Adverse Events during Vitrectomy under Adequacy of Anesthesia—An Additional Report

The intraprocedural immobilization of selected subsets of patients undergoing pars plana vitrectomy (PPV) requires the performance of general anesthesia (GA), which entails the intraoperative use of hypnotics and titration of opioids. The Adequacy of Anesthesia (AoA) concept of GA guidance optimizes the intraoperative dosage of hypnotics and opioids. Pre-emptive analgesia (PA) is added to GA to minimize intraoperative opioid (IO) usage. The current additional analysis evaluated the advantages of PA using either COX-3 inhibitors or regional techniques when added to AoA-guided GA on the rate of presence of postoperative nausea and vomiting (PONV), oculo-emetic (OER), and oculo-cardiac reflex (OCR) in patients undergoing PPV. A total of 176 patients undergoing PPV were randomly allocated into 5 groups: (1) Group GA, including patients who received general anesthesia alone; (2) Group T, including patients who received preventive topical analgesia by triple instillation of 2% proparacaine 15 min before induction of GA; (3) Group PBB, including patients who received PBB; (4) Group M, including patients who received PA using a single dose of 1 g of metamizole; (5) Group P, including patients who received PA using a single dose of 1 g of acetaminophen. The incidence rates of PONV, OCR, and OER were studied as a secondary outcome. Despite the group allocation, intraoperative AoA-guided GA resulted in an overall incidence of PONV in 9%, OCR in 12%, and OER in none of the patients. No statistically significant differences were found between groups regarding the incidence of OCR. PA using COX-3 inhibitors, as compared to that of the T group, resulted in less overall PONV (<i<p</i< < 0.05). Conclusions: PA using regional techniques in patients undergoing PPV proved to have no advantage when AoA-guided GA was utilised. We recommend using intraoperative AoA-guided GA to reduce the presence of OCR, and the addition of PA using COX-3 inhibitors to reduce the rate of PONV. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Aleksandra Pluta [verfasserIn] Michał Jan Stasiowski [verfasserIn] Anita Lyssek-Boroń [verfasserIn] Seweryn Król [verfasserIn] Lech Krawczyk [verfasserIn] Ewa Niewiadomska [verfasserIn] Jakub Żak [verfasserIn] Magdalena Kawka [verfasserIn] Dariusz Dobrowolski [verfasserIn] Beniamin Oskar Grabarek [verfasserIn] Izabela Szumera [verfasserIn] Anna Missir [verfasserIn] Robert Rejdak [verfasserIn] Przemysław Jałowiecki [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	pars plana vitrectomy (PPV) adequacy of anesthesia (AoA) postoperative nausea and vomiting (PONV) oculo-emetic reflex (OER) oculo-cardiac reflex (OCR)

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 10(2021), 18, p 4172
Übergeordnetes Werk:	volume:10 ; year:2021 ; number:18, p 4172

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm10184172

Katalog-ID:	DOAJ008289581

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520			\|a The intraprocedural immobilization of selected subsets of patients undergoing pars plana vitrectomy (PPV) requires the performance of general anesthesia (GA), which entails the intraoperative use of hypnotics and titration of opioids. The Adequacy of Anesthesia (AoA) concept of GA guidance optimizes the intraoperative dosage of hypnotics and opioids. Pre-emptive analgesia (PA) is added to GA to minimize intraoperative opioid (IO) usage. The current additional analysis evaluated the advantages of PA using either COX-3 inhibitors or regional techniques when added to AoA-guided GA on the rate of presence of postoperative nausea and vomiting (PONV), oculo-emetic (OER), and oculo-cardiac reflex (OCR) in patients undergoing PPV. A total of 176 patients undergoing PPV were randomly allocated into 5 groups: (1) Group GA, including patients who received general anesthesia alone; (2) Group T, including patients who received preventive topical analgesia by triple instillation of 2% proparacaine 15 min before induction of GA; (3) Group PBB, including patients who received PBB; (4) Group M, including patients who received PA using a single dose of 1 g of metamizole; (5) Group P, including patients who received PA using a single dose of 1 g of acetaminophen. The incidence rates of PONV, OCR, and OER were studied as a secondary outcome. Despite the group allocation, intraoperative AoA-guided GA resulted in an overall incidence of PONV in 9%, OCR in 12%, and OER in none of the patients. No statistically significant differences were found between groups regarding the incidence of OCR. PA using COX-3 inhibitors, as compared to that of the T group, resulted in less overall PONV (<i<p</i< < 0.05). Conclusions: PA using regional techniques in patients undergoing PPV proved to have no advantage when AoA-guided GA was utilised. We recommend using intraoperative AoA-guided GA to reduce the presence of OCR, and the addition of PA using COX-3 inhibitors to reduce the rate of PONV.
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allfields	10.3390/jcm10184172 doi (DE-627)DOAJ008289581 (DE-599)DOAJ98b0de5db14a4545a5e4227232a9ad02 DE-627 ger DE-627 rakwb eng Aleksandra Pluta verfasserin aut Adverse Events during Vitrectomy under Adequacy of Anesthesia—An Additional Report 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The intraprocedural immobilization of selected subsets of patients undergoing pars plana vitrectomy (PPV) requires the performance of general anesthesia (GA), which entails the intraoperative use of hypnotics and titration of opioids. The Adequacy of Anesthesia (AoA) concept of GA guidance optimizes the intraoperative dosage of hypnotics and opioids. Pre-emptive analgesia (PA) is added to GA to minimize intraoperative opioid (IO) usage. The current additional analysis evaluated the advantages of PA using either COX-3 inhibitors or regional techniques when added to AoA-guided GA on the rate of presence of postoperative nausea and vomiting (PONV), oculo-emetic (OER), and oculo-cardiac reflex (OCR) in patients undergoing PPV. A total of 176 patients undergoing PPV were randomly allocated into 5 groups: (1) Group GA, including patients who received general anesthesia alone; (2) Group T, including patients who received preventive topical analgesia by triple instillation of 2% proparacaine 15 min before induction of GA; (3) Group PBB, including patients who received PBB; (4) Group M, including patients who received PA using a single dose of 1 g of metamizole; (5) Group P, including patients who received PA using a single dose of 1 g of acetaminophen. The incidence rates of PONV, OCR, and OER were studied as a secondary outcome. Despite the group allocation, intraoperative AoA-guided GA resulted in an overall incidence of PONV in 9%, OCR in 12%, and OER in none of the patients. No statistically significant differences were found between groups regarding the incidence of OCR. PA using COX-3 inhibitors, as compared to that of the T group, resulted in less overall PONV (<i<p</i< < 0.05). Conclusions: PA using regional techniques in patients undergoing PPV proved to have no advantage when AoA-guided GA was utilised. We recommend using intraoperative AoA-guided GA to reduce the presence of OCR, and the addition of PA using COX-3 inhibitors to reduce the rate of PONV. pars plana vitrectomy (PPV) adequacy of anesthesia (AoA) postoperative nausea and vomiting (PONV) oculo-emetic reflex (OER) oculo-cardiac reflex (OCR) Medicine R Michał Jan Stasiowski verfasserin aut Anita Lyssek-Boroń verfasserin aut Seweryn Król verfasserin aut Lech Krawczyk verfasserin aut Ewa Niewiadomska verfasserin aut Jakub Żak verfasserin aut Magdalena Kawka verfasserin aut Dariusz Dobrowolski verfasserin aut Beniamin Oskar Grabarek verfasserin aut Izabela Szumera verfasserin aut Anna Missir verfasserin aut Robert Rejdak verfasserin aut Przemysław Jałowiecki verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 18, p 4172 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:18, p 4172 https://doi.org/10.3390/jcm10184172 kostenfrei https://doaj.org/article/98b0de5db14a4545a5e4227232a9ad02 kostenfrei https://www.mdpi.com/2077-0383/10/18/4172 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 18, p 4172
spelling	10.3390/jcm10184172 doi (DE-627)DOAJ008289581 (DE-599)DOAJ98b0de5db14a4545a5e4227232a9ad02 DE-627 ger DE-627 rakwb eng Aleksandra Pluta verfasserin aut Adverse Events during Vitrectomy under Adequacy of Anesthesia—An Additional Report 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The intraprocedural immobilization of selected subsets of patients undergoing pars plana vitrectomy (PPV) requires the performance of general anesthesia (GA), which entails the intraoperative use of hypnotics and titration of opioids. The Adequacy of Anesthesia (AoA) concept of GA guidance optimizes the intraoperative dosage of hypnotics and opioids. Pre-emptive analgesia (PA) is added to GA to minimize intraoperative opioid (IO) usage. The current additional analysis evaluated the advantages of PA using either COX-3 inhibitors or regional techniques when added to AoA-guided GA on the rate of presence of postoperative nausea and vomiting (PONV), oculo-emetic (OER), and oculo-cardiac reflex (OCR) in patients undergoing PPV. A total of 176 patients undergoing PPV were randomly allocated into 5 groups: (1) Group GA, including patients who received general anesthesia alone; (2) Group T, including patients who received preventive topical analgesia by triple instillation of 2% proparacaine 15 min before induction of GA; (3) Group PBB, including patients who received PBB; (4) Group M, including patients who received PA using a single dose of 1 g of metamizole; (5) Group P, including patients who received PA using a single dose of 1 g of acetaminophen. The incidence rates of PONV, OCR, and OER were studied as a secondary outcome. Despite the group allocation, intraoperative AoA-guided GA resulted in an overall incidence of PONV in 9%, OCR in 12%, and OER in none of the patients. No statistically significant differences were found between groups regarding the incidence of OCR. PA using COX-3 inhibitors, as compared to that of the T group, resulted in less overall PONV (<i<p</i< < 0.05). Conclusions: PA using regional techniques in patients undergoing PPV proved to have no advantage when AoA-guided GA was utilised. We recommend using intraoperative AoA-guided GA to reduce the presence of OCR, and the addition of PA using COX-3 inhibitors to reduce the rate of PONV. pars plana vitrectomy (PPV) adequacy of anesthesia (AoA) postoperative nausea and vomiting (PONV) oculo-emetic reflex (OER) oculo-cardiac reflex (OCR) Medicine R Michał Jan Stasiowski verfasserin aut Anita Lyssek-Boroń verfasserin aut Seweryn Król verfasserin aut Lech Krawczyk verfasserin aut Ewa Niewiadomska verfasserin aut Jakub Żak verfasserin aut Magdalena Kawka verfasserin aut Dariusz Dobrowolski verfasserin aut Beniamin Oskar Grabarek verfasserin aut Izabela Szumera verfasserin aut Anna Missir verfasserin aut Robert Rejdak verfasserin aut Przemysław Jałowiecki verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 18, p 4172 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:18, p 4172 https://doi.org/10.3390/jcm10184172 kostenfrei https://doaj.org/article/98b0de5db14a4545a5e4227232a9ad02 kostenfrei https://www.mdpi.com/2077-0383/10/18/4172 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 18, p 4172
allfields_unstemmed	10.3390/jcm10184172 doi (DE-627)DOAJ008289581 (DE-599)DOAJ98b0de5db14a4545a5e4227232a9ad02 DE-627 ger DE-627 rakwb eng Aleksandra Pluta verfasserin aut Adverse Events during Vitrectomy under Adequacy of Anesthesia—An Additional Report 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The intraprocedural immobilization of selected subsets of patients undergoing pars plana vitrectomy (PPV) requires the performance of general anesthesia (GA), which entails the intraoperative use of hypnotics and titration of opioids. The Adequacy of Anesthesia (AoA) concept of GA guidance optimizes the intraoperative dosage of hypnotics and opioids. Pre-emptive analgesia (PA) is added to GA to minimize intraoperative opioid (IO) usage. The current additional analysis evaluated the advantages of PA using either COX-3 inhibitors or regional techniques when added to AoA-guided GA on the rate of presence of postoperative nausea and vomiting (PONV), oculo-emetic (OER), and oculo-cardiac reflex (OCR) in patients undergoing PPV. A total of 176 patients undergoing PPV were randomly allocated into 5 groups: (1) Group GA, including patients who received general anesthesia alone; (2) Group T, including patients who received preventive topical analgesia by triple instillation of 2% proparacaine 15 min before induction of GA; (3) Group PBB, including patients who received PBB; (4) Group M, including patients who received PA using a single dose of 1 g of metamizole; (5) Group P, including patients who received PA using a single dose of 1 g of acetaminophen. The incidence rates of PONV, OCR, and OER were studied as a secondary outcome. Despite the group allocation, intraoperative AoA-guided GA resulted in an overall incidence of PONV in 9%, OCR in 12%, and OER in none of the patients. No statistically significant differences were found between groups regarding the incidence of OCR. PA using COX-3 inhibitors, as compared to that of the T group, resulted in less overall PONV (<i<p</i< < 0.05). Conclusions: PA using regional techniques in patients undergoing PPV proved to have no advantage when AoA-guided GA was utilised. We recommend using intraoperative AoA-guided GA to reduce the presence of OCR, and the addition of PA using COX-3 inhibitors to reduce the rate of PONV. pars plana vitrectomy (PPV) adequacy of anesthesia (AoA) postoperative nausea and vomiting (PONV) oculo-emetic reflex (OER) oculo-cardiac reflex (OCR) Medicine R Michał Jan Stasiowski verfasserin aut Anita Lyssek-Boroń verfasserin aut Seweryn Król verfasserin aut Lech Krawczyk verfasserin aut Ewa Niewiadomska verfasserin aut Jakub Żak verfasserin aut Magdalena Kawka verfasserin aut Dariusz Dobrowolski verfasserin aut Beniamin Oskar Grabarek verfasserin aut Izabela Szumera verfasserin aut Anna Missir verfasserin aut Robert Rejdak verfasserin aut Przemysław Jałowiecki verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 18, p 4172 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:18, p 4172 https://doi.org/10.3390/jcm10184172 kostenfrei https://doaj.org/article/98b0de5db14a4545a5e4227232a9ad02 kostenfrei https://www.mdpi.com/2077-0383/10/18/4172 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 18, p 4172
allfieldsGer	10.3390/jcm10184172 doi (DE-627)DOAJ008289581 (DE-599)DOAJ98b0de5db14a4545a5e4227232a9ad02 DE-627 ger DE-627 rakwb eng Aleksandra Pluta verfasserin aut Adverse Events during Vitrectomy under Adequacy of Anesthesia—An Additional Report 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The intraprocedural immobilization of selected subsets of patients undergoing pars plana vitrectomy (PPV) requires the performance of general anesthesia (GA), which entails the intraoperative use of hypnotics and titration of opioids. The Adequacy of Anesthesia (AoA) concept of GA guidance optimizes the intraoperative dosage of hypnotics and opioids. Pre-emptive analgesia (PA) is added to GA to minimize intraoperative opioid (IO) usage. The current additional analysis evaluated the advantages of PA using either COX-3 inhibitors or regional techniques when added to AoA-guided GA on the rate of presence of postoperative nausea and vomiting (PONV), oculo-emetic (OER), and oculo-cardiac reflex (OCR) in patients undergoing PPV. A total of 176 patients undergoing PPV were randomly allocated into 5 groups: (1) Group GA, including patients who received general anesthesia alone; (2) Group T, including patients who received preventive topical analgesia by triple instillation of 2% proparacaine 15 min before induction of GA; (3) Group PBB, including patients who received PBB; (4) Group M, including patients who received PA using a single dose of 1 g of metamizole; (5) Group P, including patients who received PA using a single dose of 1 g of acetaminophen. The incidence rates of PONV, OCR, and OER were studied as a secondary outcome. Despite the group allocation, intraoperative AoA-guided GA resulted in an overall incidence of PONV in 9%, OCR in 12%, and OER in none of the patients. No statistically significant differences were found between groups regarding the incidence of OCR. PA using COX-3 inhibitors, as compared to that of the T group, resulted in less overall PONV (<i<p</i< < 0.05). Conclusions: PA using regional techniques in patients undergoing PPV proved to have no advantage when AoA-guided GA was utilised. We recommend using intraoperative AoA-guided GA to reduce the presence of OCR, and the addition of PA using COX-3 inhibitors to reduce the rate of PONV. pars plana vitrectomy (PPV) adequacy of anesthesia (AoA) postoperative nausea and vomiting (PONV) oculo-emetic reflex (OER) oculo-cardiac reflex (OCR) Medicine R Michał Jan Stasiowski verfasserin aut Anita Lyssek-Boroń verfasserin aut Seweryn Król verfasserin aut Lech Krawczyk verfasserin aut Ewa Niewiadomska verfasserin aut Jakub Żak verfasserin aut Magdalena Kawka verfasserin aut Dariusz Dobrowolski verfasserin aut Beniamin Oskar Grabarek verfasserin aut Izabela Szumera verfasserin aut Anna Missir verfasserin aut Robert Rejdak verfasserin aut Przemysław Jałowiecki verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 18, p 4172 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:18, p 4172 https://doi.org/10.3390/jcm10184172 kostenfrei https://doaj.org/article/98b0de5db14a4545a5e4227232a9ad02 kostenfrei https://www.mdpi.com/2077-0383/10/18/4172 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 18, p 4172
allfieldsSound	10.3390/jcm10184172 doi (DE-627)DOAJ008289581 (DE-599)DOAJ98b0de5db14a4545a5e4227232a9ad02 DE-627 ger DE-627 rakwb eng Aleksandra Pluta verfasserin aut Adverse Events during Vitrectomy under Adequacy of Anesthesia—An Additional Report 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The intraprocedural immobilization of selected subsets of patients undergoing pars plana vitrectomy (PPV) requires the performance of general anesthesia (GA), which entails the intraoperative use of hypnotics and titration of opioids. The Adequacy of Anesthesia (AoA) concept of GA guidance optimizes the intraoperative dosage of hypnotics and opioids. Pre-emptive analgesia (PA) is added to GA to minimize intraoperative opioid (IO) usage. The current additional analysis evaluated the advantages of PA using either COX-3 inhibitors or regional techniques when added to AoA-guided GA on the rate of presence of postoperative nausea and vomiting (PONV), oculo-emetic (OER), and oculo-cardiac reflex (OCR) in patients undergoing PPV. A total of 176 patients undergoing PPV were randomly allocated into 5 groups: (1) Group GA, including patients who received general anesthesia alone; (2) Group T, including patients who received preventive topical analgesia by triple instillation of 2% proparacaine 15 min before induction of GA; (3) Group PBB, including patients who received PBB; (4) Group M, including patients who received PA using a single dose of 1 g of metamizole; (5) Group P, including patients who received PA using a single dose of 1 g of acetaminophen. The incidence rates of PONV, OCR, and OER were studied as a secondary outcome. Despite the group allocation, intraoperative AoA-guided GA resulted in an overall incidence of PONV in 9%, OCR in 12%, and OER in none of the patients. No statistically significant differences were found between groups regarding the incidence of OCR. PA using COX-3 inhibitors, as compared to that of the T group, resulted in less overall PONV (<i<p</i< < 0.05). Conclusions: PA using regional techniques in patients undergoing PPV proved to have no advantage when AoA-guided GA was utilised. We recommend using intraoperative AoA-guided GA to reduce the presence of OCR, and the addition of PA using COX-3 inhibitors to reduce the rate of PONV. pars plana vitrectomy (PPV) adequacy of anesthesia (AoA) postoperative nausea and vomiting (PONV) oculo-emetic reflex (OER) oculo-cardiac reflex (OCR) Medicine R Michał Jan Stasiowski verfasserin aut Anita Lyssek-Boroń verfasserin aut Seweryn Król verfasserin aut Lech Krawczyk verfasserin aut Ewa Niewiadomska verfasserin aut Jakub Żak verfasserin aut Magdalena Kawka verfasserin aut Dariusz Dobrowolski verfasserin aut Beniamin Oskar Grabarek verfasserin aut Izabela Szumera verfasserin aut Anna Missir verfasserin aut Robert Rejdak verfasserin aut Przemysław Jałowiecki verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 10(2021), 18, p 4172 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:10 year:2021 number:18, p 4172 https://doi.org/10.3390/jcm10184172 kostenfrei https://doaj.org/article/98b0de5db14a4545a5e4227232a9ad02 kostenfrei https://www.mdpi.com/2077-0383/10/18/4172 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2021 18, p 4172
language	English
source	In Journal of Clinical Medicine 10(2021), 18, p 4172 volume:10 year:2021 number:18, p 4172
sourceStr	In Journal of Clinical Medicine 10(2021), 18, p 4172 volume:10 year:2021 number:18, p 4172
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	pars plana vitrectomy (PPV) adequacy of anesthesia (AoA) postoperative nausea and vomiting (PONV) oculo-emetic reflex (OER) oculo-cardiac reflex (OCR) Medicine R
isfreeaccess_bool	true
container_title	Journal of Clinical Medicine
authorswithroles_txt_mv	Aleksandra Pluta @@aut@@ Michał Jan Stasiowski @@aut@@ Anita Lyssek-Boroń @@aut@@ Seweryn Król @@aut@@ Lech Krawczyk @@aut@@ Ewa Niewiadomska @@aut@@ Jakub Żak @@aut@@ Magdalena Kawka @@aut@@ Dariusz Dobrowolski @@aut@@ Beniamin Oskar Grabarek @@aut@@ Izabela Szumera @@aut@@ Anna Missir @@aut@@ Robert Rejdak @@aut@@ Przemysław Jałowiecki @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	718632478
id	DOAJ008289581
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ008289581</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240412160447.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230225s2021 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/jcm10184172</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ008289581</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ98b0de5db14a4545a5e4227232a9ad02</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Aleksandra Pluta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Adverse Events during Vitrectomy under Adequacy of Anesthesia—An Additional Report</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The intraprocedural immobilization of selected subsets of patients undergoing pars plana vitrectomy (PPV) requires the performance of general anesthesia (GA), which entails the intraoperative use of hypnotics and titration of opioids. The Adequacy of Anesthesia (AoA) concept of GA guidance optimizes the intraoperative dosage of hypnotics and opioids. Pre-emptive analgesia (PA) is added to GA to minimize intraoperative opioid (IO) usage. The current additional analysis evaluated the advantages of PA using either COX-3 inhibitors or regional techniques when added to AoA-guided GA on the rate of presence of postoperative nausea and vomiting (PONV), oculo-emetic (OER), and oculo-cardiac reflex (OCR) in patients undergoing PPV. A total of 176 patients undergoing PPV were randomly allocated into 5 groups: (1) Group GA, including patients who received general anesthesia alone; (2) Group T, including patients who received preventive topical analgesia by triple instillation of 2% proparacaine 15 min before induction of GA; (3) Group PBB, including patients who received PBB; (4) Group M, including patients who received PA using a single dose of 1 g of metamizole; (5) Group P, including patients who received PA using a single dose of 1 g of acetaminophen. The incidence rates of PONV, OCR, and OER were studied as a secondary outcome. Despite the group allocation, intraoperative AoA-guided GA resulted in an overall incidence of PONV in 9%, OCR in 12%, and OER in none of the patients. No statistically significant differences were found between groups regarding the incidence of OCR. PA using COX-3 inhibitors, as compared to that of the T group, resulted in less overall PONV (<i<p</i< < 0.05). Conclusions: PA using regional techniques in patients undergoing PPV proved to have no advantage when AoA-guided GA was utilised. 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author	Aleksandra Pluta
spellingShingle	Aleksandra Pluta misc pars plana vitrectomy (PPV) misc adequacy of anesthesia (AoA) misc postoperative nausea and vomiting (PONV) misc oculo-emetic reflex (OER) misc oculo-cardiac reflex (OCR) misc Medicine misc R Adverse Events during Vitrectomy under Adequacy of Anesthesia—An Additional Report
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topic_title	Adverse Events during Vitrectomy under Adequacy of Anesthesia—An Additional Report pars plana vitrectomy (PPV) adequacy of anesthesia (AoA) postoperative nausea and vomiting (PONV) oculo-emetic reflex (OER) oculo-cardiac reflex (OCR)
topic	misc pars plana vitrectomy (PPV) misc adequacy of anesthesia (AoA) misc postoperative nausea and vomiting (PONV) misc oculo-emetic reflex (OER) misc oculo-cardiac reflex (OCR) misc Medicine misc R
topic_unstemmed	misc pars plana vitrectomy (PPV) misc adequacy of anesthesia (AoA) misc postoperative nausea and vomiting (PONV) misc oculo-emetic reflex (OER) misc oculo-cardiac reflex (OCR) misc Medicine misc R
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title	Adverse Events during Vitrectomy under Adequacy of Anesthesia—An Additional Report
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title_full	Adverse Events during Vitrectomy under Adequacy of Anesthesia—An Additional Report
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author_browse	Aleksandra Pluta Michał Jan Stasiowski Anita Lyssek-Boroń Seweryn Król Lech Krawczyk Ewa Niewiadomska Jakub Żak Magdalena Kawka Dariusz Dobrowolski Beniamin Oskar Grabarek Izabela Szumera Anna Missir Robert Rejdak Przemysław Jałowiecki
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title_sort	adverse events during vitrectomy under adequacy of anesthesia—an additional report
title_auth	Adverse Events during Vitrectomy under Adequacy of Anesthesia—An Additional Report
abstract	The intraprocedural immobilization of selected subsets of patients undergoing pars plana vitrectomy (PPV) requires the performance of general anesthesia (GA), which entails the intraoperative use of hypnotics and titration of opioids. The Adequacy of Anesthesia (AoA) concept of GA guidance optimizes the intraoperative dosage of hypnotics and opioids. Pre-emptive analgesia (PA) is added to GA to minimize intraoperative opioid (IO) usage. The current additional analysis evaluated the advantages of PA using either COX-3 inhibitors or regional techniques when added to AoA-guided GA on the rate of presence of postoperative nausea and vomiting (PONV), oculo-emetic (OER), and oculo-cardiac reflex (OCR) in patients undergoing PPV. A total of 176 patients undergoing PPV were randomly allocated into 5 groups: (1) Group GA, including patients who received general anesthesia alone; (2) Group T, including patients who received preventive topical analgesia by triple instillation of 2% proparacaine 15 min before induction of GA; (3) Group PBB, including patients who received PBB; (4) Group M, including patients who received PA using a single dose of 1 g of metamizole; (5) Group P, including patients who received PA using a single dose of 1 g of acetaminophen. The incidence rates of PONV, OCR, and OER were studied as a secondary outcome. Despite the group allocation, intraoperative AoA-guided GA resulted in an overall incidence of PONV in 9%, OCR in 12%, and OER in none of the patients. No statistically significant differences were found between groups regarding the incidence of OCR. PA using COX-3 inhibitors, as compared to that of the T group, resulted in less overall PONV (<i<p</i< < 0.05). Conclusions: PA using regional techniques in patients undergoing PPV proved to have no advantage when AoA-guided GA was utilised. We recommend using intraoperative AoA-guided GA to reduce the presence of OCR, and the addition of PA using COX-3 inhibitors to reduce the rate of PONV.
abstractGer	The intraprocedural immobilization of selected subsets of patients undergoing pars plana vitrectomy (PPV) requires the performance of general anesthesia (GA), which entails the intraoperative use of hypnotics and titration of opioids. The Adequacy of Anesthesia (AoA) concept of GA guidance optimizes the intraoperative dosage of hypnotics and opioids. Pre-emptive analgesia (PA) is added to GA to minimize intraoperative opioid (IO) usage. The current additional analysis evaluated the advantages of PA using either COX-3 inhibitors or regional techniques when added to AoA-guided GA on the rate of presence of postoperative nausea and vomiting (PONV), oculo-emetic (OER), and oculo-cardiac reflex (OCR) in patients undergoing PPV. A total of 176 patients undergoing PPV were randomly allocated into 5 groups: (1) Group GA, including patients who received general anesthesia alone; (2) Group T, including patients who received preventive topical analgesia by triple instillation of 2% proparacaine 15 min before induction of GA; (3) Group PBB, including patients who received PBB; (4) Group M, including patients who received PA using a single dose of 1 g of metamizole; (5) Group P, including patients who received PA using a single dose of 1 g of acetaminophen. The incidence rates of PONV, OCR, and OER were studied as a secondary outcome. Despite the group allocation, intraoperative AoA-guided GA resulted in an overall incidence of PONV in 9%, OCR in 12%, and OER in none of the patients. No statistically significant differences were found between groups regarding the incidence of OCR. PA using COX-3 inhibitors, as compared to that of the T group, resulted in less overall PONV (<i<p</i< < 0.05). Conclusions: PA using regional techniques in patients undergoing PPV proved to have no advantage when AoA-guided GA was utilised. We recommend using intraoperative AoA-guided GA to reduce the presence of OCR, and the addition of PA using COX-3 inhibitors to reduce the rate of PONV.
abstract_unstemmed	The intraprocedural immobilization of selected subsets of patients undergoing pars plana vitrectomy (PPV) requires the performance of general anesthesia (GA), which entails the intraoperative use of hypnotics and titration of opioids. The Adequacy of Anesthesia (AoA) concept of GA guidance optimizes the intraoperative dosage of hypnotics and opioids. Pre-emptive analgesia (PA) is added to GA to minimize intraoperative opioid (IO) usage. The current additional analysis evaluated the advantages of PA using either COX-3 inhibitors or regional techniques when added to AoA-guided GA on the rate of presence of postoperative nausea and vomiting (PONV), oculo-emetic (OER), and oculo-cardiac reflex (OCR) in patients undergoing PPV. A total of 176 patients undergoing PPV were randomly allocated into 5 groups: (1) Group GA, including patients who received general anesthesia alone; (2) Group T, including patients who received preventive topical analgesia by triple instillation of 2% proparacaine 15 min before induction of GA; (3) Group PBB, including patients who received PBB; (4) Group M, including patients who received PA using a single dose of 1 g of metamizole; (5) Group P, including patients who received PA using a single dose of 1 g of acetaminophen. The incidence rates of PONV, OCR, and OER were studied as a secondary outcome. Despite the group allocation, intraoperative AoA-guided GA resulted in an overall incidence of PONV in 9%, OCR in 12%, and OER in none of the patients. No statistically significant differences were found between groups regarding the incidence of OCR. PA using COX-3 inhibitors, as compared to that of the T group, resulted in less overall PONV (<i<p</i< < 0.05). Conclusions: PA using regional techniques in patients undergoing PPV proved to have no advantage when AoA-guided GA was utilised. We recommend using intraoperative AoA-guided GA to reduce the presence of OCR, and the addition of PA using COX-3 inhibitors to reduce the rate of PONV.
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title_short	Adverse Events during Vitrectomy under Adequacy of Anesthesia—An Additional Report
url	https://doi.org/10.3390/jcm10184172 https://doaj.org/article/98b0de5db14a4545a5e4227232a9ad02 https://www.mdpi.com/2077-0383/10/18/4172 https://doaj.org/toc/2077-0383
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author2	Michał Jan Stasiowski Anita Lyssek-Boroń Seweryn Król Lech Krawczyk Ewa Niewiadomska Jakub Żak Magdalena Kawka Dariusz Dobrowolski Beniamin Oskar Grabarek Izabela Szumera Anna Missir Robert Rejdak Przemysław Jałowiecki
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