Trimethylamine N-Oxide in Heart Failure: A Meta-Analysis of Prognostic Value

ObjectiveThe present study aimed to explore the prognostic value of trimethylamine N-oxide (TMAO) in heart failure (HF).MethodsPubMed, Excerpta Medica Database (EMBASE), Cochrane Library, Web of Science, Wanfang Database, SINOMED, China Science and Technology Journal Database (VIP), and China Nation...
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Gespeichert in:

Autor*in:	Xingxing Li [verfasserIn] Zongjing Fan [verfasserIn] Jie Cui [verfasserIn] Dong Li [verfasserIn] Jinjin Lu [verfasserIn] Xiaoyun Cui [verfasserIn] Liandi Xie [verfasserIn] Yang Wu [verfasserIn] Qian Lin [verfasserIn] Yan Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	heart failure trimethylamine N-oxide major adverse cardiovascular events all-cause mortality meta-analysis

Übergeordnetes Werk:	In: Frontiers in Cardiovascular Medicine - Frontiers Media S.A., 2015, 9(2022)
Übergeordnetes Werk:	volume:9 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fcvm.2022.817396

Katalog-ID:	DOAJ008040664

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520			\|a ObjectiveThe present study aimed to explore the prognostic value of trimethylamine N-oxide (TMAO) in heart failure (HF).MethodsPubMed, Excerpta Medica Database (EMBASE), Cochrane Library, Web of Science, Wanfang Database, SINOMED, China Science and Technology Journal Database (VIP), and China National Knowledge Infrastructure (CNKI) were searched up to June 1, 2021. Studies recording the major adverse cardiovascular events (MACEs) or all-cause mortality in HF patients and their circulating TMAO concentrations were included. Meta-analysis was performed using Stata 13.0.ResultsTen articles (12 studies) involving 13,425 participants from 2014 to 2021 were considered. Compared to low-level TMAO, elevated TMAO was correlated with MACEs and all-cause mortality in HF (RR: 1.28, 95% CI: 1.17, 1.39, P < 0.0001, random-effects model and RR: 1.35, 95% CI: 1.28, 1.42, P < 0.0001, random-effects model, respectively). Consistent results were obtained in all examined subgroups as well as in the sensitivity analysis.ConclusionElevated TMAO may be an adverse prognostic indicator in patients with HF.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=267208
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allfields	10.3389/fcvm.2022.817396 doi (DE-627)DOAJ008040664 (DE-599)DOAJd0f75980ec814cd581a71818f31b4e48 DE-627 ger DE-627 rakwb eng RC666-701 Xingxing Li verfasserin aut Trimethylamine N-Oxide in Heart Failure: A Meta-Analysis of Prognostic Value 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectiveThe present study aimed to explore the prognostic value of trimethylamine N-oxide (TMAO) in heart failure (HF).MethodsPubMed, Excerpta Medica Database (EMBASE), Cochrane Library, Web of Science, Wanfang Database, SINOMED, China Science and Technology Journal Database (VIP), and China National Knowledge Infrastructure (CNKI) were searched up to June 1, 2021. Studies recording the major adverse cardiovascular events (MACEs) or all-cause mortality in HF patients and their circulating TMAO concentrations were included. Meta-analysis was performed using Stata 13.0.ResultsTen articles (12 studies) involving 13,425 participants from 2014 to 2021 were considered. Compared to low-level TMAO, elevated TMAO was correlated with MACEs and all-cause mortality in HF (RR: 1.28, 95% CI: 1.17, 1.39, P < 0.0001, random-effects model and RR: 1.35, 95% CI: 1.28, 1.42, P < 0.0001, random-effects model, respectively). Consistent results were obtained in all examined subgroups as well as in the sensitivity analysis.ConclusionElevated TMAO may be an adverse prognostic indicator in patients with HF.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=267208 heart failure trimethylamine N-oxide major adverse cardiovascular events all-cause mortality meta-analysis Diseases of the circulatory (Cardiovascular) system Zongjing Fan verfasserin aut Jie Cui verfasserin aut Dong Li verfasserin aut Jinjin Lu verfasserin aut Xiaoyun Cui verfasserin aut Liandi Xie verfasserin aut Yang Wu verfasserin aut Qian Lin verfasserin aut Yan Li verfasserin aut In Frontiers in Cardiovascular Medicine Frontiers Media S.A., 2015 9(2022) (DE-627)793951607 (DE-600)2781496-8 2297055X nnns volume:9 year:2022 https://doi.org/10.3389/fcvm.2022.817396 kostenfrei https://doaj.org/article/d0f75980ec814cd581a71818f31b4e48 kostenfrei https://www.frontiersin.org/articles/10.3389/fcvm.2022.817396/full kostenfrei https://doaj.org/toc/2297-055X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
spelling	10.3389/fcvm.2022.817396 doi (DE-627)DOAJ008040664 (DE-599)DOAJd0f75980ec814cd581a71818f31b4e48 DE-627 ger DE-627 rakwb eng RC666-701 Xingxing Li verfasserin aut Trimethylamine N-Oxide in Heart Failure: A Meta-Analysis of Prognostic Value 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectiveThe present study aimed to explore the prognostic value of trimethylamine N-oxide (TMAO) in heart failure (HF).MethodsPubMed, Excerpta Medica Database (EMBASE), Cochrane Library, Web of Science, Wanfang Database, SINOMED, China Science and Technology Journal Database (VIP), and China National Knowledge Infrastructure (CNKI) were searched up to June 1, 2021. Studies recording the major adverse cardiovascular events (MACEs) or all-cause mortality in HF patients and their circulating TMAO concentrations were included. Meta-analysis was performed using Stata 13.0.ResultsTen articles (12 studies) involving 13,425 participants from 2014 to 2021 were considered. Compared to low-level TMAO, elevated TMAO was correlated with MACEs and all-cause mortality in HF (RR: 1.28, 95% CI: 1.17, 1.39, P < 0.0001, random-effects model and RR: 1.35, 95% CI: 1.28, 1.42, P < 0.0001, random-effects model, respectively). Consistent results were obtained in all examined subgroups as well as in the sensitivity analysis.ConclusionElevated TMAO may be an adverse prognostic indicator in patients with HF.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=267208 heart failure trimethylamine N-oxide major adverse cardiovascular events all-cause mortality meta-analysis Diseases of the circulatory (Cardiovascular) system Zongjing Fan verfasserin aut Jie Cui verfasserin aut Dong Li verfasserin aut Jinjin Lu verfasserin aut Xiaoyun Cui verfasserin aut Liandi Xie verfasserin aut Yang Wu verfasserin aut Qian Lin verfasserin aut Yan Li verfasserin aut In Frontiers in Cardiovascular Medicine Frontiers Media S.A., 2015 9(2022) (DE-627)793951607 (DE-600)2781496-8 2297055X nnns volume:9 year:2022 https://doi.org/10.3389/fcvm.2022.817396 kostenfrei https://doaj.org/article/d0f75980ec814cd581a71818f31b4e48 kostenfrei https://www.frontiersin.org/articles/10.3389/fcvm.2022.817396/full kostenfrei https://doaj.org/toc/2297-055X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
allfields_unstemmed	10.3389/fcvm.2022.817396 doi (DE-627)DOAJ008040664 (DE-599)DOAJd0f75980ec814cd581a71818f31b4e48 DE-627 ger DE-627 rakwb eng RC666-701 Xingxing Li verfasserin aut Trimethylamine N-Oxide in Heart Failure: A Meta-Analysis of Prognostic Value 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectiveThe present study aimed to explore the prognostic value of trimethylamine N-oxide (TMAO) in heart failure (HF).MethodsPubMed, Excerpta Medica Database (EMBASE), Cochrane Library, Web of Science, Wanfang Database, SINOMED, China Science and Technology Journal Database (VIP), and China National Knowledge Infrastructure (CNKI) were searched up to June 1, 2021. Studies recording the major adverse cardiovascular events (MACEs) or all-cause mortality in HF patients and their circulating TMAO concentrations were included. Meta-analysis was performed using Stata 13.0.ResultsTen articles (12 studies) involving 13,425 participants from 2014 to 2021 were considered. Compared to low-level TMAO, elevated TMAO was correlated with MACEs and all-cause mortality in HF (RR: 1.28, 95% CI: 1.17, 1.39, P < 0.0001, random-effects model and RR: 1.35, 95% CI: 1.28, 1.42, P < 0.0001, random-effects model, respectively). Consistent results were obtained in all examined subgroups as well as in the sensitivity analysis.ConclusionElevated TMAO may be an adverse prognostic indicator in patients with HF.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=267208 heart failure trimethylamine N-oxide major adverse cardiovascular events all-cause mortality meta-analysis Diseases of the circulatory (Cardiovascular) system Zongjing Fan verfasserin aut Jie Cui verfasserin aut Dong Li verfasserin aut Jinjin Lu verfasserin aut Xiaoyun Cui verfasserin aut Liandi Xie verfasserin aut Yang Wu verfasserin aut Qian Lin verfasserin aut Yan Li verfasserin aut In Frontiers in Cardiovascular Medicine Frontiers Media S.A., 2015 9(2022) (DE-627)793951607 (DE-600)2781496-8 2297055X nnns volume:9 year:2022 https://doi.org/10.3389/fcvm.2022.817396 kostenfrei https://doaj.org/article/d0f75980ec814cd581a71818f31b4e48 kostenfrei https://www.frontiersin.org/articles/10.3389/fcvm.2022.817396/full kostenfrei https://doaj.org/toc/2297-055X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
allfieldsGer	10.3389/fcvm.2022.817396 doi (DE-627)DOAJ008040664 (DE-599)DOAJd0f75980ec814cd581a71818f31b4e48 DE-627 ger DE-627 rakwb eng RC666-701 Xingxing Li verfasserin aut Trimethylamine N-Oxide in Heart Failure: A Meta-Analysis of Prognostic Value 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectiveThe present study aimed to explore the prognostic value of trimethylamine N-oxide (TMAO) in heart failure (HF).MethodsPubMed, Excerpta Medica Database (EMBASE), Cochrane Library, Web of Science, Wanfang Database, SINOMED, China Science and Technology Journal Database (VIP), and China National Knowledge Infrastructure (CNKI) were searched up to June 1, 2021. Studies recording the major adverse cardiovascular events (MACEs) or all-cause mortality in HF patients and their circulating TMAO concentrations were included. Meta-analysis was performed using Stata 13.0.ResultsTen articles (12 studies) involving 13,425 participants from 2014 to 2021 were considered. Compared to low-level TMAO, elevated TMAO was correlated with MACEs and all-cause mortality in HF (RR: 1.28, 95% CI: 1.17, 1.39, P < 0.0001, random-effects model and RR: 1.35, 95% CI: 1.28, 1.42, P < 0.0001, random-effects model, respectively). Consistent results were obtained in all examined subgroups as well as in the sensitivity analysis.ConclusionElevated TMAO may be an adverse prognostic indicator in patients with HF.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=267208 heart failure trimethylamine N-oxide major adverse cardiovascular events all-cause mortality meta-analysis Diseases of the circulatory (Cardiovascular) system Zongjing Fan verfasserin aut Jie Cui verfasserin aut Dong Li verfasserin aut Jinjin Lu verfasserin aut Xiaoyun Cui verfasserin aut Liandi Xie verfasserin aut Yang Wu verfasserin aut Qian Lin verfasserin aut Yan Li verfasserin aut In Frontiers in Cardiovascular Medicine Frontiers Media S.A., 2015 9(2022) (DE-627)793951607 (DE-600)2781496-8 2297055X nnns volume:9 year:2022 https://doi.org/10.3389/fcvm.2022.817396 kostenfrei https://doaj.org/article/d0f75980ec814cd581a71818f31b4e48 kostenfrei https://www.frontiersin.org/articles/10.3389/fcvm.2022.817396/full kostenfrei https://doaj.org/toc/2297-055X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
allfieldsSound	10.3389/fcvm.2022.817396 doi (DE-627)DOAJ008040664 (DE-599)DOAJd0f75980ec814cd581a71818f31b4e48 DE-627 ger DE-627 rakwb eng RC666-701 Xingxing Li verfasserin aut Trimethylamine N-Oxide in Heart Failure: A Meta-Analysis of Prognostic Value 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ObjectiveThe present study aimed to explore the prognostic value of trimethylamine N-oxide (TMAO) in heart failure (HF).MethodsPubMed, Excerpta Medica Database (EMBASE), Cochrane Library, Web of Science, Wanfang Database, SINOMED, China Science and Technology Journal Database (VIP), and China National Knowledge Infrastructure (CNKI) were searched up to June 1, 2021. Studies recording the major adverse cardiovascular events (MACEs) or all-cause mortality in HF patients and their circulating TMAO concentrations were included. Meta-analysis was performed using Stata 13.0.ResultsTen articles (12 studies) involving 13,425 participants from 2014 to 2021 were considered. Compared to low-level TMAO, elevated TMAO was correlated with MACEs and all-cause mortality in HF (RR: 1.28, 95% CI: 1.17, 1.39, P < 0.0001, random-effects model and RR: 1.35, 95% CI: 1.28, 1.42, P < 0.0001, random-effects model, respectively). Consistent results were obtained in all examined subgroups as well as in the sensitivity analysis.ConclusionElevated TMAO may be an adverse prognostic indicator in patients with HF.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=267208 heart failure trimethylamine N-oxide major adverse cardiovascular events all-cause mortality meta-analysis Diseases of the circulatory (Cardiovascular) system Zongjing Fan verfasserin aut Jie Cui verfasserin aut Dong Li verfasserin aut Jinjin Lu verfasserin aut Xiaoyun Cui verfasserin aut Liandi Xie verfasserin aut Yang Wu verfasserin aut Qian Lin verfasserin aut Yan Li verfasserin aut In Frontiers in Cardiovascular Medicine Frontiers Media S.A., 2015 9(2022) (DE-627)793951607 (DE-600)2781496-8 2297055X nnns volume:9 year:2022 https://doi.org/10.3389/fcvm.2022.817396 kostenfrei https://doaj.org/article/d0f75980ec814cd581a71818f31b4e48 kostenfrei https://www.frontiersin.org/articles/10.3389/fcvm.2022.817396/full kostenfrei https://doaj.org/toc/2297-055X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2022
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Studies recording the major adverse cardiovascular events (MACEs) or all-cause mortality in HF patients and their circulating TMAO concentrations were included. Meta-analysis was performed using Stata 13.0.ResultsTen articles (12 studies) involving 13,425 participants from 2014 to 2021 were considered. Compared to low-level TMAO, elevated TMAO was correlated with MACEs and all-cause mortality in HF (RR: 1.28, 95% CI: 1.17, 1.39, P &lt; 0.0001, random-effects model and RR: 1.35, 95% CI: 1.28, 1.42, P &lt; 0.0001, random-effects model, respectively). Consistent results were obtained in all examined subgroups as well as in the sensitivity analysis.ConclusionElevated TMAO may be an adverse prognostic indicator in patients with HF.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=267208</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">heart failure</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">trimethylamine N-oxide</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">major adverse cardiovascular events</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">all-cause mortality</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">meta-analysis</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Diseases of the circulatory (Cardiovascular) system</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield 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callnumber-first	R - Medicine
author	Xingxing Li
spellingShingle	Xingxing Li misc RC666-701 misc heart failure misc trimethylamine N-oxide misc major adverse cardiovascular events misc all-cause mortality misc meta-analysis misc Diseases of the circulatory (Cardiovascular) system Trimethylamine N-Oxide in Heart Failure: A Meta-Analysis of Prognostic Value
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topic_title	RC666-701 Trimethylamine N-Oxide in Heart Failure: A Meta-Analysis of Prognostic Value heart failure trimethylamine N-oxide major adverse cardiovascular events all-cause mortality meta-analysis
topic	misc RC666-701 misc heart failure misc trimethylamine N-oxide misc major adverse cardiovascular events misc all-cause mortality misc meta-analysis misc Diseases of the circulatory (Cardiovascular) system
topic_unstemmed	misc RC666-701 misc heart failure misc trimethylamine N-oxide misc major adverse cardiovascular events misc all-cause mortality misc meta-analysis misc Diseases of the circulatory (Cardiovascular) system
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title	Trimethylamine N-Oxide in Heart Failure: A Meta-Analysis of Prognostic Value
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title_full	Trimethylamine N-Oxide in Heart Failure: A Meta-Analysis of Prognostic Value
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author_browse	Xingxing Li Zongjing Fan Jie Cui Dong Li Jinjin Lu Xiaoyun Cui Liandi Xie Yang Wu Qian Lin Yan Li
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doi_str_mv	10.3389/fcvm.2022.817396
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title_sort	trimethylamine n-oxide in heart failure: a meta-analysis of prognostic value
callnumber	RC666-701
title_auth	Trimethylamine N-Oxide in Heart Failure: A Meta-Analysis of Prognostic Value
abstract	ObjectiveThe present study aimed to explore the prognostic value of trimethylamine N-oxide (TMAO) in heart failure (HF).MethodsPubMed, Excerpta Medica Database (EMBASE), Cochrane Library, Web of Science, Wanfang Database, SINOMED, China Science and Technology Journal Database (VIP), and China National Knowledge Infrastructure (CNKI) were searched up to June 1, 2021. Studies recording the major adverse cardiovascular events (MACEs) or all-cause mortality in HF patients and their circulating TMAO concentrations were included. Meta-analysis was performed using Stata 13.0.ResultsTen articles (12 studies) involving 13,425 participants from 2014 to 2021 were considered. Compared to low-level TMAO, elevated TMAO was correlated with MACEs and all-cause mortality in HF (RR: 1.28, 95% CI: 1.17, 1.39, P < 0.0001, random-effects model and RR: 1.35, 95% CI: 1.28, 1.42, P < 0.0001, random-effects model, respectively). Consistent results were obtained in all examined subgroups as well as in the sensitivity analysis.ConclusionElevated TMAO may be an adverse prognostic indicator in patients with HF.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=267208
abstractGer	ObjectiveThe present study aimed to explore the prognostic value of trimethylamine N-oxide (TMAO) in heart failure (HF).MethodsPubMed, Excerpta Medica Database (EMBASE), Cochrane Library, Web of Science, Wanfang Database, SINOMED, China Science and Technology Journal Database (VIP), and China National Knowledge Infrastructure (CNKI) were searched up to June 1, 2021. Studies recording the major adverse cardiovascular events (MACEs) or all-cause mortality in HF patients and their circulating TMAO concentrations were included. Meta-analysis was performed using Stata 13.0.ResultsTen articles (12 studies) involving 13,425 participants from 2014 to 2021 were considered. Compared to low-level TMAO, elevated TMAO was correlated with MACEs and all-cause mortality in HF (RR: 1.28, 95% CI: 1.17, 1.39, P < 0.0001, random-effects model and RR: 1.35, 95% CI: 1.28, 1.42, P < 0.0001, random-effects model, respectively). Consistent results were obtained in all examined subgroups as well as in the sensitivity analysis.ConclusionElevated TMAO may be an adverse prognostic indicator in patients with HF.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=267208
abstract_unstemmed	ObjectiveThe present study aimed to explore the prognostic value of trimethylamine N-oxide (TMAO) in heart failure (HF).MethodsPubMed, Excerpta Medica Database (EMBASE), Cochrane Library, Web of Science, Wanfang Database, SINOMED, China Science and Technology Journal Database (VIP), and China National Knowledge Infrastructure (CNKI) were searched up to June 1, 2021. Studies recording the major adverse cardiovascular events (MACEs) or all-cause mortality in HF patients and their circulating TMAO concentrations were included. Meta-analysis was performed using Stata 13.0.ResultsTen articles (12 studies) involving 13,425 participants from 2014 to 2021 were considered. Compared to low-level TMAO, elevated TMAO was correlated with MACEs and all-cause mortality in HF (RR: 1.28, 95% CI: 1.17, 1.39, P < 0.0001, random-effects model and RR: 1.35, 95% CI: 1.28, 1.42, P < 0.0001, random-effects model, respectively). Consistent results were obtained in all examined subgroups as well as in the sensitivity analysis.ConclusionElevated TMAO may be an adverse prognostic indicator in patients with HF.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=267208
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title_short	Trimethylamine N-Oxide in Heart Failure: A Meta-Analysis of Prognostic Value
url	https://doi.org/10.3389/fcvm.2022.817396 https://doaj.org/article/d0f75980ec814cd581a71818f31b4e48 https://www.frontiersin.org/articles/10.3389/fcvm.2022.817396/full https://doaj.org/toc/2297-055X
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author2	Zongjing Fan Jie Cui Dong Li Jinjin Lu Xiaoyun Cui Liandi Xie Yang Wu Qian Lin Yan Li
author2Str	Zongjing Fan Jie Cui Dong Li Jinjin Lu Xiaoyun Cui Liandi Xie Yang Wu Qian Lin Yan Li
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up_date	2024-07-03T15:37:52.842Z
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Studies recording the major adverse cardiovascular events (MACEs) or all-cause mortality in HF patients and their circulating TMAO concentrations were included. Meta-analysis was performed using Stata 13.0.ResultsTen articles (12 studies) involving 13,425 participants from 2014 to 2021 were considered. Compared to low-level TMAO, elevated TMAO was correlated with MACEs and all-cause mortality in HF (RR: 1.28, 95% CI: 1.17, 1.39, P &lt; 0.0001, random-effects model and RR: 1.35, 95% CI: 1.28, 1.42, P &lt; 0.0001, random-effects model, respectively). Consistent results were obtained in all examined subgroups as well as in the sensitivity analysis.ConclusionElevated TMAO may be an adverse prognostic indicator in patients with HF.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=267208</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">heart failure</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">trimethylamine N-oxide</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">major adverse cardiovascular events</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">all-cause mortality</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">meta-analysis</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Diseases of the circulatory (Cardiovascular) system</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield 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Trimethylamine N-Oxide in Heart Failure: A Meta-Analysis of Prognostic Value

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