Cognitive Behavioral Therapy Lowers Elevated Functional Connectivity in Depressed Adolescents

Imaging studies have implicated altered functional connectivity in adults with major depressive disorder (MDD). Whether similar dysfunction is present in adolescent patients is unclear. The degree of resting-state functional connectivity (rsFC) may reflect abnormalities within emotional (‘hot’) and...
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Autor*in:	Shayanti Chattopadhyay [verfasserIn] Roger Tait [verfasserIn] Tiago Simas [verfasserIn] Adrienne van Nieuwenhuizen [verfasserIn] Cindy C. Hagan [verfasserIn] Rosemary J. Holt [verfasserIn] Julia Graham [verfasserIn] Barbara J. Sahakian [verfasserIn] Paul O. Wilkinson [verfasserIn] Ian M. Goodyer [verfasserIn] John Suckling [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Depression Adolescence Resting-state Functional connectivity Fronto-limbic Cortical thickness

Übergeordnetes Werk:	In: EBioMedicine - Elsevier, 2015, 17(2017), C, Seite 216-222
Übergeordnetes Werk:	volume:17 ; year:2017 ; number:C ; pages:216-222

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.ebiom.2017.02.010

Katalog-ID:	DOAJ007339178

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520			\|a Imaging studies have implicated altered functional connectivity in adults with major depressive disorder (MDD). Whether similar dysfunction is present in adolescent patients is unclear. The degree of resting-state functional connectivity (rsFC) may reflect abnormalities within emotional (‘hot’) and cognitive control (‘cold’) neural systems. Here, we investigate rsFC of these systems in adolescent patients and changes following cognitive behavioral therapy (CBT). Functional Magnetic Resonance Imaging (fMRI) was acquired from adolescent patients before CBT, and 24-weeks later following completed therapy. Similar data were obtained from control participants. Cross-sectional Cohort: From 82 patients and 34 controls at baseline, rsFC of the amygdala, anterior cingulate cortex (ACC), and pre-frontal cortex (PFC) was calculated for comparison. Longitudinal Cohort: From 17 patients and 30 controls with longitudinal data, treatment effects were tested on rsFC. Patients demonstrated significantly greater rsFC to left amygdala, bilateral supragenual ACC, but not with PFC. Treatment effects were observed in right insula connected to left supragenual ACC, with baseline case-control differences reduced. rsFC changes were significantly correlated with changes in depression severity. Depressed adolescents exhibited heightened connectivity in regions of ‘hot’ emotional processing, known to be associated with depression, where treatment exposure exerted positive effects, without concomitant differences in areas of ‘cold’ cognition.
650		4	\|a Depression
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spelling	10.1016/j.ebiom.2017.02.010 doi (DE-627)DOAJ007339178 (DE-599)DOAJ7d14773fd1494229aec5f5a76718388c DE-627 ger DE-627 rakwb eng R5-920 Shayanti Chattopadhyay verfasserin aut Cognitive Behavioral Therapy Lowers Elevated Functional Connectivity in Depressed Adolescents 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Imaging studies have implicated altered functional connectivity in adults with major depressive disorder (MDD). Whether similar dysfunction is present in adolescent patients is unclear. The degree of resting-state functional connectivity (rsFC) may reflect abnormalities within emotional (‘hot’) and cognitive control (‘cold’) neural systems. Here, we investigate rsFC of these systems in adolescent patients and changes following cognitive behavioral therapy (CBT). Functional Magnetic Resonance Imaging (fMRI) was acquired from adolescent patients before CBT, and 24-weeks later following completed therapy. Similar data were obtained from control participants. Cross-sectional Cohort: From 82 patients and 34 controls at baseline, rsFC of the amygdala, anterior cingulate cortex (ACC), and pre-frontal cortex (PFC) was calculated for comparison. Longitudinal Cohort: From 17 patients and 30 controls with longitudinal data, treatment effects were tested on rsFC. Patients demonstrated significantly greater rsFC to left amygdala, bilateral supragenual ACC, but not with PFC. Treatment effects were observed in right insula connected to left supragenual ACC, with baseline case-control differences reduced. rsFC changes were significantly correlated with changes in depression severity. Depressed adolescents exhibited heightened connectivity in regions of ‘hot’ emotional processing, known to be associated with depression, where treatment exposure exerted positive effects, without concomitant differences in areas of ‘cold’ cognition. Depression Adolescence Resting-state Functional connectivity Fronto-limbic Cortical thickness Medicine R Medicine (General) Roger Tait verfasserin aut Tiago Simas verfasserin aut Adrienne van Nieuwenhuizen verfasserin aut Cindy C. Hagan verfasserin aut Rosemary J. Holt verfasserin aut Julia Graham verfasserin aut Barbara J. Sahakian verfasserin aut Paul O. Wilkinson verfasserin aut Ian M. Goodyer verfasserin aut John Suckling verfasserin aut In EBioMedicine Elsevier, 2015 17(2017), C, Seite 216-222 (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:17 year:2017 number:C pages:216-222 https://doi.org/10.1016/j.ebiom.2017.02.010 kostenfrei https://doaj.org/article/7d14773fd1494229aec5f5a76718388c kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396417300695 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 17 2017 C 216-222
allfields_unstemmed	10.1016/j.ebiom.2017.02.010 doi (DE-627)DOAJ007339178 (DE-599)DOAJ7d14773fd1494229aec5f5a76718388c DE-627 ger DE-627 rakwb eng R5-920 Shayanti Chattopadhyay verfasserin aut Cognitive Behavioral Therapy Lowers Elevated Functional Connectivity in Depressed Adolescents 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Imaging studies have implicated altered functional connectivity in adults with major depressive disorder (MDD). Whether similar dysfunction is present in adolescent patients is unclear. The degree of resting-state functional connectivity (rsFC) may reflect abnormalities within emotional (‘hot’) and cognitive control (‘cold’) neural systems. Here, we investigate rsFC of these systems in adolescent patients and changes following cognitive behavioral therapy (CBT). Functional Magnetic Resonance Imaging (fMRI) was acquired from adolescent patients before CBT, and 24-weeks later following completed therapy. Similar data were obtained from control participants. Cross-sectional Cohort: From 82 patients and 34 controls at baseline, rsFC of the amygdala, anterior cingulate cortex (ACC), and pre-frontal cortex (PFC) was calculated for comparison. Longitudinal Cohort: From 17 patients and 30 controls with longitudinal data, treatment effects were tested on rsFC. Patients demonstrated significantly greater rsFC to left amygdala, bilateral supragenual ACC, but not with PFC. Treatment effects were observed in right insula connected to left supragenual ACC, with baseline case-control differences reduced. rsFC changes were significantly correlated with changes in depression severity. Depressed adolescents exhibited heightened connectivity in regions of ‘hot’ emotional processing, known to be associated with depression, where treatment exposure exerted positive effects, without concomitant differences in areas of ‘cold’ cognition. Depression Adolescence Resting-state Functional connectivity Fronto-limbic Cortical thickness Medicine R Medicine (General) Roger Tait verfasserin aut Tiago Simas verfasserin aut Adrienne van Nieuwenhuizen verfasserin aut Cindy C. Hagan verfasserin aut Rosemary J. Holt verfasserin aut Julia Graham verfasserin aut Barbara J. Sahakian verfasserin aut Paul O. Wilkinson verfasserin aut Ian M. Goodyer verfasserin aut John Suckling verfasserin aut In EBioMedicine Elsevier, 2015 17(2017), C, Seite 216-222 (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:17 year:2017 number:C pages:216-222 https://doi.org/10.1016/j.ebiom.2017.02.010 kostenfrei https://doaj.org/article/7d14773fd1494229aec5f5a76718388c kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396417300695 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 17 2017 C 216-222
allfieldsGer	10.1016/j.ebiom.2017.02.010 doi (DE-627)DOAJ007339178 (DE-599)DOAJ7d14773fd1494229aec5f5a76718388c DE-627 ger DE-627 rakwb eng R5-920 Shayanti Chattopadhyay verfasserin aut Cognitive Behavioral Therapy Lowers Elevated Functional Connectivity in Depressed Adolescents 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Imaging studies have implicated altered functional connectivity in adults with major depressive disorder (MDD). Whether similar dysfunction is present in adolescent patients is unclear. The degree of resting-state functional connectivity (rsFC) may reflect abnormalities within emotional (‘hot’) and cognitive control (‘cold’) neural systems. Here, we investigate rsFC of these systems in adolescent patients and changes following cognitive behavioral therapy (CBT). Functional Magnetic Resonance Imaging (fMRI) was acquired from adolescent patients before CBT, and 24-weeks later following completed therapy. Similar data were obtained from control participants. Cross-sectional Cohort: From 82 patients and 34 controls at baseline, rsFC of the amygdala, anterior cingulate cortex (ACC), and pre-frontal cortex (PFC) was calculated for comparison. Longitudinal Cohort: From 17 patients and 30 controls with longitudinal data, treatment effects were tested on rsFC. Patients demonstrated significantly greater rsFC to left amygdala, bilateral supragenual ACC, but not with PFC. Treatment effects were observed in right insula connected to left supragenual ACC, with baseline case-control differences reduced. rsFC changes were significantly correlated with changes in depression severity. Depressed adolescents exhibited heightened connectivity in regions of ‘hot’ emotional processing, known to be associated with depression, where treatment exposure exerted positive effects, without concomitant differences in areas of ‘cold’ cognition. Depression Adolescence Resting-state Functional connectivity Fronto-limbic Cortical thickness Medicine R Medicine (General) Roger Tait verfasserin aut Tiago Simas verfasserin aut Adrienne van Nieuwenhuizen verfasserin aut Cindy C. Hagan verfasserin aut Rosemary J. Holt verfasserin aut Julia Graham verfasserin aut Barbara J. Sahakian verfasserin aut Paul O. Wilkinson verfasserin aut Ian M. Goodyer verfasserin aut John Suckling verfasserin aut In EBioMedicine Elsevier, 2015 17(2017), C, Seite 216-222 (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:17 year:2017 number:C pages:216-222 https://doi.org/10.1016/j.ebiom.2017.02.010 kostenfrei https://doaj.org/article/7d14773fd1494229aec5f5a76718388c kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396417300695 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 17 2017 C 216-222
allfieldsSound	10.1016/j.ebiom.2017.02.010 doi (DE-627)DOAJ007339178 (DE-599)DOAJ7d14773fd1494229aec5f5a76718388c DE-627 ger DE-627 rakwb eng R5-920 Shayanti Chattopadhyay verfasserin aut Cognitive Behavioral Therapy Lowers Elevated Functional Connectivity in Depressed Adolescents 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Imaging studies have implicated altered functional connectivity in adults with major depressive disorder (MDD). Whether similar dysfunction is present in adolescent patients is unclear. The degree of resting-state functional connectivity (rsFC) may reflect abnormalities within emotional (‘hot’) and cognitive control (‘cold’) neural systems. Here, we investigate rsFC of these systems in adolescent patients and changes following cognitive behavioral therapy (CBT). Functional Magnetic Resonance Imaging (fMRI) was acquired from adolescent patients before CBT, and 24-weeks later following completed therapy. Similar data were obtained from control participants. Cross-sectional Cohort: From 82 patients and 34 controls at baseline, rsFC of the amygdala, anterior cingulate cortex (ACC), and pre-frontal cortex (PFC) was calculated for comparison. Longitudinal Cohort: From 17 patients and 30 controls with longitudinal data, treatment effects were tested on rsFC. Patients demonstrated significantly greater rsFC to left amygdala, bilateral supragenual ACC, but not with PFC. Treatment effects were observed in right insula connected to left supragenual ACC, with baseline case-control differences reduced. rsFC changes were significantly correlated with changes in depression severity. Depressed adolescents exhibited heightened connectivity in regions of ‘hot’ emotional processing, known to be associated with depression, where treatment exposure exerted positive effects, without concomitant differences in areas of ‘cold’ cognition. Depression Adolescence Resting-state Functional connectivity Fronto-limbic Cortical thickness Medicine R Medicine (General) Roger Tait verfasserin aut Tiago Simas verfasserin aut Adrienne van Nieuwenhuizen verfasserin aut Cindy C. Hagan verfasserin aut Rosemary J. Holt verfasserin aut Julia Graham verfasserin aut Barbara J. Sahakian verfasserin aut Paul O. Wilkinson verfasserin aut Ian M. Goodyer verfasserin aut John Suckling verfasserin aut In EBioMedicine Elsevier, 2015 17(2017), C, Seite 216-222 (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:17 year:2017 number:C pages:216-222 https://doi.org/10.1016/j.ebiom.2017.02.010 kostenfrei https://doaj.org/article/7d14773fd1494229aec5f5a76718388c kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396417300695 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 17 2017 C 216-222
language	English
source	In EBioMedicine 17(2017), C, Seite 216-222 volume:17 year:2017 number:C pages:216-222
sourceStr	In EBioMedicine 17(2017), C, Seite 216-222 volume:17 year:2017 number:C pages:216-222
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Depression Adolescence Resting-state Functional connectivity Fronto-limbic Cortical thickness Medicine R Medicine (General)
isfreeaccess_bool	true
container_title	EBioMedicine
authorswithroles_txt_mv	Shayanti Chattopadhyay @@aut@@ Roger Tait @@aut@@ Tiago Simas @@aut@@ Adrienne van Nieuwenhuizen @@aut@@ Cindy C. Hagan @@aut@@ Rosemary J. Holt @@aut@@ Julia Graham @@aut@@ Barbara J. Sahakian @@aut@@ Paul O. Wilkinson @@aut@@ Ian M. Goodyer @@aut@@ John Suckling @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
hierarchy_top_id	802540074
id	DOAJ007339178
language_de	englisch
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callnumber-first	R - Medicine
author	Shayanti Chattopadhyay
spellingShingle	Shayanti Chattopadhyay misc R5-920 misc Depression misc Adolescence misc Resting-state misc Functional connectivity misc Fronto-limbic misc Cortical thickness misc Medicine misc R misc Medicine (General) Cognitive Behavioral Therapy Lowers Elevated Functional Connectivity in Depressed Adolescents
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topic_title	R5-920 Cognitive Behavioral Therapy Lowers Elevated Functional Connectivity in Depressed Adolescents Depression Adolescence Resting-state Functional connectivity Fronto-limbic Cortical thickness
topic	misc R5-920 misc Depression misc Adolescence misc Resting-state misc Functional connectivity misc Fronto-limbic misc Cortical thickness misc Medicine misc R misc Medicine (General)
topic_unstemmed	misc R5-920 misc Depression misc Adolescence misc Resting-state misc Functional connectivity misc Fronto-limbic misc Cortical thickness misc Medicine misc R misc Medicine (General)
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title	Cognitive Behavioral Therapy Lowers Elevated Functional Connectivity in Depressed Adolescents
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title_full	Cognitive Behavioral Therapy Lowers Elevated Functional Connectivity in Depressed Adolescents
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title_sort	cognitive behavioral therapy lowers elevated functional connectivity in depressed adolescents
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title_auth	Cognitive Behavioral Therapy Lowers Elevated Functional Connectivity in Depressed Adolescents
abstract	Imaging studies have implicated altered functional connectivity in adults with major depressive disorder (MDD). Whether similar dysfunction is present in adolescent patients is unclear. The degree of resting-state functional connectivity (rsFC) may reflect abnormalities within emotional (‘hot’) and cognitive control (‘cold’) neural systems. Here, we investigate rsFC of these systems in adolescent patients and changes following cognitive behavioral therapy (CBT). Functional Magnetic Resonance Imaging (fMRI) was acquired from adolescent patients before CBT, and 24-weeks later following completed therapy. Similar data were obtained from control participants. Cross-sectional Cohort: From 82 patients and 34 controls at baseline, rsFC of the amygdala, anterior cingulate cortex (ACC), and pre-frontal cortex (PFC) was calculated for comparison. Longitudinal Cohort: From 17 patients and 30 controls with longitudinal data, treatment effects were tested on rsFC. Patients demonstrated significantly greater rsFC to left amygdala, bilateral supragenual ACC, but not with PFC. Treatment effects were observed in right insula connected to left supragenual ACC, with baseline case-control differences reduced. rsFC changes were significantly correlated with changes in depression severity. Depressed adolescents exhibited heightened connectivity in regions of ‘hot’ emotional processing, known to be associated with depression, where treatment exposure exerted positive effects, without concomitant differences in areas of ‘cold’ cognition.
abstractGer	Imaging studies have implicated altered functional connectivity in adults with major depressive disorder (MDD). Whether similar dysfunction is present in adolescent patients is unclear. The degree of resting-state functional connectivity (rsFC) may reflect abnormalities within emotional (‘hot’) and cognitive control (‘cold’) neural systems. Here, we investigate rsFC of these systems in adolescent patients and changes following cognitive behavioral therapy (CBT). Functional Magnetic Resonance Imaging (fMRI) was acquired from adolescent patients before CBT, and 24-weeks later following completed therapy. Similar data were obtained from control participants. Cross-sectional Cohort: From 82 patients and 34 controls at baseline, rsFC of the amygdala, anterior cingulate cortex (ACC), and pre-frontal cortex (PFC) was calculated for comparison. Longitudinal Cohort: From 17 patients and 30 controls with longitudinal data, treatment effects were tested on rsFC. Patients demonstrated significantly greater rsFC to left amygdala, bilateral supragenual ACC, but not with PFC. Treatment effects were observed in right insula connected to left supragenual ACC, with baseline case-control differences reduced. rsFC changes were significantly correlated with changes in depression severity. Depressed adolescents exhibited heightened connectivity in regions of ‘hot’ emotional processing, known to be associated with depression, where treatment exposure exerted positive effects, without concomitant differences in areas of ‘cold’ cognition.
abstract_unstemmed	Imaging studies have implicated altered functional connectivity in adults with major depressive disorder (MDD). Whether similar dysfunction is present in adolescent patients is unclear. The degree of resting-state functional connectivity (rsFC) may reflect abnormalities within emotional (‘hot’) and cognitive control (‘cold’) neural systems. Here, we investigate rsFC of these systems in adolescent patients and changes following cognitive behavioral therapy (CBT). Functional Magnetic Resonance Imaging (fMRI) was acquired from adolescent patients before CBT, and 24-weeks later following completed therapy. Similar data were obtained from control participants. Cross-sectional Cohort: From 82 patients and 34 controls at baseline, rsFC of the amygdala, anterior cingulate cortex (ACC), and pre-frontal cortex (PFC) was calculated for comparison. Longitudinal Cohort: From 17 patients and 30 controls with longitudinal data, treatment effects were tested on rsFC. Patients demonstrated significantly greater rsFC to left amygdala, bilateral supragenual ACC, but not with PFC. Treatment effects were observed in right insula connected to left supragenual ACC, with baseline case-control differences reduced. rsFC changes were significantly correlated with changes in depression severity. Depressed adolescents exhibited heightened connectivity in regions of ‘hot’ emotional processing, known to be associated with depression, where treatment exposure exerted positive effects, without concomitant differences in areas of ‘cold’ cognition.
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title_short	Cognitive Behavioral Therapy Lowers Elevated Functional Connectivity in Depressed Adolescents
url	https://doi.org/10.1016/j.ebiom.2017.02.010 https://doaj.org/article/7d14773fd1494229aec5f5a76718388c http://www.sciencedirect.com/science/article/pii/S2352396417300695 https://doaj.org/toc/2352-3964
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Whether similar dysfunction is present in adolescent patients is unclear. The degree of resting-state functional connectivity (rsFC) may reflect abnormalities within emotional (‘hot’) and cognitive control (‘cold’) neural systems. Here, we investigate rsFC of these systems in adolescent patients and changes following cognitive behavioral therapy (CBT). Functional Magnetic Resonance Imaging (fMRI) was acquired from adolescent patients before CBT, and 24-weeks later following completed therapy. Similar data were obtained from control participants. Cross-sectional Cohort: From 82 patients and 34 controls at baseline, rsFC of the amygdala, anterior cingulate cortex (ACC), and pre-frontal cortex (PFC) was calculated for comparison. Longitudinal Cohort: From 17 patients and 30 controls with longitudinal data, treatment effects were tested on rsFC. Patients demonstrated significantly greater rsFC to left amygdala, bilateral supragenual ACC, but not with PFC. Treatment effects were observed in right insula connected to left supragenual ACC, with baseline case-control differences reduced. rsFC changes were significantly correlated with changes in depression severity. Depressed adolescents exhibited heightened connectivity in regions of ‘hot’ emotional processing, known to be associated with depression, where treatment exposure exerted positive effects, without concomitant differences in areas of ‘cold’ cognition.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Depression</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Adolescence</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Resting-state</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Functional connectivity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Fronto-limbic</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cortical thickness</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">R</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine (General)</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Roger Tait</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tiago Simas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adrienne van Nieuwenhuizen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Cindy C. 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Cognitive Behavioral Therapy Lowers Elevated Functional Connectivity in Depressed Adolescents

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