Liquid Biopsy in Hepatocellular Carcinoma: Where Are We Now?

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer related death worldwide. Diagnostic, prognostic, and predictive biomarkers are urgently needed in order to improve patient survival. Indeed, the most widely used biomarkers, such as alpha-fetoprotein (AFP), have limited accuracy a...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Filippo Pelizzaro [verfasserIn] Romilda Cardin [verfasserIn] Barbara Penzo [verfasserIn] Elisa Pinto [verfasserIn] Alessandro Vitale [verfasserIn] Umberto Cillo [verfasserIn] Francesco Paolo Russo [verfasserIn] Fabio Farinati [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	hepatocellular carcinoma liquid biopsy biomarkers diagnosis prognosis extracellular vesicles

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 13(2021), 9, p 2274
Übergeordnetes Werk:	volume:13 ; year:2021 ; number:9, p 2274

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers13092274

Katalog-ID:	DOAJ007935765

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520			\|a Hepatocellular carcinoma (HCC) is one of the leading causes of cancer related death worldwide. Diagnostic, prognostic, and predictive biomarkers are urgently needed in order to improve patient survival. Indeed, the most widely used biomarkers, such as alpha-fetoprotein (AFP), have limited accuracy as both diagnostic and prognostic tests. Liver biopsy provides an insight on the biology of the tumor, but it is an invasive procedure, not routinely used, and not representative of the whole neoplasia due to the demonstrated intra-tumoral heterogeneity. In recent years, liquid biopsy, defined as the molecular analysis of cancer by-products, released by the tumor in the bloodstream, emerged as an appealing source of new biomarkers. Several studies focused on evaluating extracellular vesicles, circulating tumor cells, cell-free DNA and non-coding RNA as novel reliable biomarkers. In this review, we aimed to provide a comprehensive overview on the most relevant available evidence on novel circulating biomarkers for early diagnosis, prognostic stratification, and therapeutic monitoring. Liquid biopsy seems to be a very promising instrument and, in the near future, some of these new non-invasive tools will probably change the clinical management of HCC patients.
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language	English
source	In Cancers 13(2021), 9, p 2274 volume:13 year:2021 number:9, p 2274
sourceStr	In Cancers 13(2021), 9, p 2274 volume:13 year:2021 number:9, p 2274
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	hepatocellular carcinoma liquid biopsy biomarkers diagnosis prognosis extracellular vesicles Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Cancers
authorswithroles_txt_mv	Filippo Pelizzaro @@aut@@ Romilda Cardin @@aut@@ Barbara Penzo @@aut@@ Elisa Pinto @@aut@@ Alessandro Vitale @@aut@@ Umberto Cillo @@aut@@ Francesco Paolo Russo @@aut@@ Fabio Farinati @@aut@@
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callnumber-first	R - Medicine
author	Filippo Pelizzaro
spellingShingle	Filippo Pelizzaro misc RC254-282 misc hepatocellular carcinoma misc liquid biopsy misc biomarkers misc diagnosis misc prognosis misc extracellular vesicles misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Liquid Biopsy in Hepatocellular Carcinoma: Where Are We Now?
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topic_title	RC254-282 Liquid Biopsy in Hepatocellular Carcinoma: Where Are We Now? hepatocellular carcinoma liquid biopsy biomarkers diagnosis prognosis extracellular vesicles
topic	misc RC254-282 misc hepatocellular carcinoma misc liquid biopsy misc biomarkers misc diagnosis misc prognosis misc extracellular vesicles misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc hepatocellular carcinoma misc liquid biopsy misc biomarkers misc diagnosis misc prognosis misc extracellular vesicles misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc hepatocellular carcinoma misc liquid biopsy misc biomarkers misc diagnosis misc prognosis misc extracellular vesicles misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Liquid Biopsy in Hepatocellular Carcinoma: Where Are We Now?
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title_full	Liquid Biopsy in Hepatocellular Carcinoma: Where Are We Now?
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author_browse	Filippo Pelizzaro Romilda Cardin Barbara Penzo Elisa Pinto Alessandro Vitale Umberto Cillo Francesco Paolo Russo Fabio Farinati
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title_sort	liquid biopsy in hepatocellular carcinoma: where are we now?
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title_auth	Liquid Biopsy in Hepatocellular Carcinoma: Where Are We Now?
abstract	Hepatocellular carcinoma (HCC) is one of the leading causes of cancer related death worldwide. Diagnostic, prognostic, and predictive biomarkers are urgently needed in order to improve patient survival. Indeed, the most widely used biomarkers, such as alpha-fetoprotein (AFP), have limited accuracy as both diagnostic and prognostic tests. Liver biopsy provides an insight on the biology of the tumor, but it is an invasive procedure, not routinely used, and not representative of the whole neoplasia due to the demonstrated intra-tumoral heterogeneity. In recent years, liquid biopsy, defined as the molecular analysis of cancer by-products, released by the tumor in the bloodstream, emerged as an appealing source of new biomarkers. Several studies focused on evaluating extracellular vesicles, circulating tumor cells, cell-free DNA and non-coding RNA as novel reliable biomarkers. In this review, we aimed to provide a comprehensive overview on the most relevant available evidence on novel circulating biomarkers for early diagnosis, prognostic stratification, and therapeutic monitoring. Liquid biopsy seems to be a very promising instrument and, in the near future, some of these new non-invasive tools will probably change the clinical management of HCC patients.
abstractGer	Hepatocellular carcinoma (HCC) is one of the leading causes of cancer related death worldwide. Diagnostic, prognostic, and predictive biomarkers are urgently needed in order to improve patient survival. Indeed, the most widely used biomarkers, such as alpha-fetoprotein (AFP), have limited accuracy as both diagnostic and prognostic tests. Liver biopsy provides an insight on the biology of the tumor, but it is an invasive procedure, not routinely used, and not representative of the whole neoplasia due to the demonstrated intra-tumoral heterogeneity. In recent years, liquid biopsy, defined as the molecular analysis of cancer by-products, released by the tumor in the bloodstream, emerged as an appealing source of new biomarkers. Several studies focused on evaluating extracellular vesicles, circulating tumor cells, cell-free DNA and non-coding RNA as novel reliable biomarkers. In this review, we aimed to provide a comprehensive overview on the most relevant available evidence on novel circulating biomarkers for early diagnosis, prognostic stratification, and therapeutic monitoring. Liquid biopsy seems to be a very promising instrument and, in the near future, some of these new non-invasive tools will probably change the clinical management of HCC patients.
abstract_unstemmed	Hepatocellular carcinoma (HCC) is one of the leading causes of cancer related death worldwide. Diagnostic, prognostic, and predictive biomarkers are urgently needed in order to improve patient survival. Indeed, the most widely used biomarkers, such as alpha-fetoprotein (AFP), have limited accuracy as both diagnostic and prognostic tests. Liver biopsy provides an insight on the biology of the tumor, but it is an invasive procedure, not routinely used, and not representative of the whole neoplasia due to the demonstrated intra-tumoral heterogeneity. In recent years, liquid biopsy, defined as the molecular analysis of cancer by-products, released by the tumor in the bloodstream, emerged as an appealing source of new biomarkers. Several studies focused on evaluating extracellular vesicles, circulating tumor cells, cell-free DNA and non-coding RNA as novel reliable biomarkers. In this review, we aimed to provide a comprehensive overview on the most relevant available evidence on novel circulating biomarkers for early diagnosis, prognostic stratification, and therapeutic monitoring. Liquid biopsy seems to be a very promising instrument and, in the near future, some of these new non-invasive tools will probably change the clinical management of HCC patients.
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title_short	Liquid Biopsy in Hepatocellular Carcinoma: Where Are We Now?
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author2	Romilda Cardin Barbara Penzo Elisa Pinto Alessandro Vitale Umberto Cillo Francesco Paolo Russo Fabio Farinati
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