House of cellulose – a new hideout for drug tolerant Mycobacterium tuberculosis

Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB). The treatment of TB requires administration of multiple drugs for long durations because of the unusual drug tolerance of Mtb. The phenotypic drug tolerance of genetically drug-susceptible Mtb in humans can be explained by its ability to for...
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Autor*in:	Ashwani Kumar [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Mycobacterium tuberculosis biofilms cellulose drug tolerance thiol reductive stress extracellular polymeric substance

Übergeordnetes Werk:	In: Microbial Cell - Shared Science Publishers OG, 2015, 3(2016), 7, Seite 299-301
Übergeordnetes Werk:	volume:3 ; year:2016 ; number:7 ; pages:299-301

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.15698/mic2016.07.515

Katalog-ID:	DOAJ008205132

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spelling	10.15698/mic2016.07.515 doi (DE-627)DOAJ008205132 (DE-599)DOAJda535d4c611846aa994fdf5a28e9c68d DE-627 ger DE-627 rakwb eng QH301-705.5 Ashwani Kumar verfasserin aut House of cellulose – a new hideout for drug tolerant Mycobacterium tuberculosis 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB). The treatment of TB requires administration of multiple drugs for long durations because of the unusual drug tolerance of Mtb. The phenotypic drug tolerance of genetically drug-susceptible Mtb in humans can be explained by its ability to form biofilms. Recent studies from different laboratories suggest that Mtb forms biofilms that harbour drug-tolerant bacteria. These findings have created a new area of research in the field of mycobacterial physiology. Recently, my laboratory has reported that Mtb cells organise themselves into biofilms in response to intracellular thiol reductive stress (Trivedi et al. Nature communications. 2016). Bacteria residing in these biofilms are tolerant towards antimycobacterial drugs. Cellulose is a key component of the extracellular polymeric substances that hold mycobacterial cells together in these biofilms. Here, I discuss the implications of these findings and new hypotheses arising from this study on the biology of Mtb biofilms. Mycobacterium tuberculosis biofilms cellulose drug tolerance thiol reductive stress extracellular polymeric substance Biology (General) In Microbial Cell Shared Science Publishers OG, 2015 3(2016), 7, Seite 299-301 (DE-627)820688738 (DE-600)2814756-X 23112638 nnns volume:3 year:2016 number:7 pages:299-301 https://doi.org/10.15698/mic2016.07.515 kostenfrei https://doaj.org/article/da535d4c611846aa994fdf5a28e9c68d kostenfrei http://microbialcell.com/researcharticles/house-of-cellulose-a-new-hideout-for-drug-tolerant-mycobacterium-tuberculosis/ kostenfrei https://doaj.org/toc/2311-2638 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2016 7 299-301
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allfieldsGer	10.15698/mic2016.07.515 doi (DE-627)DOAJ008205132 (DE-599)DOAJda535d4c611846aa994fdf5a28e9c68d DE-627 ger DE-627 rakwb eng QH301-705.5 Ashwani Kumar verfasserin aut House of cellulose – a new hideout for drug tolerant Mycobacterium tuberculosis 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB). The treatment of TB requires administration of multiple drugs for long durations because of the unusual drug tolerance of Mtb. The phenotypic drug tolerance of genetically drug-susceptible Mtb in humans can be explained by its ability to form biofilms. Recent studies from different laboratories suggest that Mtb forms biofilms that harbour drug-tolerant bacteria. These findings have created a new area of research in the field of mycobacterial physiology. Recently, my laboratory has reported that Mtb cells organise themselves into biofilms in response to intracellular thiol reductive stress (Trivedi et al. Nature communications. 2016). Bacteria residing in these biofilms are tolerant towards antimycobacterial drugs. Cellulose is a key component of the extracellular polymeric substances that hold mycobacterial cells together in these biofilms. Here, I discuss the implications of these findings and new hypotheses arising from this study on the biology of Mtb biofilms. Mycobacterium tuberculosis biofilms cellulose drug tolerance thiol reductive stress extracellular polymeric substance Biology (General) In Microbial Cell Shared Science Publishers OG, 2015 3(2016), 7, Seite 299-301 (DE-627)820688738 (DE-600)2814756-X 23112638 nnns volume:3 year:2016 number:7 pages:299-301 https://doi.org/10.15698/mic2016.07.515 kostenfrei https://doaj.org/article/da535d4c611846aa994fdf5a28e9c68d kostenfrei http://microbialcell.com/researcharticles/house-of-cellulose-a-new-hideout-for-drug-tolerant-mycobacterium-tuberculosis/ kostenfrei https://doaj.org/toc/2311-2638 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2016 7 299-301
allfieldsSound	10.15698/mic2016.07.515 doi (DE-627)DOAJ008205132 (DE-599)DOAJda535d4c611846aa994fdf5a28e9c68d DE-627 ger DE-627 rakwb eng QH301-705.5 Ashwani Kumar verfasserin aut House of cellulose – a new hideout for drug tolerant Mycobacterium tuberculosis 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB). The treatment of TB requires administration of multiple drugs for long durations because of the unusual drug tolerance of Mtb. The phenotypic drug tolerance of genetically drug-susceptible Mtb in humans can be explained by its ability to form biofilms. Recent studies from different laboratories suggest that Mtb forms biofilms that harbour drug-tolerant bacteria. These findings have created a new area of research in the field of mycobacterial physiology. Recently, my laboratory has reported that Mtb cells organise themselves into biofilms in response to intracellular thiol reductive stress (Trivedi et al. Nature communications. 2016). Bacteria residing in these biofilms are tolerant towards antimycobacterial drugs. Cellulose is a key component of the extracellular polymeric substances that hold mycobacterial cells together in these biofilms. Here, I discuss the implications of these findings and new hypotheses arising from this study on the biology of Mtb biofilms. Mycobacterium tuberculosis biofilms cellulose drug tolerance thiol reductive stress extracellular polymeric substance Biology (General) In Microbial Cell Shared Science Publishers OG, 2015 3(2016), 7, Seite 299-301 (DE-627)820688738 (DE-600)2814756-X 23112638 nnns volume:3 year:2016 number:7 pages:299-301 https://doi.org/10.15698/mic2016.07.515 kostenfrei https://doaj.org/article/da535d4c611846aa994fdf5a28e9c68d kostenfrei http://microbialcell.com/researcharticles/house-of-cellulose-a-new-hideout-for-drug-tolerant-mycobacterium-tuberculosis/ kostenfrei https://doaj.org/toc/2311-2638 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2016 7 299-301
language	English
source	In Microbial Cell 3(2016), 7, Seite 299-301 volume:3 year:2016 number:7 pages:299-301
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container_title	Microbial Cell
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callnumber-first	Q - Science
author	Ashwani Kumar
spellingShingle	Ashwani Kumar misc QH301-705.5 misc Mycobacterium tuberculosis misc biofilms misc cellulose misc drug tolerance misc thiol reductive stress misc extracellular polymeric substance misc Biology (General) House of cellulose – a new hideout for drug tolerant Mycobacterium tuberculosis
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topic_title	QH301-705.5 House of cellulose – a new hideout for drug tolerant Mycobacterium tuberculosis Mycobacterium tuberculosis biofilms cellulose drug tolerance thiol reductive stress extracellular polymeric substance
topic	misc QH301-705.5 misc Mycobacterium tuberculosis misc biofilms misc cellulose misc drug tolerance misc thiol reductive stress misc extracellular polymeric substance misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc Mycobacterium tuberculosis misc biofilms misc cellulose misc drug tolerance misc thiol reductive stress misc extracellular polymeric substance misc Biology (General)
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title	House of cellulose – a new hideout for drug tolerant Mycobacterium tuberculosis
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title_full	House of cellulose – a new hideout for drug tolerant Mycobacterium tuberculosis
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title_sort	house of cellulose – a new hideout for drug tolerant mycobacterium tuberculosis
callnumber	QH301-705.5
title_auth	House of cellulose – a new hideout for drug tolerant Mycobacterium tuberculosis
abstract	Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB). The treatment of TB requires administration of multiple drugs for long durations because of the unusual drug tolerance of Mtb. The phenotypic drug tolerance of genetically drug-susceptible Mtb in humans can be explained by its ability to form biofilms. Recent studies from different laboratories suggest that Mtb forms biofilms that harbour drug-tolerant bacteria. These findings have created a new area of research in the field of mycobacterial physiology. Recently, my laboratory has reported that Mtb cells organise themselves into biofilms in response to intracellular thiol reductive stress (Trivedi et al. Nature communications. 2016). Bacteria residing in these biofilms are tolerant towards antimycobacterial drugs. Cellulose is a key component of the extracellular polymeric substances that hold mycobacterial cells together in these biofilms. Here, I discuss the implications of these findings and new hypotheses arising from this study on the biology of Mtb biofilms.
abstractGer	Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB). The treatment of TB requires administration of multiple drugs for long durations because of the unusual drug tolerance of Mtb. The phenotypic drug tolerance of genetically drug-susceptible Mtb in humans can be explained by its ability to form biofilms. Recent studies from different laboratories suggest that Mtb forms biofilms that harbour drug-tolerant bacteria. These findings have created a new area of research in the field of mycobacterial physiology. Recently, my laboratory has reported that Mtb cells organise themselves into biofilms in response to intracellular thiol reductive stress (Trivedi et al. Nature communications. 2016). Bacteria residing in these biofilms are tolerant towards antimycobacterial drugs. Cellulose is a key component of the extracellular polymeric substances that hold mycobacterial cells together in these biofilms. Here, I discuss the implications of these findings and new hypotheses arising from this study on the biology of Mtb biofilms.
abstract_unstemmed	Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB). The treatment of TB requires administration of multiple drugs for long durations because of the unusual drug tolerance of Mtb. The phenotypic drug tolerance of genetically drug-susceptible Mtb in humans can be explained by its ability to form biofilms. Recent studies from different laboratories suggest that Mtb forms biofilms that harbour drug-tolerant bacteria. These findings have created a new area of research in the field of mycobacterial physiology. Recently, my laboratory has reported that Mtb cells organise themselves into biofilms in response to intracellular thiol reductive stress (Trivedi et al. Nature communications. 2016). Bacteria residing in these biofilms are tolerant towards antimycobacterial drugs. Cellulose is a key component of the extracellular polymeric substances that hold mycobacterial cells together in these biofilms. Here, I discuss the implications of these findings and new hypotheses arising from this study on the biology of Mtb biofilms.
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title_short	House of cellulose – a new hideout for drug tolerant Mycobacterium tuberculosis
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