Chronic Alcohol Treatment-Induced GABA-Aα5 Histone H3K4 Trimethylation Upregulation Leads to Increased GABA-Aα5 Expression and Susceptibility to Alcohol Addiction in the Offspring of Wistar Rats

Gamma-aminobutyric acid (GABA)-Aα5 is considered to be associated with alcohol-induced memory deficits. However, whether it participates in the formation of alcohol addiction or in the regulation of its susceptibility is unknown. Here, we used a chronic alcohol treatment model to obtain alcohol-addi...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Kuan Zeng [verfasserIn] Aimin Xie [verfasserIn] Xiaojie Zhang [verfasserIn] Baoliang Zhong [verfasserIn] Xuebing Liu [verfasserIn] Wei Hao [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	alcohol addiction GABA-Aα5 histone H3K4 trimethylation offspring

Übergeordnetes Werk:	In: Frontiers in Psychiatry - Frontiers Media S.A., 2010, 9(2018)
Übergeordnetes Werk:	volume:9 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fpsyt.2018.00468

Katalog-ID:	DOAJ007158343

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source	In Frontiers in Psychiatry 9(2018) volume:9 year:2018
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topic_facet	alcohol addiction GABA-Aα5 histone H3K4 trimethylation offspring Psychiatry
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container_title	Frontiers in Psychiatry
authorswithroles_txt_mv	Kuan Zeng @@aut@@ Aimin Xie @@aut@@ Xiaojie Zhang @@aut@@ Baoliang Zhong @@aut@@ Xuebing Liu @@aut@@ Wei Hao @@aut@@
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callnumber-first	R - Medicine
author	Kuan Zeng
spellingShingle	Kuan Zeng misc RC435-571 misc alcohol misc addiction misc GABA-Aα5 misc histone H3K4 trimethylation misc offspring misc Psychiatry Chronic Alcohol Treatment-Induced GABA-Aα5 Histone H3K4 Trimethylation Upregulation Leads to Increased GABA-Aα5 Expression and Susceptibility to Alcohol Addiction in the Offspring of Wistar Rats
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topic_title	RC435-571 Chronic Alcohol Treatment-Induced GABA-Aα5 Histone H3K4 Trimethylation Upregulation Leads to Increased GABA-Aα5 Expression and Susceptibility to Alcohol Addiction in the Offspring of Wistar Rats alcohol addiction GABA-Aα5 histone H3K4 trimethylation offspring
topic	misc RC435-571 misc alcohol misc addiction misc GABA-Aα5 misc histone H3K4 trimethylation misc offspring misc Psychiatry
topic_unstemmed	misc RC435-571 misc alcohol misc addiction misc GABA-Aα5 misc histone H3K4 trimethylation misc offspring misc Psychiatry
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title	Chronic Alcohol Treatment-Induced GABA-Aα5 Histone H3K4 Trimethylation Upregulation Leads to Increased GABA-Aα5 Expression and Susceptibility to Alcohol Addiction in the Offspring of Wistar Rats
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title_full	Chronic Alcohol Treatment-Induced GABA-Aα5 Histone H3K4 Trimethylation Upregulation Leads to Increased GABA-Aα5 Expression and Susceptibility to Alcohol Addiction in the Offspring of Wistar Rats
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title_sort	chronic alcohol treatment-induced gaba-aα5 histone h3k4 trimethylation upregulation leads to increased gaba-aα5 expression and susceptibility to alcohol addiction in the offspring of wistar rats
callnumber	RC435-571
title_auth	Chronic Alcohol Treatment-Induced GABA-Aα5 Histone H3K4 Trimethylation Upregulation Leads to Increased GABA-Aα5 Expression and Susceptibility to Alcohol Addiction in the Offspring of Wistar Rats
abstract	Gamma-aminobutyric acid (GABA)-Aα5 is considered to be associated with alcohol-induced memory deficits. However, whether it participates in the formation of alcohol addiction or in the regulation of its susceptibility is unknown. Here, we used a chronic alcohol treatment model to obtain alcohol-addicted Wistar rats. Long-term alcoholism increased the expression of prefrontal cortex GABA-Aα5 by inducing its histone H3K4 trimethylation, and these changes could be hereditary and lead to increased vulnerability to alcohol addiction in offspring. This study indicates the risk of long-term alcoholism in future generations, emphasizes the importance of GABA-Aα5 in the formation of alcohol addiction and the regulation of its susceptibility, and provides new evidence regarding the mechanisms underlying alcohol addiction.
abstractGer	Gamma-aminobutyric acid (GABA)-Aα5 is considered to be associated with alcohol-induced memory deficits. However, whether it participates in the formation of alcohol addiction or in the regulation of its susceptibility is unknown. Here, we used a chronic alcohol treatment model to obtain alcohol-addicted Wistar rats. Long-term alcoholism increased the expression of prefrontal cortex GABA-Aα5 by inducing its histone H3K4 trimethylation, and these changes could be hereditary and lead to increased vulnerability to alcohol addiction in offspring. This study indicates the risk of long-term alcoholism in future generations, emphasizes the importance of GABA-Aα5 in the formation of alcohol addiction and the regulation of its susceptibility, and provides new evidence regarding the mechanisms underlying alcohol addiction.
abstract_unstemmed	Gamma-aminobutyric acid (GABA)-Aα5 is considered to be associated with alcohol-induced memory deficits. However, whether it participates in the formation of alcohol addiction or in the regulation of its susceptibility is unknown. Here, we used a chronic alcohol treatment model to obtain alcohol-addicted Wistar rats. Long-term alcoholism increased the expression of prefrontal cortex GABA-Aα5 by inducing its histone H3K4 trimethylation, and these changes could be hereditary and lead to increased vulnerability to alcohol addiction in offspring. This study indicates the risk of long-term alcoholism in future generations, emphasizes the importance of GABA-Aα5 in the formation of alcohol addiction and the regulation of its susceptibility, and provides new evidence regarding the mechanisms underlying alcohol addiction.
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title_short	Chronic Alcohol Treatment-Induced GABA-Aα5 Histone H3K4 Trimethylation Upregulation Leads to Increased GABA-Aα5 Expression and Susceptibility to Alcohol Addiction in the Offspring of Wistar Rats
url	https://doi.org/10.3389/fpsyt.2018.00468 https://doaj.org/article/e0b76c7c25214da6866765b1b45f361d https://www.frontiersin.org/article/10.3389/fpsyt.2018.00468/full https://doaj.org/toc/1664-0640
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Chronic Alcohol Treatment-Induced GABA-Aα5 Histone H3K4 Trimethylation Upregulation Leads to Increased GABA-Aα5 Expression and Susceptibility to Alcohol Addiction in the Offspring of Wistar Rats

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