childhood rickets with systematic review and meta-analysis. Materials and Methods: Seven articles published from 1975 to 2018 were recruited. The literature search was performed in the Scientific Information Database, Google Scholar, PubMed, and Elsevier databases using related keywords. For meta-analysis, the results of the studies were pooled using the random-effects model. The heterogeneity between the studies was checked using Q test and I2 index. Results: The total sample population consisted of 933 children with biochemical symptoms of rickets (133 participants per article). According to our findings, the mean serum levels of PO4, Ca, and alkaline phosphatase in children with rickets were 4.18 (95% confidence interval [CI]: 3.75–4.61, I2 = 98.3%,P <0.001), 9.23 (95% CI: 8.78–9.68, I2 = 99.6%,P < 0.001), and 1.33 (95% CI: 1.23–1.44, I2 = 95.6%,P < 0.001), respectively. Conclusion: Characterizing the biochemical symptoms of rickets in children can help to early diagnose and prevent the disease in children. Furthermore, educating parents about biochemical symptoms can lead to early diagnosis and successful treatment of rickets in children.
abstractGer	Background: Many causes can lead to childhood rickets. We aimed to investigate the biochemical symptoms of childhood rickets with systematic review and meta-analysis. Materials and Methods: Seven articles published from 1975 to 2018 were recruited. The literature search was performed in the Scientific Information Database, Google Scholar, PubMed, and Elsevier databases using related keywords. For meta-analysis, the results of the studies were pooled using the random-effects model. The heterogeneity between the studies was checked using Q test and I2 index. Results: The total sample population consisted of 933 children with biochemical symptoms of rickets (133 participants per article). According to our findings, the mean serum levels of PO4, Ca, and alkaline phosphatase in children with rickets were 4.18 (95% confidence interval [CI]: 3.75–4.61, I2 = 98.3%,P <0.001), 9.23 (95% CI: 8.78–9.68, I2 = 99.6%,P < 0.001), and 1.33 (95% CI: 1.23–1.44, I2 = 95.6%,P < 0.001), respectively. Conclusion: Characterizing the biochemical symptoms of rickets in children can help to early diagnose and prevent the disease in children. Furthermore, educating parents about biochemical symptoms can lead to early diagnosis and successful treatment of rickets in children.
abstract_unstemmed	Background: Many causes can lead to childhood rickets. We aimed to investigate the biochemical symptoms of childhood rickets with systematic review and meta-analysis. Materials and Methods: Seven articles published from 1975 to 2018 were recruited. The literature search was performed in the Scientific Information Database, Google Scholar, PubMed, and Elsevier databases using related keywords. For meta-analysis, the results of the studies were pooled using the random-effects model. The heterogeneity between the studies was checked using Q test and I2 index. Results: The total sample population consisted of 933 children with biochemical symptoms of rickets (133 participants per article). According to our findings, the mean serum levels of PO4, Ca, and alkaline phosphatase in children with rickets were 4.18 (95% confidence interval [CI]: 3.75–4.61, I2 = 98.3%,P <0.001), 9.23 (95% CI: 8.78–9.68, I2 = 99.6%,P < 0.001), and 1.33 (95% CI: 1.23–1.44, I2 = 95.6%,P < 0.001), respectively. Conclusion: Characterizing the biochemical symptoms of rickets in children can help to early diagnose and prevent the disease in children. Furthermore, educating parents about biochemical symptoms can lead to early diagnosis and successful treatment of rickets in children.
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title_short	Biochemical parameters of rickets in Iranian children: A systematic review and meta-analysis
url	https://doi.org/10.4103/jrms.JRMS_354_18 https://doaj.org/article/038a5d9a9efb46a4bd6416644180f811 http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2019;volume=24;issue=1;spage=76;epage=76;aulast=Sayehmiri https://doaj.org/toc/1735-1995 https://doaj.org/toc/1735-7136
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author2	Masoumeh Shohani Gholamreza Kalvandi Reza Najafi Hamed Tavan
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up_date	2024-07-03T23:35:30.924Z
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Biochemical parameters of rickets in Iranian children: A systematic review and meta-analysis

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