Specifically altered brain responses to threat in generalized anxiety disorder relative to social anxiety disorder and panic disorder

Background: Despite considerable effort, the neurobiological underpinnings of hyper-responsive threat processing specific to patients suffering from generalized anxiety disorder (GAD) remain poorly understood. The current functional magnetic resonance imaging (fMRI) study aims to delineate GAD-speci...
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Autor*in:	Christine Buff [verfasserIn] Leonie Brinkmann [verfasserIn] Paula Neumeister [verfasserIn] Katharina Feldker [verfasserIn] Carina Heitmann [verfasserIn] Bettina Gathmann [verfasserIn] Tanja Andor [verfasserIn] Thomas Straube [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Cingulate cortex Prefrontal cortex Anterior insula Threat processing RDoC

Übergeordnetes Werk:	In: NeuroImage: Clinical - Elsevier, 2015, 12(2016), C, Seite 698-706
Übergeordnetes Werk:	volume:12 ; year:2016 ; number:C ; pages:698-706

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.nicl.2016.09.023

Katalog-ID:	DOAJ007015569

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245	1	0	\|a Specifically altered brain responses to threat in generalized anxiety disorder relative to social anxiety disorder and panic disorder
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520			\|a Background: Despite considerable effort, the neurobiological underpinnings of hyper-responsive threat processing specific to patients suffering from generalized anxiety disorder (GAD) remain poorly understood. The current functional magnetic resonance imaging (fMRI) study aims to delineate GAD-specific brain activity during immediate threat processing by comparing GAD patients to healthy controls (HC), to social anxiety disorder (SAD) and to panic disorder (PD) patients. Method: Brain activation and functional connectivity patterns to threat vs. neutral pictures were investigated using event-related fMRI. The sample consisted of 21 GAD, 21 PD, 21 SAD and 21 HC. Results: GAD-specific elevated activity to threat vs. neutral pictures was found in cingulate cortex, dorsal anterior insula/frontal operculum (daI/FO) and posterior dorsolateral prefrontal cortex (dlPFC). Defining these effects as seed regions, we detected GAD-specific increased functional connectivity to threat vs. neutral pictures between posterior dlPFC and ventrolateral prefrontal cortex, between cingulate cortex and amygdala, between cingulate cortex and anterior insula, as well as decreased functional connectivity between daI/FO and mid-dlPFC. Conclusion: The findings present the first evidence for GAD-specific neural correlates of hyper-responsive threat processing, possibly reflecting exaggerated threat sensitivity, maladaptive appraisal and attention-allocation processes.
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650		4	\|a Anterior insula
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700	0		\|a Katharina Feldker \|e verfasserin \|4 aut
700	0		\|a Carina Heitmann \|e verfasserin \|4 aut
700	0		\|a Bettina Gathmann \|e verfasserin \|4 aut
700	0		\|a Tanja Andor \|e verfasserin \|4 aut
700	0		\|a Thomas Straube \|e verfasserin \|4 aut
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spelling	10.1016/j.nicl.2016.09.023 doi (DE-627)DOAJ007015569 (DE-599)DOAJ20bd1e8fd4a043f98b015e24aec1d957 DE-627 ger DE-627 rakwb eng R858-859.7 RC346-429 Christine Buff verfasserin aut Specifically altered brain responses to threat in generalized anxiety disorder relative to social anxiety disorder and panic disorder 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Despite considerable effort, the neurobiological underpinnings of hyper-responsive threat processing specific to patients suffering from generalized anxiety disorder (GAD) remain poorly understood. The current functional magnetic resonance imaging (fMRI) study aims to delineate GAD-specific brain activity during immediate threat processing by comparing GAD patients to healthy controls (HC), to social anxiety disorder (SAD) and to panic disorder (PD) patients. Method: Brain activation and functional connectivity patterns to threat vs. neutral pictures were investigated using event-related fMRI. The sample consisted of 21 GAD, 21 PD, 21 SAD and 21 HC. Results: GAD-specific elevated activity to threat vs. neutral pictures was found in cingulate cortex, dorsal anterior insula/frontal operculum (daI/FO) and posterior dorsolateral prefrontal cortex (dlPFC). Defining these effects as seed regions, we detected GAD-specific increased functional connectivity to threat vs. neutral pictures between posterior dlPFC and ventrolateral prefrontal cortex, between cingulate cortex and amygdala, between cingulate cortex and anterior insula, as well as decreased functional connectivity between daI/FO and mid-dlPFC. Conclusion: The findings present the first evidence for GAD-specific neural correlates of hyper-responsive threat processing, possibly reflecting exaggerated threat sensitivity, maladaptive appraisal and attention-allocation processes. Cingulate cortex Prefrontal cortex Anterior insula Threat processing RDoC Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system Leonie Brinkmann verfasserin aut Paula Neumeister verfasserin aut Katharina Feldker verfasserin aut Carina Heitmann verfasserin aut Bettina Gathmann verfasserin aut Tanja Andor verfasserin aut Thomas Straube verfasserin aut In NeuroImage: Clinical Elsevier, 2015 12(2016), C, Seite 698-706 (DE-627)735358869 (DE-600)2701571-3 22131582 nnns volume:12 year:2016 number:C pages:698-706 https://doi.org/10.1016/j.nicl.2016.09.023 kostenfrei https://doaj.org/article/20bd1e8fd4a043f98b015e24aec1d957 kostenfrei http://www.sciencedirect.com/science/article/pii/S221315821630184X kostenfrei https://doaj.org/toc/2213-1582 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 12 2016 C 698-706
allfields_unstemmed	10.1016/j.nicl.2016.09.023 doi (DE-627)DOAJ007015569 (DE-599)DOAJ20bd1e8fd4a043f98b015e24aec1d957 DE-627 ger DE-627 rakwb eng R858-859.7 RC346-429 Christine Buff verfasserin aut Specifically altered brain responses to threat in generalized anxiety disorder relative to social anxiety disorder and panic disorder 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Despite considerable effort, the neurobiological underpinnings of hyper-responsive threat processing specific to patients suffering from generalized anxiety disorder (GAD) remain poorly understood. The current functional magnetic resonance imaging (fMRI) study aims to delineate GAD-specific brain activity during immediate threat processing by comparing GAD patients to healthy controls (HC), to social anxiety disorder (SAD) and to panic disorder (PD) patients. Method: Brain activation and functional connectivity patterns to threat vs. neutral pictures were investigated using event-related fMRI. The sample consisted of 21 GAD, 21 PD, 21 SAD and 21 HC. Results: GAD-specific elevated activity to threat vs. neutral pictures was found in cingulate cortex, dorsal anterior insula/frontal operculum (daI/FO) and posterior dorsolateral prefrontal cortex (dlPFC). Defining these effects as seed regions, we detected GAD-specific increased functional connectivity to threat vs. neutral pictures between posterior dlPFC and ventrolateral prefrontal cortex, between cingulate cortex and amygdala, between cingulate cortex and anterior insula, as well as decreased functional connectivity between daI/FO and mid-dlPFC. Conclusion: The findings present the first evidence for GAD-specific neural correlates of hyper-responsive threat processing, possibly reflecting exaggerated threat sensitivity, maladaptive appraisal and attention-allocation processes. Cingulate cortex Prefrontal cortex Anterior insula Threat processing RDoC Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system Leonie Brinkmann verfasserin aut Paula Neumeister verfasserin aut Katharina Feldker verfasserin aut Carina Heitmann verfasserin aut Bettina Gathmann verfasserin aut Tanja Andor verfasserin aut Thomas Straube verfasserin aut In NeuroImage: Clinical Elsevier, 2015 12(2016), C, Seite 698-706 (DE-627)735358869 (DE-600)2701571-3 22131582 nnns volume:12 year:2016 number:C pages:698-706 https://doi.org/10.1016/j.nicl.2016.09.023 kostenfrei https://doaj.org/article/20bd1e8fd4a043f98b015e24aec1d957 kostenfrei http://www.sciencedirect.com/science/article/pii/S221315821630184X kostenfrei https://doaj.org/toc/2213-1582 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 12 2016 C 698-706
allfieldsGer	10.1016/j.nicl.2016.09.023 doi (DE-627)DOAJ007015569 (DE-599)DOAJ20bd1e8fd4a043f98b015e24aec1d957 DE-627 ger DE-627 rakwb eng R858-859.7 RC346-429 Christine Buff verfasserin aut Specifically altered brain responses to threat in generalized anxiety disorder relative to social anxiety disorder and panic disorder 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Despite considerable effort, the neurobiological underpinnings of hyper-responsive threat processing specific to patients suffering from generalized anxiety disorder (GAD) remain poorly understood. The current functional magnetic resonance imaging (fMRI) study aims to delineate GAD-specific brain activity during immediate threat processing by comparing GAD patients to healthy controls (HC), to social anxiety disorder (SAD) and to panic disorder (PD) patients. Method: Brain activation and functional connectivity patterns to threat vs. neutral pictures were investigated using event-related fMRI. The sample consisted of 21 GAD, 21 PD, 21 SAD and 21 HC. Results: GAD-specific elevated activity to threat vs. neutral pictures was found in cingulate cortex, dorsal anterior insula/frontal operculum (daI/FO) and posterior dorsolateral prefrontal cortex (dlPFC). Defining these effects as seed regions, we detected GAD-specific increased functional connectivity to threat vs. neutral pictures between posterior dlPFC and ventrolateral prefrontal cortex, between cingulate cortex and amygdala, between cingulate cortex and anterior insula, as well as decreased functional connectivity between daI/FO and mid-dlPFC. Conclusion: The findings present the first evidence for GAD-specific neural correlates of hyper-responsive threat processing, possibly reflecting exaggerated threat sensitivity, maladaptive appraisal and attention-allocation processes. Cingulate cortex Prefrontal cortex Anterior insula Threat processing RDoC Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system Leonie Brinkmann verfasserin aut Paula Neumeister verfasserin aut Katharina Feldker verfasserin aut Carina Heitmann verfasserin aut Bettina Gathmann verfasserin aut Tanja Andor verfasserin aut Thomas Straube verfasserin aut In NeuroImage: Clinical Elsevier, 2015 12(2016), C, Seite 698-706 (DE-627)735358869 (DE-600)2701571-3 22131582 nnns volume:12 year:2016 number:C pages:698-706 https://doi.org/10.1016/j.nicl.2016.09.023 kostenfrei https://doaj.org/article/20bd1e8fd4a043f98b015e24aec1d957 kostenfrei http://www.sciencedirect.com/science/article/pii/S221315821630184X kostenfrei https://doaj.org/toc/2213-1582 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 12 2016 C 698-706
allfieldsSound	10.1016/j.nicl.2016.09.023 doi (DE-627)DOAJ007015569 (DE-599)DOAJ20bd1e8fd4a043f98b015e24aec1d957 DE-627 ger DE-627 rakwb eng R858-859.7 RC346-429 Christine Buff verfasserin aut Specifically altered brain responses to threat in generalized anxiety disorder relative to social anxiety disorder and panic disorder 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Despite considerable effort, the neurobiological underpinnings of hyper-responsive threat processing specific to patients suffering from generalized anxiety disorder (GAD) remain poorly understood. The current functional magnetic resonance imaging (fMRI) study aims to delineate GAD-specific brain activity during immediate threat processing by comparing GAD patients to healthy controls (HC), to social anxiety disorder (SAD) and to panic disorder (PD) patients. Method: Brain activation and functional connectivity patterns to threat vs. neutral pictures were investigated using event-related fMRI. The sample consisted of 21 GAD, 21 PD, 21 SAD and 21 HC. Results: GAD-specific elevated activity to threat vs. neutral pictures was found in cingulate cortex, dorsal anterior insula/frontal operculum (daI/FO) and posterior dorsolateral prefrontal cortex (dlPFC). Defining these effects as seed regions, we detected GAD-specific increased functional connectivity to threat vs. neutral pictures between posterior dlPFC and ventrolateral prefrontal cortex, between cingulate cortex and amygdala, between cingulate cortex and anterior insula, as well as decreased functional connectivity between daI/FO and mid-dlPFC. Conclusion: The findings present the first evidence for GAD-specific neural correlates of hyper-responsive threat processing, possibly reflecting exaggerated threat sensitivity, maladaptive appraisal and attention-allocation processes. Cingulate cortex Prefrontal cortex Anterior insula Threat processing RDoC Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system Leonie Brinkmann verfasserin aut Paula Neumeister verfasserin aut Katharina Feldker verfasserin aut Carina Heitmann verfasserin aut Bettina Gathmann verfasserin aut Tanja Andor verfasserin aut Thomas Straube verfasserin aut In NeuroImage: Clinical Elsevier, 2015 12(2016), C, Seite 698-706 (DE-627)735358869 (DE-600)2701571-3 22131582 nnns volume:12 year:2016 number:C pages:698-706 https://doi.org/10.1016/j.nicl.2016.09.023 kostenfrei https://doaj.org/article/20bd1e8fd4a043f98b015e24aec1d957 kostenfrei http://www.sciencedirect.com/science/article/pii/S221315821630184X kostenfrei https://doaj.org/toc/2213-1582 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 12 2016 C 698-706
language	English
source	In NeuroImage: Clinical 12(2016), C, Seite 698-706 volume:12 year:2016 number:C pages:698-706
sourceStr	In NeuroImage: Clinical 12(2016), C, Seite 698-706 volume:12 year:2016 number:C pages:698-706
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Cingulate cortex Prefrontal cortex Anterior insula Threat processing RDoC Computer applications to medicine. Medical informatics Neurology. Diseases of the nervous system
isfreeaccess_bool	true
container_title	NeuroImage: Clinical
authorswithroles_txt_mv	Christine Buff @@aut@@ Leonie Brinkmann @@aut@@ Paula Neumeister @@aut@@ Katharina Feldker @@aut@@ Carina Heitmann @@aut@@ Bettina Gathmann @@aut@@ Tanja Andor @@aut@@ Thomas Straube @@aut@@
publishDateDaySort_date	2016-01-01T00:00:00Z
hierarchy_top_id	735358869
id	DOAJ007015569
language_de	englisch
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The current functional magnetic resonance imaging (fMRI) study aims to delineate GAD-specific brain activity during immediate threat processing by comparing GAD patients to healthy controls (HC), to social anxiety disorder (SAD) and to panic disorder (PD) patients. Method: Brain activation and functional connectivity patterns to threat vs. neutral pictures were investigated using event-related fMRI. The sample consisted of 21 GAD, 21 PD, 21 SAD and 21 HC. Results: GAD-specific elevated activity to threat vs. neutral pictures was found in cingulate cortex, dorsal anterior insula/frontal operculum (daI/FO) and posterior dorsolateral prefrontal cortex (dlPFC). Defining these effects as seed regions, we detected GAD-specific increased functional connectivity to threat vs. neutral pictures between posterior dlPFC and ventrolateral prefrontal cortex, between cingulate cortex and amygdala, between cingulate cortex and anterior insula, as well as decreased functional connectivity between daI/FO and mid-dlPFC. 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callnumber-first	R - Medicine
author	Christine Buff
spellingShingle	Christine Buff misc R858-859.7 misc RC346-429 misc Cingulate cortex misc Prefrontal cortex misc Anterior insula misc Threat processing misc RDoC misc Computer applications to medicine. Medical informatics misc Neurology. Diseases of the nervous system Specifically altered brain responses to threat in generalized anxiety disorder relative to social anxiety disorder and panic disorder
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topic_title	R858-859.7 RC346-429 Specifically altered brain responses to threat in generalized anxiety disorder relative to social anxiety disorder and panic disorder Cingulate cortex Prefrontal cortex Anterior insula Threat processing RDoC
topic	misc R858-859.7 misc RC346-429 misc Cingulate cortex misc Prefrontal cortex misc Anterior insula misc Threat processing misc RDoC misc Computer applications to medicine. Medical informatics misc Neurology. Diseases of the nervous system
topic_unstemmed	misc R858-859.7 misc RC346-429 misc Cingulate cortex misc Prefrontal cortex misc Anterior insula misc Threat processing misc RDoC misc Computer applications to medicine. Medical informatics misc Neurology. Diseases of the nervous system
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title	Specifically altered brain responses to threat in generalized anxiety disorder relative to social anxiety disorder and panic disorder
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title_full	Specifically altered brain responses to threat in generalized anxiety disorder relative to social anxiety disorder and panic disorder
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author_browse	Christine Buff Leonie Brinkmann Paula Neumeister Katharina Feldker Carina Heitmann Bettina Gathmann Tanja Andor Thomas Straube
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title_sort	specifically altered brain responses to threat in generalized anxiety disorder relative to social anxiety disorder and panic disorder
callnumber	R858-859.7
title_auth	Specifically altered brain responses to threat in generalized anxiety disorder relative to social anxiety disorder and panic disorder
abstract	Background: Despite considerable effort, the neurobiological underpinnings of hyper-responsive threat processing specific to patients suffering from generalized anxiety disorder (GAD) remain poorly understood. The current functional magnetic resonance imaging (fMRI) study aims to delineate GAD-specific brain activity during immediate threat processing by comparing GAD patients to healthy controls (HC), to social anxiety disorder (SAD) and to panic disorder (PD) patients. Method: Brain activation and functional connectivity patterns to threat vs. neutral pictures were investigated using event-related fMRI. The sample consisted of 21 GAD, 21 PD, 21 SAD and 21 HC. Results: GAD-specific elevated activity to threat vs. neutral pictures was found in cingulate cortex, dorsal anterior insula/frontal operculum (daI/FO) and posterior dorsolateral prefrontal cortex (dlPFC). Defining these effects as seed regions, we detected GAD-specific increased functional connectivity to threat vs. neutral pictures between posterior dlPFC and ventrolateral prefrontal cortex, between cingulate cortex and amygdala, between cingulate cortex and anterior insula, as well as decreased functional connectivity between daI/FO and mid-dlPFC. Conclusion: The findings present the first evidence for GAD-specific neural correlates of hyper-responsive threat processing, possibly reflecting exaggerated threat sensitivity, maladaptive appraisal and attention-allocation processes.
abstractGer	Background: Despite considerable effort, the neurobiological underpinnings of hyper-responsive threat processing specific to patients suffering from generalized anxiety disorder (GAD) remain poorly understood. The current functional magnetic resonance imaging (fMRI) study aims to delineate GAD-specific brain activity during immediate threat processing by comparing GAD patients to healthy controls (HC), to social anxiety disorder (SAD) and to panic disorder (PD) patients. Method: Brain activation and functional connectivity patterns to threat vs. neutral pictures were investigated using event-related fMRI. The sample consisted of 21 GAD, 21 PD, 21 SAD and 21 HC. Results: GAD-specific elevated activity to threat vs. neutral pictures was found in cingulate cortex, dorsal anterior insula/frontal operculum (daI/FO) and posterior dorsolateral prefrontal cortex (dlPFC). Defining these effects as seed regions, we detected GAD-specific increased functional connectivity to threat vs. neutral pictures between posterior dlPFC and ventrolateral prefrontal cortex, between cingulate cortex and amygdala, between cingulate cortex and anterior insula, as well as decreased functional connectivity between daI/FO and mid-dlPFC. Conclusion: The findings present the first evidence for GAD-specific neural correlates of hyper-responsive threat processing, possibly reflecting exaggerated threat sensitivity, maladaptive appraisal and attention-allocation processes.
abstract_unstemmed	Background: Despite considerable effort, the neurobiological underpinnings of hyper-responsive threat processing specific to patients suffering from generalized anxiety disorder (GAD) remain poorly understood. The current functional magnetic resonance imaging (fMRI) study aims to delineate GAD-specific brain activity during immediate threat processing by comparing GAD patients to healthy controls (HC), to social anxiety disorder (SAD) and to panic disorder (PD) patients. Method: Brain activation and functional connectivity patterns to threat vs. neutral pictures were investigated using event-related fMRI. The sample consisted of 21 GAD, 21 PD, 21 SAD and 21 HC. Results: GAD-specific elevated activity to threat vs. neutral pictures was found in cingulate cortex, dorsal anterior insula/frontal operculum (daI/FO) and posterior dorsolateral prefrontal cortex (dlPFC). Defining these effects as seed regions, we detected GAD-specific increased functional connectivity to threat vs. neutral pictures between posterior dlPFC and ventrolateral prefrontal cortex, between cingulate cortex and amygdala, between cingulate cortex and anterior insula, as well as decreased functional connectivity between daI/FO and mid-dlPFC. Conclusion: The findings present the first evidence for GAD-specific neural correlates of hyper-responsive threat processing, possibly reflecting exaggerated threat sensitivity, maladaptive appraisal and attention-allocation processes.
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title_short	Specifically altered brain responses to threat in generalized anxiety disorder relative to social anxiety disorder and panic disorder
url	https://doi.org/10.1016/j.nicl.2016.09.023 https://doaj.org/article/20bd1e8fd4a043f98b015e24aec1d957 http://www.sciencedirect.com/science/article/pii/S221315821630184X https://doaj.org/toc/2213-1582
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The current functional magnetic resonance imaging (fMRI) study aims to delineate GAD-specific brain activity during immediate threat processing by comparing GAD patients to healthy controls (HC), to social anxiety disorder (SAD) and to panic disorder (PD) patients. Method: Brain activation and functional connectivity patterns to threat vs. neutral pictures were investigated using event-related fMRI. The sample consisted of 21 GAD, 21 PD, 21 SAD and 21 HC. Results: GAD-specific elevated activity to threat vs. neutral pictures was found in cingulate cortex, dorsal anterior insula/frontal operculum (daI/FO) and posterior dorsolateral prefrontal cortex (dlPFC). Defining these effects as seed regions, we detected GAD-specific increased functional connectivity to threat vs. neutral pictures between posterior dlPFC and ventrolateral prefrontal cortex, between cingulate cortex and amygdala, between cingulate cortex and anterior insula, as well as decreased functional connectivity between daI/FO and mid-dlPFC. 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Specifically altered brain responses to threat in generalized anxiety disorder relative to social anxiety disorder and panic disorder

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