Treatment patterns among patients with malignant pleural mesothelioma: An Italian, population‐based nationwide study
Abstract Background Malignant pleural mesothelioma (MPM) is a rare cancer with a poor prognosis. Centralization of rare cancer in dedicated centers is recommended to ensure expertise, multidisciplinarity and access to innovation. In Italy, expert centers for MPM have not been identified in all regio...
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| Autor*in: |
Annalisa Trama [verfasserIn] Claudia Proto [verfasserIn] Diego Signorelli [verfasserIn] Marina C. Garassino [verfasserIn] Giuseppe Lo Russo [verfasserIn] Monica Ganzinelli [verfasserIn] Arsela Prelaj [verfasserIn] Carolina Mensi [verfasserIn] Manuela Gangemi [verfasserIn] Valerio Gennaro [verfasserIn] Elisabetta Chellini [verfasserIn] Adele Caldarella [verfasserIn] Italo F. Angelillo [verfasserIn] Valeria Ascoli [verfasserIn] Cristiana Pascucci [verfasserIn] Giovanna Tagliabue [verfasserIn] Rosanna Cusimano [verfasserIn] Francesca Bella [verfasserIn] Fabio Falcini [verfasserIn] Enzo Merler [verfasserIn] Giuseppe Masanotti [verfasserIn] Antonio Ziino [verfasserIn] Maria Michiara [verfasserIn] Gemma Gola [verfasserIn] Cinzia Storchi [verfasserIn] Lucia Mangone [verfasserIn] Maria F. Vitale [verfasserIn] Claudia Cirilli [verfasserIn] Rosario Tumino [verfasserIn] Tiziana Scuderi [verfasserIn] Anna C. Fanetti [verfasserIn] Silvano Piffer [verfasserIn] Marcello Tiseo [verfasserIn] Gemma Gatta [verfasserIn] Laura Botta [verfasserIn] the LUME study WG [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Übergeordnetes Werk: |
In: Thoracic Cancer - Wiley, 2015, 11(2020), 6, Seite 1661-1669 |
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| Übergeordnetes Werk: |
volume:11 ; year:2020 ; number:6 ; pages:1661-1669 |
| Links: |
Link aufrufen |
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| DOI / URN: |
10.1111/1759-7714.13456 |
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| Katalog-ID: |
DOAJ008190658 |
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| 520 | |a Abstract Background Malignant pleural mesothelioma (MPM) is a rare cancer with a poor prognosis. Centralization of rare cancer in dedicated centers is recommended to ensure expertise, multidisciplinarity and access to innovation. In Italy, expert centers for MPM have not been identified in all regions. We aimed to describe the treatment patterns among MPM patients across different Italian regions and to identify factors associated with the treatment patterns across the regions. Methods We performed an observational study on a random sample of 2026 MPM patients diagnosed in 2003–2008. We included 26 population‐based registries covering 70% of the Italian population. To identify factors associated with treatment patterns, across the different regions, we fitted a multinomial logistic regression model adjusted by age, sex, stage, histology and hospital with thoracic surgical department. Results MPM patients mostly received chemotherapy alone (41%) or no cancer‐directed therapy (36%) especially the older patients. The first course of treatment for MPM patients differed across regions. Patients from Piedmont, Liguria and Campania were more likely to receive no cancer‐directed therapy; those living in Tuscany and Sicily were more likely to get surgery; patients from Marche and Lazio were more likely to receive chemotherapy. These differences were not explained by age, sex, stage, histology and availability of a thoracic surgery department. Conclusions There is limited expertise available and lack of a network able to maximize the expertise available may contribute to explaining the results of our study. Our findings support the need to ensure the appropriate care of all MPM patients in reorganizing the health care services. Key points Significant findings of the study: MPM patients mostly received chemotherapy alone or no cancer‐directed therapy especially the older patients. The first course of treatment for MPM patients differed across Italian regions. What this study adds: Differences in MPM clinical management are not explained by the age, stage, histology nor by the availability of a thoracic surgery department. Limited expertise for MPM contribute to explaining the unequal access to appropriate care for MPM patients in Italy. | ||
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10.1111/1759-7714.13456 doi (DE-627)DOAJ008190658 (DE-599)DOAJ02f86e80f4c448e49c3063f248286927 DE-627 ger DE-627 rakwb eng RC254-282 Annalisa Trama verfasserin aut Treatment patterns among patients with malignant pleural mesothelioma: An Italian, population‐based nationwide study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Malignant pleural mesothelioma (MPM) is a rare cancer with a poor prognosis. Centralization of rare cancer in dedicated centers is recommended to ensure expertise, multidisciplinarity and access to innovation. In Italy, expert centers for MPM have not been identified in all regions. We aimed to describe the treatment patterns among MPM patients across different Italian regions and to identify factors associated with the treatment patterns across the regions. Methods We performed an observational study on a random sample of 2026 MPM patients diagnosed in 2003–2008. We included 26 population‐based registries covering 70% of the Italian population. To identify factors associated with treatment patterns, across the different regions, we fitted a multinomial logistic regression model adjusted by age, sex, stage, histology and hospital with thoracic surgical department. Results MPM patients mostly received chemotherapy alone (41%) or no cancer‐directed therapy (36%) especially the older patients. The first course of treatment for MPM patients differed across regions. Patients from Piedmont, Liguria and Campania were more likely to receive no cancer‐directed therapy; those living in Tuscany and Sicily were more likely to get surgery; patients from Marche and Lazio were more likely to receive chemotherapy. These differences were not explained by age, sex, stage, histology and availability of a thoracic surgery department. Conclusions There is limited expertise available and lack of a network able to maximize the expertise available may contribute to explaining the results of our study. Our findings support the need to ensure the appropriate care of all MPM patients in reorganizing the health care services. Key points Significant findings of the study: MPM patients mostly received chemotherapy alone or no cancer‐directed therapy especially the older patients. The first course of treatment for MPM patients differed across Italian regions. What this study adds: Differences in MPM clinical management are not explained by the age, stage, histology nor by the availability of a thoracic surgery department. Limited expertise for MPM contribute to explaining the unequal access to appropriate care for MPM patients in Italy. Logistic models mesothelioma malignant registries therapeutics Neoplasms. Tumors. Oncology. Including cancer and carcinogens Claudia Proto verfasserin aut Diego Signorelli verfasserin aut Marina C. Garassino verfasserin aut Giuseppe Lo Russo verfasserin aut Monica Ganzinelli verfasserin aut Arsela Prelaj verfasserin aut Carolina Mensi verfasserin aut Manuela Gangemi verfasserin aut Valerio Gennaro verfasserin aut Elisabetta Chellini verfasserin aut Adele Caldarella verfasserin aut Italo F. Angelillo verfasserin aut Valeria Ascoli verfasserin aut Cristiana Pascucci verfasserin aut Giovanna Tagliabue verfasserin aut Rosanna Cusimano verfasserin aut Francesca Bella verfasserin aut Fabio Falcini verfasserin aut Enzo Merler verfasserin aut Giuseppe Masanotti verfasserin aut Antonio Ziino verfasserin aut Maria Michiara verfasserin aut Gemma Gola verfasserin aut Cinzia Storchi verfasserin aut Lucia Mangone verfasserin aut Maria F. Vitale verfasserin aut Claudia Cirilli verfasserin aut Rosario Tumino verfasserin aut Tiziana Scuderi verfasserin aut Anna C. Fanetti verfasserin aut Silvano Piffer verfasserin aut Marcello Tiseo verfasserin aut Gemma Gatta verfasserin aut Laura Botta verfasserin aut the LUME study WG verfasserin aut In Thoracic Cancer Wiley, 2015 11(2020), 6, Seite 1661-1669 (DE-627)629836809 (DE-600)2559245-2 17597714 nnns volume:11 year:2020 number:6 pages:1661-1669 https://doi.org/10.1111/1759-7714.13456 kostenfrei https://doaj.org/article/02f86e80f4c448e49c3063f248286927 kostenfrei https://doi.org/10.1111/1759-7714.13456 kostenfrei https://doaj.org/toc/1759-7706 Journal toc kostenfrei https://doaj.org/toc/1759-7714 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 6 1661-1669 |
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10.1111/1759-7714.13456 doi (DE-627)DOAJ008190658 (DE-599)DOAJ02f86e80f4c448e49c3063f248286927 DE-627 ger DE-627 rakwb eng RC254-282 Annalisa Trama verfasserin aut Treatment patterns among patients with malignant pleural mesothelioma: An Italian, population‐based nationwide study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Malignant pleural mesothelioma (MPM) is a rare cancer with a poor prognosis. Centralization of rare cancer in dedicated centers is recommended to ensure expertise, multidisciplinarity and access to innovation. In Italy, expert centers for MPM have not been identified in all regions. We aimed to describe the treatment patterns among MPM patients across different Italian regions and to identify factors associated with the treatment patterns across the regions. Methods We performed an observational study on a random sample of 2026 MPM patients diagnosed in 2003–2008. We included 26 population‐based registries covering 70% of the Italian population. To identify factors associated with treatment patterns, across the different regions, we fitted a multinomial logistic regression model adjusted by age, sex, stage, histology and hospital with thoracic surgical department. Results MPM patients mostly received chemotherapy alone (41%) or no cancer‐directed therapy (36%) especially the older patients. The first course of treatment for MPM patients differed across regions. Patients from Piedmont, Liguria and Campania were more likely to receive no cancer‐directed therapy; those living in Tuscany and Sicily were more likely to get surgery; patients from Marche and Lazio were more likely to receive chemotherapy. These differences were not explained by age, sex, stage, histology and availability of a thoracic surgery department. Conclusions There is limited expertise available and lack of a network able to maximize the expertise available may contribute to explaining the results of our study. Our findings support the need to ensure the appropriate care of all MPM patients in reorganizing the health care services. Key points Significant findings of the study: MPM patients mostly received chemotherapy alone or no cancer‐directed therapy especially the older patients. The first course of treatment for MPM patients differed across Italian regions. What this study adds: Differences in MPM clinical management are not explained by the age, stage, histology nor by the availability of a thoracic surgery department. Limited expertise for MPM contribute to explaining the unequal access to appropriate care for MPM patients in Italy. Logistic models mesothelioma malignant registries therapeutics Neoplasms. Tumors. Oncology. Including cancer and carcinogens Claudia Proto verfasserin aut Diego Signorelli verfasserin aut Marina C. Garassino verfasserin aut Giuseppe Lo Russo verfasserin aut Monica Ganzinelli verfasserin aut Arsela Prelaj verfasserin aut Carolina Mensi verfasserin aut Manuela Gangemi verfasserin aut Valerio Gennaro verfasserin aut Elisabetta Chellini verfasserin aut Adele Caldarella verfasserin aut Italo F. Angelillo verfasserin aut Valeria Ascoli verfasserin aut Cristiana Pascucci verfasserin aut Giovanna Tagliabue verfasserin aut Rosanna Cusimano verfasserin aut Francesca Bella verfasserin aut Fabio Falcini verfasserin aut Enzo Merler verfasserin aut Giuseppe Masanotti verfasserin aut Antonio Ziino verfasserin aut Maria Michiara verfasserin aut Gemma Gola verfasserin aut Cinzia Storchi verfasserin aut Lucia Mangone verfasserin aut Maria F. Vitale verfasserin aut Claudia Cirilli verfasserin aut Rosario Tumino verfasserin aut Tiziana Scuderi verfasserin aut Anna C. Fanetti verfasserin aut Silvano Piffer verfasserin aut Marcello Tiseo verfasserin aut Gemma Gatta verfasserin aut Laura Botta verfasserin aut the LUME study WG verfasserin aut In Thoracic Cancer Wiley, 2015 11(2020), 6, Seite 1661-1669 (DE-627)629836809 (DE-600)2559245-2 17597714 nnns volume:11 year:2020 number:6 pages:1661-1669 https://doi.org/10.1111/1759-7714.13456 kostenfrei https://doaj.org/article/02f86e80f4c448e49c3063f248286927 kostenfrei https://doi.org/10.1111/1759-7714.13456 kostenfrei https://doaj.org/toc/1759-7706 Journal toc kostenfrei https://doaj.org/toc/1759-7714 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 6 1661-1669 |
| allfields_unstemmed |
10.1111/1759-7714.13456 doi (DE-627)DOAJ008190658 (DE-599)DOAJ02f86e80f4c448e49c3063f248286927 DE-627 ger DE-627 rakwb eng RC254-282 Annalisa Trama verfasserin aut Treatment patterns among patients with malignant pleural mesothelioma: An Italian, population‐based nationwide study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Malignant pleural mesothelioma (MPM) is a rare cancer with a poor prognosis. Centralization of rare cancer in dedicated centers is recommended to ensure expertise, multidisciplinarity and access to innovation. In Italy, expert centers for MPM have not been identified in all regions. We aimed to describe the treatment patterns among MPM patients across different Italian regions and to identify factors associated with the treatment patterns across the regions. Methods We performed an observational study on a random sample of 2026 MPM patients diagnosed in 2003–2008. We included 26 population‐based registries covering 70% of the Italian population. To identify factors associated with treatment patterns, across the different regions, we fitted a multinomial logistic regression model adjusted by age, sex, stage, histology and hospital with thoracic surgical department. Results MPM patients mostly received chemotherapy alone (41%) or no cancer‐directed therapy (36%) especially the older patients. The first course of treatment for MPM patients differed across regions. Patients from Piedmont, Liguria and Campania were more likely to receive no cancer‐directed therapy; those living in Tuscany and Sicily were more likely to get surgery; patients from Marche and Lazio were more likely to receive chemotherapy. These differences were not explained by age, sex, stage, histology and availability of a thoracic surgery department. Conclusions There is limited expertise available and lack of a network able to maximize the expertise available may contribute to explaining the results of our study. Our findings support the need to ensure the appropriate care of all MPM patients in reorganizing the health care services. Key points Significant findings of the study: MPM patients mostly received chemotherapy alone or no cancer‐directed therapy especially the older patients. The first course of treatment for MPM patients differed across Italian regions. What this study adds: Differences in MPM clinical management are not explained by the age, stage, histology nor by the availability of a thoracic surgery department. Limited expertise for MPM contribute to explaining the unequal access to appropriate care for MPM patients in Italy. Logistic models mesothelioma malignant registries therapeutics Neoplasms. Tumors. Oncology. Including cancer and carcinogens Claudia Proto verfasserin aut Diego Signorelli verfasserin aut Marina C. Garassino verfasserin aut Giuseppe Lo Russo verfasserin aut Monica Ganzinelli verfasserin aut Arsela Prelaj verfasserin aut Carolina Mensi verfasserin aut Manuela Gangemi verfasserin aut Valerio Gennaro verfasserin aut Elisabetta Chellini verfasserin aut Adele Caldarella verfasserin aut Italo F. Angelillo verfasserin aut Valeria Ascoli verfasserin aut Cristiana Pascucci verfasserin aut Giovanna Tagliabue verfasserin aut Rosanna Cusimano verfasserin aut Francesca Bella verfasserin aut Fabio Falcini verfasserin aut Enzo Merler verfasserin aut Giuseppe Masanotti verfasserin aut Antonio Ziino verfasserin aut Maria Michiara verfasserin aut Gemma Gola verfasserin aut Cinzia Storchi verfasserin aut Lucia Mangone verfasserin aut Maria F. Vitale verfasserin aut Claudia Cirilli verfasserin aut Rosario Tumino verfasserin aut Tiziana Scuderi verfasserin aut Anna C. Fanetti verfasserin aut Silvano Piffer verfasserin aut Marcello Tiseo verfasserin aut Gemma Gatta verfasserin aut Laura Botta verfasserin aut the LUME study WG verfasserin aut In Thoracic Cancer Wiley, 2015 11(2020), 6, Seite 1661-1669 (DE-627)629836809 (DE-600)2559245-2 17597714 nnns volume:11 year:2020 number:6 pages:1661-1669 https://doi.org/10.1111/1759-7714.13456 kostenfrei https://doaj.org/article/02f86e80f4c448e49c3063f248286927 kostenfrei https://doi.org/10.1111/1759-7714.13456 kostenfrei https://doaj.org/toc/1759-7706 Journal toc kostenfrei https://doaj.org/toc/1759-7714 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 6 1661-1669 |
| allfieldsGer |
10.1111/1759-7714.13456 doi (DE-627)DOAJ008190658 (DE-599)DOAJ02f86e80f4c448e49c3063f248286927 DE-627 ger DE-627 rakwb eng RC254-282 Annalisa Trama verfasserin aut Treatment patterns among patients with malignant pleural mesothelioma: An Italian, population‐based nationwide study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Malignant pleural mesothelioma (MPM) is a rare cancer with a poor prognosis. Centralization of rare cancer in dedicated centers is recommended to ensure expertise, multidisciplinarity and access to innovation. In Italy, expert centers for MPM have not been identified in all regions. We aimed to describe the treatment patterns among MPM patients across different Italian regions and to identify factors associated with the treatment patterns across the regions. Methods We performed an observational study on a random sample of 2026 MPM patients diagnosed in 2003–2008. We included 26 population‐based registries covering 70% of the Italian population. To identify factors associated with treatment patterns, across the different regions, we fitted a multinomial logistic regression model adjusted by age, sex, stage, histology and hospital with thoracic surgical department. Results MPM patients mostly received chemotherapy alone (41%) or no cancer‐directed therapy (36%) especially the older patients. The first course of treatment for MPM patients differed across regions. Patients from Piedmont, Liguria and Campania were more likely to receive no cancer‐directed therapy; those living in Tuscany and Sicily were more likely to get surgery; patients from Marche and Lazio were more likely to receive chemotherapy. These differences were not explained by age, sex, stage, histology and availability of a thoracic surgery department. Conclusions There is limited expertise available and lack of a network able to maximize the expertise available may contribute to explaining the results of our study. Our findings support the need to ensure the appropriate care of all MPM patients in reorganizing the health care services. Key points Significant findings of the study: MPM patients mostly received chemotherapy alone or no cancer‐directed therapy especially the older patients. The first course of treatment for MPM patients differed across Italian regions. What this study adds: Differences in MPM clinical management are not explained by the age, stage, histology nor by the availability of a thoracic surgery department. Limited expertise for MPM contribute to explaining the unequal access to appropriate care for MPM patients in Italy. Logistic models mesothelioma malignant registries therapeutics Neoplasms. Tumors. Oncology. Including cancer and carcinogens Claudia Proto verfasserin aut Diego Signorelli verfasserin aut Marina C. Garassino verfasserin aut Giuseppe Lo Russo verfasserin aut Monica Ganzinelli verfasserin aut Arsela Prelaj verfasserin aut Carolina Mensi verfasserin aut Manuela Gangemi verfasserin aut Valerio Gennaro verfasserin aut Elisabetta Chellini verfasserin aut Adele Caldarella verfasserin aut Italo F. Angelillo verfasserin aut Valeria Ascoli verfasserin aut Cristiana Pascucci verfasserin aut Giovanna Tagliabue verfasserin aut Rosanna Cusimano verfasserin aut Francesca Bella verfasserin aut Fabio Falcini verfasserin aut Enzo Merler verfasserin aut Giuseppe Masanotti verfasserin aut Antonio Ziino verfasserin aut Maria Michiara verfasserin aut Gemma Gola verfasserin aut Cinzia Storchi verfasserin aut Lucia Mangone verfasserin aut Maria F. Vitale verfasserin aut Claudia Cirilli verfasserin aut Rosario Tumino verfasserin aut Tiziana Scuderi verfasserin aut Anna C. Fanetti verfasserin aut Silvano Piffer verfasserin aut Marcello Tiseo verfasserin aut Gemma Gatta verfasserin aut Laura Botta verfasserin aut the LUME study WG verfasserin aut In Thoracic Cancer Wiley, 2015 11(2020), 6, Seite 1661-1669 (DE-627)629836809 (DE-600)2559245-2 17597714 nnns volume:11 year:2020 number:6 pages:1661-1669 https://doi.org/10.1111/1759-7714.13456 kostenfrei https://doaj.org/article/02f86e80f4c448e49c3063f248286927 kostenfrei https://doi.org/10.1111/1759-7714.13456 kostenfrei https://doaj.org/toc/1759-7706 Journal toc kostenfrei https://doaj.org/toc/1759-7714 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 6 1661-1669 |
| allfieldsSound |
10.1111/1759-7714.13456 doi (DE-627)DOAJ008190658 (DE-599)DOAJ02f86e80f4c448e49c3063f248286927 DE-627 ger DE-627 rakwb eng RC254-282 Annalisa Trama verfasserin aut Treatment patterns among patients with malignant pleural mesothelioma: An Italian, population‐based nationwide study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Malignant pleural mesothelioma (MPM) is a rare cancer with a poor prognosis. Centralization of rare cancer in dedicated centers is recommended to ensure expertise, multidisciplinarity and access to innovation. In Italy, expert centers for MPM have not been identified in all regions. We aimed to describe the treatment patterns among MPM patients across different Italian regions and to identify factors associated with the treatment patterns across the regions. Methods We performed an observational study on a random sample of 2026 MPM patients diagnosed in 2003–2008. We included 26 population‐based registries covering 70% of the Italian population. To identify factors associated with treatment patterns, across the different regions, we fitted a multinomial logistic regression model adjusted by age, sex, stage, histology and hospital with thoracic surgical department. Results MPM patients mostly received chemotherapy alone (41%) or no cancer‐directed therapy (36%) especially the older patients. The first course of treatment for MPM patients differed across regions. Patients from Piedmont, Liguria and Campania were more likely to receive no cancer‐directed therapy; those living in Tuscany and Sicily were more likely to get surgery; patients from Marche and Lazio were more likely to receive chemotherapy. These differences were not explained by age, sex, stage, histology and availability of a thoracic surgery department. Conclusions There is limited expertise available and lack of a network able to maximize the expertise available may contribute to explaining the results of our study. Our findings support the need to ensure the appropriate care of all MPM patients in reorganizing the health care services. Key points Significant findings of the study: MPM patients mostly received chemotherapy alone or no cancer‐directed therapy especially the older patients. The first course of treatment for MPM patients differed across Italian regions. What this study adds: Differences in MPM clinical management are not explained by the age, stage, histology nor by the availability of a thoracic surgery department. Limited expertise for MPM contribute to explaining the unequal access to appropriate care for MPM patients in Italy. Logistic models mesothelioma malignant registries therapeutics Neoplasms. Tumors. Oncology. Including cancer and carcinogens Claudia Proto verfasserin aut Diego Signorelli verfasserin aut Marina C. Garassino verfasserin aut Giuseppe Lo Russo verfasserin aut Monica Ganzinelli verfasserin aut Arsela Prelaj verfasserin aut Carolina Mensi verfasserin aut Manuela Gangemi verfasserin aut Valerio Gennaro verfasserin aut Elisabetta Chellini verfasserin aut Adele Caldarella verfasserin aut Italo F. Angelillo verfasserin aut Valeria Ascoli verfasserin aut Cristiana Pascucci verfasserin aut Giovanna Tagliabue verfasserin aut Rosanna Cusimano verfasserin aut Francesca Bella verfasserin aut Fabio Falcini verfasserin aut Enzo Merler verfasserin aut Giuseppe Masanotti verfasserin aut Antonio Ziino verfasserin aut Maria Michiara verfasserin aut Gemma Gola verfasserin aut Cinzia Storchi verfasserin aut Lucia Mangone verfasserin aut Maria F. Vitale verfasserin aut Claudia Cirilli verfasserin aut Rosario Tumino verfasserin aut Tiziana Scuderi verfasserin aut Anna C. Fanetti verfasserin aut Silvano Piffer verfasserin aut Marcello Tiseo verfasserin aut Gemma Gatta verfasserin aut Laura Botta verfasserin aut the LUME study WG verfasserin aut In Thoracic Cancer Wiley, 2015 11(2020), 6, Seite 1661-1669 (DE-627)629836809 (DE-600)2559245-2 17597714 nnns volume:11 year:2020 number:6 pages:1661-1669 https://doi.org/10.1111/1759-7714.13456 kostenfrei https://doaj.org/article/02f86e80f4c448e49c3063f248286927 kostenfrei https://doi.org/10.1111/1759-7714.13456 kostenfrei https://doaj.org/toc/1759-7706 Journal toc kostenfrei https://doaj.org/toc/1759-7714 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020 6 1661-1669 |
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In Thoracic Cancer 11(2020), 6, Seite 1661-1669 volume:11 year:2020 number:6 pages:1661-1669 |
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In Thoracic Cancer 11(2020), 6, Seite 1661-1669 volume:11 year:2020 number:6 pages:1661-1669 |
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Logistic models mesothelioma malignant registries therapeutics Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
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Annalisa Trama @@aut@@ Claudia Proto @@aut@@ Diego Signorelli @@aut@@ Marina C. Garassino @@aut@@ Giuseppe Lo Russo @@aut@@ Monica Ganzinelli @@aut@@ Arsela Prelaj @@aut@@ Carolina Mensi @@aut@@ Manuela Gangemi @@aut@@ Valerio Gennaro @@aut@@ Elisabetta Chellini @@aut@@ Adele Caldarella @@aut@@ Italo F. Angelillo @@aut@@ Valeria Ascoli @@aut@@ Cristiana Pascucci @@aut@@ Giovanna Tagliabue @@aut@@ Rosanna Cusimano @@aut@@ Francesca Bella @@aut@@ Fabio Falcini @@aut@@ Enzo Merler @@aut@@ Giuseppe Masanotti @@aut@@ Antonio Ziino @@aut@@ Maria Michiara @@aut@@ Gemma Gola @@aut@@ Cinzia Storchi @@aut@@ Lucia Mangone @@aut@@ Maria F. Vitale @@aut@@ Claudia Cirilli @@aut@@ Rosario Tumino @@aut@@ Tiziana Scuderi @@aut@@ Anna C. Fanetti @@aut@@ Silvano Piffer @@aut@@ Marcello Tiseo @@aut@@ Gemma Gatta @@aut@@ Laura Botta @@aut@@ the LUME study WG @@aut@@ |
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2020-01-01T00:00:00Z |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ008190658</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230310004831.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230225s2020 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/1759-7714.13456</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ008190658</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ02f86e80f4c448e49c3063f248286927</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC254-282</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Annalisa Trama</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Treatment patterns among patients with malignant pleural mesothelioma: An Italian, population‐based nationwide study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background Malignant pleural mesothelioma (MPM) is a rare cancer with a poor prognosis. Centralization of rare cancer in dedicated centers is recommended to ensure expertise, multidisciplinarity and access to innovation. In Italy, expert centers for MPM have not been identified in all regions. We aimed to describe the treatment patterns among MPM patients across different Italian regions and to identify factors associated with the treatment patterns across the regions. Methods We performed an observational study on a random sample of 2026 MPM patients diagnosed in 2003–2008. We included 26 population‐based registries covering 70% of the Italian population. To identify factors associated with treatment patterns, across the different regions, we fitted a multinomial logistic regression model adjusted by age, sex, stage, histology and hospital with thoracic surgical department. Results MPM patients mostly received chemotherapy alone (41%) or no cancer‐directed therapy (36%) especially the older patients. The first course of treatment for MPM patients differed across regions. Patients from Piedmont, Liguria and Campania were more likely to receive no cancer‐directed therapy; those living in Tuscany and Sicily were more likely to get surgery; patients from Marche and Lazio were more likely to receive chemotherapy. These differences were not explained by age, sex, stage, histology and availability of a thoracic surgery department. Conclusions There is limited expertise available and lack of a network able to maximize the expertise available may contribute to explaining the results of our study. Our findings support the need to ensure the appropriate care of all MPM patients in reorganizing the health care services. Key points Significant findings of the study: MPM patients mostly received chemotherapy alone or no cancer‐directed therapy especially the older patients. The first course of treatment for MPM patients differed across Italian regions. What this study adds: Differences in MPM clinical management are not explained by the age, stage, histology nor by the availability of a thoracic surgery department. Limited expertise for MPM contribute to explaining the unequal access to appropriate care for MPM patients in Italy.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Logistic models</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">mesothelioma malignant</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">registries</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">therapeutics</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neoplasms. Tumors. Oncology. 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R - Medicine |
| author |
Annalisa Trama |
| spellingShingle |
Annalisa Trama misc RC254-282 misc Logistic models misc mesothelioma malignant misc registries misc therapeutics misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Treatment patterns among patients with malignant pleural mesothelioma: An Italian, population‐based nationwide study |
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Annalisa Trama |
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RC254-282 |
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17597714 |
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RC254-282 Treatment patterns among patients with malignant pleural mesothelioma: An Italian, population‐based nationwide study Logistic models mesothelioma malignant registries therapeutics |
| topic |
misc RC254-282 misc Logistic models misc mesothelioma malignant misc registries misc therapeutics misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
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misc RC254-282 misc Logistic models misc mesothelioma malignant misc registries misc therapeutics misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
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misc RC254-282 misc Logistic models misc mesothelioma malignant misc registries misc therapeutics misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
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Treatment patterns among patients with malignant pleural mesothelioma: An Italian, population‐based nationwide study |
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Treatment patterns among patients with malignant pleural mesothelioma: An Italian, population‐based nationwide study |
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Annalisa Trama |
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Annalisa Trama Claudia Proto Diego Signorelli Marina C. Garassino Giuseppe Lo Russo Monica Ganzinelli Arsela Prelaj Carolina Mensi Manuela Gangemi Valerio Gennaro Elisabetta Chellini Adele Caldarella Italo F. Angelillo Valeria Ascoli Cristiana Pascucci Giovanna Tagliabue Rosanna Cusimano Francesca Bella Fabio Falcini Enzo Merler Giuseppe Masanotti Antonio Ziino Maria Michiara Gemma Gola Cinzia Storchi Lucia Mangone Maria F. Vitale Claudia Cirilli Rosario Tumino Tiziana Scuderi Anna C. Fanetti Silvano Piffer Marcello Tiseo Gemma Gatta Laura Botta the LUME study WG |
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treatment patterns among patients with malignant pleural mesothelioma: an italian, population‐based nationwide study |
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Treatment patterns among patients with malignant pleural mesothelioma: An Italian, population‐based nationwide study |
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Abstract Background Malignant pleural mesothelioma (MPM) is a rare cancer with a poor prognosis. Centralization of rare cancer in dedicated centers is recommended to ensure expertise, multidisciplinarity and access to innovation. In Italy, expert centers for MPM have not been identified in all regions. We aimed to describe the treatment patterns among MPM patients across different Italian regions and to identify factors associated with the treatment patterns across the regions. Methods We performed an observational study on a random sample of 2026 MPM patients diagnosed in 2003–2008. We included 26 population‐based registries covering 70% of the Italian population. To identify factors associated with treatment patterns, across the different regions, we fitted a multinomial logistic regression model adjusted by age, sex, stage, histology and hospital with thoracic surgical department. Results MPM patients mostly received chemotherapy alone (41%) or no cancer‐directed therapy (36%) especially the older patients. The first course of treatment for MPM patients differed across regions. Patients from Piedmont, Liguria and Campania were more likely to receive no cancer‐directed therapy; those living in Tuscany and Sicily were more likely to get surgery; patients from Marche and Lazio were more likely to receive chemotherapy. These differences were not explained by age, sex, stage, histology and availability of a thoracic surgery department. Conclusions There is limited expertise available and lack of a network able to maximize the expertise available may contribute to explaining the results of our study. Our findings support the need to ensure the appropriate care of all MPM patients in reorganizing the health care services. Key points Significant findings of the study: MPM patients mostly received chemotherapy alone or no cancer‐directed therapy especially the older patients. The first course of treatment for MPM patients differed across Italian regions. What this study adds: Differences in MPM clinical management are not explained by the age, stage, histology nor by the availability of a thoracic surgery department. Limited expertise for MPM contribute to explaining the unequal access to appropriate care for MPM patients in Italy. |
| abstractGer |
Abstract Background Malignant pleural mesothelioma (MPM) is a rare cancer with a poor prognosis. Centralization of rare cancer in dedicated centers is recommended to ensure expertise, multidisciplinarity and access to innovation. In Italy, expert centers for MPM have not been identified in all regions. We aimed to describe the treatment patterns among MPM patients across different Italian regions and to identify factors associated with the treatment patterns across the regions. Methods We performed an observational study on a random sample of 2026 MPM patients diagnosed in 2003–2008. We included 26 population‐based registries covering 70% of the Italian population. To identify factors associated with treatment patterns, across the different regions, we fitted a multinomial logistic regression model adjusted by age, sex, stage, histology and hospital with thoracic surgical department. Results MPM patients mostly received chemotherapy alone (41%) or no cancer‐directed therapy (36%) especially the older patients. The first course of treatment for MPM patients differed across regions. Patients from Piedmont, Liguria and Campania were more likely to receive no cancer‐directed therapy; those living in Tuscany and Sicily were more likely to get surgery; patients from Marche and Lazio were more likely to receive chemotherapy. These differences were not explained by age, sex, stage, histology and availability of a thoracic surgery department. Conclusions There is limited expertise available and lack of a network able to maximize the expertise available may contribute to explaining the results of our study. Our findings support the need to ensure the appropriate care of all MPM patients in reorganizing the health care services. Key points Significant findings of the study: MPM patients mostly received chemotherapy alone or no cancer‐directed therapy especially the older patients. The first course of treatment for MPM patients differed across Italian regions. What this study adds: Differences in MPM clinical management are not explained by the age, stage, histology nor by the availability of a thoracic surgery department. Limited expertise for MPM contribute to explaining the unequal access to appropriate care for MPM patients in Italy. |
| abstract_unstemmed |
Abstract Background Malignant pleural mesothelioma (MPM) is a rare cancer with a poor prognosis. Centralization of rare cancer in dedicated centers is recommended to ensure expertise, multidisciplinarity and access to innovation. In Italy, expert centers for MPM have not been identified in all regions. We aimed to describe the treatment patterns among MPM patients across different Italian regions and to identify factors associated with the treatment patterns across the regions. Methods We performed an observational study on a random sample of 2026 MPM patients diagnosed in 2003–2008. We included 26 population‐based registries covering 70% of the Italian population. To identify factors associated with treatment patterns, across the different regions, we fitted a multinomial logistic regression model adjusted by age, sex, stage, histology and hospital with thoracic surgical department. Results MPM patients mostly received chemotherapy alone (41%) or no cancer‐directed therapy (36%) especially the older patients. The first course of treatment for MPM patients differed across regions. Patients from Piedmont, Liguria and Campania were more likely to receive no cancer‐directed therapy; those living in Tuscany and Sicily were more likely to get surgery; patients from Marche and Lazio were more likely to receive chemotherapy. These differences were not explained by age, sex, stage, histology and availability of a thoracic surgery department. Conclusions There is limited expertise available and lack of a network able to maximize the expertise available may contribute to explaining the results of our study. Our findings support the need to ensure the appropriate care of all MPM patients in reorganizing the health care services. Key points Significant findings of the study: MPM patients mostly received chemotherapy alone or no cancer‐directed therapy especially the older patients. The first course of treatment for MPM patients differed across Italian regions. What this study adds: Differences in MPM clinical management are not explained by the age, stage, histology nor by the availability of a thoracic surgery department. Limited expertise for MPM contribute to explaining the unequal access to appropriate care for MPM patients in Italy. |
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Treatment patterns among patients with malignant pleural mesothelioma: An Italian, population‐based nationwide study |
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https://doi.org/10.1111/1759-7714.13456 https://doaj.org/article/02f86e80f4c448e49c3063f248286927 https://doaj.org/toc/1759-7706 https://doaj.org/toc/1759-7714 |
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Claudia Proto Diego Signorelli Marina C. Garassino Giuseppe Lo Russo Monica Ganzinelli Arsela Prelaj Carolina Mensi Manuela Gangemi Valerio Gennaro Elisabetta Chellini Adele Caldarella Italo F. Angelillo Valeria Ascoli Cristiana Pascucci Giovanna Tagliabue Rosanna Cusimano Francesca Bella Fabio Falcini Enzo Merler Giuseppe Masanotti Antonio Ziino Maria Michiara Gemma Gola Cinzia Storchi Lucia Mangone Maria F. Vitale Claudia Cirilli Rosario Tumino Tiziana Scuderi Anna C. Fanetti Silvano Piffer Marcello Tiseo Gemma Gatta Laura Botta the LUME study WG |
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Claudia Proto Diego Signorelli Marina C. Garassino Giuseppe Lo Russo Monica Ganzinelli Arsela Prelaj Carolina Mensi Manuela Gangemi Valerio Gennaro Elisabetta Chellini Adele Caldarella Italo F. Angelillo Valeria Ascoli Cristiana Pascucci Giovanna Tagliabue Rosanna Cusimano Francesca Bella Fabio Falcini Enzo Merler Giuseppe Masanotti Antonio Ziino Maria Michiara Gemma Gola Cinzia Storchi Lucia Mangone Maria F. Vitale Claudia Cirilli Rosario Tumino Tiziana Scuderi Anna C. Fanetti Silvano Piffer Marcello Tiseo Gemma Gatta Laura Botta the LUME study WG |
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