Drug-resistant pulmonary tuberculosis in western Turkey : Prevalence, clinical characteristics and treatment outcome.

<b<BACKGROUND</b< : Although high antituberculosis (anti-TB) drug resistance rates have been reported in Turkey, the clinical characteristics and implications for the outcome of anti-TB treatment have not been fully investigated. We determined the prevalence of anti-TB drug resistance an...
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Autor*in:	Surucuoglu Suheyla [verfasserIn] Ozkutuk Nuri [verfasserIn] Celik Pinar [verfasserIn] Gazi Horu [verfasserIn] Dinc Gonul [verfasserIn] Kurutepe Semra [verfasserIn] Koroglu Galip [verfasserIn] Havlucu Yavuz [verfasserIn] Tuncay Gulgun [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2005

Übergeordnetes Werk:	In: Annals of Saudi Medicine - King Faisal Specialist Hospital and Research Centre, 2018, 25(2005), 4, Seite 313-318
Übergeordnetes Werk:	volume:25 ; year:2005 ; number:4 ; pages:313-318

Links:	Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ007858396

Internformat


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520			\|a <b<BACKGROUND</b< : Although high antituberculosis (anti-TB) drug resistance rates have been reported in Turkey, the clinical characteristics and implications for the outcome of anti-TB treatment have not been fully investigated. We determined the prevalence of anti-TB drug resistance and examined demographic data, clinical characteristics and treatment outcome in relation to patterns of resistance. METHODS: From the TB case registry of a university hospital and the two largest dispensaries in Manisa city, we identified all pulmonary TB cases with a culture-proven definitive diagnosis and antimicrobial susceptibility results for a 7-year period. We collected and analyzed demographic and clinical data and information on treatment outcome for those cases in relationship to anti-TB drug resistance. <b<RESULTS</b< : Of 355 <i<M. tuberculosis </i<strains, 71.5% were susceptible to streptomycin, isoniazid, rifampicin and ethambutol. Any drug resistance and multi-drug resistance (MDR ) rates were 21.1% and 7.3% and were higher in males (53% and 9%, respectively) than in females (22% and 1%, respectively). Drug resistance was significantly higher in old cases (acquired drug resistance) vs new cases (primary drug resistance), and was associated with treatment failure (<i<P</i<< 0.001). The prevalence of MDR was significantly higher in the old cases (22.4%) than in the new cases (4.4%) (<i<P</i<< 0.001). Symptoms, radiographic findings, associated diseases, and sputum smear positivity were unrelated to the development of resistance. The prevalence of any drug resistance and MDR was significantly higher in those with treatment failure than in patients with treatment success. <b<CONCLUSION</b< : High resistance rates, particularly for acquired MDR, indicate a need for improvement in the TB control programme in our region.
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allfields	(DE-627)DOAJ007858396 (DE-599)DOAJ2fce9a6bd67a412ab3240f00e3f9bfdc DE-627 ger DE-627 rakwb eng Surucuoglu Suheyla verfasserin aut Drug-resistant pulmonary tuberculosis in western Turkey : Prevalence, clinical characteristics and treatment outcome. 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<BACKGROUND</b< : Although high antituberculosis (anti-TB) drug resistance rates have been reported in Turkey, the clinical characteristics and implications for the outcome of anti-TB treatment have not been fully investigated. We determined the prevalence of anti-TB drug resistance and examined demographic data, clinical characteristics and treatment outcome in relation to patterns of resistance. METHODS: From the TB case registry of a university hospital and the two largest dispensaries in Manisa city, we identified all pulmonary TB cases with a culture-proven definitive diagnosis and antimicrobial susceptibility results for a 7-year period. We collected and analyzed demographic and clinical data and information on treatment outcome for those cases in relationship to anti-TB drug resistance. <b<RESULTS</b< : Of 355 <i<M. tuberculosis </i<strains, 71.5% were susceptible to streptomycin, isoniazid, rifampicin and ethambutol. Any drug resistance and multi-drug resistance (MDR ) rates were 21.1% and 7.3% and were higher in males (53% and 9%, respectively) than in females (22% and 1%, respectively). Drug resistance was significantly higher in old cases (acquired drug resistance) vs new cases (primary drug resistance), and was associated with treatment failure (<i<P</i<< 0.001). The prevalence of MDR was significantly higher in the old cases (22.4%) than in the new cases (4.4%) (<i<P</i<< 0.001). Symptoms, radiographic findings, associated diseases, and sputum smear positivity were unrelated to the development of resistance. The prevalence of any drug resistance and MDR was significantly higher in those with treatment failure than in patients with treatment success. <b<CONCLUSION</b< : High resistance rates, particularly for acquired MDR, indicate a need for improvement in the TB control programme in our region. Medicine R Ozkutuk Nuri verfasserin aut Celik Pinar verfasserin aut Gazi Horu verfasserin aut Dinc Gonul verfasserin aut Kurutepe Semra verfasserin aut Koroglu Galip verfasserin aut Havlucu Yavuz verfasserin aut Tuncay Gulgun verfasserin aut In Annals of Saudi Medicine King Faisal Specialist Hospital and Research Centre, 2018 25(2005), 4, Seite 313-318 (DE-627)320622738 (DE-600)2022900-8 09754466 nnns volume:25 year:2005 number:4 pages:313-318 https://doaj.org/article/2fce9a6bd67a412ab3240f00e3f9bfdc kostenfrei http://www.saudiannals.net/article.asp?issn=0256-4947;year=2005;volume=25;issue=4;spage=313;epage=318;aulast=Surucuoglu kostenfrei https://doaj.org/toc/0256-4947 Journal toc kostenfrei https://doaj.org/toc/0975-4466 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2005 4 313-318
spelling	(DE-627)DOAJ007858396 (DE-599)DOAJ2fce9a6bd67a412ab3240f00e3f9bfdc DE-627 ger DE-627 rakwb eng Surucuoglu Suheyla verfasserin aut Drug-resistant pulmonary tuberculosis in western Turkey : Prevalence, clinical characteristics and treatment outcome. 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<BACKGROUND</b< : Although high antituberculosis (anti-TB) drug resistance rates have been reported in Turkey, the clinical characteristics and implications for the outcome of anti-TB treatment have not been fully investigated. We determined the prevalence of anti-TB drug resistance and examined demographic data, clinical characteristics and treatment outcome in relation to patterns of resistance. METHODS: From the TB case registry of a university hospital and the two largest dispensaries in Manisa city, we identified all pulmonary TB cases with a culture-proven definitive diagnosis and antimicrobial susceptibility results for a 7-year period. We collected and analyzed demographic and clinical data and information on treatment outcome for those cases in relationship to anti-TB drug resistance. <b<RESULTS</b< : Of 355 <i<M. tuberculosis </i<strains, 71.5% were susceptible to streptomycin, isoniazid, rifampicin and ethambutol. Any drug resistance and multi-drug resistance (MDR ) rates were 21.1% and 7.3% and were higher in males (53% and 9%, respectively) than in females (22% and 1%, respectively). Drug resistance was significantly higher in old cases (acquired drug resistance) vs new cases (primary drug resistance), and was associated with treatment failure (<i<P</i<< 0.001). The prevalence of MDR was significantly higher in the old cases (22.4%) than in the new cases (4.4%) (<i<P</i<< 0.001). Symptoms, radiographic findings, associated diseases, and sputum smear positivity were unrelated to the development of resistance. The prevalence of any drug resistance and MDR was significantly higher in those with treatment failure than in patients with treatment success. <b<CONCLUSION</b< : High resistance rates, particularly for acquired MDR, indicate a need for improvement in the TB control programme in our region. Medicine R Ozkutuk Nuri verfasserin aut Celik Pinar verfasserin aut Gazi Horu verfasserin aut Dinc Gonul verfasserin aut Kurutepe Semra verfasserin aut Koroglu Galip verfasserin aut Havlucu Yavuz verfasserin aut Tuncay Gulgun verfasserin aut In Annals of Saudi Medicine King Faisal Specialist Hospital and Research Centre, 2018 25(2005), 4, Seite 313-318 (DE-627)320622738 (DE-600)2022900-8 09754466 nnns volume:25 year:2005 number:4 pages:313-318 https://doaj.org/article/2fce9a6bd67a412ab3240f00e3f9bfdc kostenfrei http://www.saudiannals.net/article.asp?issn=0256-4947;year=2005;volume=25;issue=4;spage=313;epage=318;aulast=Surucuoglu kostenfrei https://doaj.org/toc/0256-4947 Journal toc kostenfrei https://doaj.org/toc/0975-4466 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2005 4 313-318
allfields_unstemmed	(DE-627)DOAJ007858396 (DE-599)DOAJ2fce9a6bd67a412ab3240f00e3f9bfdc DE-627 ger DE-627 rakwb eng Surucuoglu Suheyla verfasserin aut Drug-resistant pulmonary tuberculosis in western Turkey : Prevalence, clinical characteristics and treatment outcome. 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<BACKGROUND</b< : Although high antituberculosis (anti-TB) drug resistance rates have been reported in Turkey, the clinical characteristics and implications for the outcome of anti-TB treatment have not been fully investigated. We determined the prevalence of anti-TB drug resistance and examined demographic data, clinical characteristics and treatment outcome in relation to patterns of resistance. METHODS: From the TB case registry of a university hospital and the two largest dispensaries in Manisa city, we identified all pulmonary TB cases with a culture-proven definitive diagnosis and antimicrobial susceptibility results for a 7-year period. We collected and analyzed demographic and clinical data and information on treatment outcome for those cases in relationship to anti-TB drug resistance. <b<RESULTS</b< : Of 355 <i<M. tuberculosis </i<strains, 71.5% were susceptible to streptomycin, isoniazid, rifampicin and ethambutol. Any drug resistance and multi-drug resistance (MDR ) rates were 21.1% and 7.3% and were higher in males (53% and 9%, respectively) than in females (22% and 1%, respectively). Drug resistance was significantly higher in old cases (acquired drug resistance) vs new cases (primary drug resistance), and was associated with treatment failure (<i<P</i<< 0.001). The prevalence of MDR was significantly higher in the old cases (22.4%) than in the new cases (4.4%) (<i<P</i<< 0.001). Symptoms, radiographic findings, associated diseases, and sputum smear positivity were unrelated to the development of resistance. The prevalence of any drug resistance and MDR was significantly higher in those with treatment failure than in patients with treatment success. <b<CONCLUSION</b< : High resistance rates, particularly for acquired MDR, indicate a need for improvement in the TB control programme in our region. Medicine R Ozkutuk Nuri verfasserin aut Celik Pinar verfasserin aut Gazi Horu verfasserin aut Dinc Gonul verfasserin aut Kurutepe Semra verfasserin aut Koroglu Galip verfasserin aut Havlucu Yavuz verfasserin aut Tuncay Gulgun verfasserin aut In Annals of Saudi Medicine King Faisal Specialist Hospital and Research Centre, 2018 25(2005), 4, Seite 313-318 (DE-627)320622738 (DE-600)2022900-8 09754466 nnns volume:25 year:2005 number:4 pages:313-318 https://doaj.org/article/2fce9a6bd67a412ab3240f00e3f9bfdc kostenfrei http://www.saudiannals.net/article.asp?issn=0256-4947;year=2005;volume=25;issue=4;spage=313;epage=318;aulast=Surucuoglu kostenfrei https://doaj.org/toc/0256-4947 Journal toc kostenfrei https://doaj.org/toc/0975-4466 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2005 4 313-318
allfieldsGer	(DE-627)DOAJ007858396 (DE-599)DOAJ2fce9a6bd67a412ab3240f00e3f9bfdc DE-627 ger DE-627 rakwb eng Surucuoglu Suheyla verfasserin aut Drug-resistant pulmonary tuberculosis in western Turkey : Prevalence, clinical characteristics and treatment outcome. 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<BACKGROUND</b< : Although high antituberculosis (anti-TB) drug resistance rates have been reported in Turkey, the clinical characteristics and implications for the outcome of anti-TB treatment have not been fully investigated. We determined the prevalence of anti-TB drug resistance and examined demographic data, clinical characteristics and treatment outcome in relation to patterns of resistance. METHODS: From the TB case registry of a university hospital and the two largest dispensaries in Manisa city, we identified all pulmonary TB cases with a culture-proven definitive diagnosis and antimicrobial susceptibility results for a 7-year period. We collected and analyzed demographic and clinical data and information on treatment outcome for those cases in relationship to anti-TB drug resistance. <b<RESULTS</b< : Of 355 <i<M. tuberculosis </i<strains, 71.5% were susceptible to streptomycin, isoniazid, rifampicin and ethambutol. Any drug resistance and multi-drug resistance (MDR ) rates were 21.1% and 7.3% and were higher in males (53% and 9%, respectively) than in females (22% and 1%, respectively). Drug resistance was significantly higher in old cases (acquired drug resistance) vs new cases (primary drug resistance), and was associated with treatment failure (<i<P</i<< 0.001). The prevalence of MDR was significantly higher in the old cases (22.4%) than in the new cases (4.4%) (<i<P</i<< 0.001). Symptoms, radiographic findings, associated diseases, and sputum smear positivity were unrelated to the development of resistance. The prevalence of any drug resistance and MDR was significantly higher in those with treatment failure than in patients with treatment success. <b<CONCLUSION</b< : High resistance rates, particularly for acquired MDR, indicate a need for improvement in the TB control programme in our region. Medicine R Ozkutuk Nuri verfasserin aut Celik Pinar verfasserin aut Gazi Horu verfasserin aut Dinc Gonul verfasserin aut Kurutepe Semra verfasserin aut Koroglu Galip verfasserin aut Havlucu Yavuz verfasserin aut Tuncay Gulgun verfasserin aut In Annals of Saudi Medicine King Faisal Specialist Hospital and Research Centre, 2018 25(2005), 4, Seite 313-318 (DE-627)320622738 (DE-600)2022900-8 09754466 nnns volume:25 year:2005 number:4 pages:313-318 https://doaj.org/article/2fce9a6bd67a412ab3240f00e3f9bfdc kostenfrei http://www.saudiannals.net/article.asp?issn=0256-4947;year=2005;volume=25;issue=4;spage=313;epage=318;aulast=Surucuoglu kostenfrei https://doaj.org/toc/0256-4947 Journal toc kostenfrei https://doaj.org/toc/0975-4466 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2005 4 313-318
allfieldsSound	(DE-627)DOAJ007858396 (DE-599)DOAJ2fce9a6bd67a412ab3240f00e3f9bfdc DE-627 ger DE-627 rakwb eng Surucuoglu Suheyla verfasserin aut Drug-resistant pulmonary tuberculosis in western Turkey : Prevalence, clinical characteristics and treatment outcome. 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<BACKGROUND</b< : Although high antituberculosis (anti-TB) drug resistance rates have been reported in Turkey, the clinical characteristics and implications for the outcome of anti-TB treatment have not been fully investigated. We determined the prevalence of anti-TB drug resistance and examined demographic data, clinical characteristics and treatment outcome in relation to patterns of resistance. METHODS: From the TB case registry of a university hospital and the two largest dispensaries in Manisa city, we identified all pulmonary TB cases with a culture-proven definitive diagnosis and antimicrobial susceptibility results for a 7-year period. We collected and analyzed demographic and clinical data and information on treatment outcome for those cases in relationship to anti-TB drug resistance. <b<RESULTS</b< : Of 355 <i<M. tuberculosis </i<strains, 71.5% were susceptible to streptomycin, isoniazid, rifampicin and ethambutol. Any drug resistance and multi-drug resistance (MDR ) rates were 21.1% and 7.3% and were higher in males (53% and 9%, respectively) than in females (22% and 1%, respectively). Drug resistance was significantly higher in old cases (acquired drug resistance) vs new cases (primary drug resistance), and was associated with treatment failure (<i<P</i<< 0.001). The prevalence of MDR was significantly higher in the old cases (22.4%) than in the new cases (4.4%) (<i<P</i<< 0.001). Symptoms, radiographic findings, associated diseases, and sputum smear positivity were unrelated to the development of resistance. The prevalence of any drug resistance and MDR was significantly higher in those with treatment failure than in patients with treatment success. <b<CONCLUSION</b< : High resistance rates, particularly for acquired MDR, indicate a need for improvement in the TB control programme in our region. Medicine R Ozkutuk Nuri verfasserin aut Celik Pinar verfasserin aut Gazi Horu verfasserin aut Dinc Gonul verfasserin aut Kurutepe Semra verfasserin aut Koroglu Galip verfasserin aut Havlucu Yavuz verfasserin aut Tuncay Gulgun verfasserin aut In Annals of Saudi Medicine King Faisal Specialist Hospital and Research Centre, 2018 25(2005), 4, Seite 313-318 (DE-627)320622738 (DE-600)2022900-8 09754466 nnns volume:25 year:2005 number:4 pages:313-318 https://doaj.org/article/2fce9a6bd67a412ab3240f00e3f9bfdc kostenfrei http://www.saudiannals.net/article.asp?issn=0256-4947;year=2005;volume=25;issue=4;spage=313;epage=318;aulast=Surucuoglu kostenfrei https://doaj.org/toc/0256-4947 Journal toc kostenfrei https://doaj.org/toc/0975-4466 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2005 4 313-318
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title	Drug-resistant pulmonary tuberculosis in western Turkey : Prevalence, clinical characteristics and treatment outcome.
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title_sort	drug-resistant pulmonary tuberculosis in western turkey : prevalence, clinical characteristics and treatment outcome
title_auth	Drug-resistant pulmonary tuberculosis in western Turkey : Prevalence, clinical characteristics and treatment outcome.
abstract	<b<BACKGROUND</b< : Although high antituberculosis (anti-TB) drug resistance rates have been reported in Turkey, the clinical characteristics and implications for the outcome of anti-TB treatment have not been fully investigated. We determined the prevalence of anti-TB drug resistance and examined demographic data, clinical characteristics and treatment outcome in relation to patterns of resistance. METHODS: From the TB case registry of a university hospital and the two largest dispensaries in Manisa city, we identified all pulmonary TB cases with a culture-proven definitive diagnosis and antimicrobial susceptibility results for a 7-year period. We collected and analyzed demographic and clinical data and information on treatment outcome for those cases in relationship to anti-TB drug resistance. <b<RESULTS</b< : Of 355 <i<M. tuberculosis </i<strains, 71.5% were susceptible to streptomycin, isoniazid, rifampicin and ethambutol. Any drug resistance and multi-drug resistance (MDR ) rates were 21.1% and 7.3% and were higher in males (53% and 9%, respectively) than in females (22% and 1%, respectively). Drug resistance was significantly higher in old cases (acquired drug resistance) vs new cases (primary drug resistance), and was associated with treatment failure (<i<P</i<< 0.001). The prevalence of MDR was significantly higher in the old cases (22.4%) than in the new cases (4.4%) (<i<P</i<< 0.001). Symptoms, radiographic findings, associated diseases, and sputum smear positivity were unrelated to the development of resistance. The prevalence of any drug resistance and MDR was significantly higher in those with treatment failure than in patients with treatment success. <b<CONCLUSION</b< : High resistance rates, particularly for acquired MDR, indicate a need for improvement in the TB control programme in our region.
abstractGer	<b<BACKGROUND</b< : Although high antituberculosis (anti-TB) drug resistance rates have been reported in Turkey, the clinical characteristics and implications for the outcome of anti-TB treatment have not been fully investigated. We determined the prevalence of anti-TB drug resistance and examined demographic data, clinical characteristics and treatment outcome in relation to patterns of resistance. METHODS: From the TB case registry of a university hospital and the two largest dispensaries in Manisa city, we identified all pulmonary TB cases with a culture-proven definitive diagnosis and antimicrobial susceptibility results for a 7-year period. We collected and analyzed demographic and clinical data and information on treatment outcome for those cases in relationship to anti-TB drug resistance. <b<RESULTS</b< : Of 355 <i<M. tuberculosis </i<strains, 71.5% were susceptible to streptomycin, isoniazid, rifampicin and ethambutol. Any drug resistance and multi-drug resistance (MDR ) rates were 21.1% and 7.3% and were higher in males (53% and 9%, respectively) than in females (22% and 1%, respectively). Drug resistance was significantly higher in old cases (acquired drug resistance) vs new cases (primary drug resistance), and was associated with treatment failure (<i<P</i<< 0.001). The prevalence of MDR was significantly higher in the old cases (22.4%) than in the new cases (4.4%) (<i<P</i<< 0.001). Symptoms, radiographic findings, associated diseases, and sputum smear positivity were unrelated to the development of resistance. The prevalence of any drug resistance and MDR was significantly higher in those with treatment failure than in patients with treatment success. <b<CONCLUSION</b< : High resistance rates, particularly for acquired MDR, indicate a need for improvement in the TB control programme in our region.
abstract_unstemmed	<b<BACKGROUND</b< : Although high antituberculosis (anti-TB) drug resistance rates have been reported in Turkey, the clinical characteristics and implications for the outcome of anti-TB treatment have not been fully investigated. We determined the prevalence of anti-TB drug resistance and examined demographic data, clinical characteristics and treatment outcome in relation to patterns of resistance. METHODS: From the TB case registry of a university hospital and the two largest dispensaries in Manisa city, we identified all pulmonary TB cases with a culture-proven definitive diagnosis and antimicrobial susceptibility results for a 7-year period. We collected and analyzed demographic and clinical data and information on treatment outcome for those cases in relationship to anti-TB drug resistance. <b<RESULTS</b< : Of 355 <i<M. tuberculosis </i<strains, 71.5% were susceptible to streptomycin, isoniazid, rifampicin and ethambutol. Any drug resistance and multi-drug resistance (MDR ) rates were 21.1% and 7.3% and were higher in males (53% and 9%, respectively) than in females (22% and 1%, respectively). Drug resistance was significantly higher in old cases (acquired drug resistance) vs new cases (primary drug resistance), and was associated with treatment failure (<i<P</i<< 0.001). The prevalence of MDR was significantly higher in the old cases (22.4%) than in the new cases (4.4%) (<i<P</i<< 0.001). Symptoms, radiographic findings, associated diseases, and sputum smear positivity were unrelated to the development of resistance. The prevalence of any drug resistance and MDR was significantly higher in those with treatment failure than in patients with treatment success. <b<CONCLUSION</b< : High resistance rates, particularly for acquired MDR, indicate a need for improvement in the TB control programme in our region.
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title_short	Drug-resistant pulmonary tuberculosis in western Turkey : Prevalence, clinical characteristics and treatment outcome.
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Drug-resistant pulmonary tuberculosis in western Turkey : Prevalence, clinical characteristics and treatment outcome.

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