Daratumumab in combination with urelumab to potentiate anti-myeloma activity in lymphocyte-deficient mice reconstituted with human NK cells

Daratumumab is an anti-CD38 fully human IgG1 mAb approved for multiple myeloma treatment. One of the proposed mechanisms of action is the induction of antibody-dependent cellular cytotoxicity (ADCC) mediated by NK cells. NK cells acquire surface CD137 expression in the presence of solid-phase-attach...
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Autor*in:	Maria C. Ochoa [verfasserIn] Elisabeth Perez-Ruiz [verfasserIn] Luna Minute [verfasserIn] Carmen Oñate [verfasserIn] Guiomar Perez [verfasserIn] Inmaculada Rodriguez [verfasserIn] Aintzane Zabaleta [verfasserIn] Diego Alignani [verfasserIn] Myriam Fernandez-Sendin [verfasserIn] Ascension Lopez [verfasserIn] Aura Muntasell [verfasserIn] Miguel F. Sanmamed [verfasserIn] Bruno Paiva [verfasserIn] Miguel Lopez-Botet [verfasserIn] Pedro Berraondo [verfasserIn] Ignacio Melero [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	nk cells adcc multiple myeloma cd137 daratumumab

Übergeordnetes Werk:	In: OncoImmunology - Taylor & Francis Group, 2020, 8(2019), 7
Übergeordnetes Werk:	volume:8 ; year:2019 ; number:7

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1080/2162402X.2019.1599636

Katalog-ID:	DOAJ006970052

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allfields	10.1080/2162402X.2019.1599636 doi (DE-627)DOAJ006970052 (DE-599)DOAJ469445f7b4c148028345cf1278b80df7 DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Maria C. Ochoa verfasserin aut Daratumumab in combination with urelumab to potentiate anti-myeloma activity in lymphocyte-deficient mice reconstituted with human NK cells 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Daratumumab is an anti-CD38 fully human IgG1 mAb approved for multiple myeloma treatment. One of the proposed mechanisms of action is the induction of antibody-dependent cellular cytotoxicity (ADCC) mediated by NK cells. NK cells acquire surface CD137 expression in the presence of solid-phase-attached daratumumab and when encountering a daratumumab-coated CD38+ tumor cell line. In this setting, addition of the agonist anti-CD137 mAb urelumab enhances NK-cell activation increasing CD25 expression and IFNɣ production. However, in vitro ADCC is not increased by the addition of urelumab both in 4h or 24h lasting experiments. To study urelumab-increased daratumumab-mediated ADCC activity in vivo, we set up a mouse model based on the intravenous administration of a luciferase-transfected multiple myeloma cell line of human origin, human NK cells and daratumumab to immuno-deficient NSG mice. In this model, intravenous administration of urelumab 24h after daratumumab delayed tumor growth and prolonged mice survival. nk cells adcc multiple myeloma cd137 daratumumab Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Elisabeth Perez-Ruiz verfasserin aut Luna Minute verfasserin aut Carmen Oñate verfasserin aut Guiomar Perez verfasserin aut Inmaculada Rodriguez verfasserin aut Aintzane Zabaleta verfasserin aut Diego Alignani verfasserin aut Myriam Fernandez-Sendin verfasserin aut Ascension Lopez verfasserin aut Aura Muntasell verfasserin aut Miguel F. Sanmamed verfasserin aut Bruno Paiva verfasserin aut Miguel Lopez-Botet verfasserin aut Pedro Berraondo verfasserin aut Ignacio Melero verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 8(2019), 7 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:8 year:2019 number:7 https://doi.org/10.1080/2162402X.2019.1599636 kostenfrei https://doaj.org/article/469445f7b4c148028345cf1278b80df7 kostenfrei http://dx.doi.org/10.1080/2162402X.2019.1599636 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 7
spelling	10.1080/2162402X.2019.1599636 doi (DE-627)DOAJ006970052 (DE-599)DOAJ469445f7b4c148028345cf1278b80df7 DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Maria C. Ochoa verfasserin aut Daratumumab in combination with urelumab to potentiate anti-myeloma activity in lymphocyte-deficient mice reconstituted with human NK cells 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Daratumumab is an anti-CD38 fully human IgG1 mAb approved for multiple myeloma treatment. One of the proposed mechanisms of action is the induction of antibody-dependent cellular cytotoxicity (ADCC) mediated by NK cells. NK cells acquire surface CD137 expression in the presence of solid-phase-attached daratumumab and when encountering a daratumumab-coated CD38+ tumor cell line. In this setting, addition of the agonist anti-CD137 mAb urelumab enhances NK-cell activation increasing CD25 expression and IFNɣ production. However, in vitro ADCC is not increased by the addition of urelumab both in 4h or 24h lasting experiments. To study urelumab-increased daratumumab-mediated ADCC activity in vivo, we set up a mouse model based on the intravenous administration of a luciferase-transfected multiple myeloma cell line of human origin, human NK cells and daratumumab to immuno-deficient NSG mice. In this model, intravenous administration of urelumab 24h after daratumumab delayed tumor growth and prolonged mice survival. nk cells adcc multiple myeloma cd137 daratumumab Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Elisabeth Perez-Ruiz verfasserin aut Luna Minute verfasserin aut Carmen Oñate verfasserin aut Guiomar Perez verfasserin aut Inmaculada Rodriguez verfasserin aut Aintzane Zabaleta verfasserin aut Diego Alignani verfasserin aut Myriam Fernandez-Sendin verfasserin aut Ascension Lopez verfasserin aut Aura Muntasell verfasserin aut Miguel F. Sanmamed verfasserin aut Bruno Paiva verfasserin aut Miguel Lopez-Botet verfasserin aut Pedro Berraondo verfasserin aut Ignacio Melero verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 8(2019), 7 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:8 year:2019 number:7 https://doi.org/10.1080/2162402X.2019.1599636 kostenfrei https://doaj.org/article/469445f7b4c148028345cf1278b80df7 kostenfrei http://dx.doi.org/10.1080/2162402X.2019.1599636 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 7
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allfieldsGer	10.1080/2162402X.2019.1599636 doi (DE-627)DOAJ006970052 (DE-599)DOAJ469445f7b4c148028345cf1278b80df7 DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Maria C. Ochoa verfasserin aut Daratumumab in combination with urelumab to potentiate anti-myeloma activity in lymphocyte-deficient mice reconstituted with human NK cells 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Daratumumab is an anti-CD38 fully human IgG1 mAb approved for multiple myeloma treatment. One of the proposed mechanisms of action is the induction of antibody-dependent cellular cytotoxicity (ADCC) mediated by NK cells. NK cells acquire surface CD137 expression in the presence of solid-phase-attached daratumumab and when encountering a daratumumab-coated CD38+ tumor cell line. In this setting, addition of the agonist anti-CD137 mAb urelumab enhances NK-cell activation increasing CD25 expression and IFNɣ production. However, in vitro ADCC is not increased by the addition of urelumab both in 4h or 24h lasting experiments. To study urelumab-increased daratumumab-mediated ADCC activity in vivo, we set up a mouse model based on the intravenous administration of a luciferase-transfected multiple myeloma cell line of human origin, human NK cells and daratumumab to immuno-deficient NSG mice. In this model, intravenous administration of urelumab 24h after daratumumab delayed tumor growth and prolonged mice survival. nk cells adcc multiple myeloma cd137 daratumumab Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Elisabeth Perez-Ruiz verfasserin aut Luna Minute verfasserin aut Carmen Oñate verfasserin aut Guiomar Perez verfasserin aut Inmaculada Rodriguez verfasserin aut Aintzane Zabaleta verfasserin aut Diego Alignani verfasserin aut Myriam Fernandez-Sendin verfasserin aut Ascension Lopez verfasserin aut Aura Muntasell verfasserin aut Miguel F. Sanmamed verfasserin aut Bruno Paiva verfasserin aut Miguel Lopez-Botet verfasserin aut Pedro Berraondo verfasserin aut Ignacio Melero verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 8(2019), 7 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:8 year:2019 number:7 https://doi.org/10.1080/2162402X.2019.1599636 kostenfrei https://doaj.org/article/469445f7b4c148028345cf1278b80df7 kostenfrei http://dx.doi.org/10.1080/2162402X.2019.1599636 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 7
allfieldsSound	10.1080/2162402X.2019.1599636 doi (DE-627)DOAJ006970052 (DE-599)DOAJ469445f7b4c148028345cf1278b80df7 DE-627 ger DE-627 rakwb eng RC581-607 RC254-282 Maria C. Ochoa verfasserin aut Daratumumab in combination with urelumab to potentiate anti-myeloma activity in lymphocyte-deficient mice reconstituted with human NK cells 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Daratumumab is an anti-CD38 fully human IgG1 mAb approved for multiple myeloma treatment. One of the proposed mechanisms of action is the induction of antibody-dependent cellular cytotoxicity (ADCC) mediated by NK cells. NK cells acquire surface CD137 expression in the presence of solid-phase-attached daratumumab and when encountering a daratumumab-coated CD38+ tumor cell line. In this setting, addition of the agonist anti-CD137 mAb urelumab enhances NK-cell activation increasing CD25 expression and IFNɣ production. However, in vitro ADCC is not increased by the addition of urelumab both in 4h or 24h lasting experiments. To study urelumab-increased daratumumab-mediated ADCC activity in vivo, we set up a mouse model based on the intravenous administration of a luciferase-transfected multiple myeloma cell line of human origin, human NK cells and daratumumab to immuno-deficient NSG mice. In this model, intravenous administration of urelumab 24h after daratumumab delayed tumor growth and prolonged mice survival. nk cells adcc multiple myeloma cd137 daratumumab Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Elisabeth Perez-Ruiz verfasserin aut Luna Minute verfasserin aut Carmen Oñate verfasserin aut Guiomar Perez verfasserin aut Inmaculada Rodriguez verfasserin aut Aintzane Zabaleta verfasserin aut Diego Alignani verfasserin aut Myriam Fernandez-Sendin verfasserin aut Ascension Lopez verfasserin aut Aura Muntasell verfasserin aut Miguel F. Sanmamed verfasserin aut Bruno Paiva verfasserin aut Miguel Lopez-Botet verfasserin aut Pedro Berraondo verfasserin aut Ignacio Melero verfasserin aut In OncoImmunology Taylor & Francis Group, 2020 8(2019), 7 (DE-627)683365428 (DE-600)2645309-5 2162402X nnns volume:8 year:2019 number:7 https://doi.org/10.1080/2162402X.2019.1599636 kostenfrei https://doaj.org/article/469445f7b4c148028345cf1278b80df7 kostenfrei http://dx.doi.org/10.1080/2162402X.2019.1599636 kostenfrei https://doaj.org/toc/2162-402X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2019 7
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source	In OncoImmunology 8(2019), 7 volume:8 year:2019 number:7
sourceStr	In OncoImmunology 8(2019), 7 volume:8 year:2019 number:7
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topic_facet	nk cells adcc multiple myeloma cd137 daratumumab Immunologic diseases. Allergy Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	OncoImmunology
authorswithroles_txt_mv	Maria C. Ochoa @@aut@@ Elisabeth Perez-Ruiz @@aut@@ Luna Minute @@aut@@ Carmen Oñate @@aut@@ Guiomar Perez @@aut@@ Inmaculada Rodriguez @@aut@@ Aintzane Zabaleta @@aut@@ Diego Alignani @@aut@@ Myriam Fernandez-Sendin @@aut@@ Ascension Lopez @@aut@@ Aura Muntasell @@aut@@ Miguel F. Sanmamed @@aut@@ Bruno Paiva @@aut@@ Miguel Lopez-Botet @@aut@@ Pedro Berraondo @@aut@@ Ignacio Melero @@aut@@
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callnumber-first	R - Medicine
author	Maria C. Ochoa
spellingShingle	Maria C. Ochoa misc RC581-607 misc RC254-282 misc nk cells misc adcc misc multiple myeloma misc cd137 misc daratumumab misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Daratumumab in combination with urelumab to potentiate anti-myeloma activity in lymphocyte-deficient mice reconstituted with human NK cells
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topic_title	RC581-607 RC254-282 Daratumumab in combination with urelumab to potentiate anti-myeloma activity in lymphocyte-deficient mice reconstituted with human NK cells nk cells adcc multiple myeloma cd137 daratumumab
topic	misc RC581-607 misc RC254-282 misc nk cells misc adcc misc multiple myeloma misc cd137 misc daratumumab misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC581-607 misc RC254-282 misc nk cells misc adcc misc multiple myeloma misc cd137 misc daratumumab misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC581-607 misc RC254-282 misc nk cells misc adcc misc multiple myeloma misc cd137 misc daratumumab misc Immunologic diseases. Allergy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Daratumumab in combination with urelumab to potentiate anti-myeloma activity in lymphocyte-deficient mice reconstituted with human NK cells
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title_full	Daratumumab in combination with urelumab to potentiate anti-myeloma activity in lymphocyte-deficient mice reconstituted with human NK cells
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author_browse	Maria C. Ochoa Elisabeth Perez-Ruiz Luna Minute Carmen Oñate Guiomar Perez Inmaculada Rodriguez Aintzane Zabaleta Diego Alignani Myriam Fernandez-Sendin Ascension Lopez Aura Muntasell Miguel F. Sanmamed Bruno Paiva Miguel Lopez-Botet Pedro Berraondo Ignacio Melero
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title_sort	daratumumab in combination with urelumab to potentiate anti-myeloma activity in lymphocyte-deficient mice reconstituted with human nk cells
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title_auth	Daratumumab in combination with urelumab to potentiate anti-myeloma activity in lymphocyte-deficient mice reconstituted with human NK cells
abstract	Daratumumab is an anti-CD38 fully human IgG1 mAb approved for multiple myeloma treatment. One of the proposed mechanisms of action is the induction of antibody-dependent cellular cytotoxicity (ADCC) mediated by NK cells. NK cells acquire surface CD137 expression in the presence of solid-phase-attached daratumumab and when encountering a daratumumab-coated CD38+ tumor cell line. In this setting, addition of the agonist anti-CD137 mAb urelumab enhances NK-cell activation increasing CD25 expression and IFNɣ production. However, in vitro ADCC is not increased by the addition of urelumab both in 4h or 24h lasting experiments. To study urelumab-increased daratumumab-mediated ADCC activity in vivo, we set up a mouse model based on the intravenous administration of a luciferase-transfected multiple myeloma cell line of human origin, human NK cells and daratumumab to immuno-deficient NSG mice. In this model, intravenous administration of urelumab 24h after daratumumab delayed tumor growth and prolonged mice survival.
abstractGer	Daratumumab is an anti-CD38 fully human IgG1 mAb approved for multiple myeloma treatment. One of the proposed mechanisms of action is the induction of antibody-dependent cellular cytotoxicity (ADCC) mediated by NK cells. NK cells acquire surface CD137 expression in the presence of solid-phase-attached daratumumab and when encountering a daratumumab-coated CD38+ tumor cell line. In this setting, addition of the agonist anti-CD137 mAb urelumab enhances NK-cell activation increasing CD25 expression and IFNɣ production. However, in vitro ADCC is not increased by the addition of urelumab both in 4h or 24h lasting experiments. To study urelumab-increased daratumumab-mediated ADCC activity in vivo, we set up a mouse model based on the intravenous administration of a luciferase-transfected multiple myeloma cell line of human origin, human NK cells and daratumumab to immuno-deficient NSG mice. In this model, intravenous administration of urelumab 24h after daratumumab delayed tumor growth and prolonged mice survival.
abstract_unstemmed	Daratumumab is an anti-CD38 fully human IgG1 mAb approved for multiple myeloma treatment. One of the proposed mechanisms of action is the induction of antibody-dependent cellular cytotoxicity (ADCC) mediated by NK cells. NK cells acquire surface CD137 expression in the presence of solid-phase-attached daratumumab and when encountering a daratumumab-coated CD38+ tumor cell line. In this setting, addition of the agonist anti-CD137 mAb urelumab enhances NK-cell activation increasing CD25 expression and IFNɣ production. However, in vitro ADCC is not increased by the addition of urelumab both in 4h or 24h lasting experiments. To study urelumab-increased daratumumab-mediated ADCC activity in vivo, we set up a mouse model based on the intravenous administration of a luciferase-transfected multiple myeloma cell line of human origin, human NK cells and daratumumab to immuno-deficient NSG mice. In this model, intravenous administration of urelumab 24h after daratumumab delayed tumor growth and prolonged mice survival.
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title_short	Daratumumab in combination with urelumab to potentiate anti-myeloma activity in lymphocyte-deficient mice reconstituted with human NK cells
url	https://doi.org/10.1080/2162402X.2019.1599636 https://doaj.org/article/469445f7b4c148028345cf1278b80df7 http://dx.doi.org/10.1080/2162402X.2019.1599636 https://doaj.org/toc/2162-402X
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author2	Elisabeth Perez-Ruiz Luna Minute Carmen Oñate Guiomar Perez Inmaculada Rodriguez Aintzane Zabaleta Diego Alignani Myriam Fernandez-Sendin Ascension Lopez Aura Muntasell Miguel F. Sanmamed Bruno Paiva Miguel Lopez-Botet Pedro Berraondo Ignacio Melero
author2Str	Elisabeth Perez-Ruiz Luna Minute Carmen Oñate Guiomar Perez Inmaculada Rodriguez Aintzane Zabaleta Diego Alignani Myriam Fernandez-Sendin Ascension Lopez Aura Muntasell Miguel F. Sanmamed Bruno Paiva Miguel Lopez-Botet Pedro Berraondo Ignacio Melero
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up_date	2024-07-03T23:44:49.486Z
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Daratumumab in combination with urelumab to potentiate anti-myeloma activity in lymphocyte-deficient mice reconstituted with human NK cells

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