Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population

Abstract Background Type 2 diabetes mellitus (T2DM) is a chronic disorder of which stress is a major contributor. Under stressful condition, body synthesizes a family of molecular chaperone called Heat‐shock proteins (HSPs). Current study assessed the frequency and association of HSP70‐hom + 2,437 T...
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Autor*in:	Md. Moniruzzaman [verfasserIn] Irfan Ahmed [verfasserIn] Saaimatul Huq [verfasserIn] Md. Shakur All Mahmud [verfasserIn] Sonya Begum [verfasserIn] U.S. Mahzabin Amin [verfasserIn] Md. Hadisur Rahman [verfasserIn] Palash Kumar Sarker [verfasserIn] Mohammad Uzzal Hossain [verfasserIn] Keshob Chandra Das [verfasserIn] Md. Salimullah [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	bioinformatics diabetes mellitus heat–shock proteins polymorphism stress

Übergeordnetes Werk:	In: Molecular Genetics & Genomic Medicine - Wiley, 2014, 8(2020), 2, Seite n/a-n/a
Übergeordnetes Werk:	volume:8 ; year:2020 ; number:2 ; pages:n/a-n/a

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1002/mgg3.1073

Katalog-ID:	DOAJ007102518

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520			\|a Abstract Background Type 2 diabetes mellitus (T2DM) is a chronic disorder of which stress is a major contributor. Under stressful condition, body synthesizes a family of molecular chaperone called Heat‐shock proteins (HSPs). Current study assessed the frequency and association of HSP70‐hom + 2,437 T/C polymorphism with T2DM risk among Bangladeshis. Methods This polymorphism was selected through bioinformatics analyses and identified by PCR‐RFLP method. Results Bioinformatics analysis identified this SNP as missense mutation which could destabilize the final HSP product. Heterozygous mutant (CT) genotype was significantly associated with T2DM incidence among the studied populations (p = .015). Further analysis revealed a strong association with female patients (p = .002), while the male group showed no association (p = .958). Moreover, the C allele was significantly associated among all diabetic patients (p = .016) and particularly in the female patient group (p = .001). However, under stressful condition, males with CT genotype were at high risk for T2DM incidence whereas, females with CT genotype showed no significant association. Conclusions HSP70‐hom + 2,437 T/C polymorphism was found to be significantly associated with T2DM incidence in the Bangladeshi population in both stress‐dependent and independent manners.
650		4	\|a bioinformatics
650		4	\|a diabetes mellitus
650		4	\|a heat–shock proteins
650		4	\|a polymorphism
650		4	\|a stress
653		0	\|a Genetics
700	0		\|a Irfan Ahmed \|e verfasserin \|4 aut
700	0		\|a Saaimatul Huq \|e verfasserin \|4 aut
700	0		\|a Md. Shakur All Mahmud \|e verfasserin \|4 aut
700	0		\|a Sonya Begum \|e verfasserin \|4 aut
700	0		\|a U.S. Mahzabin Amin \|e verfasserin \|4 aut
700	0		\|a Md. Hadisur Rahman \|e verfasserin \|4 aut
700	0		\|a Palash Kumar Sarker \|e verfasserin \|4 aut
700	0		\|a Mohammad Uzzal Hossain \|e verfasserin \|4 aut
700	0		\|a Keshob Chandra Das \|e verfasserin \|4 aut
700	0		\|a Md. Salimullah \|e verfasserin \|4 aut
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author_variant	m m mm i a ia s h sh m s a m msam s b sb u m a uma m h r mhr p k s pks m u h muh k c d kcd m s ms
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allfields	10.1002/mgg3.1073 doi (DE-627)DOAJ007102518 (DE-599)DOAJ0fe0901996e2453e973f77e701c66448 DE-627 ger DE-627 rakwb eng QH426-470 Md. Moniruzzaman verfasserin aut Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Type 2 diabetes mellitus (T2DM) is a chronic disorder of which stress is a major contributor. Under stressful condition, body synthesizes a family of molecular chaperone called Heat‐shock proteins (HSPs). Current study assessed the frequency and association of HSP70‐hom + 2,437 T/C polymorphism with T2DM risk among Bangladeshis. Methods This polymorphism was selected through bioinformatics analyses and identified by PCR‐RFLP method. Results Bioinformatics analysis identified this SNP as missense mutation which could destabilize the final HSP product. Heterozygous mutant (CT) genotype was significantly associated with T2DM incidence among the studied populations (p = .015). Further analysis revealed a strong association with female patients (p = .002), while the male group showed no association (p = .958). Moreover, the C allele was significantly associated among all diabetic patients (p = .016) and particularly in the female patient group (p = .001). However, under stressful condition, males with CT genotype were at high risk for T2DM incidence whereas, females with CT genotype showed no significant association. Conclusions HSP70‐hom + 2,437 T/C polymorphism was found to be significantly associated with T2DM incidence in the Bangladeshi population in both stress‐dependent and independent manners. bioinformatics diabetes mellitus heat–shock proteins polymorphism stress Genetics Irfan Ahmed verfasserin aut Saaimatul Huq verfasserin aut Md. Shakur All Mahmud verfasserin aut Sonya Begum verfasserin aut U.S. Mahzabin Amin verfasserin aut Md. Hadisur Rahman verfasserin aut Palash Kumar Sarker verfasserin aut Mohammad Uzzal Hossain verfasserin aut Keshob Chandra Das verfasserin aut Md. Salimullah verfasserin aut In Molecular Genetics & Genomic Medicine Wiley, 2014 8(2020), 2, Seite n/a-n/a (DE-627)769222234 (DE-600)2734884-2 23249269 nnns volume:8 year:2020 number:2 pages:n/a-n/a https://doi.org/10.1002/mgg3.1073 kostenfrei https://doaj.org/article/0fe0901996e2453e973f77e701c66448 kostenfrei https://doi.org/10.1002/mgg3.1073 kostenfrei https://doaj.org/toc/2324-9269 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 2 n/a-n/a
spelling	10.1002/mgg3.1073 doi (DE-627)DOAJ007102518 (DE-599)DOAJ0fe0901996e2453e973f77e701c66448 DE-627 ger DE-627 rakwb eng QH426-470 Md. Moniruzzaman verfasserin aut Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Type 2 diabetes mellitus (T2DM) is a chronic disorder of which stress is a major contributor. Under stressful condition, body synthesizes a family of molecular chaperone called Heat‐shock proteins (HSPs). Current study assessed the frequency and association of HSP70‐hom + 2,437 T/C polymorphism with T2DM risk among Bangladeshis. Methods This polymorphism was selected through bioinformatics analyses and identified by PCR‐RFLP method. Results Bioinformatics analysis identified this SNP as missense mutation which could destabilize the final HSP product. Heterozygous mutant (CT) genotype was significantly associated with T2DM incidence among the studied populations (p = .015). Further analysis revealed a strong association with female patients (p = .002), while the male group showed no association (p = .958). Moreover, the C allele was significantly associated among all diabetic patients (p = .016) and particularly in the female patient group (p = .001). However, under stressful condition, males with CT genotype were at high risk for T2DM incidence whereas, females with CT genotype showed no significant association. Conclusions HSP70‐hom + 2,437 T/C polymorphism was found to be significantly associated with T2DM incidence in the Bangladeshi population in both stress‐dependent and independent manners. bioinformatics diabetes mellitus heat–shock proteins polymorphism stress Genetics Irfan Ahmed verfasserin aut Saaimatul Huq verfasserin aut Md. Shakur All Mahmud verfasserin aut Sonya Begum verfasserin aut U.S. Mahzabin Amin verfasserin aut Md. Hadisur Rahman verfasserin aut Palash Kumar Sarker verfasserin aut Mohammad Uzzal Hossain verfasserin aut Keshob Chandra Das verfasserin aut Md. Salimullah verfasserin aut In Molecular Genetics & Genomic Medicine Wiley, 2014 8(2020), 2, Seite n/a-n/a (DE-627)769222234 (DE-600)2734884-2 23249269 nnns volume:8 year:2020 number:2 pages:n/a-n/a https://doi.org/10.1002/mgg3.1073 kostenfrei https://doaj.org/article/0fe0901996e2453e973f77e701c66448 kostenfrei https://doi.org/10.1002/mgg3.1073 kostenfrei https://doaj.org/toc/2324-9269 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 2 n/a-n/a
allfields_unstemmed	10.1002/mgg3.1073 doi (DE-627)DOAJ007102518 (DE-599)DOAJ0fe0901996e2453e973f77e701c66448 DE-627 ger DE-627 rakwb eng QH426-470 Md. Moniruzzaman verfasserin aut Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Type 2 diabetes mellitus (T2DM) is a chronic disorder of which stress is a major contributor. Under stressful condition, body synthesizes a family of molecular chaperone called Heat‐shock proteins (HSPs). Current study assessed the frequency and association of HSP70‐hom + 2,437 T/C polymorphism with T2DM risk among Bangladeshis. Methods This polymorphism was selected through bioinformatics analyses and identified by PCR‐RFLP method. Results Bioinformatics analysis identified this SNP as missense mutation which could destabilize the final HSP product. Heterozygous mutant (CT) genotype was significantly associated with T2DM incidence among the studied populations (p = .015). Further analysis revealed a strong association with female patients (p = .002), while the male group showed no association (p = .958). Moreover, the C allele was significantly associated among all diabetic patients (p = .016) and particularly in the female patient group (p = .001). However, under stressful condition, males with CT genotype were at high risk for T2DM incidence whereas, females with CT genotype showed no significant association. Conclusions HSP70‐hom + 2,437 T/C polymorphism was found to be significantly associated with T2DM incidence in the Bangladeshi population in both stress‐dependent and independent manners. bioinformatics diabetes mellitus heat–shock proteins polymorphism stress Genetics Irfan Ahmed verfasserin aut Saaimatul Huq verfasserin aut Md. Shakur All Mahmud verfasserin aut Sonya Begum verfasserin aut U.S. Mahzabin Amin verfasserin aut Md. Hadisur Rahman verfasserin aut Palash Kumar Sarker verfasserin aut Mohammad Uzzal Hossain verfasserin aut Keshob Chandra Das verfasserin aut Md. Salimullah verfasserin aut In Molecular Genetics & Genomic Medicine Wiley, 2014 8(2020), 2, Seite n/a-n/a (DE-627)769222234 (DE-600)2734884-2 23249269 nnns volume:8 year:2020 number:2 pages:n/a-n/a https://doi.org/10.1002/mgg3.1073 kostenfrei https://doaj.org/article/0fe0901996e2453e973f77e701c66448 kostenfrei https://doi.org/10.1002/mgg3.1073 kostenfrei https://doaj.org/toc/2324-9269 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 2 n/a-n/a
allfieldsGer	10.1002/mgg3.1073 doi (DE-627)DOAJ007102518 (DE-599)DOAJ0fe0901996e2453e973f77e701c66448 DE-627 ger DE-627 rakwb eng QH426-470 Md. Moniruzzaman verfasserin aut Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Type 2 diabetes mellitus (T2DM) is a chronic disorder of which stress is a major contributor. Under stressful condition, body synthesizes a family of molecular chaperone called Heat‐shock proteins (HSPs). Current study assessed the frequency and association of HSP70‐hom + 2,437 T/C polymorphism with T2DM risk among Bangladeshis. Methods This polymorphism was selected through bioinformatics analyses and identified by PCR‐RFLP method. Results Bioinformatics analysis identified this SNP as missense mutation which could destabilize the final HSP product. Heterozygous mutant (CT) genotype was significantly associated with T2DM incidence among the studied populations (p = .015). Further analysis revealed a strong association with female patients (p = .002), while the male group showed no association (p = .958). Moreover, the C allele was significantly associated among all diabetic patients (p = .016) and particularly in the female patient group (p = .001). However, under stressful condition, males with CT genotype were at high risk for T2DM incidence whereas, females with CT genotype showed no significant association. Conclusions HSP70‐hom + 2,437 T/C polymorphism was found to be significantly associated with T2DM incidence in the Bangladeshi population in both stress‐dependent and independent manners. bioinformatics diabetes mellitus heat–shock proteins polymorphism stress Genetics Irfan Ahmed verfasserin aut Saaimatul Huq verfasserin aut Md. Shakur All Mahmud verfasserin aut Sonya Begum verfasserin aut U.S. Mahzabin Amin verfasserin aut Md. Hadisur Rahman verfasserin aut Palash Kumar Sarker verfasserin aut Mohammad Uzzal Hossain verfasserin aut Keshob Chandra Das verfasserin aut Md. Salimullah verfasserin aut In Molecular Genetics & Genomic Medicine Wiley, 2014 8(2020), 2, Seite n/a-n/a (DE-627)769222234 (DE-600)2734884-2 23249269 nnns volume:8 year:2020 number:2 pages:n/a-n/a https://doi.org/10.1002/mgg3.1073 kostenfrei https://doaj.org/article/0fe0901996e2453e973f77e701c66448 kostenfrei https://doi.org/10.1002/mgg3.1073 kostenfrei https://doaj.org/toc/2324-9269 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 2 n/a-n/a
allfieldsSound	10.1002/mgg3.1073 doi (DE-627)DOAJ007102518 (DE-599)DOAJ0fe0901996e2453e973f77e701c66448 DE-627 ger DE-627 rakwb eng QH426-470 Md. Moniruzzaman verfasserin aut Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Type 2 diabetes mellitus (T2DM) is a chronic disorder of which stress is a major contributor. Under stressful condition, body synthesizes a family of molecular chaperone called Heat‐shock proteins (HSPs). Current study assessed the frequency and association of HSP70‐hom + 2,437 T/C polymorphism with T2DM risk among Bangladeshis. Methods This polymorphism was selected through bioinformatics analyses and identified by PCR‐RFLP method. Results Bioinformatics analysis identified this SNP as missense mutation which could destabilize the final HSP product. Heterozygous mutant (CT) genotype was significantly associated with T2DM incidence among the studied populations (p = .015). Further analysis revealed a strong association with female patients (p = .002), while the male group showed no association (p = .958). Moreover, the C allele was significantly associated among all diabetic patients (p = .016) and particularly in the female patient group (p = .001). However, under stressful condition, males with CT genotype were at high risk for T2DM incidence whereas, females with CT genotype showed no significant association. Conclusions HSP70‐hom + 2,437 T/C polymorphism was found to be significantly associated with T2DM incidence in the Bangladeshi population in both stress‐dependent and independent manners. bioinformatics diabetes mellitus heat–shock proteins polymorphism stress Genetics Irfan Ahmed verfasserin aut Saaimatul Huq verfasserin aut Md. Shakur All Mahmud verfasserin aut Sonya Begum verfasserin aut U.S. Mahzabin Amin verfasserin aut Md. Hadisur Rahman verfasserin aut Palash Kumar Sarker verfasserin aut Mohammad Uzzal Hossain verfasserin aut Keshob Chandra Das verfasserin aut Md. Salimullah verfasserin aut In Molecular Genetics & Genomic Medicine Wiley, 2014 8(2020), 2, Seite n/a-n/a (DE-627)769222234 (DE-600)2734884-2 23249269 nnns volume:8 year:2020 number:2 pages:n/a-n/a https://doi.org/10.1002/mgg3.1073 kostenfrei https://doaj.org/article/0fe0901996e2453e973f77e701c66448 kostenfrei https://doi.org/10.1002/mgg3.1073 kostenfrei https://doaj.org/toc/2324-9269 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 2 n/a-n/a
language	English
source	In Molecular Genetics & Genomic Medicine 8(2020), 2, Seite n/a-n/a volume:8 year:2020 number:2 pages:n/a-n/a
sourceStr	In Molecular Genetics & Genomic Medicine 8(2020), 2, Seite n/a-n/a volume:8 year:2020 number:2 pages:n/a-n/a
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	bioinformatics diabetes mellitus heat–shock proteins polymorphism stress Genetics
isfreeaccess_bool	true
container_title	Molecular Genetics & Genomic Medicine
authorswithroles_txt_mv	Md. Moniruzzaman @@aut@@ Irfan Ahmed @@aut@@ Saaimatul Huq @@aut@@ Md. Shakur All Mahmud @@aut@@ Sonya Begum @@aut@@ U.S. Mahzabin Amin @@aut@@ Md. Hadisur Rahman @@aut@@ Palash Kumar Sarker @@aut@@ Mohammad Uzzal Hossain @@aut@@ Keshob Chandra Das @@aut@@ Md. Salimullah @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	769222234
id	DOAJ007102518
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ007102518</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240414092129.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230225s2020 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1002/mgg3.1073</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ007102518</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ0fe0901996e2453e973f77e701c66448</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH426-470</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Md. Moniruzzaman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background Type 2 diabetes mellitus (T2DM) is a chronic disorder of which stress is a major contributor. Under stressful condition, body synthesizes a family of molecular chaperone called Heat‐shock proteins (HSPs). Current study assessed the frequency and association of HSP70‐hom + 2,437 T/C polymorphism with T2DM risk among Bangladeshis. Methods This polymorphism was selected through bioinformatics analyses and identified by PCR‐RFLP method. Results Bioinformatics analysis identified this SNP as missense mutation which could destabilize the final HSP product. Heterozygous mutant (CT) genotype was significantly associated with T2DM incidence among the studied populations (p = .015). Further analysis revealed a strong association with female patients (p = .002), while the male group showed no association (p = .958). Moreover, the C allele was significantly associated among all diabetic patients (p = .016) and particularly in the female patient group (p = .001). However, under stressful condition, males with CT genotype were at high risk for T2DM incidence whereas, females with CT genotype showed no significant association. Conclusions HSP70‐hom + 2,437 T/C polymorphism was found to be significantly associated with T2DM incidence in the Bangladeshi population in both stress‐dependent and independent manners.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">bioinformatics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">diabetes mellitus</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">heat–shock proteins</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">polymorphism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">stress</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Genetics</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Irfan Ahmed</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Saaimatul Huq</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Md. 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callnumber-first	Q - Science
author	Md. Moniruzzaman
spellingShingle	Md. Moniruzzaman misc QH426-470 misc bioinformatics misc diabetes mellitus misc heat–shock proteins misc polymorphism misc stress misc Genetics Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population
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topic_title	QH426-470 Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population bioinformatics diabetes mellitus heat–shock proteins polymorphism stress
topic	misc QH426-470 misc bioinformatics misc diabetes mellitus misc heat–shock proteins misc polymorphism misc stress misc Genetics
topic_unstemmed	misc QH426-470 misc bioinformatics misc diabetes mellitus misc heat–shock proteins misc polymorphism misc stress misc Genetics
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title	Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population
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title_full	Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population
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author_browse	Md. Moniruzzaman Irfan Ahmed Saaimatul Huq Md. Shakur All Mahmud Sonya Begum U.S. Mahzabin Amin Md. Hadisur Rahman Palash Kumar Sarker Mohammad Uzzal Hossain Keshob Chandra Das Md. Salimullah
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title_sort	association of polymorphism in heat shock protein 70 genes with type 2 diabetes in bangladeshi population
callnumber	QH426-470
title_auth	Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population
abstract	Abstract Background Type 2 diabetes mellitus (T2DM) is a chronic disorder of which stress is a major contributor. Under stressful condition, body synthesizes a family of molecular chaperone called Heat‐shock proteins (HSPs). Current study assessed the frequency and association of HSP70‐hom + 2,437 T/C polymorphism with T2DM risk among Bangladeshis. Methods This polymorphism was selected through bioinformatics analyses and identified by PCR‐RFLP method. Results Bioinformatics analysis identified this SNP as missense mutation which could destabilize the final HSP product. Heterozygous mutant (CT) genotype was significantly associated with T2DM incidence among the studied populations (p = .015). Further analysis revealed a strong association with female patients (p = .002), while the male group showed no association (p = .958). Moreover, the C allele was significantly associated among all diabetic patients (p = .016) and particularly in the female patient group (p = .001). However, under stressful condition, males with CT genotype were at high risk for T2DM incidence whereas, females with CT genotype showed no significant association. Conclusions HSP70‐hom + 2,437 T/C polymorphism was found to be significantly associated with T2DM incidence in the Bangladeshi population in both stress‐dependent and independent manners.
abstractGer	Abstract Background Type 2 diabetes mellitus (T2DM) is a chronic disorder of which stress is a major contributor. Under stressful condition, body synthesizes a family of molecular chaperone called Heat‐shock proteins (HSPs). Current study assessed the frequency and association of HSP70‐hom + 2,437 T/C polymorphism with T2DM risk among Bangladeshis. Methods This polymorphism was selected through bioinformatics analyses and identified by PCR‐RFLP method. Results Bioinformatics analysis identified this SNP as missense mutation which could destabilize the final HSP product. Heterozygous mutant (CT) genotype was significantly associated with T2DM incidence among the studied populations (p = .015). Further analysis revealed a strong association with female patients (p = .002), while the male group showed no association (p = .958). Moreover, the C allele was significantly associated among all diabetic patients (p = .016) and particularly in the female patient group (p = .001). However, under stressful condition, males with CT genotype were at high risk for T2DM incidence whereas, females with CT genotype showed no significant association. Conclusions HSP70‐hom + 2,437 T/C polymorphism was found to be significantly associated with T2DM incidence in the Bangladeshi population in both stress‐dependent and independent manners.
abstract_unstemmed	Abstract Background Type 2 diabetes mellitus (T2DM) is a chronic disorder of which stress is a major contributor. Under stressful condition, body synthesizes a family of molecular chaperone called Heat‐shock proteins (HSPs). Current study assessed the frequency and association of HSP70‐hom + 2,437 T/C polymorphism with T2DM risk among Bangladeshis. Methods This polymorphism was selected through bioinformatics analyses and identified by PCR‐RFLP method. Results Bioinformatics analysis identified this SNP as missense mutation which could destabilize the final HSP product. Heterozygous mutant (CT) genotype was significantly associated with T2DM incidence among the studied populations (p = .015). Further analysis revealed a strong association with female patients (p = .002), while the male group showed no association (p = .958). Moreover, the C allele was significantly associated among all diabetic patients (p = .016) and particularly in the female patient group (p = .001). However, under stressful condition, males with CT genotype were at high risk for T2DM incidence whereas, females with CT genotype showed no significant association. Conclusions HSP70‐hom + 2,437 T/C polymorphism was found to be significantly associated with T2DM incidence in the Bangladeshi population in both stress‐dependent and independent manners.
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title_short	Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population
url	https://doi.org/10.1002/mgg3.1073 https://doaj.org/article/0fe0901996e2453e973f77e701c66448 https://doaj.org/toc/2324-9269
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author2	Irfan Ahmed Saaimatul Huq Md. Shakur All Mahmud Sonya Begum U.S. Mahzabin Amin Md. Hadisur Rahman Palash Kumar Sarker Mohammad Uzzal Hossain Keshob Chandra Das Md. Salimullah
author2Str	Irfan Ahmed Saaimatul Huq Md. Shakur All Mahmud Sonya Begum U.S. Mahzabin Amin Md. Hadisur Rahman Palash Kumar Sarker Mohammad Uzzal Hossain Keshob Chandra Das Md. Salimullah
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up_date	2024-07-04T00:17:10.031Z
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Moniruzzaman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background Type 2 diabetes mellitus (T2DM) is a chronic disorder of which stress is a major contributor. Under stressful condition, body synthesizes a family of molecular chaperone called Heat‐shock proteins (HSPs). Current study assessed the frequency and association of HSP70‐hom + 2,437 T/C polymorphism with T2DM risk among Bangladeshis. Methods This polymorphism was selected through bioinformatics analyses and identified by PCR‐RFLP method. Results Bioinformatics analysis identified this SNP as missense mutation which could destabilize the final HSP product. Heterozygous mutant (CT) genotype was significantly associated with T2DM incidence among the studied populations (p = .015). Further analysis revealed a strong association with female patients (p = .002), while the male group showed no association (p = .958). Moreover, the C allele was significantly associated among all diabetic patients (p = .016) and particularly in the female patient group (p = .001). However, under stressful condition, males with CT genotype were at high risk for T2DM incidence whereas, females with CT genotype showed no significant association. Conclusions HSP70‐hom + 2,437 T/C polymorphism was found to be significantly associated with T2DM incidence in the Bangladeshi population in both stress‐dependent and independent manners.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">bioinformatics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">diabetes mellitus</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">heat–shock proteins</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">polymorphism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">stress</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Genetics</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Irfan Ahmed</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Saaimatul Huq</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Md. Shakur All Mahmud</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sonya Begum</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">U.S. Mahzabin Amin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Md. 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Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population

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