Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD
Studies evaluating neuroimaging, genetically predicted gene expression, and pre-clinical genetic models of PTSD, have identified PTSD-related abnormalities in the prefrontal cortex (PFC) of the brain, particularly in dorsolateral and ventromedial PFC (dlPFC and vmPFC). In this study, RNA sequencing...
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| Autor*in: |
Mark W. Logue [verfasserIn] Zhenwei Zhou [verfasserIn] Filomene G. Morrison [verfasserIn] Erika J. Wolf [verfasserIn] Nikolaos P. Daskalakis [verfasserIn] Christos Chatzinakos [verfasserIn] Foivos Georgiadis [verfasserIn] Adam T. Labadorf [verfasserIn] Matthew J. Girgenti [verfasserIn] Keith A. Young [verfasserIn] Douglas E. Williamson [verfasserIn] Xiang Zhao [verfasserIn] Jaclyn Garza Grenier [verfasserIn] Bertrand Russell Huber [verfasserIn] Mark W. Miller [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Neurobiology of Stress - Elsevier, 2016, 15(2021), Seite 100398- |
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| Übergeordnetes Werk: |
volume:15 ; year:2021 ; pages:100398- |
| Links: |
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| DOI / URN: |
10.1016/j.ynstr.2021.100398 |
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| Katalog-ID: |
DOAJ007573715 |
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| 245 | 1 | 0 | |a Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD |
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| 520 | |a Studies evaluating neuroimaging, genetically predicted gene expression, and pre-clinical genetic models of PTSD, have identified PTSD-related abnormalities in the prefrontal cortex (PFC) of the brain, particularly in dorsolateral and ventromedial PFC (dlPFC and vmPFC). In this study, RNA sequencing was used to examine gene expression in the dlPFC and vmPFC using tissue from the VA National PTSD Brain Bank in donors with histories of PTSD with or without depression (dlPFC n = 38, vmPFC n = 35), depression cases without PTSD (n = 32), and psychopathology-free controls (dlPFC n = 24, vmPFC n = 20). Analyses compared PTSD cases to controls. Follow-up analyses contrasted depression cases to controls. Twenty-one genes were differentially expressed in PTSD after strict multiple testing correction. PTSD-associated genes with roles in learning and memory (FOS, NR4A1), immune regulation (CFH, KPNA1) and myelination (MBP, MOBP, ERMN) were identified. PTSD-associated genes partially overlapped depression-associated genes. Co-expression network analyses identified PTSD-associated networks enriched for immune-related genes across the two brain regions. However, the immune-related genes and association patterns were distinct. The immune gene IL1B was significantly associated with PTSD in candidate-gene analysis and was an upstream regulator of PTSD-associated genes in both regions. There was evidence of replication of dlPFC associations in an independent cohort from a recent study, and a strong correlation between the dlPFC PTSD effect sizes for significant genes in the two studies (r = 0.66, p < 2.2 × 10−16). In conclusion, this study identified several novel PTSD-associated genes and brain region specific PTSD-associated immune-related networks. | ||
| 650 | 4 | |a PTSD | |
| 650 | 4 | |a RNAseq | |
| 650 | 4 | |a vmPFC | |
| 650 | 4 | |a dlPFC | |
| 650 | 4 | |a Expression | |
| 653 | 0 | |a Neurosciences. Biological psychiatry. Neuropsychiatry | |
| 653 | 0 | |a Neurology. Diseases of the nervous system | |
| 653 | 0 | |a Neurophysiology and neuropsychology | |
| 700 | 0 | |a Zhenwei Zhou |e verfasserin |4 aut | |
| 700 | 0 | |a Filomene G. Morrison |e verfasserin |4 aut | |
| 700 | 0 | |a Erika J. Wolf |e verfasserin |4 aut | |
| 700 | 0 | |a Nikolaos P. Daskalakis |e verfasserin |4 aut | |
| 700 | 0 | |a Christos Chatzinakos |e verfasserin |4 aut | |
| 700 | 0 | |a Foivos Georgiadis |e verfasserin |4 aut | |
| 700 | 0 | |a Adam T. Labadorf |e verfasserin |4 aut | |
| 700 | 0 | |a Matthew J. Girgenti |e verfasserin |4 aut | |
| 700 | 0 | |a Keith A. Young |e verfasserin |4 aut | |
| 700 | 0 | |a Douglas E. Williamson |e verfasserin |4 aut | |
| 700 | 0 | |a Xiang Zhao |e verfasserin |4 aut | |
| 700 | 0 | |a Jaclyn Garza Grenier |e verfasserin |4 aut | |
| 700 | 0 | |a Bertrand Russell Huber |e verfasserin |4 aut | |
| 700 | 0 | |a Mark W. Miller |e verfasserin |4 aut | |
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10.1016/j.ynstr.2021.100398 doi (DE-627)DOAJ007573715 (DE-599)DOAJ9f856b09473743389bf2d11aa5c352d5 DE-627 ger DE-627 rakwb eng RC321-571 RC346-429 QP351-495 Mark W. Logue verfasserin aut Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Studies evaluating neuroimaging, genetically predicted gene expression, and pre-clinical genetic models of PTSD, have identified PTSD-related abnormalities in the prefrontal cortex (PFC) of the brain, particularly in dorsolateral and ventromedial PFC (dlPFC and vmPFC). In this study, RNA sequencing was used to examine gene expression in the dlPFC and vmPFC using tissue from the VA National PTSD Brain Bank in donors with histories of PTSD with or without depression (dlPFC n = 38, vmPFC n = 35), depression cases without PTSD (n = 32), and psychopathology-free controls (dlPFC n = 24, vmPFC n = 20). Analyses compared PTSD cases to controls. Follow-up analyses contrasted depression cases to controls. Twenty-one genes were differentially expressed in PTSD after strict multiple testing correction. PTSD-associated genes with roles in learning and memory (FOS, NR4A1), immune regulation (CFH, KPNA1) and myelination (MBP, MOBP, ERMN) were identified. PTSD-associated genes partially overlapped depression-associated genes. Co-expression network analyses identified PTSD-associated networks enriched for immune-related genes across the two brain regions. However, the immune-related genes and association patterns were distinct. The immune gene IL1B was significantly associated with PTSD in candidate-gene analysis and was an upstream regulator of PTSD-associated genes in both regions. There was evidence of replication of dlPFC associations in an independent cohort from a recent study, and a strong correlation between the dlPFC PTSD effect sizes for significant genes in the two studies (r = 0.66, p < 2.2 × 10−16). In conclusion, this study identified several novel PTSD-associated genes and brain region specific PTSD-associated immune-related networks. PTSD RNAseq vmPFC dlPFC Expression Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system Neurophysiology and neuropsychology Zhenwei Zhou verfasserin aut Filomene G. Morrison verfasserin aut Erika J. Wolf verfasserin aut Nikolaos P. Daskalakis verfasserin aut Christos Chatzinakos verfasserin aut Foivos Georgiadis verfasserin aut Adam T. Labadorf verfasserin aut Matthew J. Girgenti verfasserin aut Keith A. Young verfasserin aut Douglas E. Williamson verfasserin aut Xiang Zhao verfasserin aut Jaclyn Garza Grenier verfasserin aut Bertrand Russell Huber verfasserin aut Mark W. Miller verfasserin aut In Neurobiology of Stress Elsevier, 2016 15(2021), Seite 100398- (DE-627)821524038 (DE-600)2816500-7 23522895 nnns volume:15 year:2021 pages:100398- https://doi.org/10.1016/j.ynstr.2021.100398 kostenfrei https://doaj.org/article/9f856b09473743389bf2d11aa5c352d5 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352289521001065 kostenfrei https://doaj.org/toc/2352-2895 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 15 2021 100398- |
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10.1016/j.ynstr.2021.100398 doi (DE-627)DOAJ007573715 (DE-599)DOAJ9f856b09473743389bf2d11aa5c352d5 DE-627 ger DE-627 rakwb eng RC321-571 RC346-429 QP351-495 Mark W. Logue verfasserin aut Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Studies evaluating neuroimaging, genetically predicted gene expression, and pre-clinical genetic models of PTSD, have identified PTSD-related abnormalities in the prefrontal cortex (PFC) of the brain, particularly in dorsolateral and ventromedial PFC (dlPFC and vmPFC). In this study, RNA sequencing was used to examine gene expression in the dlPFC and vmPFC using tissue from the VA National PTSD Brain Bank in donors with histories of PTSD with or without depression (dlPFC n = 38, vmPFC n = 35), depression cases without PTSD (n = 32), and psychopathology-free controls (dlPFC n = 24, vmPFC n = 20). Analyses compared PTSD cases to controls. Follow-up analyses contrasted depression cases to controls. Twenty-one genes were differentially expressed in PTSD after strict multiple testing correction. PTSD-associated genes with roles in learning and memory (FOS, NR4A1), immune regulation (CFH, KPNA1) and myelination (MBP, MOBP, ERMN) were identified. PTSD-associated genes partially overlapped depression-associated genes. Co-expression network analyses identified PTSD-associated networks enriched for immune-related genes across the two brain regions. However, the immune-related genes and association patterns were distinct. The immune gene IL1B was significantly associated with PTSD in candidate-gene analysis and was an upstream regulator of PTSD-associated genes in both regions. There was evidence of replication of dlPFC associations in an independent cohort from a recent study, and a strong correlation between the dlPFC PTSD effect sizes for significant genes in the two studies (r = 0.66, p < 2.2 × 10−16). In conclusion, this study identified several novel PTSD-associated genes and brain region specific PTSD-associated immune-related networks. PTSD RNAseq vmPFC dlPFC Expression Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system Neurophysiology and neuropsychology Zhenwei Zhou verfasserin aut Filomene G. Morrison verfasserin aut Erika J. Wolf verfasserin aut Nikolaos P. Daskalakis verfasserin aut Christos Chatzinakos verfasserin aut Foivos Georgiadis verfasserin aut Adam T. Labadorf verfasserin aut Matthew J. Girgenti verfasserin aut Keith A. Young verfasserin aut Douglas E. Williamson verfasserin aut Xiang Zhao verfasserin aut Jaclyn Garza Grenier verfasserin aut Bertrand Russell Huber verfasserin aut Mark W. Miller verfasserin aut In Neurobiology of Stress Elsevier, 2016 15(2021), Seite 100398- (DE-627)821524038 (DE-600)2816500-7 23522895 nnns volume:15 year:2021 pages:100398- https://doi.org/10.1016/j.ynstr.2021.100398 kostenfrei https://doaj.org/article/9f856b09473743389bf2d11aa5c352d5 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352289521001065 kostenfrei https://doaj.org/toc/2352-2895 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 15 2021 100398- |
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10.1016/j.ynstr.2021.100398 doi (DE-627)DOAJ007573715 (DE-599)DOAJ9f856b09473743389bf2d11aa5c352d5 DE-627 ger DE-627 rakwb eng RC321-571 RC346-429 QP351-495 Mark W. Logue verfasserin aut Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Studies evaluating neuroimaging, genetically predicted gene expression, and pre-clinical genetic models of PTSD, have identified PTSD-related abnormalities in the prefrontal cortex (PFC) of the brain, particularly in dorsolateral and ventromedial PFC (dlPFC and vmPFC). In this study, RNA sequencing was used to examine gene expression in the dlPFC and vmPFC using tissue from the VA National PTSD Brain Bank in donors with histories of PTSD with or without depression (dlPFC n = 38, vmPFC n = 35), depression cases without PTSD (n = 32), and psychopathology-free controls (dlPFC n = 24, vmPFC n = 20). Analyses compared PTSD cases to controls. Follow-up analyses contrasted depression cases to controls. Twenty-one genes were differentially expressed in PTSD after strict multiple testing correction. PTSD-associated genes with roles in learning and memory (FOS, NR4A1), immune regulation (CFH, KPNA1) and myelination (MBP, MOBP, ERMN) were identified. PTSD-associated genes partially overlapped depression-associated genes. Co-expression network analyses identified PTSD-associated networks enriched for immune-related genes across the two brain regions. However, the immune-related genes and association patterns were distinct. The immune gene IL1B was significantly associated with PTSD in candidate-gene analysis and was an upstream regulator of PTSD-associated genes in both regions. There was evidence of replication of dlPFC associations in an independent cohort from a recent study, and a strong correlation between the dlPFC PTSD effect sizes for significant genes in the two studies (r = 0.66, p < 2.2 × 10−16). In conclusion, this study identified several novel PTSD-associated genes and brain region specific PTSD-associated immune-related networks. PTSD RNAseq vmPFC dlPFC Expression Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system Neurophysiology and neuropsychology Zhenwei Zhou verfasserin aut Filomene G. Morrison verfasserin aut Erika J. Wolf verfasserin aut Nikolaos P. Daskalakis verfasserin aut Christos Chatzinakos verfasserin aut Foivos Georgiadis verfasserin aut Adam T. Labadorf verfasserin aut Matthew J. Girgenti verfasserin aut Keith A. Young verfasserin aut Douglas E. Williamson verfasserin aut Xiang Zhao verfasserin aut Jaclyn Garza Grenier verfasserin aut Bertrand Russell Huber verfasserin aut Mark W. Miller verfasserin aut In Neurobiology of Stress Elsevier, 2016 15(2021), Seite 100398- (DE-627)821524038 (DE-600)2816500-7 23522895 nnns volume:15 year:2021 pages:100398- https://doi.org/10.1016/j.ynstr.2021.100398 kostenfrei https://doaj.org/article/9f856b09473743389bf2d11aa5c352d5 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352289521001065 kostenfrei https://doaj.org/toc/2352-2895 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 15 2021 100398- |
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10.1016/j.ynstr.2021.100398 doi (DE-627)DOAJ007573715 (DE-599)DOAJ9f856b09473743389bf2d11aa5c352d5 DE-627 ger DE-627 rakwb eng RC321-571 RC346-429 QP351-495 Mark W. Logue verfasserin aut Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Studies evaluating neuroimaging, genetically predicted gene expression, and pre-clinical genetic models of PTSD, have identified PTSD-related abnormalities in the prefrontal cortex (PFC) of the brain, particularly in dorsolateral and ventromedial PFC (dlPFC and vmPFC). In this study, RNA sequencing was used to examine gene expression in the dlPFC and vmPFC using tissue from the VA National PTSD Brain Bank in donors with histories of PTSD with or without depression (dlPFC n = 38, vmPFC n = 35), depression cases without PTSD (n = 32), and psychopathology-free controls (dlPFC n = 24, vmPFC n = 20). Analyses compared PTSD cases to controls. Follow-up analyses contrasted depression cases to controls. Twenty-one genes were differentially expressed in PTSD after strict multiple testing correction. PTSD-associated genes with roles in learning and memory (FOS, NR4A1), immune regulation (CFH, KPNA1) and myelination (MBP, MOBP, ERMN) were identified. PTSD-associated genes partially overlapped depression-associated genes. Co-expression network analyses identified PTSD-associated networks enriched for immune-related genes across the two brain regions. However, the immune-related genes and association patterns were distinct. The immune gene IL1B was significantly associated with PTSD in candidate-gene analysis and was an upstream regulator of PTSD-associated genes in both regions. There was evidence of replication of dlPFC associations in an independent cohort from a recent study, and a strong correlation between the dlPFC PTSD effect sizes for significant genes in the two studies (r = 0.66, p < 2.2 × 10−16). In conclusion, this study identified several novel PTSD-associated genes and brain region specific PTSD-associated immune-related networks. PTSD RNAseq vmPFC dlPFC Expression Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system Neurophysiology and neuropsychology Zhenwei Zhou verfasserin aut Filomene G. Morrison verfasserin aut Erika J. Wolf verfasserin aut Nikolaos P. Daskalakis verfasserin aut Christos Chatzinakos verfasserin aut Foivos Georgiadis verfasserin aut Adam T. Labadorf verfasserin aut Matthew J. Girgenti verfasserin aut Keith A. Young verfasserin aut Douglas E. Williamson verfasserin aut Xiang Zhao verfasserin aut Jaclyn Garza Grenier verfasserin aut Bertrand Russell Huber verfasserin aut Mark W. Miller verfasserin aut In Neurobiology of Stress Elsevier, 2016 15(2021), Seite 100398- (DE-627)821524038 (DE-600)2816500-7 23522895 nnns volume:15 year:2021 pages:100398- https://doi.org/10.1016/j.ynstr.2021.100398 kostenfrei https://doaj.org/article/9f856b09473743389bf2d11aa5c352d5 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352289521001065 kostenfrei https://doaj.org/toc/2352-2895 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 15 2021 100398- |
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10.1016/j.ynstr.2021.100398 doi (DE-627)DOAJ007573715 (DE-599)DOAJ9f856b09473743389bf2d11aa5c352d5 DE-627 ger DE-627 rakwb eng RC321-571 RC346-429 QP351-495 Mark W. Logue verfasserin aut Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Studies evaluating neuroimaging, genetically predicted gene expression, and pre-clinical genetic models of PTSD, have identified PTSD-related abnormalities in the prefrontal cortex (PFC) of the brain, particularly in dorsolateral and ventromedial PFC (dlPFC and vmPFC). In this study, RNA sequencing was used to examine gene expression in the dlPFC and vmPFC using tissue from the VA National PTSD Brain Bank in donors with histories of PTSD with or without depression (dlPFC n = 38, vmPFC n = 35), depression cases without PTSD (n = 32), and psychopathology-free controls (dlPFC n = 24, vmPFC n = 20). Analyses compared PTSD cases to controls. Follow-up analyses contrasted depression cases to controls. Twenty-one genes were differentially expressed in PTSD after strict multiple testing correction. PTSD-associated genes with roles in learning and memory (FOS, NR4A1), immune regulation (CFH, KPNA1) and myelination (MBP, MOBP, ERMN) were identified. PTSD-associated genes partially overlapped depression-associated genes. Co-expression network analyses identified PTSD-associated networks enriched for immune-related genes across the two brain regions. However, the immune-related genes and association patterns were distinct. The immune gene IL1B was significantly associated with PTSD in candidate-gene analysis and was an upstream regulator of PTSD-associated genes in both regions. There was evidence of replication of dlPFC associations in an independent cohort from a recent study, and a strong correlation between the dlPFC PTSD effect sizes for significant genes in the two studies (r = 0.66, p < 2.2 × 10−16). In conclusion, this study identified several novel PTSD-associated genes and brain region specific PTSD-associated immune-related networks. PTSD RNAseq vmPFC dlPFC Expression Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system Neurophysiology and neuropsychology Zhenwei Zhou verfasserin aut Filomene G. Morrison verfasserin aut Erika J. Wolf verfasserin aut Nikolaos P. Daskalakis verfasserin aut Christos Chatzinakos verfasserin aut Foivos Georgiadis verfasserin aut Adam T. Labadorf verfasserin aut Matthew J. Girgenti verfasserin aut Keith A. Young verfasserin aut Douglas E. Williamson verfasserin aut Xiang Zhao verfasserin aut Jaclyn Garza Grenier verfasserin aut Bertrand Russell Huber verfasserin aut Mark W. Miller verfasserin aut In Neurobiology of Stress Elsevier, 2016 15(2021), Seite 100398- (DE-627)821524038 (DE-600)2816500-7 23522895 nnns volume:15 year:2021 pages:100398- https://doi.org/10.1016/j.ynstr.2021.100398 kostenfrei https://doaj.org/article/9f856b09473743389bf2d11aa5c352d5 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352289521001065 kostenfrei https://doaj.org/toc/2352-2895 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 15 2021 100398- |
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Mark W. Logue @@aut@@ Zhenwei Zhou @@aut@@ Filomene G. Morrison @@aut@@ Erika J. Wolf @@aut@@ Nikolaos P. Daskalakis @@aut@@ Christos Chatzinakos @@aut@@ Foivos Georgiadis @@aut@@ Adam T. Labadorf @@aut@@ Matthew J. Girgenti @@aut@@ Keith A. Young @@aut@@ Douglas E. Williamson @@aut@@ Xiang Zhao @@aut@@ Jaclyn Garza Grenier @@aut@@ Bertrand Russell Huber @@aut@@ Mark W. Miller @@aut@@ |
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In this study, RNA sequencing was used to examine gene expression in the dlPFC and vmPFC using tissue from the VA National PTSD Brain Bank in donors with histories of PTSD with or without depression (dlPFC n = 38, vmPFC n = 35), depression cases without PTSD (n = 32), and psychopathology-free controls (dlPFC n = 24, vmPFC n = 20). Analyses compared PTSD cases to controls. Follow-up analyses contrasted depression cases to controls. Twenty-one genes were differentially expressed in PTSD after strict multiple testing correction. PTSD-associated genes with roles in learning and memory (FOS, NR4A1), immune regulation (CFH, KPNA1) and myelination (MBP, MOBP, ERMN) were identified. PTSD-associated genes partially overlapped depression-associated genes. Co-expression network analyses identified PTSD-associated networks enriched for immune-related genes across the two brain regions. However, the immune-related genes and association patterns were distinct. 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Mark W. Logue |
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Mark W. Logue misc RC321-571 misc RC346-429 misc QP351-495 misc PTSD misc RNAseq misc vmPFC misc dlPFC misc Expression misc Neurosciences. Biological psychiatry. Neuropsychiatry misc Neurology. Diseases of the nervous system misc Neurophysiology and neuropsychology Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD |
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RC321-571 RC346-429 QP351-495 Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD PTSD RNAseq vmPFC dlPFC Expression |
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Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD |
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Mark W. Logue Zhenwei Zhou Filomene G. Morrison Erika J. Wolf Nikolaos P. Daskalakis Christos Chatzinakos Foivos Georgiadis Adam T. Labadorf Matthew J. Girgenti Keith A. Young Douglas E. Williamson Xiang Zhao Jaclyn Garza Grenier Bertrand Russell Huber Mark W. Miller |
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gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in ptsd |
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Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD |
| abstract |
Studies evaluating neuroimaging, genetically predicted gene expression, and pre-clinical genetic models of PTSD, have identified PTSD-related abnormalities in the prefrontal cortex (PFC) of the brain, particularly in dorsolateral and ventromedial PFC (dlPFC and vmPFC). In this study, RNA sequencing was used to examine gene expression in the dlPFC and vmPFC using tissue from the VA National PTSD Brain Bank in donors with histories of PTSD with or without depression (dlPFC n = 38, vmPFC n = 35), depression cases without PTSD (n = 32), and psychopathology-free controls (dlPFC n = 24, vmPFC n = 20). Analyses compared PTSD cases to controls. Follow-up analyses contrasted depression cases to controls. Twenty-one genes were differentially expressed in PTSD after strict multiple testing correction. PTSD-associated genes with roles in learning and memory (FOS, NR4A1), immune regulation (CFH, KPNA1) and myelination (MBP, MOBP, ERMN) were identified. PTSD-associated genes partially overlapped depression-associated genes. Co-expression network analyses identified PTSD-associated networks enriched for immune-related genes across the two brain regions. However, the immune-related genes and association patterns were distinct. The immune gene IL1B was significantly associated with PTSD in candidate-gene analysis and was an upstream regulator of PTSD-associated genes in both regions. There was evidence of replication of dlPFC associations in an independent cohort from a recent study, and a strong correlation between the dlPFC PTSD effect sizes for significant genes in the two studies (r = 0.66, p < 2.2 × 10−16). In conclusion, this study identified several novel PTSD-associated genes and brain region specific PTSD-associated immune-related networks. |
| abstractGer |
Studies evaluating neuroimaging, genetically predicted gene expression, and pre-clinical genetic models of PTSD, have identified PTSD-related abnormalities in the prefrontal cortex (PFC) of the brain, particularly in dorsolateral and ventromedial PFC (dlPFC and vmPFC). In this study, RNA sequencing was used to examine gene expression in the dlPFC and vmPFC using tissue from the VA National PTSD Brain Bank in donors with histories of PTSD with or without depression (dlPFC n = 38, vmPFC n = 35), depression cases without PTSD (n = 32), and psychopathology-free controls (dlPFC n = 24, vmPFC n = 20). Analyses compared PTSD cases to controls. Follow-up analyses contrasted depression cases to controls. Twenty-one genes were differentially expressed in PTSD after strict multiple testing correction. PTSD-associated genes with roles in learning and memory (FOS, NR4A1), immune regulation (CFH, KPNA1) and myelination (MBP, MOBP, ERMN) were identified. PTSD-associated genes partially overlapped depression-associated genes. Co-expression network analyses identified PTSD-associated networks enriched for immune-related genes across the two brain regions. However, the immune-related genes and association patterns were distinct. The immune gene IL1B was significantly associated with PTSD in candidate-gene analysis and was an upstream regulator of PTSD-associated genes in both regions. There was evidence of replication of dlPFC associations in an independent cohort from a recent study, and a strong correlation between the dlPFC PTSD effect sizes for significant genes in the two studies (r = 0.66, p < 2.2 × 10−16). In conclusion, this study identified several novel PTSD-associated genes and brain region specific PTSD-associated immune-related networks. |
| abstract_unstemmed |
Studies evaluating neuroimaging, genetically predicted gene expression, and pre-clinical genetic models of PTSD, have identified PTSD-related abnormalities in the prefrontal cortex (PFC) of the brain, particularly in dorsolateral and ventromedial PFC (dlPFC and vmPFC). In this study, RNA sequencing was used to examine gene expression in the dlPFC and vmPFC using tissue from the VA National PTSD Brain Bank in donors with histories of PTSD with or without depression (dlPFC n = 38, vmPFC n = 35), depression cases without PTSD (n = 32), and psychopathology-free controls (dlPFC n = 24, vmPFC n = 20). Analyses compared PTSD cases to controls. Follow-up analyses contrasted depression cases to controls. Twenty-one genes were differentially expressed in PTSD after strict multiple testing correction. PTSD-associated genes with roles in learning and memory (FOS, NR4A1), immune regulation (CFH, KPNA1) and myelination (MBP, MOBP, ERMN) were identified. PTSD-associated genes partially overlapped depression-associated genes. Co-expression network analyses identified PTSD-associated networks enriched for immune-related genes across the two brain regions. However, the immune-related genes and association patterns were distinct. The immune gene IL1B was significantly associated with PTSD in candidate-gene analysis and was an upstream regulator of PTSD-associated genes in both regions. There was evidence of replication of dlPFC associations in an independent cohort from a recent study, and a strong correlation between the dlPFC PTSD effect sizes for significant genes in the two studies (r = 0.66, p < 2.2 × 10−16). In conclusion, this study identified several novel PTSD-associated genes and brain region specific PTSD-associated immune-related networks. |
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Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD |
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https://doi.org/10.1016/j.ynstr.2021.100398 https://doaj.org/article/9f856b09473743389bf2d11aa5c352d5 http://www.sciencedirect.com/science/article/pii/S2352289521001065 https://doaj.org/toc/2352-2895 |
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Zhenwei Zhou Filomene G. Morrison Erika J. Wolf Nikolaos P. Daskalakis Christos Chatzinakos Foivos Georgiadis Adam T. Labadorf Matthew J. Girgenti Keith A. Young Douglas E. Williamson Xiang Zhao Jaclyn Garza Grenier Bertrand Russell Huber Mark W. Miller |
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Zhenwei Zhou Filomene G. Morrison Erika J. Wolf Nikolaos P. Daskalakis Christos Chatzinakos Foivos Georgiadis Adam T. Labadorf Matthew J. Girgenti Keith A. Young Douglas E. Williamson Xiang Zhao Jaclyn Garza Grenier Bertrand Russell Huber Mark W. Miller |
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2024-07-04T02:04:55.368Z |
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