The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments

Natural killer (NK) cells are critical immune effector cells in the fight against cancer. As NK cells in cancer patients are highly dysfunctional and reduced in number, adoptive transfer of large numbers of cytolytic NK cells and their potential to induce relevant antitumor responses are widely expl...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	John P. Veluchamy [verfasserIn] Nina Kok [verfasserIn] Hans J. van der Vliet [verfasserIn] Henk M. W. Verheul [verfasserIn] Tanja D. de Gruijl [verfasserIn] Jan Spanholtz [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	hematopoietic stem cell transplantation autologous natural killer cells allogeneic natural killer cells adoptive natural killer cell therapy natural killer cell biotech companies natural killer cell combinatorial studies

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 8(2017)
Übergeordnetes Werk:	volume:8 ; year:2017

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2017.00631

Katalog-ID:	DOAJ007398441

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spelling	10.3389/fimmu.2017.00631 doi (DE-627)DOAJ007398441 (DE-599)DOAJ64f543aec174413db67dc06b1cfe3add DE-627 ger DE-627 rakwb eng RC581-607 John P. Veluchamy verfasserin aut The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Natural killer (NK) cells are critical immune effector cells in the fight against cancer. As NK cells in cancer patients are highly dysfunctional and reduced in number, adoptive transfer of large numbers of cytolytic NK cells and their potential to induce relevant antitumor responses are widely explored in cancer immunotherapy. Early studies from autologous NK cells have failed to demonstrate significant clinical benefit. In this review, the clinical benefits of adoptively transferred allogeneic NK cells in a transplant and non-transplant setting are compared and discussed in the context of relevant NK cell platforms that are being developed and optimized by various biotech industries with a special focus on augmenting NK cell functions. hematopoietic stem cell transplantation autologous natural killer cells allogeneic natural killer cells adoptive natural killer cell therapy natural killer cell biotech companies natural killer cell combinatorial studies Immunologic diseases. Allergy John P. Veluchamy verfasserin aut Nina Kok verfasserin aut Hans J. van der Vliet verfasserin aut Henk M. W. Verheul verfasserin aut Tanja D. de Gruijl verfasserin aut Jan Spanholtz verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 8(2017) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:8 year:2017 https://doi.org/10.3389/fimmu.2017.00631 kostenfrei https://doaj.org/article/64f543aec174413db67dc06b1cfe3add kostenfrei http://journal.frontiersin.org/article/10.3389/fimmu.2017.00631/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017
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allfieldsSound	10.3389/fimmu.2017.00631 doi (DE-627)DOAJ007398441 (DE-599)DOAJ64f543aec174413db67dc06b1cfe3add DE-627 ger DE-627 rakwb eng RC581-607 John P. Veluchamy verfasserin aut The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Natural killer (NK) cells are critical immune effector cells in the fight against cancer. As NK cells in cancer patients are highly dysfunctional and reduced in number, adoptive transfer of large numbers of cytolytic NK cells and their potential to induce relevant antitumor responses are widely explored in cancer immunotherapy. Early studies from autologous NK cells have failed to demonstrate significant clinical benefit. In this review, the clinical benefits of adoptively transferred allogeneic NK cells in a transplant and non-transplant setting are compared and discussed in the context of relevant NK cell platforms that are being developed and optimized by various biotech industries with a special focus on augmenting NK cell functions. hematopoietic stem cell transplantation autologous natural killer cells allogeneic natural killer cells adoptive natural killer cell therapy natural killer cell biotech companies natural killer cell combinatorial studies Immunologic diseases. Allergy John P. Veluchamy verfasserin aut Nina Kok verfasserin aut Hans J. van der Vliet verfasserin aut Henk M. W. Verheul verfasserin aut Tanja D. de Gruijl verfasserin aut Jan Spanholtz verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 8(2017) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:8 year:2017 https://doi.org/10.3389/fimmu.2017.00631 kostenfrei https://doaj.org/article/64f543aec174413db67dc06b1cfe3add kostenfrei http://journal.frontiersin.org/article/10.3389/fimmu.2017.00631/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017
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topic_facet	hematopoietic stem cell transplantation autologous natural killer cells allogeneic natural killer cells adoptive natural killer cell therapy natural killer cell biotech companies natural killer cell combinatorial studies Immunologic diseases. Allergy
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authorswithroles_txt_mv	John P. Veluchamy @@aut@@ Nina Kok @@aut@@ Hans J. van der Vliet @@aut@@ Henk M. W. Verheul @@aut@@ Tanja D. de Gruijl @@aut@@ Jan Spanholtz @@aut@@
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callnumber-first	R - Medicine
author	John P. Veluchamy
spellingShingle	John P. Veluchamy misc RC581-607 misc hematopoietic stem cell transplantation misc autologous natural killer cells misc allogeneic natural killer cells misc adoptive natural killer cell therapy misc natural killer cell biotech companies misc natural killer cell combinatorial studies misc Immunologic diseases. Allergy The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments
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topic_title	RC581-607 The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments hematopoietic stem cell transplantation autologous natural killer cells allogeneic natural killer cells adoptive natural killer cell therapy natural killer cell biotech companies natural killer cell combinatorial studies
topic	misc RC581-607 misc hematopoietic stem cell transplantation misc autologous natural killer cells misc allogeneic natural killer cells misc adoptive natural killer cell therapy misc natural killer cell biotech companies misc natural killer cell combinatorial studies misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc hematopoietic stem cell transplantation misc autologous natural killer cells misc allogeneic natural killer cells misc adoptive natural killer cell therapy misc natural killer cell biotech companies misc natural killer cell combinatorial studies misc Immunologic diseases. Allergy
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title	The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments
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title_full	The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments
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title_sort	rise of allogeneic natural killer cells as a platform for cancer immunotherapy: recent innovations and future developments
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title_auth	The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments
abstract	Natural killer (NK) cells are critical immune effector cells in the fight against cancer. As NK cells in cancer patients are highly dysfunctional and reduced in number, adoptive transfer of large numbers of cytolytic NK cells and their potential to induce relevant antitumor responses are widely explored in cancer immunotherapy. Early studies from autologous NK cells have failed to demonstrate significant clinical benefit. In this review, the clinical benefits of adoptively transferred allogeneic NK cells in a transplant and non-transplant setting are compared and discussed in the context of relevant NK cell platforms that are being developed and optimized by various biotech industries with a special focus on augmenting NK cell functions.
abstractGer	Natural killer (NK) cells are critical immune effector cells in the fight against cancer. As NK cells in cancer patients are highly dysfunctional and reduced in number, adoptive transfer of large numbers of cytolytic NK cells and their potential to induce relevant antitumor responses are widely explored in cancer immunotherapy. Early studies from autologous NK cells have failed to demonstrate significant clinical benefit. In this review, the clinical benefits of adoptively transferred allogeneic NK cells in a transplant and non-transplant setting are compared and discussed in the context of relevant NK cell platforms that are being developed and optimized by various biotech industries with a special focus on augmenting NK cell functions.
abstract_unstemmed	Natural killer (NK) cells are critical immune effector cells in the fight against cancer. As NK cells in cancer patients are highly dysfunctional and reduced in number, adoptive transfer of large numbers of cytolytic NK cells and their potential to induce relevant antitumor responses are widely explored in cancer immunotherapy. Early studies from autologous NK cells have failed to demonstrate significant clinical benefit. In this review, the clinical benefits of adoptively transferred allogeneic NK cells in a transplant and non-transplant setting are compared and discussed in the context of relevant NK cell platforms that are being developed and optimized by various biotech industries with a special focus on augmenting NK cell functions.
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title_short	The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments
url	https://doi.org/10.3389/fimmu.2017.00631 https://doaj.org/article/64f543aec174413db67dc06b1cfe3add http://journal.frontiersin.org/article/10.3389/fimmu.2017.00631/full https://doaj.org/toc/1664-3224
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