Immunohistochemical study of janus kinase 1/signal transducer and activator of transcription 3 in psoriasis vulgaris
Azza Gaber Antar Farag,1 Rehab Samaka,2 Eman Nabil Elshafey,1 Wafaa Ahmed Shehata,1 Eman Gamal El Sherbiny,3 Mostafa Ahmed Hammam11Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Shebin AlKom, Egypt; 2Department of Histopathology, Faculty of Medicine, Menoufi...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Farag AGA [verfasserIn] Samaka R [verfasserIn] Elshafey EN [verfasserIn] Shehata WA [verfasserIn] El Sherbiny EG [verfasserIn] Hammam MA [verfasserIn] |
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E-Artikel |
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Englisch |
| Erschienen: |
2019 |
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In: Clinical, Cosmetic and Investigational Dermatology - Dove Medical Press, 2009, (2019), Seite 497-508 |
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| Übergeordnetes Werk: |
year:2019 ; pages:497-508 |
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| 520 | |a Azza Gaber Antar Farag,1 Rehab Samaka,2 Eman Nabil Elshafey,1 Wafaa Ahmed Shehata,1 Eman Gamal El Sherbiny,3 Mostafa Ahmed Hammam11Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Shebin AlKom, Egypt; 2Department of Histopathology, Faculty of Medicine, Menoufia University, Shebin AlKom, Egypt; 3Dermatology, Andrology and STDs, Ministry of Health, Berkt Alsaba, Menoufia, EgyptBackground: Human JAKs are responsible for generating docking sites for human SSTAT phosphorylation. The role of JAKs in psoriasis pathogenesis has not been clearly explained.Aim: To investigate the role of JAK1 in psoriasis pathogenesis and to assess if this role is mediated through STAT3 or not, through evaluation of their immunohistochemical expression in the skin of psoriatic patients.Methods: This case–control study was carried out on 26 patients presenting with psoriasis vulgaris versus 26 age- and sex-matched apparently healthy volunteers. Psoriasis Area and Severity Index (PASI) scores were used to evaluate psoriasis severity. From all controls and cases (lesional and perilesional), skin biopsies were taken for histopathological and immunohistochemical JAK1 and STAT3 evaluation.Results: There was significant stepwise upregulation of JAK1 from controls to perilesional to lesional psoriatic skin of the patient group in both epidermis and dermis (P≤0.001 for both). Dermal JAK1 H-score was significantly associated with psoriasis severity (P=0.01). STAT3 was significantly overexpressed in lesional psoriatic skin over nonlesional skin (P<0.001). There were significant positive correlations between lesional H-scores for STAT3 and Psoriasis Area and Severity Index scores in epidermis (r=0.63, P<0.001), and in dermis (r=0.47, P=0.04). There was a significant positive correlation between JAK1 and STAT3 expression in epidermal lesional psoriatic skin (r=0.44, P=0.03).Conclusion: JAK1 has a proinflammatory effect in psoriasis pathogenesis, which could be mediated through increasing STAT3 expression in psoriasis. JAK1 and STAT3 tissue expression could be markers of psoriasis severity. JAK1 may be used as a target for immunotherapy in psoriasis-management programs.Keywords: JAK1, STAT3, psoriasis, immunohistochemistry | ||
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(DE-627)DOAJ007333528 (DE-599)DOAJfcd700aa8ab24ca5aff9122587f06968 DE-627 ger DE-627 rakwb eng RL1-803 Farag AGA verfasserin aut Immunohistochemical study of janus kinase 1/signal transducer and activator of transcription 3 in psoriasis vulgaris 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Azza Gaber Antar Farag,1 Rehab Samaka,2 Eman Nabil Elshafey,1 Wafaa Ahmed Shehata,1 Eman Gamal El Sherbiny,3 Mostafa Ahmed Hammam11Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Shebin AlKom, Egypt; 2Department of Histopathology, Faculty of Medicine, Menoufia University, Shebin AlKom, Egypt; 3Dermatology, Andrology and STDs, Ministry of Health, Berkt Alsaba, Menoufia, EgyptBackground: Human JAKs are responsible for generating docking sites for human SSTAT phosphorylation. The role of JAKs in psoriasis pathogenesis has not been clearly explained.Aim: To investigate the role of JAK1 in psoriasis pathogenesis and to assess if this role is mediated through STAT3 or not, through evaluation of their immunohistochemical expression in the skin of psoriatic patients.Methods: This case–control study was carried out on 26 patients presenting with psoriasis vulgaris versus 26 age- and sex-matched apparently healthy volunteers. Psoriasis Area and Severity Index (PASI) scores were used to evaluate psoriasis severity. From all controls and cases (lesional and perilesional), skin biopsies were taken for histopathological and immunohistochemical JAK1 and STAT3 evaluation.Results: There was significant stepwise upregulation of JAK1 from controls to perilesional to lesional psoriatic skin of the patient group in both epidermis and dermis (P≤0.001 for both). Dermal JAK1 H-score was significantly associated with psoriasis severity (P=0.01). STAT3 was significantly overexpressed in lesional psoriatic skin over nonlesional skin (P<0.001). There were significant positive correlations between lesional H-scores for STAT3 and Psoriasis Area and Severity Index scores in epidermis (r=0.63, P<0.001), and in dermis (r=0.47, P=0.04). There was a significant positive correlation between JAK1 and STAT3 expression in epidermal lesional psoriatic skin (r=0.44, P=0.03).Conclusion: JAK1 has a proinflammatory effect in psoriasis pathogenesis, which could be mediated through increasing STAT3 expression in psoriasis. JAK1 and STAT3 tissue expression could be markers of psoriasis severity. JAK1 may be used as a target for immunotherapy in psoriasis-management programs.Keywords: JAK1, STAT3, psoriasis, immunohistochemistry JAK1 STAT3 psoriasis immunohistochemistry. Dermatology Samaka R verfasserin aut Elshafey EN verfasserin aut Shehata WA verfasserin aut El Sherbiny EG verfasserin aut Hammam MA verfasserin aut In Clinical, Cosmetic and Investigational Dermatology Dove Medical Press, 2009 (2019), Seite 497-508 (DE-627)600305953 (DE-600)2494852-4 11787015 nnns year:2019 pages:497-508 https://doaj.org/article/fcd700aa8ab24ca5aff9122587f06968 kostenfrei https://www.dovepress.com/immunohistochemical-study-of-janus-kinase-1signal-transducer-and-activ-peer-reviewed-article-CCID kostenfrei https://doaj.org/toc/1178-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019 497-508 |
| spelling |
(DE-627)DOAJ007333528 (DE-599)DOAJfcd700aa8ab24ca5aff9122587f06968 DE-627 ger DE-627 rakwb eng RL1-803 Farag AGA verfasserin aut Immunohistochemical study of janus kinase 1/signal transducer and activator of transcription 3 in psoriasis vulgaris 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Azza Gaber Antar Farag,1 Rehab Samaka,2 Eman Nabil Elshafey,1 Wafaa Ahmed Shehata,1 Eman Gamal El Sherbiny,3 Mostafa Ahmed Hammam11Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Shebin AlKom, Egypt; 2Department of Histopathology, Faculty of Medicine, Menoufia University, Shebin AlKom, Egypt; 3Dermatology, Andrology and STDs, Ministry of Health, Berkt Alsaba, Menoufia, EgyptBackground: Human JAKs are responsible for generating docking sites for human SSTAT phosphorylation. The role of JAKs in psoriasis pathogenesis has not been clearly explained.Aim: To investigate the role of JAK1 in psoriasis pathogenesis and to assess if this role is mediated through STAT3 or not, through evaluation of their immunohistochemical expression in the skin of psoriatic patients.Methods: This case–control study was carried out on 26 patients presenting with psoriasis vulgaris versus 26 age- and sex-matched apparently healthy volunteers. Psoriasis Area and Severity Index (PASI) scores were used to evaluate psoriasis severity. From all controls and cases (lesional and perilesional), skin biopsies were taken for histopathological and immunohistochemical JAK1 and STAT3 evaluation.Results: There was significant stepwise upregulation of JAK1 from controls to perilesional to lesional psoriatic skin of the patient group in both epidermis and dermis (P≤0.001 for both). Dermal JAK1 H-score was significantly associated with psoriasis severity (P=0.01). STAT3 was significantly overexpressed in lesional psoriatic skin over nonlesional skin (P<0.001). There were significant positive correlations between lesional H-scores for STAT3 and Psoriasis Area and Severity Index scores in epidermis (r=0.63, P<0.001), and in dermis (r=0.47, P=0.04). There was a significant positive correlation between JAK1 and STAT3 expression in epidermal lesional psoriatic skin (r=0.44, P=0.03).Conclusion: JAK1 has a proinflammatory effect in psoriasis pathogenesis, which could be mediated through increasing STAT3 expression in psoriasis. JAK1 and STAT3 tissue expression could be markers of psoriasis severity. JAK1 may be used as a target for immunotherapy in psoriasis-management programs.Keywords: JAK1, STAT3, psoriasis, immunohistochemistry JAK1 STAT3 psoriasis immunohistochemistry. Dermatology Samaka R verfasserin aut Elshafey EN verfasserin aut Shehata WA verfasserin aut El Sherbiny EG verfasserin aut Hammam MA verfasserin aut In Clinical, Cosmetic and Investigational Dermatology Dove Medical Press, 2009 (2019), Seite 497-508 (DE-627)600305953 (DE-600)2494852-4 11787015 nnns year:2019 pages:497-508 https://doaj.org/article/fcd700aa8ab24ca5aff9122587f06968 kostenfrei https://www.dovepress.com/immunohistochemical-study-of-janus-kinase-1signal-transducer-and-activ-peer-reviewed-article-CCID kostenfrei https://doaj.org/toc/1178-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019 497-508 |
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(DE-627)DOAJ007333528 (DE-599)DOAJfcd700aa8ab24ca5aff9122587f06968 DE-627 ger DE-627 rakwb eng RL1-803 Farag AGA verfasserin aut Immunohistochemical study of janus kinase 1/signal transducer and activator of transcription 3 in psoriasis vulgaris 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Azza Gaber Antar Farag,1 Rehab Samaka,2 Eman Nabil Elshafey,1 Wafaa Ahmed Shehata,1 Eman Gamal El Sherbiny,3 Mostafa Ahmed Hammam11Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Shebin AlKom, Egypt; 2Department of Histopathology, Faculty of Medicine, Menoufia University, Shebin AlKom, Egypt; 3Dermatology, Andrology and STDs, Ministry of Health, Berkt Alsaba, Menoufia, EgyptBackground: Human JAKs are responsible for generating docking sites for human SSTAT phosphorylation. The role of JAKs in psoriasis pathogenesis has not been clearly explained.Aim: To investigate the role of JAK1 in psoriasis pathogenesis and to assess if this role is mediated through STAT3 or not, through evaluation of their immunohistochemical expression in the skin of psoriatic patients.Methods: This case–control study was carried out on 26 patients presenting with psoriasis vulgaris versus 26 age- and sex-matched apparently healthy volunteers. Psoriasis Area and Severity Index (PASI) scores were used to evaluate psoriasis severity. From all controls and cases (lesional and perilesional), skin biopsies were taken for histopathological and immunohistochemical JAK1 and STAT3 evaluation.Results: There was significant stepwise upregulation of JAK1 from controls to perilesional to lesional psoriatic skin of the patient group in both epidermis and dermis (P≤0.001 for both). Dermal JAK1 H-score was significantly associated with psoriasis severity (P=0.01). STAT3 was significantly overexpressed in lesional psoriatic skin over nonlesional skin (P<0.001). There were significant positive correlations between lesional H-scores for STAT3 and Psoriasis Area and Severity Index scores in epidermis (r=0.63, P<0.001), and in dermis (r=0.47, P=0.04). There was a significant positive correlation between JAK1 and STAT3 expression in epidermal lesional psoriatic skin (r=0.44, P=0.03).Conclusion: JAK1 has a proinflammatory effect in psoriasis pathogenesis, which could be mediated through increasing STAT3 expression in psoriasis. JAK1 and STAT3 tissue expression could be markers of psoriasis severity. JAK1 may be used as a target for immunotherapy in psoriasis-management programs.Keywords: JAK1, STAT3, psoriasis, immunohistochemistry JAK1 STAT3 psoriasis immunohistochemistry. Dermatology Samaka R verfasserin aut Elshafey EN verfasserin aut Shehata WA verfasserin aut El Sherbiny EG verfasserin aut Hammam MA verfasserin aut In Clinical, Cosmetic and Investigational Dermatology Dove Medical Press, 2009 (2019), Seite 497-508 (DE-627)600305953 (DE-600)2494852-4 11787015 nnns year:2019 pages:497-508 https://doaj.org/article/fcd700aa8ab24ca5aff9122587f06968 kostenfrei https://www.dovepress.com/immunohistochemical-study-of-janus-kinase-1signal-transducer-and-activ-peer-reviewed-article-CCID kostenfrei https://doaj.org/toc/1178-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019 497-508 |
| allfieldsGer |
(DE-627)DOAJ007333528 (DE-599)DOAJfcd700aa8ab24ca5aff9122587f06968 DE-627 ger DE-627 rakwb eng RL1-803 Farag AGA verfasserin aut Immunohistochemical study of janus kinase 1/signal transducer and activator of transcription 3 in psoriasis vulgaris 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Azza Gaber Antar Farag,1 Rehab Samaka,2 Eman Nabil Elshafey,1 Wafaa Ahmed Shehata,1 Eman Gamal El Sherbiny,3 Mostafa Ahmed Hammam11Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Shebin AlKom, Egypt; 2Department of Histopathology, Faculty of Medicine, Menoufia University, Shebin AlKom, Egypt; 3Dermatology, Andrology and STDs, Ministry of Health, Berkt Alsaba, Menoufia, EgyptBackground: Human JAKs are responsible for generating docking sites for human SSTAT phosphorylation. The role of JAKs in psoriasis pathogenesis has not been clearly explained.Aim: To investigate the role of JAK1 in psoriasis pathogenesis and to assess if this role is mediated through STAT3 or not, through evaluation of their immunohistochemical expression in the skin of psoriatic patients.Methods: This case–control study was carried out on 26 patients presenting with psoriasis vulgaris versus 26 age- and sex-matched apparently healthy volunteers. Psoriasis Area and Severity Index (PASI) scores were used to evaluate psoriasis severity. From all controls and cases (lesional and perilesional), skin biopsies were taken for histopathological and immunohistochemical JAK1 and STAT3 evaluation.Results: There was significant stepwise upregulation of JAK1 from controls to perilesional to lesional psoriatic skin of the patient group in both epidermis and dermis (P≤0.001 for both). Dermal JAK1 H-score was significantly associated with psoriasis severity (P=0.01). STAT3 was significantly overexpressed in lesional psoriatic skin over nonlesional skin (P<0.001). There were significant positive correlations between lesional H-scores for STAT3 and Psoriasis Area and Severity Index scores in epidermis (r=0.63, P<0.001), and in dermis (r=0.47, P=0.04). There was a significant positive correlation between JAK1 and STAT3 expression in epidermal lesional psoriatic skin (r=0.44, P=0.03).Conclusion: JAK1 has a proinflammatory effect in psoriasis pathogenesis, which could be mediated through increasing STAT3 expression in psoriasis. JAK1 and STAT3 tissue expression could be markers of psoriasis severity. JAK1 may be used as a target for immunotherapy in psoriasis-management programs.Keywords: JAK1, STAT3, psoriasis, immunohistochemistry JAK1 STAT3 psoriasis immunohistochemistry. Dermatology Samaka R verfasserin aut Elshafey EN verfasserin aut Shehata WA verfasserin aut El Sherbiny EG verfasserin aut Hammam MA verfasserin aut In Clinical, Cosmetic and Investigational Dermatology Dove Medical Press, 2009 (2019), Seite 497-508 (DE-627)600305953 (DE-600)2494852-4 11787015 nnns year:2019 pages:497-508 https://doaj.org/article/fcd700aa8ab24ca5aff9122587f06968 kostenfrei https://www.dovepress.com/immunohistochemical-study-of-janus-kinase-1signal-transducer-and-activ-peer-reviewed-article-CCID kostenfrei https://doaj.org/toc/1178-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019 497-508 |
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(DE-627)DOAJ007333528 (DE-599)DOAJfcd700aa8ab24ca5aff9122587f06968 DE-627 ger DE-627 rakwb eng RL1-803 Farag AGA verfasserin aut Immunohistochemical study of janus kinase 1/signal transducer and activator of transcription 3 in psoriasis vulgaris 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Azza Gaber Antar Farag,1 Rehab Samaka,2 Eman Nabil Elshafey,1 Wafaa Ahmed Shehata,1 Eman Gamal El Sherbiny,3 Mostafa Ahmed Hammam11Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Shebin AlKom, Egypt; 2Department of Histopathology, Faculty of Medicine, Menoufia University, Shebin AlKom, Egypt; 3Dermatology, Andrology and STDs, Ministry of Health, Berkt Alsaba, Menoufia, EgyptBackground: Human JAKs are responsible for generating docking sites for human SSTAT phosphorylation. The role of JAKs in psoriasis pathogenesis has not been clearly explained.Aim: To investigate the role of JAK1 in psoriasis pathogenesis and to assess if this role is mediated through STAT3 or not, through evaluation of their immunohistochemical expression in the skin of psoriatic patients.Methods: This case–control study was carried out on 26 patients presenting with psoriasis vulgaris versus 26 age- and sex-matched apparently healthy volunteers. Psoriasis Area and Severity Index (PASI) scores were used to evaluate psoriasis severity. From all controls and cases (lesional and perilesional), skin biopsies were taken for histopathological and immunohistochemical JAK1 and STAT3 evaluation.Results: There was significant stepwise upregulation of JAK1 from controls to perilesional to lesional psoriatic skin of the patient group in both epidermis and dermis (P≤0.001 for both). Dermal JAK1 H-score was significantly associated with psoriasis severity (P=0.01). STAT3 was significantly overexpressed in lesional psoriatic skin over nonlesional skin (P<0.001). There were significant positive correlations between lesional H-scores for STAT3 and Psoriasis Area and Severity Index scores in epidermis (r=0.63, P<0.001), and in dermis (r=0.47, P=0.04). There was a significant positive correlation between JAK1 and STAT3 expression in epidermal lesional psoriatic skin (r=0.44, P=0.03).Conclusion: JAK1 has a proinflammatory effect in psoriasis pathogenesis, which could be mediated through increasing STAT3 expression in psoriasis. JAK1 and STAT3 tissue expression could be markers of psoriasis severity. JAK1 may be used as a target for immunotherapy in psoriasis-management programs.Keywords: JAK1, STAT3, psoriasis, immunohistochemistry JAK1 STAT3 psoriasis immunohistochemistry. Dermatology Samaka R verfasserin aut Elshafey EN verfasserin aut Shehata WA verfasserin aut El Sherbiny EG verfasserin aut Hammam MA verfasserin aut In Clinical, Cosmetic and Investigational Dermatology Dove Medical Press, 2009 (2019), Seite 497-508 (DE-627)600305953 (DE-600)2494852-4 11787015 nnns year:2019 pages:497-508 https://doaj.org/article/fcd700aa8ab24ca5aff9122587f06968 kostenfrei https://www.dovepress.com/immunohistochemical-study-of-janus-kinase-1signal-transducer-and-activ-peer-reviewed-article-CCID kostenfrei https://doaj.org/toc/1178-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019 497-508 |
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STAT3 was significantly overexpressed in lesional psoriatic skin over nonlesional skin (P&lt;0.001). There were significant positive correlations between lesional H-scores for STAT3 and Psoriasis Area and Severity Index scores in epidermis (r=0.63, P&lt;0.001), and in dermis (r=0.47, P=0.04). There was a significant positive correlation between JAK1 and STAT3 expression in epidermal lesional psoriatic skin (r=0.44, P=0.03).Conclusion: JAK1 has a proinflammatory effect in psoriasis pathogenesis, which could be mediated through increasing STAT3 expression in psoriasis. JAK1 and STAT3 tissue expression could be markers of psoriasis severity. 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Immunohistochemical study of janus kinase 1/signal transducer and activator of transcription 3 in psoriasis vulgaris |
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Azza Gaber Antar Farag,1 Rehab Samaka,2 Eman Nabil Elshafey,1 Wafaa Ahmed Shehata,1 Eman Gamal El Sherbiny,3 Mostafa Ahmed Hammam11Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Shebin AlKom, Egypt; 2Department of Histopathology, Faculty of Medicine, Menoufia University, Shebin AlKom, Egypt; 3Dermatology, Andrology and STDs, Ministry of Health, Berkt Alsaba, Menoufia, EgyptBackground: Human JAKs are responsible for generating docking sites for human SSTAT phosphorylation. The role of JAKs in psoriasis pathogenesis has not been clearly explained.Aim: To investigate the role of JAK1 in psoriasis pathogenesis and to assess if this role is mediated through STAT3 or not, through evaluation of their immunohistochemical expression in the skin of psoriatic patients.Methods: This case–control study was carried out on 26 patients presenting with psoriasis vulgaris versus 26 age- and sex-matched apparently healthy volunteers. Psoriasis Area and Severity Index (PASI) scores were used to evaluate psoriasis severity. From all controls and cases (lesional and perilesional), skin biopsies were taken for histopathological and immunohistochemical JAK1 and STAT3 evaluation.Results: There was significant stepwise upregulation of JAK1 from controls to perilesional to lesional psoriatic skin of the patient group in both epidermis and dermis (P≤0.001 for both). Dermal JAK1 H-score was significantly associated with psoriasis severity (P=0.01). STAT3 was significantly overexpressed in lesional psoriatic skin over nonlesional skin (P<0.001). There were significant positive correlations between lesional H-scores for STAT3 and Psoriasis Area and Severity Index scores in epidermis (r=0.63, P<0.001), and in dermis (r=0.47, P=0.04). There was a significant positive correlation between JAK1 and STAT3 expression in epidermal lesional psoriatic skin (r=0.44, P=0.03).Conclusion: JAK1 has a proinflammatory effect in psoriasis pathogenesis, which could be mediated through increasing STAT3 expression in psoriasis. JAK1 and STAT3 tissue expression could be markers of psoriasis severity. JAK1 may be used as a target for immunotherapy in psoriasis-management programs.Keywords: JAK1, STAT3, psoriasis, immunohistochemistry |
| abstractGer |
Azza Gaber Antar Farag,1 Rehab Samaka,2 Eman Nabil Elshafey,1 Wafaa Ahmed Shehata,1 Eman Gamal El Sherbiny,3 Mostafa Ahmed Hammam11Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Shebin AlKom, Egypt; 2Department of Histopathology, Faculty of Medicine, Menoufia University, Shebin AlKom, Egypt; 3Dermatology, Andrology and STDs, Ministry of Health, Berkt Alsaba, Menoufia, EgyptBackground: Human JAKs are responsible for generating docking sites for human SSTAT phosphorylation. The role of JAKs in psoriasis pathogenesis has not been clearly explained.Aim: To investigate the role of JAK1 in psoriasis pathogenesis and to assess if this role is mediated through STAT3 or not, through evaluation of their immunohistochemical expression in the skin of psoriatic patients.Methods: This case–control study was carried out on 26 patients presenting with psoriasis vulgaris versus 26 age- and sex-matched apparently healthy volunteers. Psoriasis Area and Severity Index (PASI) scores were used to evaluate psoriasis severity. From all controls and cases (lesional and perilesional), skin biopsies were taken for histopathological and immunohistochemical JAK1 and STAT3 evaluation.Results: There was significant stepwise upregulation of JAK1 from controls to perilesional to lesional psoriatic skin of the patient group in both epidermis and dermis (P≤0.001 for both). Dermal JAK1 H-score was significantly associated with psoriasis severity (P=0.01). STAT3 was significantly overexpressed in lesional psoriatic skin over nonlesional skin (P<0.001). There were significant positive correlations between lesional H-scores for STAT3 and Psoriasis Area and Severity Index scores in epidermis (r=0.63, P<0.001), and in dermis (r=0.47, P=0.04). There was a significant positive correlation between JAK1 and STAT3 expression in epidermal lesional psoriatic skin (r=0.44, P=0.03).Conclusion: JAK1 has a proinflammatory effect in psoriasis pathogenesis, which could be mediated through increasing STAT3 expression in psoriasis. JAK1 and STAT3 tissue expression could be markers of psoriasis severity. JAK1 may be used as a target for immunotherapy in psoriasis-management programs.Keywords: JAK1, STAT3, psoriasis, immunohistochemistry |
| abstract_unstemmed |
Azza Gaber Antar Farag,1 Rehab Samaka,2 Eman Nabil Elshafey,1 Wafaa Ahmed Shehata,1 Eman Gamal El Sherbiny,3 Mostafa Ahmed Hammam11Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Shebin AlKom, Egypt; 2Department of Histopathology, Faculty of Medicine, Menoufia University, Shebin AlKom, Egypt; 3Dermatology, Andrology and STDs, Ministry of Health, Berkt Alsaba, Menoufia, EgyptBackground: Human JAKs are responsible for generating docking sites for human SSTAT phosphorylation. The role of JAKs in psoriasis pathogenesis has not been clearly explained.Aim: To investigate the role of JAK1 in psoriasis pathogenesis and to assess if this role is mediated through STAT3 or not, through evaluation of their immunohistochemical expression in the skin of psoriatic patients.Methods: This case–control study was carried out on 26 patients presenting with psoriasis vulgaris versus 26 age- and sex-matched apparently healthy volunteers. Psoriasis Area and Severity Index (PASI) scores were used to evaluate psoriasis severity. From all controls and cases (lesional and perilesional), skin biopsies were taken for histopathological and immunohistochemical JAK1 and STAT3 evaluation.Results: There was significant stepwise upregulation of JAK1 from controls to perilesional to lesional psoriatic skin of the patient group in both epidermis and dermis (P≤0.001 for both). Dermal JAK1 H-score was significantly associated with psoriasis severity (P=0.01). STAT3 was significantly overexpressed in lesional psoriatic skin over nonlesional skin (P<0.001). There were significant positive correlations between lesional H-scores for STAT3 and Psoriasis Area and Severity Index scores in epidermis (r=0.63, P<0.001), and in dermis (r=0.47, P=0.04). There was a significant positive correlation between JAK1 and STAT3 expression in epidermal lesional psoriatic skin (r=0.44, P=0.03).Conclusion: JAK1 has a proinflammatory effect in psoriasis pathogenesis, which could be mediated through increasing STAT3 expression in psoriasis. JAK1 and STAT3 tissue expression could be markers of psoriasis severity. JAK1 may be used as a target for immunotherapy in psoriasis-management programs.Keywords: JAK1, STAT3, psoriasis, immunohistochemistry |
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| title_short |
Immunohistochemical study of janus kinase 1/signal transducer and activator of transcription 3 in psoriasis vulgaris |
| url |
https://doaj.org/article/fcd700aa8ab24ca5aff9122587f06968 https://www.dovepress.com/immunohistochemical-study-of-janus-kinase-1signal-transducer-and-activ-peer-reviewed-article-CCID https://doaj.org/toc/1178-7015 |
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The role of JAKs in psoriasis pathogenesis has not been clearly explained.Aim: To investigate the role of JAK1 in psoriasis pathogenesis and to assess if this role is mediated through STAT3 or not, through evaluation of their immunohistochemical expression in the skin of psoriatic patients.Methods: This case&ndash;control study was carried out on 26 patients presenting with psoriasis vulgaris versus 26 age- and sex-matched apparently healthy volunteers. Psoriasis Area and Severity Index (PASI) scores were used to evaluate psoriasis severity. From all controls and cases (lesional and perilesional), skin biopsies were taken for histopathological and immunohistochemical JAK1 and STAT3 evaluation.Results: There was significant stepwise upregulation of JAK1 from controls to perilesional to lesional psoriatic skin of the patient group in both epidermis and dermis (P&le;0.001 for both). Dermal JAK1 H-score was significantly associated with psoriasis severity (P=0.01). 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