Clinical Utility of <i<LCT</i< Genotyping in Children with Suspected Functional Gastrointestinal Disorder

Genetic testing is a good predictor of lactase persistence (LP) in specific populations but its clinical utility in children is less clear. We assessed the role of lactose malabsorption in functional gastrointestinal disorders (FGID) in children and the correlation between the lactase non-persistenc...
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Autor*in:	María L. Couce [verfasserIn] Paula Sánchez-Pintos [verfasserIn] Emiliano González-Vioque [verfasserIn] Rosaura Leis [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	lactose intolerance lactose malabsorption C/T-13910 polymorphism functional gastrointestinal disorders

Übergeordnetes Werk:	In: Nutrients - MDPI AG, 2009, 12(2020), 10, p 3017
Übergeordnetes Werk:	volume:12 ; year:2020 ; number:10, p 3017

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nu12103017

Katalog-ID:	DOAJ007917775

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520			\|a Genetic testing is a good predictor of lactase persistence (LP) in specific populations but its clinical utility in children is less clear. We assessed the role of lactose malabsorption in functional gastrointestinal disorders (FGID) in children and the correlation between the lactase non-persistence (LNP) genotype and phenotype, based on exhaled hydrogen and gastrointestinal symptoms, during a hydrogen breath test (HBT). We also evaluate dairy consumption in this sample. We conducted a 10-year cross-sectional study in a cohort of 493 children with suspected FGID defined by Roma IV criteria. Distribution of the C/T-13910 genotype was as follows: CC, 46.0%; TT, 14.4% (LP allele frequency, 34.1%). The phenotype frequencies of lactose malabsorption and intolerance were 36.3% and 41.5%, respectively. We observed a strong correlation between genotype and both lactose malabsorption (Cramér’s V, 0.28) and intolerance (Cramér’s V, 0.54). The frequency of the LNP genotype (<i<p</i< = 0.002) and of malabsorption and intolerance increased with age (<i<p</i< = 0.001 and 0.002, respectively). In 61% of children, evaluated dairy consumption was less than recommended. No association was observed between dairy intake and diagnosis. In conclusion, we found a significant correlation between genotype and phenotype, greater in older children, suggesting that the clinical value of genetic testing increases with age.
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language	English
source	In Nutrients 12(2020), 10, p 3017 volume:12 year:2020 number:10, p 3017
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callnumber-first	T - Technology
author	María L. Couce
spellingShingle	María L. Couce misc TX341-641 misc lactose intolerance misc lactose malabsorption misc C/T-13910 polymorphism misc functional gastrointestinal disorders misc Nutrition. Foods and food supply Clinical Utility of <i<LCT</i< Genotyping in Children with Suspected Functional Gastrointestinal Disorder
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topic_title	TX341-641 Clinical Utility of <i<LCT</i< Genotyping in Children with Suspected Functional Gastrointestinal Disorder lactose intolerance lactose malabsorption C/T-13910 polymorphism functional gastrointestinal disorders
topic	misc TX341-641 misc lactose intolerance misc lactose malabsorption misc C/T-13910 polymorphism misc functional gastrointestinal disorders misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc lactose intolerance misc lactose malabsorption misc C/T-13910 polymorphism misc functional gastrointestinal disorders misc Nutrition. Foods and food supply
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title	Clinical Utility of <i<LCT</i< Genotyping in Children with Suspected Functional Gastrointestinal Disorder
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title_full	Clinical Utility of <i<LCT</i< Genotyping in Children with Suspected Functional Gastrointestinal Disorder
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author_browse	María L. Couce Paula Sánchez-Pintos Emiliano González-Vioque Rosaura Leis
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title_sort	clinical utility of <i<lct</i< genotyping in children with suspected functional gastrointestinal disorder
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title_auth	Clinical Utility of <i<LCT</i< Genotyping in Children with Suspected Functional Gastrointestinal Disorder
abstract	Genetic testing is a good predictor of lactase persistence (LP) in specific populations but its clinical utility in children is less clear. We assessed the role of lactose malabsorption in functional gastrointestinal disorders (FGID) in children and the correlation between the lactase non-persistence (LNP) genotype and phenotype, based on exhaled hydrogen and gastrointestinal symptoms, during a hydrogen breath test (HBT). We also evaluate dairy consumption in this sample. We conducted a 10-year cross-sectional study in a cohort of 493 children with suspected FGID defined by Roma IV criteria. Distribution of the C/T-13910 genotype was as follows: CC, 46.0%; TT, 14.4% (LP allele frequency, 34.1%). The phenotype frequencies of lactose malabsorption and intolerance were 36.3% and 41.5%, respectively. We observed a strong correlation between genotype and both lactose malabsorption (Cramér’s V, 0.28) and intolerance (Cramér’s V, 0.54). The frequency of the LNP genotype (<i<p</i< = 0.002) and of malabsorption and intolerance increased with age (<i<p</i< = 0.001 and 0.002, respectively). In 61% of children, evaluated dairy consumption was less than recommended. No association was observed between dairy intake and diagnosis. In conclusion, we found a significant correlation between genotype and phenotype, greater in older children, suggesting that the clinical value of genetic testing increases with age.
abstractGer	Genetic testing is a good predictor of lactase persistence (LP) in specific populations but its clinical utility in children is less clear. We assessed the role of lactose malabsorption in functional gastrointestinal disorders (FGID) in children and the correlation between the lactase non-persistence (LNP) genotype and phenotype, based on exhaled hydrogen and gastrointestinal symptoms, during a hydrogen breath test (HBT). We also evaluate dairy consumption in this sample. We conducted a 10-year cross-sectional study in a cohort of 493 children with suspected FGID defined by Roma IV criteria. Distribution of the C/T-13910 genotype was as follows: CC, 46.0%; TT, 14.4% (LP allele frequency, 34.1%). The phenotype frequencies of lactose malabsorption and intolerance were 36.3% and 41.5%, respectively. We observed a strong correlation between genotype and both lactose malabsorption (Cramér’s V, 0.28) and intolerance (Cramér’s V, 0.54). The frequency of the LNP genotype (<i<p</i< = 0.002) and of malabsorption and intolerance increased with age (<i<p</i< = 0.001 and 0.002, respectively). In 61% of children, evaluated dairy consumption was less than recommended. No association was observed between dairy intake and diagnosis. In conclusion, we found a significant correlation between genotype and phenotype, greater in older children, suggesting that the clinical value of genetic testing increases with age.
abstract_unstemmed	Genetic testing is a good predictor of lactase persistence (LP) in specific populations but its clinical utility in children is less clear. We assessed the role of lactose malabsorption in functional gastrointestinal disorders (FGID) in children and the correlation between the lactase non-persistence (LNP) genotype and phenotype, based on exhaled hydrogen and gastrointestinal symptoms, during a hydrogen breath test (HBT). We also evaluate dairy consumption in this sample. We conducted a 10-year cross-sectional study in a cohort of 493 children with suspected FGID defined by Roma IV criteria. Distribution of the C/T-13910 genotype was as follows: CC, 46.0%; TT, 14.4% (LP allele frequency, 34.1%). The phenotype frequencies of lactose malabsorption and intolerance were 36.3% and 41.5%, respectively. We observed a strong correlation between genotype and both lactose malabsorption (Cramér’s V, 0.28) and intolerance (Cramér’s V, 0.54). The frequency of the LNP genotype (<i<p</i< = 0.002) and of malabsorption and intolerance increased with age (<i<p</i< = 0.001 and 0.002, respectively). In 61% of children, evaluated dairy consumption was less than recommended. No association was observed between dairy intake and diagnosis. In conclusion, we found a significant correlation between genotype and phenotype, greater in older children, suggesting that the clinical value of genetic testing increases with age.
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