The clinical spectrum of frontotemporal dementia
Objectives: Frontotemporal dementia (FTD) is the second most common form of degenerative dementia in early onset dementia (EOD) patients. The core disorders in the FTD spectrum are: behavioral variant of FTD (FTDbv) with predominant early changes in behavior (such are disinhibition, apathy, loss of...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mandić-Stojmenović Gorana [verfasserIn] Kostić Vladimir [verfasserIn] Stefanova Elka [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch ; srp |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Medicinski Podmladak - University of Belgrade, Medical Faculty, 2017, 69(2018), 2, Seite 9-15 |
|---|---|
| Übergeordnetes Werk: |
volume:69 ; year:2018 ; number:2 ; pages:9-15 |
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| 520 | |a Objectives: Frontotemporal dementia (FTD) is the second most common form of degenerative dementia in early onset dementia (EOD) patients. The core disorders in the FTD spectrum are: behavioral variant of FTD (FTDbv) with predominant early changes in behavior (such are disinhibition, apathy, loss of empathy, compulsive behaviour..); and language variants - primary progressive aphasias (PPA) where language is the primary impairment (difficulties in speech, understanding, repetition..). Patients with sporadic, as well as genetic forms of FTD, can develop motor symptoms of motor neuron disease (before, after or at the same time with cognitive/behavioural features) or atypical parkinsonism-progressive supranuclear palsy or corticobasal syndrome, which are all part of the clinical FTD spectrum. The FTD is still poorly recognised entity and the heterogeneity of clinical presentations, early onset (most frequently before the age of 65), as well as overlap of early FTDbv symptoms and psychiatric diseases, often results in wrong diagnosis and presents a challenge, even in tertiary referral centres. It has been shown that delay in correct dementia diagnosis contributes to the caregiver's and patient's distress. The early and precise diagnosis is important for consideration of prognosis and course of the disease with family members; possibilities of improving patient's quality of life by giving them adequate symptomatic therapy; guiding the genetic analysis which is especially important for family members who also could be in risk of carring or passing the mutation to their offspring. Aim: In this mini review paper we tried to point out the specificity of clinical manifestation in the FTD spectrum, which could be helpful in making the early and accurate diagnosis among the variety of EOD cases. Conclusion: Early and accurate FTD diagnosis is important for the insight of the disease course, giving adequate symptomatic therapy and guiding the genetic analysis which reduces the caregiver's and patient's distress. | ||
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(DE-627)DOAJ007527217 (DE-599)DOAJ5271e8cb060047ba880bc469b632660b DE-627 ger DE-627 rakwb eng srp Mandić-Stojmenović Gorana verfasserin aut The clinical spectrum of frontotemporal dementia 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Frontotemporal dementia (FTD) is the second most common form of degenerative dementia in early onset dementia (EOD) patients. The core disorders in the FTD spectrum are: behavioral variant of FTD (FTDbv) with predominant early changes in behavior (such are disinhibition, apathy, loss of empathy, compulsive behaviour..); and language variants - primary progressive aphasias (PPA) where language is the primary impairment (difficulties in speech, understanding, repetition..). Patients with sporadic, as well as genetic forms of FTD, can develop motor symptoms of motor neuron disease (before, after or at the same time with cognitive/behavioural features) or atypical parkinsonism-progressive supranuclear palsy or corticobasal syndrome, which are all part of the clinical FTD spectrum. The FTD is still poorly recognised entity and the heterogeneity of clinical presentations, early onset (most frequently before the age of 65), as well as overlap of early FTDbv symptoms and psychiatric diseases, often results in wrong diagnosis and presents a challenge, even in tertiary referral centres. It has been shown that delay in correct dementia diagnosis contributes to the caregiver's and patient's distress. The early and precise diagnosis is important for consideration of prognosis and course of the disease with family members; possibilities of improving patient's quality of life by giving them adequate symptomatic therapy; guiding the genetic analysis which is especially important for family members who also could be in risk of carring or passing the mutation to their offspring. Aim: In this mini review paper we tried to point out the specificity of clinical manifestation in the FTD spectrum, which could be helpful in making the early and accurate diagnosis among the variety of EOD cases. Conclusion: Early and accurate FTD diagnosis is important for the insight of the disease course, giving adequate symptomatic therapy and guiding the genetic analysis which reduces the caregiver's and patient's distress. spectrum of frontotemporal dementia (FTD) clinical features behavioural variant of FTD primary progressive aphasias Medicine R Kostić Vladimir verfasserin aut Stefanova Elka verfasserin aut In Medicinski Podmladak University of Belgrade, Medical Faculty, 2017 69(2018), 2, Seite 9-15 (DE-627)1760607606 24665525 nnns volume:69 year:2018 number:2 pages:9-15 https://doaj.org/article/5271e8cb060047ba880bc469b632660b kostenfrei https://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2018/0369-15271802009M.pdf kostenfrei https://doaj.org/toc/0369-1527 Journal toc kostenfrei https://doaj.org/toc/2466-5525 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 69 2018 2 9-15 |
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(DE-627)DOAJ007527217 (DE-599)DOAJ5271e8cb060047ba880bc469b632660b DE-627 ger DE-627 rakwb eng srp Mandić-Stojmenović Gorana verfasserin aut The clinical spectrum of frontotemporal dementia 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Frontotemporal dementia (FTD) is the second most common form of degenerative dementia in early onset dementia (EOD) patients. The core disorders in the FTD spectrum are: behavioral variant of FTD (FTDbv) with predominant early changes in behavior (such are disinhibition, apathy, loss of empathy, compulsive behaviour..); and language variants - primary progressive aphasias (PPA) where language is the primary impairment (difficulties in speech, understanding, repetition..). Patients with sporadic, as well as genetic forms of FTD, can develop motor symptoms of motor neuron disease (before, after or at the same time with cognitive/behavioural features) or atypical parkinsonism-progressive supranuclear palsy or corticobasal syndrome, which are all part of the clinical FTD spectrum. The FTD is still poorly recognised entity and the heterogeneity of clinical presentations, early onset (most frequently before the age of 65), as well as overlap of early FTDbv symptoms and psychiatric diseases, often results in wrong diagnosis and presents a challenge, even in tertiary referral centres. It has been shown that delay in correct dementia diagnosis contributes to the caregiver's and patient's distress. The early and precise diagnosis is important for consideration of prognosis and course of the disease with family members; possibilities of improving patient's quality of life by giving them adequate symptomatic therapy; guiding the genetic analysis which is especially important for family members who also could be in risk of carring or passing the mutation to their offspring. Aim: In this mini review paper we tried to point out the specificity of clinical manifestation in the FTD spectrum, which could be helpful in making the early and accurate diagnosis among the variety of EOD cases. Conclusion: Early and accurate FTD diagnosis is important for the insight of the disease course, giving adequate symptomatic therapy and guiding the genetic analysis which reduces the caregiver's and patient's distress. spectrum of frontotemporal dementia (FTD) clinical features behavioural variant of FTD primary progressive aphasias Medicine R Kostić Vladimir verfasserin aut Stefanova Elka verfasserin aut In Medicinski Podmladak University of Belgrade, Medical Faculty, 2017 69(2018), 2, Seite 9-15 (DE-627)1760607606 24665525 nnns volume:69 year:2018 number:2 pages:9-15 https://doaj.org/article/5271e8cb060047ba880bc469b632660b kostenfrei https://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2018/0369-15271802009M.pdf kostenfrei https://doaj.org/toc/0369-1527 Journal toc kostenfrei https://doaj.org/toc/2466-5525 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 69 2018 2 9-15 |
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(DE-627)DOAJ007527217 (DE-599)DOAJ5271e8cb060047ba880bc469b632660b DE-627 ger DE-627 rakwb eng srp Mandić-Stojmenović Gorana verfasserin aut The clinical spectrum of frontotemporal dementia 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives: Frontotemporal dementia (FTD) is the second most common form of degenerative dementia in early onset dementia (EOD) patients. The core disorders in the FTD spectrum are: behavioral variant of FTD (FTDbv) with predominant early changes in behavior (such are disinhibition, apathy, loss of empathy, compulsive behaviour..); and language variants - primary progressive aphasias (PPA) where language is the primary impairment (difficulties in speech, understanding, repetition..). Patients with sporadic, as well as genetic forms of FTD, can develop motor symptoms of motor neuron disease (before, after or at the same time with cognitive/behavioural features) or atypical parkinsonism-progressive supranuclear palsy or corticobasal syndrome, which are all part of the clinical FTD spectrum. The FTD is still poorly recognised entity and the heterogeneity of clinical presentations, early onset (most frequently before the age of 65), as well as overlap of early FTDbv symptoms and psychiatric diseases, often results in wrong diagnosis and presents a challenge, even in tertiary referral centres. It has been shown that delay in correct dementia diagnosis contributes to the caregiver's and patient's distress. The early and precise diagnosis is important for consideration of prognosis and course of the disease with family members; possibilities of improving patient's quality of life by giving them adequate symptomatic therapy; guiding the genetic analysis which is especially important for family members who also could be in risk of carring or passing the mutation to their offspring. Aim: In this mini review paper we tried to point out the specificity of clinical manifestation in the FTD spectrum, which could be helpful in making the early and accurate diagnosis among the variety of EOD cases. Conclusion: Early and accurate FTD diagnosis is important for the insight of the disease course, giving adequate symptomatic therapy and guiding the genetic analysis which reduces the caregiver's and patient's distress. spectrum of frontotemporal dementia (FTD) clinical features behavioural variant of FTD primary progressive aphasias Medicine R Kostić Vladimir verfasserin aut Stefanova Elka verfasserin aut In Medicinski Podmladak University of Belgrade, Medical Faculty, 2017 69(2018), 2, Seite 9-15 (DE-627)1760607606 24665525 nnns volume:69 year:2018 number:2 pages:9-15 https://doaj.org/article/5271e8cb060047ba880bc469b632660b kostenfrei https://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2018/0369-15271802009M.pdf kostenfrei https://doaj.org/toc/0369-1527 Journal toc kostenfrei https://doaj.org/toc/2466-5525 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 69 2018 2 9-15 |
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The clinical spectrum of frontotemporal dementia |
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The clinical spectrum of frontotemporal dementia |
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Mandić-Stojmenović Gorana |
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Mandić-Stojmenović Gorana Kostić Vladimir Stefanova Elka |
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clinical spectrum of frontotemporal dementia |
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The clinical spectrum of frontotemporal dementia |
| abstract |
Objectives: Frontotemporal dementia (FTD) is the second most common form of degenerative dementia in early onset dementia (EOD) patients. The core disorders in the FTD spectrum are: behavioral variant of FTD (FTDbv) with predominant early changes in behavior (such are disinhibition, apathy, loss of empathy, compulsive behaviour..); and language variants - primary progressive aphasias (PPA) where language is the primary impairment (difficulties in speech, understanding, repetition..). Patients with sporadic, as well as genetic forms of FTD, can develop motor symptoms of motor neuron disease (before, after or at the same time with cognitive/behavioural features) or atypical parkinsonism-progressive supranuclear palsy or corticobasal syndrome, which are all part of the clinical FTD spectrum. The FTD is still poorly recognised entity and the heterogeneity of clinical presentations, early onset (most frequently before the age of 65), as well as overlap of early FTDbv symptoms and psychiatric diseases, often results in wrong diagnosis and presents a challenge, even in tertiary referral centres. It has been shown that delay in correct dementia diagnosis contributes to the caregiver's and patient's distress. The early and precise diagnosis is important for consideration of prognosis and course of the disease with family members; possibilities of improving patient's quality of life by giving them adequate symptomatic therapy; guiding the genetic analysis which is especially important for family members who also could be in risk of carring or passing the mutation to their offspring. Aim: In this mini review paper we tried to point out the specificity of clinical manifestation in the FTD spectrum, which could be helpful in making the early and accurate diagnosis among the variety of EOD cases. Conclusion: Early and accurate FTD diagnosis is important for the insight of the disease course, giving adequate symptomatic therapy and guiding the genetic analysis which reduces the caregiver's and patient's distress. |
| abstractGer |
Objectives: Frontotemporal dementia (FTD) is the second most common form of degenerative dementia in early onset dementia (EOD) patients. The core disorders in the FTD spectrum are: behavioral variant of FTD (FTDbv) with predominant early changes in behavior (such are disinhibition, apathy, loss of empathy, compulsive behaviour..); and language variants - primary progressive aphasias (PPA) where language is the primary impairment (difficulties in speech, understanding, repetition..). Patients with sporadic, as well as genetic forms of FTD, can develop motor symptoms of motor neuron disease (before, after or at the same time with cognitive/behavioural features) or atypical parkinsonism-progressive supranuclear palsy or corticobasal syndrome, which are all part of the clinical FTD spectrum. The FTD is still poorly recognised entity and the heterogeneity of clinical presentations, early onset (most frequently before the age of 65), as well as overlap of early FTDbv symptoms and psychiatric diseases, often results in wrong diagnosis and presents a challenge, even in tertiary referral centres. It has been shown that delay in correct dementia diagnosis contributes to the caregiver's and patient's distress. The early and precise diagnosis is important for consideration of prognosis and course of the disease with family members; possibilities of improving patient's quality of life by giving them adequate symptomatic therapy; guiding the genetic analysis which is especially important for family members who also could be in risk of carring or passing the mutation to their offspring. Aim: In this mini review paper we tried to point out the specificity of clinical manifestation in the FTD spectrum, which could be helpful in making the early and accurate diagnosis among the variety of EOD cases. Conclusion: Early and accurate FTD diagnosis is important for the insight of the disease course, giving adequate symptomatic therapy and guiding the genetic analysis which reduces the caregiver's and patient's distress. |
| abstract_unstemmed |
Objectives: Frontotemporal dementia (FTD) is the second most common form of degenerative dementia in early onset dementia (EOD) patients. The core disorders in the FTD spectrum are: behavioral variant of FTD (FTDbv) with predominant early changes in behavior (such are disinhibition, apathy, loss of empathy, compulsive behaviour..); and language variants - primary progressive aphasias (PPA) where language is the primary impairment (difficulties in speech, understanding, repetition..). Patients with sporadic, as well as genetic forms of FTD, can develop motor symptoms of motor neuron disease (before, after or at the same time with cognitive/behavioural features) or atypical parkinsonism-progressive supranuclear palsy or corticobasal syndrome, which are all part of the clinical FTD spectrum. The FTD is still poorly recognised entity and the heterogeneity of clinical presentations, early onset (most frequently before the age of 65), as well as overlap of early FTDbv symptoms and psychiatric diseases, often results in wrong diagnosis and presents a challenge, even in tertiary referral centres. It has been shown that delay in correct dementia diagnosis contributes to the caregiver's and patient's distress. The early and precise diagnosis is important for consideration of prognosis and course of the disease with family members; possibilities of improving patient's quality of life by giving them adequate symptomatic therapy; guiding the genetic analysis which is especially important for family members who also could be in risk of carring or passing the mutation to their offspring. Aim: In this mini review paper we tried to point out the specificity of clinical manifestation in the FTD spectrum, which could be helpful in making the early and accurate diagnosis among the variety of EOD cases. Conclusion: Early and accurate FTD diagnosis is important for the insight of the disease course, giving adequate symptomatic therapy and guiding the genetic analysis which reduces the caregiver's and patient's distress. |
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The clinical spectrum of frontotemporal dementia |
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https://doaj.org/article/5271e8cb060047ba880bc469b632660b https://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2018/0369-15271802009M.pdf https://doaj.org/toc/0369-1527 https://doaj.org/toc/2466-5525 |
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Kostić Vladimir Stefanova Elka |
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