Performance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States
Summary: Many US states published crisis standards of care (CSC) guidelines for allocating scarce critical care resources during the COVID-19 pandemic. However, the performance of these guidelines in maximizing their population benefit has not been well tested. In 2,272 adults with COVID-19 requirin...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Julia L. Jezmir [verfasserIn] Maheetha Bharadwaj [verfasserIn] Alexander Chaitoff [verfasserIn] Bradford Diephuis [verfasserIn] Conor P. Crowley [verfasserIn] Sandeep P. Kishore [verfasserIn] Eric Goralnick [verfasserIn] Louis T. Merriam [verfasserIn] Aimee Milliken [verfasserIn] Chanu Rhee [verfasserIn] Nicholas Sadovnikoff [verfasserIn] Sejal B. Shah [verfasserIn] Shruti Gupta [verfasserIn] David E. Leaf [verfasserIn] William B. Feldman [verfasserIn] Edy Y. Kim [verfasserIn] Carl P. Walther [verfasserIn] Samaya J. Anumudu [verfasserIn] Justin Arunthamakun [verfasserIn] Kathleen F. Kopecky [verfasserIn] Gregory P. Milligan [verfasserIn] Peter A. McCullough [verfasserIn] Thuy-Duyen Nguyen [verfasserIn] Shahzad Shaefi [verfasserIn] Megan L. Krajewski [verfasserIn] Sidharth Shankar [verfasserIn] Ameeka Pannu [verfasserIn] Juan D. Valencia [verfasserIn] Sushrut S. Waikar [verfasserIn] Zoe A. Kibbelaar [verfasserIn] Ambarish M. Athavale [verfasserIn] Peter Hart [verfasserIn] Shristi Upadhyay [verfasserIn] Ishaan Vohra [verfasserIn] Ajiboye Oyintayo [verfasserIn] Adam Green [verfasserIn] Jean-Sebastien Rachoin [verfasserIn] Christa A. Schorr [verfasserIn] Lisa Shea [verfasserIn] Daniel L. Edmonston [verfasserIn] Christopher L. Mosher [verfasserIn] Alexandre M. Shehata [verfasserIn] Zaza Cohen [verfasserIn] Valerie Allusson [verfasserIn] Gabriela Bambrick-Santoyo [verfasserIn] Noor ul aain Bhatti [verfasserIn] Bijal Mehta [verfasserIn] Aquino Williams [verfasserIn] Samantha K. Brenner [verfasserIn] Patricia Walters [verfasserIn] Ronaldo C. Go [verfasserIn] Keith M. Rose [verfasserIn] Miguel A. Hernán [verfasserIn] Amy M. Zhou [verfasserIn] Ethan C. Kim [verfasserIn] Rebecca Lisk [verfasserIn] Lili Chan [verfasserIn] Kusum S. Mathews [verfasserIn] Steven G. Coca [verfasserIn] Deena R. Altman [verfasserIn] Aparna Saha [verfasserIn] Howard Soh [verfasserIn] Huei Hsun Wen [verfasserIn] Sonali Bose [verfasserIn] Emily A. Leven [verfasserIn] Jing G. Wang [verfasserIn] Gohar Mosoyan [verfasserIn] Girish N. Nadkarni [verfasserIn] Pattharawin Pattharanitima [verfasserIn] Allon N. Friedman [verfasserIn] John Guirguis [verfasserIn] Rajat Kapoor [verfasserIn] Christopher Meshberger [verfasserIn] Katherine J. Kelly [verfasserIn] Chirag R. Parikh [verfasserIn] Brian T. Garibaldi [verfasserIn] Celia P. Corona-Villalobos [verfasserIn] Yumeng Wen [verfasserIn] Steven Menez [verfasserIn] Rubab F. Malik [verfasserIn] Elena Cervantes [verfasserIn] Samir Gautam [verfasserIn] Mary C. Mallappallil [verfasserIn] Jie Ouyang [verfasserIn] Sabu John [verfasserIn] Ernie Yap [verfasserIn] Yohannes Melaku [verfasserIn] Ibrahim Mohamed [verfasserIn] Siddartha Bajracharya [verfasserIn] Isha Puri [verfasserIn] Mariah Thaxton [verfasserIn] Jyotsna Bhattacharya [verfasserIn] John Wagner [verfasserIn] Leon Boudourakis [verfasserIn] H. Bryant Nguyen [verfasserIn] Afshin Ahoubim [verfasserIn] Leslie F. Thomas [verfasserIn] Dheeraj Reddy Sirganagari [verfasserIn] Pramod K. Guru [verfasserIn] Kianoush Kashani [verfasserIn] Yan Zhou [verfasserIn] Paul A. Bergl [verfasserIn] Jesus Rodriguez [verfasserIn] Jatan A. Shah [verfasserIn] Mrigank S. Gupta [verfasserIn] Princy N. Kumar [verfasserIn] Deepa G. Lazarous [verfasserIn] Seble G. Kassaye [verfasserIn] Michal L. Melamed [verfasserIn] Tanya S. Johns [verfasserIn] Ryan Mocerino [verfasserIn] Kalyan Prudhvi [verfasserIn] Denzel Zhu [verfasserIn] Rebecca V. Levy [verfasserIn] Yorg Azzi [verfasserIn] Molly Fisher [verfasserIn] Milagros Yunes [verfasserIn] Kaltrina Sedaliu [verfasserIn] Ladan Golestaneh [verfasserIn] Maureen Brogan [verfasserIn] Neelja Kumar [verfasserIn] Michael Chang [verfasserIn] Ritesh Raichoudhury [verfasserIn] Akshay Athreya [verfasserIn] Mohamed Farag [verfasserIn] Edward J. Schenck [verfasserIn] Soo Jung Cho [verfasserIn] Maria Plataki [verfasserIn] Sergio L. Alvarez-Mulett [verfasserIn] Luis G. Gomez-Escobar [verfasserIn] Di Pan [verfasserIn] Stefi Lee [verfasserIn] Jamuna Krishnan [verfasserIn] William Whalen [verfasserIn] David Charytan [verfasserIn] Ashley Macina [verfasserIn] Sobaata Chaudhry [verfasserIn] Benjamin Wu [verfasserIn] Frank Modersitzki [verfasserIn] Anand Srivastava [verfasserIn] Alexander S. Leidner [verfasserIn] Carlos Martinez [verfasserIn] Jacqueline M. Kruser [verfasserIn] Richard G. Wunderink [verfasserIn] Alexander J. Hodakowski [verfasserIn] Juan Carlos Q. Velez [verfasserIn] Eboni G. Price-Haywood [verfasserIn] Luis A. Matute-Trochez [verfasserIn] Anna E. Hasty [verfasserIn] Muner MB. Mohamed [verfasserIn] Rupali S. Avasare [verfasserIn] David Zonies [verfasserIn] Meghan E. Sise [verfasserIn] Erik T. Newman [verfasserIn] Samah Abu Omar [verfasserIn] Kapil K. Pokharel [verfasserIn] Shreyak Sharma [verfasserIn] Harkarandeep Singh [verfasserIn] Simon Correa [verfasserIn] Tanveer Shaukat [verfasserIn] Omer Kamal [verfasserIn] Wei Wang [verfasserIn] Heather Yang [verfasserIn] Jeffery O. Boateng [verfasserIn] Meghan Lee [verfasserIn] Ian A. Strohbehn [verfasserIn] Jiahua Li [verfasserIn] Ariel L. Mueller [verfasserIn] Roberta Redfern [verfasserIn] Nicholas S. Cairl [verfasserIn] Gabriel Naimy [verfasserIn] Abeer Abu-Saif [verfasserIn] Danyell Hall [verfasserIn] Laura Bickley [verfasserIn] Chris Rowan [verfasserIn] Farah Madhani-Lovely [verfasserIn] Vivian S. Cruz [verfasserIn] Kristen M. Hess [verfasserIn] Alanna L. Jacobs [verfasserIn] Vasil Peev [verfasserIn] Jochen Reiser [verfasserIn] John J. Byun [verfasserIn] Andrew Vissing [verfasserIn] Esha M. Kapania [verfasserIn] Zoe Post [verfasserIn] Nilam P. Patel [verfasserIn] Joy-Marie Hermes [verfasserIn] Anne K. Sutherland [verfasserIn] Amee Patrawalla [verfasserIn] Diana G. Finkel [verfasserIn] Barbara A. Danek [verfasserIn] Sowminya Arikapudi [verfasserIn] Jeffrey M. Paer [verfasserIn] Peter Cangialosi [verfasserIn] Mark Liotta [verfasserIn] Jared Radbel [verfasserIn] Sonika Puri [verfasserIn] Jag Sunderram [verfasserIn] Matthew T. Scharf [verfasserIn] Ayesha Ahmed [verfasserIn] Ilya Berim [verfasserIn] Jayanth S. Vatson [verfasserIn] Shuchi Anand [verfasserIn] Joseph E. Levitt [verfasserIn] Suzanne M. Boyle [verfasserIn] Rui Song [verfasserIn] Jingjing Zhang [verfasserIn] Sang Hoon Woo [verfasserIn] Xiaoying Deng [verfasserIn] Goni Katz-Greenberg [verfasserIn] Katharine Senter [verfasserIn] Moh’d A. Sharshir [verfasserIn] Vadym V. Rusnak [verfasserIn] Muhammad Imran Ali [verfasserIn] Anip Bansal [verfasserIn] Amber S. Podoll [verfasserIn] Michel Chonchol [verfasserIn] Sunita Sharma [verfasserIn] Ellen L. Burnham [verfasserIn] Arash Rashidi [verfasserIn] Rana Hejal [verfasserIn] Eric Judd [verfasserIn] Laura Latta [verfasserIn] Ashita Tolwani [verfasserIn] Timothy E. Albertson [verfasserIn] Jason Y. Adams [verfasserIn] Steven Y. Chang [verfasserIn] Rebecca M. Beutler [verfasserIn] Etienne Macedo [verfasserIn] Harin Rhee [verfasserIn] Kathleen D. Liu [verfasserIn] Vasantha K. Jotwani [verfasserIn] Jay L. Koyner [verfasserIn] Chintan V. Shah [verfasserIn] Vishal Jaikaransingh [verfasserIn] Stephanie M. Toth-Manikowski [verfasserIn] Min J. Joo [verfasserIn] James P. Lash [verfasserIn] Javier A. Neyra [verfasserIn] Nourhan Chaaban [verfasserIn] Madona Elias [verfasserIn] Yahya Ahmad [verfasserIn] Alfredo Iardino [verfasserIn] Elizabeth H. Au [verfasserIn] Jill H. Sharma [verfasserIn] Marie Anne Sosa [verfasserIn] Sabrina Taldone [verfasserIn] Gabriel Contreras [verfasserIn] David De La Zerda [verfasserIn] Hayley B. Gershengorn [verfasserIn] Bhavarth Shukla [verfasserIn] Alessia Fornoni [verfasserIn] Tanira Ferreira [verfasserIn] Salim S. Hayek [verfasserIn] Pennelope Blakely [verfasserIn] Hanna Berlin [verfasserIn] Tariq U. Azam [verfasserIn] Husam Shadid [verfasserIn] Michael Pan [verfasserIn] Patrick O’ Hayer [verfasserIn] Chelsea Meloche [verfasserIn] Rafey Feroze [verfasserIn] Rayan Kaakati [verfasserIn] Danny Perry [verfasserIn] Abbas Bitar [verfasserIn] Elizabeth Anderson [verfasserIn] Kishan J. Padalia [verfasserIn] John P. Donnelly [verfasserIn] Andrew J. Admon [verfasserIn] Jennifer E. Flythe [verfasserIn] Matthew J. Tugman [verfasserIn] Emily H. Chang [verfasserIn] Brent R. Brown [verfasserIn] Amanda K. Leonberg-Yoo [verfasserIn] Ryan C. Spiardi [verfasserIn] Todd A. Miano [verfasserIn] Meaghan S. Roche [verfasserIn] Charles R. Vasquez [verfasserIn] Amar D. Bansal [verfasserIn] Natalie C. Ernecoff [verfasserIn] Sanjana Kapoor [verfasserIn] Siddharth Verma [verfasserIn] Csaba P. Kovesdy [verfasserIn] Miklos Z. Molnar [verfasserIn] Ambreen Azhar [verfasserIn] S. Susan Hedayati [verfasserIn] Mridula V. Nadamuni [verfasserIn] Shani Shastri [verfasserIn] Duwayne L. Willett [verfasserIn] Samuel A.P. Short [verfasserIn] Amanda D. Renaghan [verfasserIn] Kyle B. Enfield [verfasserIn] Pavan K. Bhatraju [verfasserIn] A. Bilal Malik [verfasserIn] Matthew W. Semler [verfasserIn] Anitha Vijayan [verfasserIn] Christina Mariyam Joy [verfasserIn] Tingting Li [verfasserIn] Seth Goldberg [verfasserIn] Patricia F. Kao [verfasserIn] Greg L. Schumaker [verfasserIn] Nitender Goyal [verfasserIn] Anthony J. Faugno [verfasserIn] Caroline M. Hsu [verfasserIn] Asma Tariq [verfasserIn] Leah Meyer [verfasserIn] Ravi K. Kshirsagar [verfasserIn] Daniel E. Weiner [verfasserIn] Aju Jose [verfasserIn] Marta Christov [verfasserIn] Jennifer Griffiths [verfasserIn] Sanjeev Gupta [verfasserIn] Aromma Kapoor [verfasserIn] Perry Wilson [verfasserIn] Tanima Arora [verfasserIn] Ugochukwu Ugwuowo [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Cell Reports Medicine - Elsevier, 2020, 2(2021), 9, Seite 100376- |
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| Übergeordnetes Werk: |
volume:2 ; year:2021 ; number:9 ; pages:100376- |
| Links: |
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| DOI / URN: |
10.1016/j.xcrm.2021.100376 |
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| Katalog-ID: |
DOAJ008310599 |
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| 024 | 7 | |a 10.1016/j.xcrm.2021.100376 |2 doi | |
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| 041 | |a eng | ||
| 050 | 0 | |a R5-920 | |
| 100 | 0 | |a Julia L. Jezmir |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Performance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
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| 520 | |a Summary: Many US states published crisis standards of care (CSC) guidelines for allocating scarce critical care resources during the COVID-19 pandemic. However, the performance of these guidelines in maximizing their population benefit has not been well tested. In 2,272 adults with COVID-19 requiring mechanical ventilation drawn from the Study of the Treatment and Outcomes in Critically Ill Patients with COVID-19 (STOP-COVID) multicenter cohort, we test the following three approaches to CSC algorithms: Sequential Organ Failure Assessment (SOFA) scores grouped into ranges, SOFA score ranges plus comorbidities, and a hypothetical approach using raw SOFA scores not grouped into ranges. We find that area under receiver operating characteristic (AUROC) curves for all three algorithms demonstrate only modest discrimination for 28-day mortality. Adding comorbidity scoring modestly improves algorithm performance over SOFA scores alone. The algorithm incorporating comorbidities has modestly worse predictive performance for Black compared to white patients. CSC algorithms should be empirically examined to refine approaches to the allocation of scarce resources during pandemics and to avoid potential exacerbation of racial inequities. | ||
| 650 | 4 | |a medical ethics | |
| 650 | 4 | |a crisis standards of care | |
| 650 | 4 | |a triage | |
| 650 | 4 | |a critical care | |
| 650 | 4 | |a intensive care | |
| 650 | 4 | |a COVID-19 | |
| 653 | 0 | |a Medicine (General) | |
| 700 | 0 | |a Maheetha Bharadwaj |e verfasserin |4 aut | |
| 700 | 0 | |a Alexander Chaitoff |e verfasserin |4 aut | |
| 700 | 0 | |a Bradford Diephuis |e verfasserin |4 aut | |
| 700 | 0 | |a Conor P. Crowley |e verfasserin |4 aut | |
| 700 | 0 | |a Sandeep P. Kishore |e verfasserin |4 aut | |
| 700 | 0 | |a Eric Goralnick |e verfasserin |4 aut | |
| 700 | 0 | |a Louis T. Merriam |e verfasserin |4 aut | |
| 700 | 0 | |a Aimee Milliken |e verfasserin |4 aut | |
| 700 | 0 | |a Chanu Rhee |e verfasserin |4 aut | |
| 700 | 0 | |a Nicholas Sadovnikoff |e verfasserin |4 aut | |
| 700 | 0 | |a Sejal B. Shah |e verfasserin |4 aut | |
| 700 | 0 | |a Shruti Gupta |e verfasserin |4 aut | |
| 700 | 0 | |a David E. Leaf |e verfasserin |4 aut | |
| 700 | 0 | |a William B. Feldman |e verfasserin |4 aut | |
| 700 | 0 | |a Edy Y. Kim |e verfasserin |4 aut | |
| 700 | 0 | |a Carl P. Walther |e verfasserin |4 aut | |
| 700 | 0 | |a Samaya J. Anumudu |e verfasserin |4 aut | |
| 700 | 0 | |a Justin Arunthamakun |e verfasserin |4 aut | |
| 700 | 0 | |a Kathleen F. Kopecky |e verfasserin |4 aut | |
| 700 | 0 | |a Gregory P. Milligan |e verfasserin |4 aut | |
| 700 | 0 | |a Peter A. McCullough |e verfasserin |4 aut | |
| 700 | 0 | |a Thuy-Duyen Nguyen |e verfasserin |4 aut | |
| 700 | 0 | |a Shahzad Shaefi |e verfasserin |4 aut | |
| 700 | 0 | |a Megan L. Krajewski |e verfasserin |4 aut | |
| 700 | 0 | |a Sidharth Shankar |e verfasserin |4 aut | |
| 700 | 0 | |a Ameeka Pannu |e verfasserin |4 aut | |
| 700 | 0 | |a Juan D. Valencia |e verfasserin |4 aut | |
| 700 | 0 | |a Sushrut S. Waikar |e verfasserin |4 aut | |
| 700 | 0 | |a Zoe A. Kibbelaar |e verfasserin |4 aut | |
| 700 | 0 | |a Ambarish M. Athavale |e verfasserin |4 aut | |
| 700 | 0 | |a Peter Hart |e verfasserin |4 aut | |
| 700 | 0 | |a Shristi Upadhyay |e verfasserin |4 aut | |
| 700 | 0 | |a Ishaan Vohra |e verfasserin |4 aut | |
| 700 | 0 | |a Ajiboye Oyintayo |e verfasserin |4 aut | |
| 700 | 0 | |a Adam Green |e verfasserin |4 aut | |
| 700 | 0 | |a Jean-Sebastien Rachoin |e verfasserin |4 aut | |
| 700 | 0 | |a Christa A. Schorr |e verfasserin |4 aut | |
| 700 | 0 | |a Lisa Shea |e verfasserin |4 aut | |
| 700 | 0 | |a Daniel L. Edmonston |e verfasserin |4 aut | |
| 700 | 0 | |a Christopher L. Mosher |e verfasserin |4 aut | |
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| 700 | 0 | |a Bijal Mehta |e verfasserin |4 aut | |
| 700 | 0 | |a Aquino Williams |e verfasserin |4 aut | |
| 700 | 0 | |a Samantha K. Brenner |e verfasserin |4 aut | |
| 700 | 0 | |a Patricia Walters |e verfasserin |4 aut | |
| 700 | 0 | |a Ronaldo C. Go |e verfasserin |4 aut | |
| 700 | 0 | |a Keith M. Rose |e verfasserin |4 aut | |
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| 700 | 0 | |a Amy M. Zhou |e verfasserin |4 aut | |
| 700 | 0 | |a Ethan C. Kim |e verfasserin |4 aut | |
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| 700 | 0 | |a Lili Chan |e verfasserin |4 aut | |
| 700 | 0 | |a Kusum S. Mathews |e verfasserin |4 aut | |
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| 700 | 0 | |a Aparna Saha |e verfasserin |4 aut | |
| 700 | 0 | |a Howard Soh |e verfasserin |4 aut | |
| 700 | 0 | |a Huei Hsun Wen |e verfasserin |4 aut | |
| 700 | 0 | |a Sonali Bose |e verfasserin |4 aut | |
| 700 | 0 | |a Emily A. Leven |e verfasserin |4 aut | |
| 700 | 0 | |a Jing G. Wang |e verfasserin |4 aut | |
| 700 | 0 | |a Gohar Mosoyan |e verfasserin |4 aut | |
| 700 | 0 | |a Girish N. Nadkarni |e verfasserin |4 aut | |
| 700 | 0 | |a Pattharawin Pattharanitima |e verfasserin |4 aut | |
| 700 | 0 | |a Allon N. Friedman |e verfasserin |4 aut | |
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| 700 | 0 | |a Rajat Kapoor |e verfasserin |4 aut | |
| 700 | 0 | |a Christopher Meshberger |e verfasserin |4 aut | |
| 700 | 0 | |a Katherine J. Kelly |e verfasserin |4 aut | |
| 700 | 0 | |a Chirag R. Parikh |e verfasserin |4 aut | |
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| 700 | 0 | |a Yumeng Wen |e verfasserin |4 aut | |
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| 700 | 0 | |a Jyotsna Bhattacharya |e verfasserin |4 aut | |
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| 700 | 0 | |a Leon Boudourakis |e verfasserin |4 aut | |
| 700 | 0 | |a H. Bryant Nguyen |e verfasserin |4 aut | |
| 700 | 0 | |a Afshin Ahoubim |e verfasserin |4 aut | |
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| 700 | 0 | |a Kianoush Kashani |e verfasserin |4 aut | |
| 700 | 0 | |a Yan Zhou |e verfasserin |4 aut | |
| 700 | 0 | |a Paul A. Bergl |e verfasserin |4 aut | |
| 700 | 0 | |a Jesus Rodriguez |e verfasserin |4 aut | |
| 700 | 0 | |a Jatan A. Shah |e verfasserin |4 aut | |
| 700 | 0 | |a Mrigank S. Gupta |e verfasserin |4 aut | |
| 700 | 0 | |a Princy N. Kumar |e verfasserin |4 aut | |
| 700 | 0 | |a Deepa G. Lazarous |e verfasserin |4 aut | |
| 700 | 0 | |a Seble G. Kassaye |e verfasserin |4 aut | |
| 700 | 0 | |a Michal L. Melamed |e verfasserin |4 aut | |
| 700 | 0 | |a Tanya S. Johns |e verfasserin |4 aut | |
| 700 | 0 | |a Ryan Mocerino |e verfasserin |4 aut | |
| 700 | 0 | |a Kalyan Prudhvi |e verfasserin |4 aut | |
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| 700 | 0 | |a Ritesh Raichoudhury |e verfasserin |4 aut | |
| 700 | 0 | |a Akshay Athreya |e verfasserin |4 aut | |
| 700 | 0 | |a Mohamed Farag |e verfasserin |4 aut | |
| 700 | 0 | |a Edward J. Schenck |e verfasserin |4 aut | |
| 700 | 0 | |a Soo Jung Cho |e verfasserin |4 aut | |
| 700 | 0 | |a Maria Plataki |e verfasserin |4 aut | |
| 700 | 0 | |a Sergio L. Alvarez-Mulett |e verfasserin |4 aut | |
| 700 | 0 | |a Luis G. Gomez-Escobar |e verfasserin |4 aut | |
| 700 | 0 | |a Di Pan |e verfasserin |4 aut | |
| 700 | 0 | |a Stefi Lee |e verfasserin |4 aut | |
| 700 | 0 | |a Jamuna Krishnan |e verfasserin |4 aut | |
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| 700 | 0 | |a David Charytan |e verfasserin |4 aut | |
| 700 | 0 | |a Ashley Macina |e verfasserin |4 aut | |
| 700 | 0 | |a Sobaata Chaudhry |e verfasserin |4 aut | |
| 700 | 0 | |a Benjamin Wu |e verfasserin |4 aut | |
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10.1016/j.xcrm.2021.100376 doi (DE-627)DOAJ008310599 (DE-599)DOAJe507af4fd08b4bc8875ca9ab94685a56 DE-627 ger DE-627 rakwb eng R5-920 Julia L. Jezmir verfasserin aut Performance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Many US states published crisis standards of care (CSC) guidelines for allocating scarce critical care resources during the COVID-19 pandemic. However, the performance of these guidelines in maximizing their population benefit has not been well tested. In 2,272 adults with COVID-19 requiring mechanical ventilation drawn from the Study of the Treatment and Outcomes in Critically Ill Patients with COVID-19 (STOP-COVID) multicenter cohort, we test the following three approaches to CSC algorithms: Sequential Organ Failure Assessment (SOFA) scores grouped into ranges, SOFA score ranges plus comorbidities, and a hypothetical approach using raw SOFA scores not grouped into ranges. We find that area under receiver operating characteristic (AUROC) curves for all three algorithms demonstrate only modest discrimination for 28-day mortality. Adding comorbidity scoring modestly improves algorithm performance over SOFA scores alone. The algorithm incorporating comorbidities has modestly worse predictive performance for Black compared to white patients. CSC algorithms should be empirically examined to refine approaches to the allocation of scarce resources during pandemics and to avoid potential exacerbation of racial inequities. medical ethics crisis standards of care triage critical care intensive care COVID-19 Medicine (General) Maheetha Bharadwaj verfasserin aut Alexander Chaitoff verfasserin aut Bradford Diephuis verfasserin aut Conor P. Crowley verfasserin aut Sandeep P. Kishore verfasserin aut Eric Goralnick verfasserin aut Louis T. Merriam verfasserin aut Aimee Milliken verfasserin aut Chanu Rhee verfasserin aut Nicholas Sadovnikoff verfasserin aut Sejal B. Shah verfasserin aut Shruti Gupta verfasserin aut David E. Leaf verfasserin aut William B. Feldman verfasserin aut Edy Y. Kim verfasserin aut Carl P. Walther verfasserin aut Samaya J. Anumudu verfasserin aut Justin Arunthamakun verfasserin aut Kathleen F. Kopecky verfasserin aut Gregory P. Milligan verfasserin aut Peter A. McCullough verfasserin aut Thuy-Duyen Nguyen verfasserin aut Shahzad Shaefi verfasserin aut Megan L. Krajewski verfasserin aut Sidharth Shankar verfasserin aut Ameeka Pannu verfasserin aut Juan D. Valencia verfasserin aut Sushrut S. Waikar verfasserin aut Zoe A. Kibbelaar verfasserin aut Ambarish M. Athavale verfasserin aut Peter Hart verfasserin aut Shristi Upadhyay verfasserin aut Ishaan Vohra verfasserin aut Ajiboye Oyintayo verfasserin aut Adam Green verfasserin aut Jean-Sebastien Rachoin verfasserin aut Christa A. Schorr verfasserin aut Lisa Shea verfasserin aut Daniel L. Edmonston verfasserin aut Christopher L. Mosher verfasserin aut Alexandre M. Shehata verfasserin aut Zaza Cohen verfasserin aut Valerie Allusson verfasserin aut Gabriela Bambrick-Santoyo verfasserin aut Noor ul aain Bhatti verfasserin aut Bijal Mehta verfasserin aut Aquino Williams verfasserin aut Samantha K. Brenner verfasserin aut Patricia Walters verfasserin aut Ronaldo C. Go verfasserin aut Keith M. Rose verfasserin aut Miguel A. Hernán verfasserin aut Amy M. Zhou verfasserin aut Ethan C. Kim verfasserin aut Rebecca Lisk verfasserin aut Lili Chan verfasserin aut Kusum S. Mathews verfasserin aut Steven G. Coca verfasserin aut Deena R. Altman verfasserin aut Aparna Saha verfasserin aut Howard Soh verfasserin aut Huei Hsun Wen verfasserin aut Sonali Bose verfasserin aut Emily A. Leven verfasserin aut Jing G. Wang verfasserin aut Gohar Mosoyan verfasserin aut Girish N. Nadkarni verfasserin aut Pattharawin Pattharanitima verfasserin aut Allon N. Friedman verfasserin aut John Guirguis verfasserin aut Rajat Kapoor verfasserin aut Christopher Meshberger verfasserin aut Katherine J. Kelly verfasserin aut Chirag R. Parikh verfasserin aut Brian T. Garibaldi verfasserin aut Celia P. Corona-Villalobos verfasserin aut Yumeng Wen verfasserin aut Steven Menez verfasserin aut Rubab F. Malik verfasserin aut Elena Cervantes verfasserin aut Samir Gautam verfasserin aut Mary C. Mallappallil verfasserin aut Jie Ouyang verfasserin aut Sabu John verfasserin aut Ernie Yap verfasserin aut Yohannes Melaku verfasserin aut Ibrahim Mohamed verfasserin aut Siddartha Bajracharya verfasserin aut Isha Puri verfasserin aut Mariah Thaxton verfasserin aut Jyotsna Bhattacharya verfasserin aut John Wagner verfasserin aut Leon Boudourakis verfasserin aut H. Bryant Nguyen verfasserin aut Afshin Ahoubim verfasserin aut Leslie F. Thomas verfasserin aut Dheeraj Reddy Sirganagari verfasserin aut Pramod K. Guru verfasserin aut Kianoush Kashani verfasserin aut Yan Zhou verfasserin aut Paul A. Bergl verfasserin aut Jesus Rodriguez verfasserin aut Jatan A. Shah verfasserin aut Mrigank S. Gupta verfasserin aut Princy N. Kumar verfasserin aut Deepa G. Lazarous verfasserin aut Seble G. Kassaye verfasserin aut Michal L. Melamed verfasserin aut Tanya S. Johns verfasserin aut Ryan Mocerino verfasserin aut Kalyan Prudhvi verfasserin aut Denzel Zhu verfasserin aut Rebecca V. Levy verfasserin aut Yorg Azzi verfasserin aut Molly Fisher verfasserin aut Milagros Yunes verfasserin aut Kaltrina Sedaliu verfasserin aut Ladan Golestaneh verfasserin aut Maureen Brogan verfasserin aut Neelja Kumar verfasserin aut Michael Chang verfasserin aut Ritesh Raichoudhury verfasserin aut Akshay Athreya verfasserin aut Mohamed Farag verfasserin aut Edward J. Schenck verfasserin aut Soo Jung Cho verfasserin aut Maria Plataki verfasserin aut Sergio L. Alvarez-Mulett verfasserin aut Luis G. Gomez-Escobar verfasserin aut Di Pan verfasserin aut Stefi Lee verfasserin aut Jamuna Krishnan verfasserin aut William Whalen verfasserin aut David Charytan verfasserin aut Ashley Macina verfasserin aut Sobaata Chaudhry verfasserin aut Benjamin Wu verfasserin aut Frank Modersitzki verfasserin aut Anand Srivastava verfasserin aut Alexander S. Leidner verfasserin aut Carlos Martinez verfasserin aut Jacqueline M. Kruser verfasserin aut Richard G. Wunderink verfasserin aut Alexander J. Hodakowski verfasserin aut Juan Carlos Q. Velez verfasserin aut Eboni G. Price-Haywood verfasserin aut Luis A. Matute-Trochez verfasserin aut Anna E. Hasty verfasserin aut Muner MB. Mohamed verfasserin aut Rupali S. Avasare verfasserin aut David Zonies verfasserin aut David E. Leaf verfasserin aut Shruti Gupta verfasserin aut Meghan E. Sise verfasserin aut Erik T. Newman verfasserin aut Samah Abu Omar verfasserin aut Kapil K. Pokharel verfasserin aut Shreyak Sharma verfasserin aut Harkarandeep Singh verfasserin aut Simon Correa verfasserin aut Tanveer Shaukat verfasserin aut Omer Kamal verfasserin aut Wei Wang verfasserin aut Heather Yang verfasserin aut Jeffery O. Boateng verfasserin aut Meghan Lee verfasserin aut Ian A. Strohbehn verfasserin aut Jiahua Li verfasserin aut Ariel L. Mueller verfasserin aut Roberta Redfern verfasserin aut Nicholas S. Cairl verfasserin aut Gabriel Naimy verfasserin aut Abeer Abu-Saif verfasserin aut Danyell Hall verfasserin aut Laura Bickley verfasserin aut Chris Rowan verfasserin aut Farah Madhani-Lovely verfasserin aut Vivian S. Cruz verfasserin aut Kristen M. Hess verfasserin aut Alanna L. Jacobs verfasserin aut Vasil Peev verfasserin aut Jochen Reiser verfasserin aut John J. Byun verfasserin aut Andrew Vissing verfasserin aut Esha M. Kapania verfasserin aut Zoe Post verfasserin aut Nilam P. Patel verfasserin aut Joy-Marie Hermes verfasserin aut Anne K. Sutherland verfasserin aut Amee Patrawalla verfasserin aut Diana G. Finkel verfasserin aut Barbara A. Danek verfasserin aut Sowminya Arikapudi verfasserin aut Jeffrey M. Paer verfasserin aut Peter Cangialosi verfasserin aut Mark Liotta verfasserin aut Jared Radbel verfasserin aut Sonika Puri verfasserin aut Jag Sunderram verfasserin aut Matthew T. Scharf verfasserin aut Ayesha Ahmed verfasserin aut Ilya Berim verfasserin aut Jayanth S. Vatson verfasserin aut Shuchi Anand verfasserin aut Joseph E. Levitt verfasserin aut Suzanne M. Boyle verfasserin aut Rui Song verfasserin aut Jingjing Zhang verfasserin aut Sang Hoon Woo verfasserin aut Xiaoying Deng verfasserin aut Goni Katz-Greenberg verfasserin aut Katharine Senter verfasserin aut Moh’d A. Sharshir verfasserin aut Vadym V. Rusnak verfasserin aut Muhammad Imran Ali verfasserin aut Anip Bansal verfasserin aut Amber S. Podoll verfasserin aut Michel Chonchol verfasserin aut Sunita Sharma verfasserin aut Ellen L. Burnham verfasserin aut Arash Rashidi verfasserin aut Rana Hejal verfasserin aut Eric Judd verfasserin aut Laura Latta verfasserin aut Ashita Tolwani verfasserin aut Timothy E. Albertson verfasserin aut Jason Y. Adams verfasserin aut Steven Y. Chang verfasserin aut Rebecca M. Beutler verfasserin aut Etienne Macedo verfasserin aut Harin Rhee verfasserin aut Kathleen D. Liu verfasserin aut Vasantha K. Jotwani verfasserin aut Jay L. Koyner verfasserin aut Chintan V. Shah verfasserin aut Vishal Jaikaransingh verfasserin aut Stephanie M. Toth-Manikowski verfasserin aut Min J. Joo verfasserin aut James P. Lash verfasserin aut Javier A. Neyra verfasserin aut Nourhan Chaaban verfasserin aut Madona Elias verfasserin aut Yahya Ahmad verfasserin aut Alfredo Iardino verfasserin aut Elizabeth H. Au verfasserin aut Jill H. Sharma verfasserin aut Marie Anne Sosa verfasserin aut Sabrina Taldone verfasserin aut Gabriel Contreras verfasserin aut David De La Zerda verfasserin aut Hayley B. Gershengorn verfasserin aut Bhavarth Shukla verfasserin aut Alessia Fornoni verfasserin aut Tanira Ferreira verfasserin aut Salim S. Hayek verfasserin aut Pennelope Blakely verfasserin aut Hanna Berlin verfasserin aut Tariq U. Azam verfasserin aut Husam Shadid verfasserin aut Michael Pan verfasserin aut Patrick O’ Hayer verfasserin aut Chelsea Meloche verfasserin aut Rafey Feroze verfasserin aut Rayan Kaakati verfasserin aut Danny Perry verfasserin aut Abbas Bitar verfasserin aut Elizabeth Anderson verfasserin aut Kishan J. Padalia verfasserin aut John P. Donnelly verfasserin aut Andrew J. Admon verfasserin aut Jennifer E. Flythe verfasserin aut Matthew J. Tugman verfasserin aut Emily H. Chang verfasserin aut Brent R. Brown verfasserin aut Amanda K. Leonberg-Yoo verfasserin aut Ryan C. Spiardi verfasserin aut Todd A. Miano verfasserin aut Meaghan S. Roche verfasserin aut Charles R. Vasquez verfasserin aut Amar D. Bansal verfasserin aut Natalie C. Ernecoff verfasserin aut Sanjana Kapoor verfasserin aut Siddharth Verma verfasserin aut Csaba P. Kovesdy verfasserin aut Miklos Z. Molnar verfasserin aut Ambreen Azhar verfasserin aut S. Susan Hedayati verfasserin aut Mridula V. Nadamuni verfasserin aut Shani Shastri verfasserin aut Duwayne L. Willett verfasserin aut Samuel A.P. Short verfasserin aut Amanda D. Renaghan verfasserin aut Kyle B. Enfield verfasserin aut Pavan K. Bhatraju verfasserin aut A. Bilal Malik verfasserin aut Matthew W. Semler verfasserin aut Anitha Vijayan verfasserin aut Christina Mariyam Joy verfasserin aut Tingting Li verfasserin aut Seth Goldberg verfasserin aut Patricia F. Kao verfasserin aut Greg L. Schumaker verfasserin aut Nitender Goyal verfasserin aut Anthony J. Faugno verfasserin aut Greg L. Schumaker verfasserin aut Caroline M. Hsu verfasserin aut Asma Tariq verfasserin aut Leah Meyer verfasserin aut Ravi K. Kshirsagar verfasserin aut Daniel E. Weiner verfasserin aut Aju Jose verfasserin aut Marta Christov verfasserin aut Jennifer Griffiths verfasserin aut Sanjeev Gupta verfasserin aut Aromma Kapoor verfasserin aut Perry Wilson verfasserin aut Tanima Arora verfasserin aut Ugochukwu Ugwuowo verfasserin aut In Cell Reports Medicine Elsevier, 2020 2(2021), 9, Seite 100376- (DE-627)1696877792 26663791 nnns volume:2 year:2021 number:9 pages:100376- https://doi.org/10.1016/j.xcrm.2021.100376 kostenfrei https://doaj.org/article/e507af4fd08b4bc8875ca9ab94685a56 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666379121002305 kostenfrei https://doaj.org/toc/2666-3791 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2021 9 100376- |
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10.1016/j.xcrm.2021.100376 doi (DE-627)DOAJ008310599 (DE-599)DOAJe507af4fd08b4bc8875ca9ab94685a56 DE-627 ger DE-627 rakwb eng R5-920 Julia L. Jezmir verfasserin aut Performance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Many US states published crisis standards of care (CSC) guidelines for allocating scarce critical care resources during the COVID-19 pandemic. However, the performance of these guidelines in maximizing their population benefit has not been well tested. In 2,272 adults with COVID-19 requiring mechanical ventilation drawn from the Study of the Treatment and Outcomes in Critically Ill Patients with COVID-19 (STOP-COVID) multicenter cohort, we test the following three approaches to CSC algorithms: Sequential Organ Failure Assessment (SOFA) scores grouped into ranges, SOFA score ranges plus comorbidities, and a hypothetical approach using raw SOFA scores not grouped into ranges. We find that area under receiver operating characteristic (AUROC) curves for all three algorithms demonstrate only modest discrimination for 28-day mortality. Adding comorbidity scoring modestly improves algorithm performance over SOFA scores alone. The algorithm incorporating comorbidities has modestly worse predictive performance for Black compared to white patients. CSC algorithms should be empirically examined to refine approaches to the allocation of scarce resources during pandemics and to avoid potential exacerbation of racial inequities. medical ethics crisis standards of care triage critical care intensive care COVID-19 Medicine (General) Maheetha Bharadwaj verfasserin aut Alexander Chaitoff verfasserin aut Bradford Diephuis verfasserin aut Conor P. Crowley verfasserin aut Sandeep P. Kishore verfasserin aut Eric Goralnick verfasserin aut Louis T. Merriam verfasserin aut Aimee Milliken verfasserin aut Chanu Rhee verfasserin aut Nicholas Sadovnikoff verfasserin aut Sejal B. Shah verfasserin aut Shruti Gupta verfasserin aut David E. Leaf verfasserin aut William B. Feldman verfasserin aut Edy Y. Kim verfasserin aut Carl P. Walther verfasserin aut Samaya J. Anumudu verfasserin aut Justin Arunthamakun verfasserin aut Kathleen F. Kopecky verfasserin aut Gregory P. Milligan verfasserin aut Peter A. McCullough verfasserin aut Thuy-Duyen Nguyen verfasserin aut Shahzad Shaefi verfasserin aut Megan L. Krajewski verfasserin aut Sidharth Shankar verfasserin aut Ameeka Pannu verfasserin aut Juan D. Valencia verfasserin aut Sushrut S. Waikar verfasserin aut Zoe A. Kibbelaar verfasserin aut Ambarish M. Athavale verfasserin aut Peter Hart verfasserin aut Shristi Upadhyay verfasserin aut Ishaan Vohra verfasserin aut Ajiboye Oyintayo verfasserin aut Adam Green verfasserin aut Jean-Sebastien Rachoin verfasserin aut Christa A. Schorr verfasserin aut Lisa Shea verfasserin aut Daniel L. Edmonston verfasserin aut Christopher L. Mosher verfasserin aut Alexandre M. Shehata verfasserin aut Zaza Cohen verfasserin aut Valerie Allusson verfasserin aut Gabriela Bambrick-Santoyo verfasserin aut Noor ul aain Bhatti verfasserin aut Bijal Mehta verfasserin aut Aquino Williams verfasserin aut Samantha K. Brenner verfasserin aut Patricia Walters verfasserin aut Ronaldo C. Go verfasserin aut Keith M. Rose verfasserin aut Miguel A. Hernán verfasserin aut Amy M. Zhou verfasserin aut Ethan C. Kim verfasserin aut Rebecca Lisk verfasserin aut Lili Chan verfasserin aut Kusum S. Mathews verfasserin aut Steven G. Coca verfasserin aut Deena R. Altman verfasserin aut Aparna Saha verfasserin aut Howard Soh verfasserin aut Huei Hsun Wen verfasserin aut Sonali Bose verfasserin aut Emily A. Leven verfasserin aut Jing G. Wang verfasserin aut Gohar Mosoyan verfasserin aut Girish N. Nadkarni verfasserin aut Pattharawin Pattharanitima verfasserin aut Allon N. Friedman verfasserin aut John Guirguis verfasserin aut Rajat Kapoor verfasserin aut Christopher Meshberger verfasserin aut Katherine J. Kelly verfasserin aut Chirag R. Parikh verfasserin aut Brian T. Garibaldi verfasserin aut Celia P. Corona-Villalobos verfasserin aut Yumeng Wen verfasserin aut Steven Menez verfasserin aut Rubab F. Malik verfasserin aut Elena Cervantes verfasserin aut Samir Gautam verfasserin aut Mary C. Mallappallil verfasserin aut Jie Ouyang verfasserin aut Sabu John verfasserin aut Ernie Yap verfasserin aut Yohannes Melaku verfasserin aut Ibrahim Mohamed verfasserin aut Siddartha Bajracharya verfasserin aut Isha Puri verfasserin aut Mariah Thaxton verfasserin aut Jyotsna Bhattacharya verfasserin aut John Wagner verfasserin aut Leon Boudourakis verfasserin aut H. Bryant Nguyen verfasserin aut Afshin Ahoubim verfasserin aut Leslie F. Thomas verfasserin aut Dheeraj Reddy Sirganagari verfasserin aut Pramod K. Guru verfasserin aut Kianoush Kashani verfasserin aut Yan Zhou verfasserin aut Paul A. Bergl verfasserin aut Jesus Rodriguez verfasserin aut Jatan A. Shah verfasserin aut Mrigank S. Gupta verfasserin aut Princy N. Kumar verfasserin aut Deepa G. Lazarous verfasserin aut Seble G. Kassaye verfasserin aut Michal L. Melamed verfasserin aut Tanya S. Johns verfasserin aut Ryan Mocerino verfasserin aut Kalyan Prudhvi verfasserin aut Denzel Zhu verfasserin aut Rebecca V. Levy verfasserin aut Yorg Azzi verfasserin aut Molly Fisher verfasserin aut Milagros Yunes verfasserin aut Kaltrina Sedaliu verfasserin aut Ladan Golestaneh verfasserin aut Maureen Brogan verfasserin aut Neelja Kumar verfasserin aut Michael Chang verfasserin aut Ritesh Raichoudhury verfasserin aut Akshay Athreya verfasserin aut Mohamed Farag verfasserin aut Edward J. Schenck verfasserin aut Soo Jung Cho verfasserin aut Maria Plataki verfasserin aut Sergio L. Alvarez-Mulett verfasserin aut Luis G. Gomez-Escobar verfasserin aut Di Pan verfasserin aut Stefi Lee verfasserin aut Jamuna Krishnan verfasserin aut William Whalen verfasserin aut David Charytan verfasserin aut Ashley Macina verfasserin aut Sobaata Chaudhry verfasserin aut Benjamin Wu verfasserin aut Frank Modersitzki verfasserin aut Anand Srivastava verfasserin aut Alexander S. Leidner verfasserin aut Carlos Martinez verfasserin aut Jacqueline M. Kruser verfasserin aut Richard G. Wunderink verfasserin aut Alexander J. Hodakowski verfasserin aut Juan Carlos Q. Velez verfasserin aut Eboni G. Price-Haywood verfasserin aut Luis A. Matute-Trochez verfasserin aut Anna E. Hasty verfasserin aut Muner MB. Mohamed verfasserin aut Rupali S. Avasare verfasserin aut David Zonies verfasserin aut David E. Leaf verfasserin aut Shruti Gupta verfasserin aut Meghan E. Sise verfasserin aut Erik T. Newman verfasserin aut Samah Abu Omar verfasserin aut Kapil K. Pokharel verfasserin aut Shreyak Sharma verfasserin aut Harkarandeep Singh verfasserin aut Simon Correa verfasserin aut Tanveer Shaukat verfasserin aut Omer Kamal verfasserin aut Wei Wang verfasserin aut Heather Yang verfasserin aut Jeffery O. Boateng verfasserin aut Meghan Lee verfasserin aut Ian A. Strohbehn verfasserin aut Jiahua Li verfasserin aut Ariel L. Mueller verfasserin aut Roberta Redfern verfasserin aut Nicholas S. Cairl verfasserin aut Gabriel Naimy verfasserin aut Abeer Abu-Saif verfasserin aut Danyell Hall verfasserin aut Laura Bickley verfasserin aut Chris Rowan verfasserin aut Farah Madhani-Lovely verfasserin aut Vivian S. Cruz verfasserin aut Kristen M. Hess verfasserin aut Alanna L. Jacobs verfasserin aut Vasil Peev verfasserin aut Jochen Reiser verfasserin aut John J. Byun verfasserin aut Andrew Vissing verfasserin aut Esha M. Kapania verfasserin aut Zoe Post verfasserin aut Nilam P. Patel verfasserin aut Joy-Marie Hermes verfasserin aut Anne K. Sutherland verfasserin aut Amee Patrawalla verfasserin aut Diana G. Finkel verfasserin aut Barbara A. Danek verfasserin aut Sowminya Arikapudi verfasserin aut Jeffrey M. Paer verfasserin aut Peter Cangialosi verfasserin aut Mark Liotta verfasserin aut Jared Radbel verfasserin aut Sonika Puri verfasserin aut Jag Sunderram verfasserin aut Matthew T. Scharf verfasserin aut Ayesha Ahmed verfasserin aut Ilya Berim verfasserin aut Jayanth S. Vatson verfasserin aut Shuchi Anand verfasserin aut Joseph E. Levitt verfasserin aut Suzanne M. Boyle verfasserin aut Rui Song verfasserin aut Jingjing Zhang verfasserin aut Sang Hoon Woo verfasserin aut Xiaoying Deng verfasserin aut Goni Katz-Greenberg verfasserin aut Katharine Senter verfasserin aut Moh’d A. Sharshir verfasserin aut Vadym V. Rusnak verfasserin aut Muhammad Imran Ali verfasserin aut Anip Bansal verfasserin aut Amber S. Podoll verfasserin aut Michel Chonchol verfasserin aut Sunita Sharma verfasserin aut Ellen L. Burnham verfasserin aut Arash Rashidi verfasserin aut Rana Hejal verfasserin aut Eric Judd verfasserin aut Laura Latta verfasserin aut Ashita Tolwani verfasserin aut Timothy E. Albertson verfasserin aut Jason Y. Adams verfasserin aut Steven Y. Chang verfasserin aut Rebecca M. Beutler verfasserin aut Etienne Macedo verfasserin aut Harin Rhee verfasserin aut Kathleen D. Liu verfasserin aut Vasantha K. Jotwani verfasserin aut Jay L. Koyner verfasserin aut Chintan V. Shah verfasserin aut Vishal Jaikaransingh verfasserin aut Stephanie M. Toth-Manikowski verfasserin aut Min J. Joo verfasserin aut James P. Lash verfasserin aut Javier A. Neyra verfasserin aut Nourhan Chaaban verfasserin aut Madona Elias verfasserin aut Yahya Ahmad verfasserin aut Alfredo Iardino verfasserin aut Elizabeth H. Au verfasserin aut Jill H. Sharma verfasserin aut Marie Anne Sosa verfasserin aut Sabrina Taldone verfasserin aut Gabriel Contreras verfasserin aut David De La Zerda verfasserin aut Hayley B. Gershengorn verfasserin aut Bhavarth Shukla verfasserin aut Alessia Fornoni verfasserin aut Tanira Ferreira verfasserin aut Salim S. Hayek verfasserin aut Pennelope Blakely verfasserin aut Hanna Berlin verfasserin aut Tariq U. Azam verfasserin aut Husam Shadid verfasserin aut Michael Pan verfasserin aut Patrick O’ Hayer verfasserin aut Chelsea Meloche verfasserin aut Rafey Feroze verfasserin aut Rayan Kaakati verfasserin aut Danny Perry verfasserin aut Abbas Bitar verfasserin aut Elizabeth Anderson verfasserin aut Kishan J. Padalia verfasserin aut John P. Donnelly verfasserin aut Andrew J. Admon verfasserin aut Jennifer E. Flythe verfasserin aut Matthew J. Tugman verfasserin aut Emily H. Chang verfasserin aut Brent R. Brown verfasserin aut Amanda K. Leonberg-Yoo verfasserin aut Ryan C. Spiardi verfasserin aut Todd A. Miano verfasserin aut Meaghan S. Roche verfasserin aut Charles R. Vasquez verfasserin aut Amar D. Bansal verfasserin aut Natalie C. Ernecoff verfasserin aut Sanjana Kapoor verfasserin aut Siddharth Verma verfasserin aut Csaba P. Kovesdy verfasserin aut Miklos Z. Molnar verfasserin aut Ambreen Azhar verfasserin aut S. Susan Hedayati verfasserin aut Mridula V. Nadamuni verfasserin aut Shani Shastri verfasserin aut Duwayne L. Willett verfasserin aut Samuel A.P. Short verfasserin aut Amanda D. Renaghan verfasserin aut Kyle B. Enfield verfasserin aut Pavan K. Bhatraju verfasserin aut A. Bilal Malik verfasserin aut Matthew W. Semler verfasserin aut Anitha Vijayan verfasserin aut Christina Mariyam Joy verfasserin aut Tingting Li verfasserin aut Seth Goldberg verfasserin aut Patricia F. Kao verfasserin aut Greg L. Schumaker verfasserin aut Nitender Goyal verfasserin aut Anthony J. Faugno verfasserin aut Greg L. Schumaker verfasserin aut Caroline M. Hsu verfasserin aut Asma Tariq verfasserin aut Leah Meyer verfasserin aut Ravi K. Kshirsagar verfasserin aut Daniel E. Weiner verfasserin aut Aju Jose verfasserin aut Marta Christov verfasserin aut Jennifer Griffiths verfasserin aut Sanjeev Gupta verfasserin aut Aromma Kapoor verfasserin aut Perry Wilson verfasserin aut Tanima Arora verfasserin aut Ugochukwu Ugwuowo verfasserin aut In Cell Reports Medicine Elsevier, 2020 2(2021), 9, Seite 100376- (DE-627)1696877792 26663791 nnns volume:2 year:2021 number:9 pages:100376- https://doi.org/10.1016/j.xcrm.2021.100376 kostenfrei https://doaj.org/article/e507af4fd08b4bc8875ca9ab94685a56 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666379121002305 kostenfrei https://doaj.org/toc/2666-3791 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2021 9 100376- |
| allfields_unstemmed |
10.1016/j.xcrm.2021.100376 doi (DE-627)DOAJ008310599 (DE-599)DOAJe507af4fd08b4bc8875ca9ab94685a56 DE-627 ger DE-627 rakwb eng R5-920 Julia L. Jezmir verfasserin aut Performance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Many US states published crisis standards of care (CSC) guidelines for allocating scarce critical care resources during the COVID-19 pandemic. However, the performance of these guidelines in maximizing their population benefit has not been well tested. In 2,272 adults with COVID-19 requiring mechanical ventilation drawn from the Study of the Treatment and Outcomes in Critically Ill Patients with COVID-19 (STOP-COVID) multicenter cohort, we test the following three approaches to CSC algorithms: Sequential Organ Failure Assessment (SOFA) scores grouped into ranges, SOFA score ranges plus comorbidities, and a hypothetical approach using raw SOFA scores not grouped into ranges. We find that area under receiver operating characteristic (AUROC) curves for all three algorithms demonstrate only modest discrimination for 28-day mortality. Adding comorbidity scoring modestly improves algorithm performance over SOFA scores alone. The algorithm incorporating comorbidities has modestly worse predictive performance for Black compared to white patients. CSC algorithms should be empirically examined to refine approaches to the allocation of scarce resources during pandemics and to avoid potential exacerbation of racial inequities. medical ethics crisis standards of care triage critical care intensive care COVID-19 Medicine (General) Maheetha Bharadwaj verfasserin aut Alexander Chaitoff verfasserin aut Bradford Diephuis verfasserin aut Conor P. Crowley verfasserin aut Sandeep P. Kishore verfasserin aut Eric Goralnick verfasserin aut Louis T. Merriam verfasserin aut Aimee Milliken verfasserin aut Chanu Rhee verfasserin aut Nicholas Sadovnikoff verfasserin aut Sejal B. Shah verfasserin aut Shruti Gupta verfasserin aut David E. Leaf verfasserin aut William B. Feldman verfasserin aut Edy Y. Kim verfasserin aut Carl P. Walther verfasserin aut Samaya J. Anumudu verfasserin aut Justin Arunthamakun verfasserin aut Kathleen F. Kopecky verfasserin aut Gregory P. Milligan verfasserin aut Peter A. McCullough verfasserin aut Thuy-Duyen Nguyen verfasserin aut Shahzad Shaefi verfasserin aut Megan L. Krajewski verfasserin aut Sidharth Shankar verfasserin aut Ameeka Pannu verfasserin aut Juan D. Valencia verfasserin aut Sushrut S. Waikar verfasserin aut Zoe A. Kibbelaar verfasserin aut Ambarish M. Athavale verfasserin aut Peter Hart verfasserin aut Shristi Upadhyay verfasserin aut Ishaan Vohra verfasserin aut Ajiboye Oyintayo verfasserin aut Adam Green verfasserin aut Jean-Sebastien Rachoin verfasserin aut Christa A. Schorr verfasserin aut Lisa Shea verfasserin aut Daniel L. Edmonston verfasserin aut Christopher L. Mosher verfasserin aut Alexandre M. Shehata verfasserin aut Zaza Cohen verfasserin aut Valerie Allusson verfasserin aut Gabriela Bambrick-Santoyo verfasserin aut Noor ul aain Bhatti verfasserin aut Bijal Mehta verfasserin aut Aquino Williams verfasserin aut Samantha K. Brenner verfasserin aut Patricia Walters verfasserin aut Ronaldo C. Go verfasserin aut Keith M. Rose verfasserin aut Miguel A. Hernán verfasserin aut Amy M. Zhou verfasserin aut Ethan C. Kim verfasserin aut Rebecca Lisk verfasserin aut Lili Chan verfasserin aut Kusum S. Mathews verfasserin aut Steven G. Coca verfasserin aut Deena R. Altman verfasserin aut Aparna Saha verfasserin aut Howard Soh verfasserin aut Huei Hsun Wen verfasserin aut Sonali Bose verfasserin aut Emily A. Leven verfasserin aut Jing G. Wang verfasserin aut Gohar Mosoyan verfasserin aut Girish N. Nadkarni verfasserin aut Pattharawin Pattharanitima verfasserin aut Allon N. Friedman verfasserin aut John Guirguis verfasserin aut Rajat Kapoor verfasserin aut Christopher Meshberger verfasserin aut Katherine J. Kelly verfasserin aut Chirag R. Parikh verfasserin aut Brian T. Garibaldi verfasserin aut Celia P. Corona-Villalobos verfasserin aut Yumeng Wen verfasserin aut Steven Menez verfasserin aut Rubab F. Malik verfasserin aut Elena Cervantes verfasserin aut Samir Gautam verfasserin aut Mary C. Mallappallil verfasserin aut Jie Ouyang verfasserin aut Sabu John verfasserin aut Ernie Yap verfasserin aut Yohannes Melaku verfasserin aut Ibrahim Mohamed verfasserin aut Siddartha Bajracharya verfasserin aut Isha Puri verfasserin aut Mariah Thaxton verfasserin aut Jyotsna Bhattacharya verfasserin aut John Wagner verfasserin aut Leon Boudourakis verfasserin aut H. Bryant Nguyen verfasserin aut Afshin Ahoubim verfasserin aut Leslie F. Thomas verfasserin aut Dheeraj Reddy Sirganagari verfasserin aut Pramod K. Guru verfasserin aut Kianoush Kashani verfasserin aut Yan Zhou verfasserin aut Paul A. Bergl verfasserin aut Jesus Rodriguez verfasserin aut Jatan A. Shah verfasserin aut Mrigank S. Gupta verfasserin aut Princy N. Kumar verfasserin aut Deepa G. Lazarous verfasserin aut Seble G. Kassaye verfasserin aut Michal L. Melamed verfasserin aut Tanya S. Johns verfasserin aut Ryan Mocerino verfasserin aut Kalyan Prudhvi verfasserin aut Denzel Zhu verfasserin aut Rebecca V. Levy verfasserin aut Yorg Azzi verfasserin aut Molly Fisher verfasserin aut Milagros Yunes verfasserin aut Kaltrina Sedaliu verfasserin aut Ladan Golestaneh verfasserin aut Maureen Brogan verfasserin aut Neelja Kumar verfasserin aut Michael Chang verfasserin aut Ritesh Raichoudhury verfasserin aut Akshay Athreya verfasserin aut Mohamed Farag verfasserin aut Edward J. Schenck verfasserin aut Soo Jung Cho verfasserin aut Maria Plataki verfasserin aut Sergio L. Alvarez-Mulett verfasserin aut Luis G. Gomez-Escobar verfasserin aut Di Pan verfasserin aut Stefi Lee verfasserin aut Jamuna Krishnan verfasserin aut William Whalen verfasserin aut David Charytan verfasserin aut Ashley Macina verfasserin aut Sobaata Chaudhry verfasserin aut Benjamin Wu verfasserin aut Frank Modersitzki verfasserin aut Anand Srivastava verfasserin aut Alexander S. Leidner verfasserin aut Carlos Martinez verfasserin aut Jacqueline M. Kruser verfasserin aut Richard G. Wunderink verfasserin aut Alexander J. Hodakowski verfasserin aut Juan Carlos Q. Velez verfasserin aut Eboni G. Price-Haywood verfasserin aut Luis A. Matute-Trochez verfasserin aut Anna E. Hasty verfasserin aut Muner MB. Mohamed verfasserin aut Rupali S. Avasare verfasserin aut David Zonies verfasserin aut David E. Leaf verfasserin aut Shruti Gupta verfasserin aut Meghan E. Sise verfasserin aut Erik T. Newman verfasserin aut Samah Abu Omar verfasserin aut Kapil K. Pokharel verfasserin aut Shreyak Sharma verfasserin aut Harkarandeep Singh verfasserin aut Simon Correa verfasserin aut Tanveer Shaukat verfasserin aut Omer Kamal verfasserin aut Wei Wang verfasserin aut Heather Yang verfasserin aut Jeffery O. Boateng verfasserin aut Meghan Lee verfasserin aut Ian A. Strohbehn verfasserin aut Jiahua Li verfasserin aut Ariel L. Mueller verfasserin aut Roberta Redfern verfasserin aut Nicholas S. Cairl verfasserin aut Gabriel Naimy verfasserin aut Abeer Abu-Saif verfasserin aut Danyell Hall verfasserin aut Laura Bickley verfasserin aut Chris Rowan verfasserin aut Farah Madhani-Lovely verfasserin aut Vivian S. Cruz verfasserin aut Kristen M. Hess verfasserin aut Alanna L. Jacobs verfasserin aut Vasil Peev verfasserin aut Jochen Reiser verfasserin aut John J. Byun verfasserin aut Andrew Vissing verfasserin aut Esha M. Kapania verfasserin aut Zoe Post verfasserin aut Nilam P. Patel verfasserin aut Joy-Marie Hermes verfasserin aut Anne K. Sutherland verfasserin aut Amee Patrawalla verfasserin aut Diana G. Finkel verfasserin aut Barbara A. Danek verfasserin aut Sowminya Arikapudi verfasserin aut Jeffrey M. Paer verfasserin aut Peter Cangialosi verfasserin aut Mark Liotta verfasserin aut Jared Radbel verfasserin aut Sonika Puri verfasserin aut Jag Sunderram verfasserin aut Matthew T. Scharf verfasserin aut Ayesha Ahmed verfasserin aut Ilya Berim verfasserin aut Jayanth S. Vatson verfasserin aut Shuchi Anand verfasserin aut Joseph E. Levitt verfasserin aut Suzanne M. Boyle verfasserin aut Rui Song verfasserin aut Jingjing Zhang verfasserin aut Sang Hoon Woo verfasserin aut Xiaoying Deng verfasserin aut Goni Katz-Greenberg verfasserin aut Katharine Senter verfasserin aut Moh’d A. Sharshir verfasserin aut Vadym V. Rusnak verfasserin aut Muhammad Imran Ali verfasserin aut Anip Bansal verfasserin aut Amber S. Podoll verfasserin aut Michel Chonchol verfasserin aut Sunita Sharma verfasserin aut Ellen L. Burnham verfasserin aut Arash Rashidi verfasserin aut Rana Hejal verfasserin aut Eric Judd verfasserin aut Laura Latta verfasserin aut Ashita Tolwani verfasserin aut Timothy E. Albertson verfasserin aut Jason Y. Adams verfasserin aut Steven Y. Chang verfasserin aut Rebecca M. Beutler verfasserin aut Etienne Macedo verfasserin aut Harin Rhee verfasserin aut Kathleen D. Liu verfasserin aut Vasantha K. Jotwani verfasserin aut Jay L. Koyner verfasserin aut Chintan V. Shah verfasserin aut Vishal Jaikaransingh verfasserin aut Stephanie M. Toth-Manikowski verfasserin aut Min J. Joo verfasserin aut James P. Lash verfasserin aut Javier A. Neyra verfasserin aut Nourhan Chaaban verfasserin aut Madona Elias verfasserin aut Yahya Ahmad verfasserin aut Alfredo Iardino verfasserin aut Elizabeth H. Au verfasserin aut Jill H. Sharma verfasserin aut Marie Anne Sosa verfasserin aut Sabrina Taldone verfasserin aut Gabriel Contreras verfasserin aut David De La Zerda verfasserin aut Hayley B. Gershengorn verfasserin aut Bhavarth Shukla verfasserin aut Alessia Fornoni verfasserin aut Tanira Ferreira verfasserin aut Salim S. Hayek verfasserin aut Pennelope Blakely verfasserin aut Hanna Berlin verfasserin aut Tariq U. Azam verfasserin aut Husam Shadid verfasserin aut Michael Pan verfasserin aut Patrick O’ Hayer verfasserin aut Chelsea Meloche verfasserin aut Rafey Feroze verfasserin aut Rayan Kaakati verfasserin aut Danny Perry verfasserin aut Abbas Bitar verfasserin aut Elizabeth Anderson verfasserin aut Kishan J. Padalia verfasserin aut John P. Donnelly verfasserin aut Andrew J. Admon verfasserin aut Jennifer E. Flythe verfasserin aut Matthew J. Tugman verfasserin aut Emily H. Chang verfasserin aut Brent R. Brown verfasserin aut Amanda K. Leonberg-Yoo verfasserin aut Ryan C. Spiardi verfasserin aut Todd A. Miano verfasserin aut Meaghan S. Roche verfasserin aut Charles R. Vasquez verfasserin aut Amar D. Bansal verfasserin aut Natalie C. Ernecoff verfasserin aut Sanjana Kapoor verfasserin aut Siddharth Verma verfasserin aut Csaba P. Kovesdy verfasserin aut Miklos Z. Molnar verfasserin aut Ambreen Azhar verfasserin aut S. Susan Hedayati verfasserin aut Mridula V. Nadamuni verfasserin aut Shani Shastri verfasserin aut Duwayne L. Willett verfasserin aut Samuel A.P. Short verfasserin aut Amanda D. Renaghan verfasserin aut Kyle B. Enfield verfasserin aut Pavan K. Bhatraju verfasserin aut A. Bilal Malik verfasserin aut Matthew W. Semler verfasserin aut Anitha Vijayan verfasserin aut Christina Mariyam Joy verfasserin aut Tingting Li verfasserin aut Seth Goldberg verfasserin aut Patricia F. Kao verfasserin aut Greg L. Schumaker verfasserin aut Nitender Goyal verfasserin aut Anthony J. Faugno verfasserin aut Greg L. Schumaker verfasserin aut Caroline M. Hsu verfasserin aut Asma Tariq verfasserin aut Leah Meyer verfasserin aut Ravi K. Kshirsagar verfasserin aut Daniel E. Weiner verfasserin aut Aju Jose verfasserin aut Marta Christov verfasserin aut Jennifer Griffiths verfasserin aut Sanjeev Gupta verfasserin aut Aromma Kapoor verfasserin aut Perry Wilson verfasserin aut Tanima Arora verfasserin aut Ugochukwu Ugwuowo verfasserin aut In Cell Reports Medicine Elsevier, 2020 2(2021), 9, Seite 100376- (DE-627)1696877792 26663791 nnns volume:2 year:2021 number:9 pages:100376- https://doi.org/10.1016/j.xcrm.2021.100376 kostenfrei https://doaj.org/article/e507af4fd08b4bc8875ca9ab94685a56 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666379121002305 kostenfrei https://doaj.org/toc/2666-3791 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2021 9 100376- |
| allfieldsGer |
10.1016/j.xcrm.2021.100376 doi (DE-627)DOAJ008310599 (DE-599)DOAJe507af4fd08b4bc8875ca9ab94685a56 DE-627 ger DE-627 rakwb eng R5-920 Julia L. Jezmir verfasserin aut Performance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Many US states published crisis standards of care (CSC) guidelines for allocating scarce critical care resources during the COVID-19 pandemic. However, the performance of these guidelines in maximizing their population benefit has not been well tested. In 2,272 adults with COVID-19 requiring mechanical ventilation drawn from the Study of the Treatment and Outcomes in Critically Ill Patients with COVID-19 (STOP-COVID) multicenter cohort, we test the following three approaches to CSC algorithms: Sequential Organ Failure Assessment (SOFA) scores grouped into ranges, SOFA score ranges plus comorbidities, and a hypothetical approach using raw SOFA scores not grouped into ranges. We find that area under receiver operating characteristic (AUROC) curves for all three algorithms demonstrate only modest discrimination for 28-day mortality. Adding comorbidity scoring modestly improves algorithm performance over SOFA scores alone. The algorithm incorporating comorbidities has modestly worse predictive performance for Black compared to white patients. CSC algorithms should be empirically examined to refine approaches to the allocation of scarce resources during pandemics and to avoid potential exacerbation of racial inequities. medical ethics crisis standards of care triage critical care intensive care COVID-19 Medicine (General) Maheetha Bharadwaj verfasserin aut Alexander Chaitoff verfasserin aut Bradford Diephuis verfasserin aut Conor P. Crowley verfasserin aut Sandeep P. Kishore verfasserin aut Eric Goralnick verfasserin aut Louis T. Merriam verfasserin aut Aimee Milliken verfasserin aut Chanu Rhee verfasserin aut Nicholas Sadovnikoff verfasserin aut Sejal B. Shah verfasserin aut Shruti Gupta verfasserin aut David E. Leaf verfasserin aut William B. Feldman verfasserin aut Edy Y. Kim verfasserin aut Carl P. Walther verfasserin aut Samaya J. Anumudu verfasserin aut Justin Arunthamakun verfasserin aut Kathleen F. Kopecky verfasserin aut Gregory P. Milligan verfasserin aut Peter A. McCullough verfasserin aut Thuy-Duyen Nguyen verfasserin aut Shahzad Shaefi verfasserin aut Megan L. Krajewski verfasserin aut Sidharth Shankar verfasserin aut Ameeka Pannu verfasserin aut Juan D. Valencia verfasserin aut Sushrut S. Waikar verfasserin aut Zoe A. Kibbelaar verfasserin aut Ambarish M. Athavale verfasserin aut Peter Hart verfasserin aut Shristi Upadhyay verfasserin aut Ishaan Vohra verfasserin aut Ajiboye Oyintayo verfasserin aut Adam Green verfasserin aut Jean-Sebastien Rachoin verfasserin aut Christa A. Schorr verfasserin aut Lisa Shea verfasserin aut Daniel L. Edmonston verfasserin aut Christopher L. Mosher verfasserin aut Alexandre M. Shehata verfasserin aut Zaza Cohen verfasserin aut Valerie Allusson verfasserin aut Gabriela Bambrick-Santoyo verfasserin aut Noor ul aain Bhatti verfasserin aut Bijal Mehta verfasserin aut Aquino Williams verfasserin aut Samantha K. Brenner verfasserin aut Patricia Walters verfasserin aut Ronaldo C. Go verfasserin aut Keith M. Rose verfasserin aut Miguel A. Hernán verfasserin aut Amy M. Zhou verfasserin aut Ethan C. Kim verfasserin aut Rebecca Lisk verfasserin aut Lili Chan verfasserin aut Kusum S. Mathews verfasserin aut Steven G. Coca verfasserin aut Deena R. Altman verfasserin aut Aparna Saha verfasserin aut Howard Soh verfasserin aut Huei Hsun Wen verfasserin aut Sonali Bose verfasserin aut Emily A. Leven verfasserin aut Jing G. Wang verfasserin aut Gohar Mosoyan verfasserin aut Girish N. Nadkarni verfasserin aut Pattharawin Pattharanitima verfasserin aut Allon N. Friedman verfasserin aut John Guirguis verfasserin aut Rajat Kapoor verfasserin aut Christopher Meshberger verfasserin aut Katherine J. Kelly verfasserin aut Chirag R. Parikh verfasserin aut Brian T. Garibaldi verfasserin aut Celia P. Corona-Villalobos verfasserin aut Yumeng Wen verfasserin aut Steven Menez verfasserin aut Rubab F. Malik verfasserin aut Elena Cervantes verfasserin aut Samir Gautam verfasserin aut Mary C. Mallappallil verfasserin aut Jie Ouyang verfasserin aut Sabu John verfasserin aut Ernie Yap verfasserin aut Yohannes Melaku verfasserin aut Ibrahim Mohamed verfasserin aut Siddartha Bajracharya verfasserin aut Isha Puri verfasserin aut Mariah Thaxton verfasserin aut Jyotsna Bhattacharya verfasserin aut John Wagner verfasserin aut Leon Boudourakis verfasserin aut H. Bryant Nguyen verfasserin aut Afshin Ahoubim verfasserin aut Leslie F. Thomas verfasserin aut Dheeraj Reddy Sirganagari verfasserin aut Pramod K. Guru verfasserin aut Kianoush Kashani verfasserin aut Yan Zhou verfasserin aut Paul A. Bergl verfasserin aut Jesus Rodriguez verfasserin aut Jatan A. Shah verfasserin aut Mrigank S. Gupta verfasserin aut Princy N. Kumar verfasserin aut Deepa G. Lazarous verfasserin aut Seble G. Kassaye verfasserin aut Michal L. Melamed verfasserin aut Tanya S. Johns verfasserin aut Ryan Mocerino verfasserin aut Kalyan Prudhvi verfasserin aut Denzel Zhu verfasserin aut Rebecca V. Levy verfasserin aut Yorg Azzi verfasserin aut Molly Fisher verfasserin aut Milagros Yunes verfasserin aut Kaltrina Sedaliu verfasserin aut Ladan Golestaneh verfasserin aut Maureen Brogan verfasserin aut Neelja Kumar verfasserin aut Michael Chang verfasserin aut Ritesh Raichoudhury verfasserin aut Akshay Athreya verfasserin aut Mohamed Farag verfasserin aut Edward J. Schenck verfasserin aut Soo Jung Cho verfasserin aut Maria Plataki verfasserin aut Sergio L. Alvarez-Mulett verfasserin aut Luis G. Gomez-Escobar verfasserin aut Di Pan verfasserin aut Stefi Lee verfasserin aut Jamuna Krishnan verfasserin aut William Whalen verfasserin aut David Charytan verfasserin aut Ashley Macina verfasserin aut Sobaata Chaudhry verfasserin aut Benjamin Wu verfasserin aut Frank Modersitzki verfasserin aut Anand Srivastava verfasserin aut Alexander S. Leidner verfasserin aut Carlos Martinez verfasserin aut Jacqueline M. Kruser verfasserin aut Richard G. Wunderink verfasserin aut Alexander J. Hodakowski verfasserin aut Juan Carlos Q. Velez verfasserin aut Eboni G. Price-Haywood verfasserin aut Luis A. Matute-Trochez verfasserin aut Anna E. Hasty verfasserin aut Muner MB. Mohamed verfasserin aut Rupali S. Avasare verfasserin aut David Zonies verfasserin aut David E. Leaf verfasserin aut Shruti Gupta verfasserin aut Meghan E. Sise verfasserin aut Erik T. Newman verfasserin aut Samah Abu Omar verfasserin aut Kapil K. Pokharel verfasserin aut Shreyak Sharma verfasserin aut Harkarandeep Singh verfasserin aut Simon Correa verfasserin aut Tanveer Shaukat verfasserin aut Omer Kamal verfasserin aut Wei Wang verfasserin aut Heather Yang verfasserin aut Jeffery O. Boateng verfasserin aut Meghan Lee verfasserin aut Ian A. Strohbehn verfasserin aut Jiahua Li verfasserin aut Ariel L. Mueller verfasserin aut Roberta Redfern verfasserin aut Nicholas S. Cairl verfasserin aut Gabriel Naimy verfasserin aut Abeer Abu-Saif verfasserin aut Danyell Hall verfasserin aut Laura Bickley verfasserin aut Chris Rowan verfasserin aut Farah Madhani-Lovely verfasserin aut Vivian S. Cruz verfasserin aut Kristen M. Hess verfasserin aut Alanna L. Jacobs verfasserin aut Vasil Peev verfasserin aut Jochen Reiser verfasserin aut John J. Byun verfasserin aut Andrew Vissing verfasserin aut Esha M. Kapania verfasserin aut Zoe Post verfasserin aut Nilam P. Patel verfasserin aut Joy-Marie Hermes verfasserin aut Anne K. Sutherland verfasserin aut Amee Patrawalla verfasserin aut Diana G. Finkel verfasserin aut Barbara A. Danek verfasserin aut Sowminya Arikapudi verfasserin aut Jeffrey M. Paer verfasserin aut Peter Cangialosi verfasserin aut Mark Liotta verfasserin aut Jared Radbel verfasserin aut Sonika Puri verfasserin aut Jag Sunderram verfasserin aut Matthew T. Scharf verfasserin aut Ayesha Ahmed verfasserin aut Ilya Berim verfasserin aut Jayanth S. Vatson verfasserin aut Shuchi Anand verfasserin aut Joseph E. Levitt verfasserin aut Suzanne M. Boyle verfasserin aut Rui Song verfasserin aut Jingjing Zhang verfasserin aut Sang Hoon Woo verfasserin aut Xiaoying Deng verfasserin aut Goni Katz-Greenberg verfasserin aut Katharine Senter verfasserin aut Moh’d A. Sharshir verfasserin aut Vadym V. Rusnak verfasserin aut Muhammad Imran Ali verfasserin aut Anip Bansal verfasserin aut Amber S. Podoll verfasserin aut Michel Chonchol verfasserin aut Sunita Sharma verfasserin aut Ellen L. Burnham verfasserin aut Arash Rashidi verfasserin aut Rana Hejal verfasserin aut Eric Judd verfasserin aut Laura Latta verfasserin aut Ashita Tolwani verfasserin aut Timothy E. Albertson verfasserin aut Jason Y. Adams verfasserin aut Steven Y. Chang verfasserin aut Rebecca M. Beutler verfasserin aut Etienne Macedo verfasserin aut Harin Rhee verfasserin aut Kathleen D. Liu verfasserin aut Vasantha K. Jotwani verfasserin aut Jay L. Koyner verfasserin aut Chintan V. Shah verfasserin aut Vishal Jaikaransingh verfasserin aut Stephanie M. Toth-Manikowski verfasserin aut Min J. Joo verfasserin aut James P. Lash verfasserin aut Javier A. Neyra verfasserin aut Nourhan Chaaban verfasserin aut Madona Elias verfasserin aut Yahya Ahmad verfasserin aut Alfredo Iardino verfasserin aut Elizabeth H. Au verfasserin aut Jill H. Sharma verfasserin aut Marie Anne Sosa verfasserin aut Sabrina Taldone verfasserin aut Gabriel Contreras verfasserin aut David De La Zerda verfasserin aut Hayley B. Gershengorn verfasserin aut Bhavarth Shukla verfasserin aut Alessia Fornoni verfasserin aut Tanira Ferreira verfasserin aut Salim S. Hayek verfasserin aut Pennelope Blakely verfasserin aut Hanna Berlin verfasserin aut Tariq U. Azam verfasserin aut Husam Shadid verfasserin aut Michael Pan verfasserin aut Patrick O’ Hayer verfasserin aut Chelsea Meloche verfasserin aut Rafey Feroze verfasserin aut Rayan Kaakati verfasserin aut Danny Perry verfasserin aut Abbas Bitar verfasserin aut Elizabeth Anderson verfasserin aut Kishan J. Padalia verfasserin aut John P. Donnelly verfasserin aut Andrew J. Admon verfasserin aut Jennifer E. Flythe verfasserin aut Matthew J. Tugman verfasserin aut Emily H. Chang verfasserin aut Brent R. Brown verfasserin aut Amanda K. Leonberg-Yoo verfasserin aut Ryan C. Spiardi verfasserin aut Todd A. Miano verfasserin aut Meaghan S. Roche verfasserin aut Charles R. Vasquez verfasserin aut Amar D. Bansal verfasserin aut Natalie C. Ernecoff verfasserin aut Sanjana Kapoor verfasserin aut Siddharth Verma verfasserin aut Csaba P. Kovesdy verfasserin aut Miklos Z. Molnar verfasserin aut Ambreen Azhar verfasserin aut S. Susan Hedayati verfasserin aut Mridula V. Nadamuni verfasserin aut Shani Shastri verfasserin aut Duwayne L. Willett verfasserin aut Samuel A.P. Short verfasserin aut Amanda D. Renaghan verfasserin aut Kyle B. Enfield verfasserin aut Pavan K. Bhatraju verfasserin aut A. Bilal Malik verfasserin aut Matthew W. Semler verfasserin aut Anitha Vijayan verfasserin aut Christina Mariyam Joy verfasserin aut Tingting Li verfasserin aut Seth Goldberg verfasserin aut Patricia F. Kao verfasserin aut Greg L. Schumaker verfasserin aut Nitender Goyal verfasserin aut Anthony J. Faugno verfasserin aut Greg L. Schumaker verfasserin aut Caroline M. Hsu verfasserin aut Asma Tariq verfasserin aut Leah Meyer verfasserin aut Ravi K. Kshirsagar verfasserin aut Daniel E. Weiner verfasserin aut Aju Jose verfasserin aut Marta Christov verfasserin aut Jennifer Griffiths verfasserin aut Sanjeev Gupta verfasserin aut Aromma Kapoor verfasserin aut Perry Wilson verfasserin aut Tanima Arora verfasserin aut Ugochukwu Ugwuowo verfasserin aut In Cell Reports Medicine Elsevier, 2020 2(2021), 9, Seite 100376- (DE-627)1696877792 26663791 nnns volume:2 year:2021 number:9 pages:100376- https://doi.org/10.1016/j.xcrm.2021.100376 kostenfrei https://doaj.org/article/e507af4fd08b4bc8875ca9ab94685a56 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666379121002305 kostenfrei https://doaj.org/toc/2666-3791 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2021 9 100376- |
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10.1016/j.xcrm.2021.100376 doi (DE-627)DOAJ008310599 (DE-599)DOAJe507af4fd08b4bc8875ca9ab94685a56 DE-627 ger DE-627 rakwb eng R5-920 Julia L. Jezmir verfasserin aut Performance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Many US states published crisis standards of care (CSC) guidelines for allocating scarce critical care resources during the COVID-19 pandemic. However, the performance of these guidelines in maximizing their population benefit has not been well tested. In 2,272 adults with COVID-19 requiring mechanical ventilation drawn from the Study of the Treatment and Outcomes in Critically Ill Patients with COVID-19 (STOP-COVID) multicenter cohort, we test the following three approaches to CSC algorithms: Sequential Organ Failure Assessment (SOFA) scores grouped into ranges, SOFA score ranges plus comorbidities, and a hypothetical approach using raw SOFA scores not grouped into ranges. We find that area under receiver operating characteristic (AUROC) curves for all three algorithms demonstrate only modest discrimination for 28-day mortality. Adding comorbidity scoring modestly improves algorithm performance over SOFA scores alone. The algorithm incorporating comorbidities has modestly worse predictive performance for Black compared to white patients. CSC algorithms should be empirically examined to refine approaches to the allocation of scarce resources during pandemics and to avoid potential exacerbation of racial inequities. medical ethics crisis standards of care triage critical care intensive care COVID-19 Medicine (General) Maheetha Bharadwaj verfasserin aut Alexander Chaitoff verfasserin aut Bradford Diephuis verfasserin aut Conor P. Crowley verfasserin aut Sandeep P. Kishore verfasserin aut Eric Goralnick verfasserin aut Louis T. Merriam verfasserin aut Aimee Milliken verfasserin aut Chanu Rhee verfasserin aut Nicholas Sadovnikoff verfasserin aut Sejal B. Shah verfasserin aut Shruti Gupta verfasserin aut David E. Leaf verfasserin aut William B. Feldman verfasserin aut Edy Y. Kim verfasserin aut Carl P. Walther verfasserin aut Samaya J. Anumudu verfasserin aut Justin Arunthamakun verfasserin aut Kathleen F. Kopecky verfasserin aut Gregory P. Milligan verfasserin aut Peter A. McCullough verfasserin aut Thuy-Duyen Nguyen verfasserin aut Shahzad Shaefi verfasserin aut Megan L. Krajewski verfasserin aut Sidharth Shankar verfasserin aut Ameeka Pannu verfasserin aut Juan D. Valencia verfasserin aut Sushrut S. Waikar verfasserin aut Zoe A. Kibbelaar verfasserin aut Ambarish M. Athavale verfasserin aut Peter Hart verfasserin aut Shristi Upadhyay verfasserin aut Ishaan Vohra verfasserin aut Ajiboye Oyintayo verfasserin aut Adam Green verfasserin aut Jean-Sebastien Rachoin verfasserin aut Christa A. Schorr verfasserin aut Lisa Shea verfasserin aut Daniel L. Edmonston verfasserin aut Christopher L. Mosher verfasserin aut Alexandre M. Shehata verfasserin aut Zaza Cohen verfasserin aut Valerie Allusson verfasserin aut Gabriela Bambrick-Santoyo verfasserin aut Noor ul aain Bhatti verfasserin aut Bijal Mehta verfasserin aut Aquino Williams verfasserin aut Samantha K. Brenner verfasserin aut Patricia Walters verfasserin aut Ronaldo C. Go verfasserin aut Keith M. Rose verfasserin aut Miguel A. Hernán verfasserin aut Amy M. Zhou verfasserin aut Ethan C. Kim verfasserin aut Rebecca Lisk verfasserin aut Lili Chan verfasserin aut Kusum S. Mathews verfasserin aut Steven G. Coca verfasserin aut Deena R. Altman verfasserin aut Aparna Saha verfasserin aut Howard Soh verfasserin aut Huei Hsun Wen verfasserin aut Sonali Bose verfasserin aut Emily A. Leven verfasserin aut Jing G. Wang verfasserin aut Gohar Mosoyan verfasserin aut Girish N. Nadkarni verfasserin aut Pattharawin Pattharanitima verfasserin aut Allon N. Friedman verfasserin aut John Guirguis verfasserin aut Rajat Kapoor verfasserin aut Christopher Meshberger verfasserin aut Katherine J. Kelly verfasserin aut Chirag R. Parikh verfasserin aut Brian T. Garibaldi verfasserin aut Celia P. Corona-Villalobos verfasserin aut Yumeng Wen verfasserin aut Steven Menez verfasserin aut Rubab F. Malik verfasserin aut Elena Cervantes verfasserin aut Samir Gautam verfasserin aut Mary C. Mallappallil verfasserin aut Jie Ouyang verfasserin aut Sabu John verfasserin aut Ernie Yap verfasserin aut Yohannes Melaku verfasserin aut Ibrahim Mohamed verfasserin aut Siddartha Bajracharya verfasserin aut Isha Puri verfasserin aut Mariah Thaxton verfasserin aut Jyotsna Bhattacharya verfasserin aut John Wagner verfasserin aut Leon Boudourakis verfasserin aut H. Bryant Nguyen verfasserin aut Afshin Ahoubim verfasserin aut Leslie F. Thomas verfasserin aut Dheeraj Reddy Sirganagari verfasserin aut Pramod K. Guru verfasserin aut Kianoush Kashani verfasserin aut Yan Zhou verfasserin aut Paul A. Bergl verfasserin aut Jesus Rodriguez verfasserin aut Jatan A. Shah verfasserin aut Mrigank S. Gupta verfasserin aut Princy N. Kumar verfasserin aut Deepa G. Lazarous verfasserin aut Seble G. Kassaye verfasserin aut Michal L. Melamed verfasserin aut Tanya S. Johns verfasserin aut Ryan Mocerino verfasserin aut Kalyan Prudhvi verfasserin aut Denzel Zhu verfasserin aut Rebecca V. Levy verfasserin aut Yorg Azzi verfasserin aut Molly Fisher verfasserin aut Milagros Yunes verfasserin aut Kaltrina Sedaliu verfasserin aut Ladan Golestaneh verfasserin aut Maureen Brogan verfasserin aut Neelja Kumar verfasserin aut Michael Chang verfasserin aut Ritesh Raichoudhury verfasserin aut Akshay Athreya verfasserin aut Mohamed Farag verfasserin aut Edward J. Schenck verfasserin aut Soo Jung Cho verfasserin aut Maria Plataki verfasserin aut Sergio L. Alvarez-Mulett verfasserin aut Luis G. Gomez-Escobar verfasserin aut Di Pan verfasserin aut Stefi Lee verfasserin aut Jamuna Krishnan verfasserin aut William Whalen verfasserin aut David Charytan verfasserin aut Ashley Macina verfasserin aut Sobaata Chaudhry verfasserin aut Benjamin Wu verfasserin aut Frank Modersitzki verfasserin aut Anand Srivastava verfasserin aut Alexander S. Leidner verfasserin aut Carlos Martinez verfasserin aut Jacqueline M. Kruser verfasserin aut Richard G. Wunderink verfasserin aut Alexander J. Hodakowski verfasserin aut Juan Carlos Q. Velez verfasserin aut Eboni G. Price-Haywood verfasserin aut Luis A. Matute-Trochez verfasserin aut Anna E. Hasty verfasserin aut Muner MB. Mohamed verfasserin aut Rupali S. Avasare verfasserin aut David Zonies verfasserin aut David E. Leaf verfasserin aut Shruti Gupta verfasserin aut Meghan E. Sise verfasserin aut Erik T. Newman verfasserin aut Samah Abu Omar verfasserin aut Kapil K. Pokharel verfasserin aut Shreyak Sharma verfasserin aut Harkarandeep Singh verfasserin aut Simon Correa verfasserin aut Tanveer Shaukat verfasserin aut Omer Kamal verfasserin aut Wei Wang verfasserin aut Heather Yang verfasserin aut Jeffery O. Boateng verfasserin aut Meghan Lee verfasserin aut Ian A. Strohbehn verfasserin aut Jiahua Li verfasserin aut Ariel L. Mueller verfasserin aut Roberta Redfern verfasserin aut Nicholas S. Cairl verfasserin aut Gabriel Naimy verfasserin aut Abeer Abu-Saif verfasserin aut Danyell Hall verfasserin aut Laura Bickley verfasserin aut Chris Rowan verfasserin aut Farah Madhani-Lovely verfasserin aut Vivian S. Cruz verfasserin aut Kristen M. Hess verfasserin aut Alanna L. Jacobs verfasserin aut Vasil Peev verfasserin aut Jochen Reiser verfasserin aut John J. Byun verfasserin aut Andrew Vissing verfasserin aut Esha M. Kapania verfasserin aut Zoe Post verfasserin aut Nilam P. Patel verfasserin aut Joy-Marie Hermes verfasserin aut Anne K. Sutherland verfasserin aut Amee Patrawalla verfasserin aut Diana G. Finkel verfasserin aut Barbara A. Danek verfasserin aut Sowminya Arikapudi verfasserin aut Jeffrey M. Paer verfasserin aut Peter Cangialosi verfasserin aut Mark Liotta verfasserin aut Jared Radbel verfasserin aut Sonika Puri verfasserin aut Jag Sunderram verfasserin aut Matthew T. Scharf verfasserin aut Ayesha Ahmed verfasserin aut Ilya Berim verfasserin aut Jayanth S. Vatson verfasserin aut Shuchi Anand verfasserin aut Joseph E. Levitt verfasserin aut Suzanne M. Boyle verfasserin aut Rui Song verfasserin aut Jingjing Zhang verfasserin aut Sang Hoon Woo verfasserin aut Xiaoying Deng verfasserin aut Goni Katz-Greenberg verfasserin aut Katharine Senter verfasserin aut Moh’d A. Sharshir verfasserin aut Vadym V. Rusnak verfasserin aut Muhammad Imran Ali verfasserin aut Anip Bansal verfasserin aut Amber S. Podoll verfasserin aut Michel Chonchol verfasserin aut Sunita Sharma verfasserin aut Ellen L. Burnham verfasserin aut Arash Rashidi verfasserin aut Rana Hejal verfasserin aut Eric Judd verfasserin aut Laura Latta verfasserin aut Ashita Tolwani verfasserin aut Timothy E. Albertson verfasserin aut Jason Y. Adams verfasserin aut Steven Y. Chang verfasserin aut Rebecca M. Beutler verfasserin aut Etienne Macedo verfasserin aut Harin Rhee verfasserin aut Kathleen D. Liu verfasserin aut Vasantha K. Jotwani verfasserin aut Jay L. Koyner verfasserin aut Chintan V. Shah verfasserin aut Vishal Jaikaransingh verfasserin aut Stephanie M. Toth-Manikowski verfasserin aut Min J. Joo verfasserin aut James P. Lash verfasserin aut Javier A. Neyra verfasserin aut Nourhan Chaaban verfasserin aut Madona Elias verfasserin aut Yahya Ahmad verfasserin aut Alfredo Iardino verfasserin aut Elizabeth H. Au verfasserin aut Jill H. Sharma verfasserin aut Marie Anne Sosa verfasserin aut Sabrina Taldone verfasserin aut Gabriel Contreras verfasserin aut David De La Zerda verfasserin aut Hayley B. Gershengorn verfasserin aut Bhavarth Shukla verfasserin aut Alessia Fornoni verfasserin aut Tanira Ferreira verfasserin aut Salim S. Hayek verfasserin aut Pennelope Blakely verfasserin aut Hanna Berlin verfasserin aut Tariq U. Azam verfasserin aut Husam Shadid verfasserin aut Michael Pan verfasserin aut Patrick O’ Hayer verfasserin aut Chelsea Meloche verfasserin aut Rafey Feroze verfasserin aut Rayan Kaakati verfasserin aut Danny Perry verfasserin aut Abbas Bitar verfasserin aut Elizabeth Anderson verfasserin aut Kishan J. Padalia verfasserin aut John P. Donnelly verfasserin aut Andrew J. Admon verfasserin aut Jennifer E. Flythe verfasserin aut Matthew J. Tugman verfasserin aut Emily H. Chang verfasserin aut Brent R. Brown verfasserin aut Amanda K. Leonberg-Yoo verfasserin aut Ryan C. Spiardi verfasserin aut Todd A. Miano verfasserin aut Meaghan S. Roche verfasserin aut Charles R. Vasquez verfasserin aut Amar D. Bansal verfasserin aut Natalie C. Ernecoff verfasserin aut Sanjana Kapoor verfasserin aut Siddharth Verma verfasserin aut Csaba P. Kovesdy verfasserin aut Miklos Z. Molnar verfasserin aut Ambreen Azhar verfasserin aut S. Susan Hedayati verfasserin aut Mridula V. Nadamuni verfasserin aut Shani Shastri verfasserin aut Duwayne L. Willett verfasserin aut Samuel A.P. Short verfasserin aut Amanda D. Renaghan verfasserin aut Kyle B. Enfield verfasserin aut Pavan K. Bhatraju verfasserin aut A. Bilal Malik verfasserin aut Matthew W. Semler verfasserin aut Anitha Vijayan verfasserin aut Christina Mariyam Joy verfasserin aut Tingting Li verfasserin aut Seth Goldberg verfasserin aut Patricia F. Kao verfasserin aut Greg L. Schumaker verfasserin aut Nitender Goyal verfasserin aut Anthony J. Faugno verfasserin aut Greg L. Schumaker verfasserin aut Caroline M. Hsu verfasserin aut Asma Tariq verfasserin aut Leah Meyer verfasserin aut Ravi K. Kshirsagar verfasserin aut Daniel E. Weiner verfasserin aut Aju Jose verfasserin aut Marta Christov verfasserin aut Jennifer Griffiths verfasserin aut Sanjeev Gupta verfasserin aut Aromma Kapoor verfasserin aut Perry Wilson verfasserin aut Tanima Arora verfasserin aut Ugochukwu Ugwuowo verfasserin aut In Cell Reports Medicine Elsevier, 2020 2(2021), 9, Seite 100376- (DE-627)1696877792 26663791 nnns volume:2 year:2021 number:9 pages:100376- https://doi.org/10.1016/j.xcrm.2021.100376 kostenfrei https://doaj.org/article/e507af4fd08b4bc8875ca9ab94685a56 kostenfrei http://www.sciencedirect.com/science/article/pii/S2666379121002305 kostenfrei https://doaj.org/toc/2666-3791 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 2 2021 9 100376- |
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Julia L. Jezmir @@aut@@ Maheetha Bharadwaj @@aut@@ Alexander Chaitoff @@aut@@ Bradford Diephuis @@aut@@ Conor P. Crowley @@aut@@ Sandeep P. Kishore @@aut@@ Eric Goralnick @@aut@@ Louis T. Merriam @@aut@@ Aimee Milliken @@aut@@ Chanu Rhee @@aut@@ Nicholas Sadovnikoff @@aut@@ Sejal B. Shah @@aut@@ Shruti Gupta @@aut@@ David E. Leaf @@aut@@ William B. Feldman @@aut@@ Edy Y. Kim @@aut@@ Carl P. Walther @@aut@@ Samaya J. Anumudu @@aut@@ Justin Arunthamakun @@aut@@ Kathleen F. Kopecky @@aut@@ Gregory P. Milligan @@aut@@ Peter A. McCullough @@aut@@ Thuy-Duyen Nguyen @@aut@@ Shahzad Shaefi @@aut@@ Megan L. Krajewski @@aut@@ Sidharth Shankar @@aut@@ Ameeka Pannu @@aut@@ Juan D. Valencia @@aut@@ Sushrut S. Waikar @@aut@@ Zoe A. Kibbelaar @@aut@@ Ambarish M. Athavale @@aut@@ Peter Hart @@aut@@ Shristi Upadhyay @@aut@@ Ishaan Vohra @@aut@@ Ajiboye Oyintayo @@aut@@ Adam Green @@aut@@ Jean-Sebastien Rachoin @@aut@@ Christa A. Schorr @@aut@@ Lisa Shea @@aut@@ Daniel L. Edmonston @@aut@@ Christopher L. Mosher @@aut@@ Alexandre M. Shehata @@aut@@ Zaza Cohen @@aut@@ Valerie Allusson @@aut@@ Gabriela Bambrick-Santoyo @@aut@@ Noor ul aain Bhatti @@aut@@ Bijal Mehta @@aut@@ Aquino Williams @@aut@@ Samantha K. Brenner @@aut@@ Patricia Walters @@aut@@ Ronaldo C. Go @@aut@@ Keith M. Rose @@aut@@ Miguel A. Hernán @@aut@@ Amy M. Zhou @@aut@@ Ethan C. Kim @@aut@@ Rebecca Lisk @@aut@@ Lili Chan @@aut@@ Kusum S. Mathews @@aut@@ Steven G. Coca @@aut@@ Deena R. Altman @@aut@@ Aparna Saha @@aut@@ Howard Soh @@aut@@ Huei Hsun Wen @@aut@@ Sonali Bose @@aut@@ Emily A. Leven @@aut@@ Jing G. Wang @@aut@@ Gohar Mosoyan @@aut@@ Girish N. Nadkarni @@aut@@ Pattharawin Pattharanitima @@aut@@ Allon N. Friedman @@aut@@ John Guirguis @@aut@@ Rajat Kapoor @@aut@@ Christopher Meshberger @@aut@@ Katherine J. Kelly @@aut@@ Chirag R. Parikh @@aut@@ Brian T. Garibaldi @@aut@@ Celia P. Corona-Villalobos @@aut@@ Yumeng Wen @@aut@@ Steven Menez @@aut@@ Rubab F. Malik @@aut@@ Elena Cervantes @@aut@@ Samir Gautam @@aut@@ Mary C. Mallappallil @@aut@@ Jie Ouyang @@aut@@ Sabu John @@aut@@ Ernie Yap @@aut@@ Yohannes Melaku @@aut@@ Ibrahim Mohamed @@aut@@ Siddartha Bajracharya @@aut@@ Isha Puri @@aut@@ Mariah Thaxton @@aut@@ Jyotsna Bhattacharya @@aut@@ John Wagner @@aut@@ Leon Boudourakis @@aut@@ H. Bryant Nguyen @@aut@@ Afshin Ahoubim @@aut@@ Leslie F. Thomas @@aut@@ Dheeraj Reddy Sirganagari @@aut@@ Pramod K. Guru @@aut@@ Kianoush Kashani @@aut@@ Yan Zhou @@aut@@ Paul A. Bergl @@aut@@ Jesus Rodriguez @@aut@@ Jatan A. Shah @@aut@@ Mrigank S. Gupta @@aut@@ Princy N. Kumar @@aut@@ Deepa G. Lazarous @@aut@@ Seble G. Kassaye @@aut@@ Michal L. Melamed @@aut@@ Tanya S. Johns @@aut@@ Ryan Mocerino @@aut@@ Kalyan Prudhvi @@aut@@ Denzel Zhu @@aut@@ Rebecca V. Levy @@aut@@ Yorg Azzi @@aut@@ Molly Fisher @@aut@@ Milagros Yunes @@aut@@ Kaltrina Sedaliu @@aut@@ Ladan Golestaneh @@aut@@ Maureen Brogan @@aut@@ Neelja Kumar @@aut@@ Michael Chang @@aut@@ Ritesh Raichoudhury @@aut@@ Akshay Athreya @@aut@@ Mohamed Farag @@aut@@ Edward J. Schenck @@aut@@ Soo Jung Cho @@aut@@ Maria Plataki @@aut@@ Sergio L. Alvarez-Mulett @@aut@@ Luis G. Gomez-Escobar @@aut@@ Di Pan @@aut@@ Stefi Lee @@aut@@ Jamuna Krishnan @@aut@@ William Whalen @@aut@@ David Charytan @@aut@@ Ashley Macina @@aut@@ Sobaata Chaudhry @@aut@@ Benjamin Wu @@aut@@ Frank Modersitzki @@aut@@ Anand Srivastava @@aut@@ Alexander S. Leidner @@aut@@ Carlos Martinez @@aut@@ Jacqueline M. Kruser @@aut@@ Richard G. Wunderink @@aut@@ Alexander J. Hodakowski @@aut@@ Juan Carlos Q. Velez @@aut@@ Eboni G. Price-Haywood @@aut@@ Luis A. Matute-Trochez @@aut@@ Anna E. Hasty @@aut@@ Muner MB. Mohamed @@aut@@ Rupali S. Avasare @@aut@@ David Zonies @@aut@@ Meghan E. Sise @@aut@@ Erik T. Newman @@aut@@ Samah Abu Omar @@aut@@ Kapil K. Pokharel @@aut@@ Shreyak Sharma @@aut@@ Harkarandeep Singh @@aut@@ Simon Correa @@aut@@ Tanveer Shaukat @@aut@@ Omer Kamal @@aut@@ Wei Wang @@aut@@ Heather Yang @@aut@@ Jeffery O. Boateng @@aut@@ Meghan Lee @@aut@@ Ian A. Strohbehn @@aut@@ Jiahua Li @@aut@@ Ariel L. Mueller @@aut@@ Roberta Redfern @@aut@@ Nicholas S. Cairl @@aut@@ Gabriel Naimy @@aut@@ Abeer Abu-Saif @@aut@@ Danyell Hall @@aut@@ Laura Bickley @@aut@@ Chris Rowan @@aut@@ Farah Madhani-Lovely @@aut@@ Vivian S. Cruz @@aut@@ Kristen M. Hess @@aut@@ Alanna L. Jacobs @@aut@@ Vasil Peev @@aut@@ Jochen Reiser @@aut@@ John J. Byun @@aut@@ Andrew Vissing @@aut@@ Esha M. Kapania @@aut@@ Zoe Post @@aut@@ Nilam P. Patel @@aut@@ Joy-Marie Hermes @@aut@@ Anne K. Sutherland @@aut@@ Amee Patrawalla @@aut@@ Diana G. Finkel @@aut@@ Barbara A. Danek @@aut@@ Sowminya Arikapudi @@aut@@ Jeffrey M. Paer @@aut@@ Peter Cangialosi @@aut@@ Mark Liotta @@aut@@ Jared Radbel @@aut@@ Sonika Puri @@aut@@ Jag Sunderram @@aut@@ Matthew T. Scharf @@aut@@ Ayesha Ahmed @@aut@@ Ilya Berim @@aut@@ Jayanth S. Vatson @@aut@@ Shuchi Anand @@aut@@ Joseph E. Levitt @@aut@@ Suzanne M. Boyle @@aut@@ Rui Song @@aut@@ Jingjing Zhang @@aut@@ Sang Hoon Woo @@aut@@ Xiaoying Deng @@aut@@ Goni Katz-Greenberg @@aut@@ Katharine Senter @@aut@@ Moh’d A. Sharshir @@aut@@ Vadym V. Rusnak @@aut@@ Muhammad Imran Ali @@aut@@ Anip Bansal @@aut@@ Amber S. Podoll @@aut@@ Michel Chonchol @@aut@@ Sunita Sharma @@aut@@ Ellen L. Burnham @@aut@@ Arash Rashidi @@aut@@ Rana Hejal @@aut@@ Eric Judd @@aut@@ Laura Latta @@aut@@ Ashita Tolwani @@aut@@ Timothy E. Albertson @@aut@@ Jason Y. Adams @@aut@@ Steven Y. Chang @@aut@@ Rebecca M. Beutler @@aut@@ Etienne Macedo @@aut@@ Harin Rhee @@aut@@ Kathleen D. Liu @@aut@@ Vasantha K. Jotwani @@aut@@ Jay L. Koyner @@aut@@ Chintan V. Shah @@aut@@ Vishal Jaikaransingh @@aut@@ Stephanie M. Toth-Manikowski @@aut@@ Min J. Joo @@aut@@ James P. Lash @@aut@@ Javier A. Neyra @@aut@@ Nourhan Chaaban @@aut@@ Madona Elias @@aut@@ Yahya Ahmad @@aut@@ Alfredo Iardino @@aut@@ Elizabeth H. Au @@aut@@ Jill H. Sharma @@aut@@ Marie Anne Sosa @@aut@@ Sabrina Taldone @@aut@@ Gabriel Contreras @@aut@@ David De La Zerda @@aut@@ Hayley B. Gershengorn @@aut@@ Bhavarth Shukla @@aut@@ Alessia Fornoni @@aut@@ Tanira Ferreira @@aut@@ Salim S. Hayek @@aut@@ Pennelope Blakely @@aut@@ Hanna Berlin @@aut@@ Tariq U. Azam @@aut@@ Husam Shadid @@aut@@ Michael Pan @@aut@@ Patrick O’ Hayer @@aut@@ Chelsea Meloche @@aut@@ Rafey Feroze @@aut@@ Rayan Kaakati @@aut@@ Danny Perry @@aut@@ Abbas Bitar @@aut@@ Elizabeth Anderson @@aut@@ Kishan J. Padalia @@aut@@ John P. Donnelly @@aut@@ Andrew J. Admon @@aut@@ Jennifer E. Flythe @@aut@@ Matthew J. Tugman @@aut@@ Emily H. Chang @@aut@@ Brent R. Brown @@aut@@ Amanda K. Leonberg-Yoo @@aut@@ Ryan C. Spiardi @@aut@@ Todd A. Miano @@aut@@ Meaghan S. Roche @@aut@@ Charles R. Vasquez @@aut@@ Amar D. Bansal @@aut@@ Natalie C. Ernecoff @@aut@@ Sanjana Kapoor @@aut@@ Siddharth Verma @@aut@@ Csaba P. Kovesdy @@aut@@ Miklos Z. Molnar @@aut@@ Ambreen Azhar @@aut@@ S. Susan Hedayati @@aut@@ Mridula V. Nadamuni @@aut@@ Shani Shastri @@aut@@ Duwayne L. Willett @@aut@@ Samuel A.P. Short @@aut@@ Amanda D. Renaghan @@aut@@ Kyle B. Enfield @@aut@@ Pavan K. Bhatraju @@aut@@ A. Bilal Malik @@aut@@ Matthew W. Semler @@aut@@ Anitha Vijayan @@aut@@ Christina Mariyam Joy @@aut@@ Tingting Li @@aut@@ Seth Goldberg @@aut@@ Patricia F. Kao @@aut@@ Greg L. Schumaker @@aut@@ Nitender Goyal @@aut@@ Anthony J. Faugno @@aut@@ Caroline M. Hsu @@aut@@ Asma Tariq @@aut@@ Leah Meyer @@aut@@ Ravi K. Kshirsagar @@aut@@ Daniel E. Weiner @@aut@@ Aju Jose @@aut@@ Marta Christov @@aut@@ Jennifer Griffiths @@aut@@ Sanjeev Gupta @@aut@@ Aromma Kapoor @@aut@@ Perry Wilson @@aut@@ Tanima Arora @@aut@@ Ugochukwu Ugwuowo @@aut@@ |
| publishDateDaySort_date |
2021-01-01T00:00:00Z |
| hierarchy_top_id |
1696877792 |
| id |
DOAJ008310599 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ008310599</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230501175128.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230225s2021 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.xcrm.2021.100376</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ008310599</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJe507af4fd08b4bc8875ca9ab94685a56</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">R5-920</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Julia L. Jezmir</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Performance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary: Many US states published crisis standards of care (CSC) guidelines for allocating scarce critical care resources during the COVID-19 pandemic. However, the performance of these guidelines in maximizing their population benefit has not been well tested. In 2,272 adults with COVID-19 requiring mechanical ventilation drawn from the Study of the Treatment and Outcomes in Critically Ill Patients with COVID-19 (STOP-COVID) multicenter cohort, we test the following three approaches to CSC algorithms: Sequential Organ Failure Assessment (SOFA) scores grouped into ranges, SOFA score ranges plus comorbidities, and a hypothetical approach using raw SOFA scores not grouped into ranges. We find that area under receiver operating characteristic (AUROC) curves for all three algorithms demonstrate only modest discrimination for 28-day mortality. Adding comorbidity scoring modestly improves algorithm performance over SOFA scores alone. The algorithm incorporating comorbidities has modestly worse predictive performance for Black compared to white patients. CSC algorithms should be empirically examined to refine approaches to the allocation of scarce resources during pandemics and to avoid potential exacerbation of racial inequities.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">medical ethics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">crisis standards of care</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">triage</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">critical care</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">intensive care</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">COVID-19</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine (General)</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maheetha Bharadwaj</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alexander Chaitoff</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Bradford Diephuis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Conor P. Crowley</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sandeep P. Kishore</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Eric Goralnick</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Louis T. Merriam</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Aimee Milliken</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Chanu Rhee</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nicholas Sadovnikoff</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sejal B. Shah</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shruti Gupta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David E. Leaf</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">William B. Feldman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Edy Y. Kim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carl P. Walther</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Samaya J. Anumudu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Justin Arunthamakun</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kathleen F. Kopecky</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gregory P. Milligan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Peter A. McCullough</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Thuy-Duyen Nguyen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shahzad Shaefi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Megan L. Krajewski</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sidharth Shankar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ameeka Pannu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Juan D. Valencia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sushrut S. Waikar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Zoe A. Kibbelaar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ambarish M. Athavale</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Peter Hart</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shristi Upadhyay</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ishaan Vohra</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ajiboye Oyintayo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adam Green</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jean-Sebastien Rachoin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Christa A. Schorr</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lisa Shea</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniel L. Edmonston</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Christopher L. Mosher</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alexandre M. Shehata</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Zaza Cohen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Valerie Allusson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gabriela Bambrick-Santoyo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Noor ul aain Bhatti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Bijal Mehta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Aquino Williams</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Samantha K. Brenner</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Patricia Walters</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ronaldo C. Go</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Keith M. Rose</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Miguel A. Hernán</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Amy M. Zhou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ethan C. Kim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rebecca Lisk</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lili Chan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kusum S. Mathews</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Steven G. Coca</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Deena R. 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Leven</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jing G. Wang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gohar Mosoyan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Girish N. Nadkarni</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Pattharawin Pattharanitima</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Allon N. 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Mallappallil</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jie Ouyang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sabu John</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ernie Yap</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yohannes Melaku</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ibrahim Mohamed</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Siddartha Bajracharya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Isha Puri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mariah Thaxton</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jyotsna Bhattacharya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">John Wagner</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Leon Boudourakis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">H. 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Avasare</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David Zonies</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David E. Leaf</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shruti Gupta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Meghan E. Sise</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Erik T. 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Cruz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kristen M. Hess</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alanna L. Jacobs</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Vasil Peev</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jochen Reiser</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">John J. Byun</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrew Vissing</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Esha M. Kapania</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Zoe Post</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nilam P. Patel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Joy-Marie Hermes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anne K. Sutherland</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Amee Patrawalla</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Diana G. Finkel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Barbara A. Danek</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sowminya Arikapudi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jeffrey M. Paer</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Peter Cangialosi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mark Liotta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jared Radbel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sonika Puri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jag Sunderram</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Matthew T. Scharf</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ayesha Ahmed</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ilya Berim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jayanth S. Vatson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shuchi Anand</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Joseph E. Levitt</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Suzanne M. Boyle</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rui Song</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jingjing Zhang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sang Hoon Woo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Xiaoying Deng</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Goni Katz-Greenberg</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Katharine Senter</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Moh’d A. Sharshir</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Vadym V. Rusnak</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Muhammad Imran Ali</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anip Bansal</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Amber S. Podoll</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michel Chonchol</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sunita Sharma</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ellen L. Burnham</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Arash Rashidi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rana Hejal</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Eric Judd</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Laura Latta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ashita Tolwani</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Timothy E. Albertson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jason Y. Adams</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Steven Y. Chang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rebecca M. Beutler</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Etienne Macedo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Harin Rhee</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kathleen D. Liu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Vasantha K. Jotwani</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jay L. Koyner</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Chintan V. Shah</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Vishal Jaikaransingh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stephanie M. Toth-Manikowski</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Min J. Joo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">James P. Lash</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Javier A. Neyra</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nourhan Chaaban</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Madona Elias</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yahya Ahmad</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alfredo Iardino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elizabeth H. Au</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jill H. Sharma</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marie Anne Sosa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sabrina Taldone</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gabriel Contreras</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David De La Zerda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hayley B. Gershengorn</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Bhavarth Shukla</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alessia Fornoni</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tanira Ferreira</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Salim S. Hayek</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Pennelope Blakely</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hanna Berlin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tariq U. Azam</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Husam Shadid</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michael Pan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Patrick O’ Hayer</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Chelsea Meloche</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rafey Feroze</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rayan Kaakati</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Danny Perry</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Abbas Bitar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elizabeth Anderson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kishan J. Padalia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">John P. Donnelly</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrew J. Admon</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jennifer E. Flythe</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Matthew J. Tugman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emily H. Chang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Brent R. Brown</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Amanda K. Leonberg-Yoo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ryan C. Spiardi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Todd A. Miano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Meaghan S. Roche</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Charles R. Vasquez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Amar D. Bansal</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Natalie C. Ernecoff</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sanjana Kapoor</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Siddharth Verma</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Csaba P. Kovesdy</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Miklos Z. Molnar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ambreen Azhar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">S. Susan Hedayati</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mridula V. Nadamuni</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shani Shastri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Duwayne L. Willett</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Samuel A.P. Short</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Amanda D. Renaghan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kyle B. Enfield</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Pavan K. Bhatraju</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">A. Bilal Malik</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Matthew W. Semler</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anitha Vijayan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Christina Mariyam Joy</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tingting Li</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Seth Goldberg</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Patricia F. Kao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Greg L. Schumaker</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nitender Goyal</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anthony J. Faugno</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Greg L. Schumaker</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Caroline M. Hsu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Asma Tariq</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Leah Meyer</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ravi K. Kshirsagar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniel E. 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Julia L. Jezmir Maheetha Bharadwaj Alexander Chaitoff Bradford Diephuis Conor P. Crowley Sandeep P. Kishore Eric Goralnick Louis T. Merriam Aimee Milliken Chanu Rhee Nicholas Sadovnikoff Sejal B. Shah Shruti Gupta David E. Leaf William B. Feldman Edy Y. Kim Carl P. Walther Samaya J. Anumudu Justin Arunthamakun Kathleen F. Kopecky Gregory P. Milligan Peter A. McCullough Thuy-Duyen Nguyen Shahzad Shaefi Megan L. Krajewski Sidharth Shankar Ameeka Pannu Juan D. Valencia Sushrut S. Waikar Zoe A. Kibbelaar Ambarish M. Athavale Peter Hart Shristi Upadhyay Ishaan Vohra Ajiboye Oyintayo Adam Green Jean-Sebastien Rachoin Christa A. Schorr Lisa Shea Daniel L. Edmonston Christopher L. Mosher Alexandre M. Shehata Zaza Cohen Valerie Allusson Gabriela Bambrick-Santoyo Noor ul aain Bhatti Bijal Mehta Aquino Williams Samantha K. Brenner Patricia Walters Ronaldo C. Go Keith M. Rose Miguel A. Hernán Amy M. Zhou Ethan C. Kim Rebecca Lisk Lili Chan Kusum S. Mathews Steven G. Coca Deena R. Altman Aparna Saha Howard Soh Huei Hsun Wen Sonali Bose Emily A. Leven Jing G. Wang Gohar Mosoyan Girish N. Nadkarni Pattharawin Pattharanitima Allon N. Friedman John Guirguis Rajat Kapoor Christopher Meshberger Katherine J. Kelly Chirag R. Parikh Brian T. Garibaldi Celia P. Corona-Villalobos Yumeng Wen Steven Menez Rubab F. Malik Elena Cervantes Samir Gautam Mary C. Mallappallil Jie Ouyang Sabu John Ernie Yap Yohannes Melaku Ibrahim Mohamed Siddartha Bajracharya Isha Puri Mariah Thaxton Jyotsna Bhattacharya John Wagner Leon Boudourakis H. Bryant Nguyen Afshin Ahoubim Leslie F. Thomas Dheeraj Reddy Sirganagari Pramod K. Guru Kianoush Kashani Yan Zhou Paul A. Bergl Jesus Rodriguez Jatan A. Shah Mrigank S. Gupta Princy N. Kumar Deepa G. Lazarous Seble G. Kassaye Michal L. Melamed Tanya S. Johns Ryan Mocerino Kalyan Prudhvi Denzel Zhu Rebecca V. Levy Yorg Azzi Molly Fisher Milagros Yunes Kaltrina Sedaliu Ladan Golestaneh Maureen Brogan Neelja Kumar Michael Chang Ritesh Raichoudhury Akshay Athreya Mohamed Farag Edward J. Schenck Soo Jung Cho Maria Plataki Sergio L. Alvarez-Mulett Luis G. Gomez-Escobar Di Pan Stefi Lee Jamuna Krishnan William Whalen David Charytan Ashley Macina Sobaata Chaudhry Benjamin Wu Frank Modersitzki Anand Srivastava Alexander S. Leidner Carlos Martinez Jacqueline M. Kruser Richard G. Wunderink Alexander J. Hodakowski Juan Carlos Q. Velez Eboni G. Price-Haywood Luis A. Matute-Trochez Anna E. Hasty Muner MB. Mohamed Rupali S. Avasare David Zonies Meghan E. Sise Erik T. Newman Samah Abu Omar Kapil K. Pokharel Shreyak Sharma Harkarandeep Singh Simon Correa Tanveer Shaukat Omer Kamal Wei Wang Heather Yang Jeffery O. Boateng Meghan Lee Ian A. Strohbehn Jiahua Li Ariel L. Mueller Roberta Redfern Nicholas S. Cairl Gabriel Naimy Abeer Abu-Saif Danyell Hall Laura Bickley Chris Rowan Farah Madhani-Lovely Vivian S. Cruz Kristen M. Hess Alanna L. Jacobs Vasil Peev Jochen Reiser John J. Byun Andrew Vissing Esha M. Kapania Zoe Post Nilam P. Patel Joy-Marie Hermes Anne K. Sutherland Amee Patrawalla Diana G. Finkel Barbara A. Danek Sowminya Arikapudi Jeffrey M. Paer Peter Cangialosi Mark Liotta Jared Radbel Sonika Puri Jag Sunderram Matthew T. Scharf Ayesha Ahmed Ilya Berim Jayanth S. Vatson Shuchi Anand Joseph E. Levitt Suzanne M. Boyle Rui Song Jingjing Zhang Sang Hoon Woo Xiaoying Deng Goni Katz-Greenberg Katharine Senter Moh’d A. Sharshir Vadym V. Rusnak Muhammad Imran Ali Anip Bansal Amber S. Podoll Michel Chonchol Sunita Sharma Ellen L. Burnham Arash Rashidi Rana Hejal Eric Judd Laura Latta Ashita Tolwani Timothy E. Albertson Jason Y. Adams Steven Y. Chang Rebecca M. Beutler Etienne Macedo Harin Rhee Kathleen D. Liu Vasantha K. Jotwani Jay L. Koyner Chintan V. Shah Vishal Jaikaransingh Stephanie M. Toth-Manikowski Min J. Joo James P. Lash Javier A. Neyra Nourhan Chaaban Madona Elias Yahya Ahmad Alfredo Iardino Elizabeth H. Au Jill H. Sharma Marie Anne Sosa Sabrina Taldone Gabriel Contreras David De La Zerda Hayley B. Gershengorn Bhavarth Shukla Alessia Fornoni Tanira Ferreira Salim S. Hayek Pennelope Blakely Hanna Berlin Tariq U. Azam Husam Shadid Michael Pan Patrick O’ Hayer Chelsea Meloche Rafey Feroze Rayan Kaakati Danny Perry Abbas Bitar Elizabeth Anderson Kishan J. Padalia John P. Donnelly Andrew J. Admon Jennifer E. Flythe Matthew J. Tugman Emily H. Chang Brent R. Brown Amanda K. Leonberg-Yoo Ryan C. Spiardi Todd A. Miano Meaghan S. Roche Charles R. Vasquez Amar D. Bansal Natalie C. Ernecoff Sanjana Kapoor Siddharth Verma Csaba P. Kovesdy Miklos Z. Molnar Ambreen Azhar S. Susan Hedayati Mridula V. Nadamuni Shani Shastri Duwayne L. Willett Samuel A.P. Short Amanda D. Renaghan Kyle B. Enfield Pavan K. Bhatraju A. Bilal Malik Matthew W. Semler Anitha Vijayan Christina Mariyam Joy Tingting Li Seth Goldberg Patricia F. Kao Greg L. Schumaker Nitender Goyal Anthony J. Faugno Caroline M. Hsu Asma Tariq Leah Meyer Ravi K. Kshirsagar Daniel E. Weiner Aju Jose Marta Christov Jennifer Griffiths Sanjeev Gupta Aromma Kapoor Perry Wilson Tanima Arora Ugochukwu Ugwuowo |
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performance of crisis standards of care guidelines in a cohort of critically ill covid-19 patients in the united states |
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Performance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States |
| abstract |
Summary: Many US states published crisis standards of care (CSC) guidelines for allocating scarce critical care resources during the COVID-19 pandemic. However, the performance of these guidelines in maximizing their population benefit has not been well tested. In 2,272 adults with COVID-19 requiring mechanical ventilation drawn from the Study of the Treatment and Outcomes in Critically Ill Patients with COVID-19 (STOP-COVID) multicenter cohort, we test the following three approaches to CSC algorithms: Sequential Organ Failure Assessment (SOFA) scores grouped into ranges, SOFA score ranges plus comorbidities, and a hypothetical approach using raw SOFA scores not grouped into ranges. We find that area under receiver operating characteristic (AUROC) curves for all three algorithms demonstrate only modest discrimination for 28-day mortality. Adding comorbidity scoring modestly improves algorithm performance over SOFA scores alone. The algorithm incorporating comorbidities has modestly worse predictive performance for Black compared to white patients. CSC algorithms should be empirically examined to refine approaches to the allocation of scarce resources during pandemics and to avoid potential exacerbation of racial inequities. |
| abstractGer |
Summary: Many US states published crisis standards of care (CSC) guidelines for allocating scarce critical care resources during the COVID-19 pandemic. However, the performance of these guidelines in maximizing their population benefit has not been well tested. In 2,272 adults with COVID-19 requiring mechanical ventilation drawn from the Study of the Treatment and Outcomes in Critically Ill Patients with COVID-19 (STOP-COVID) multicenter cohort, we test the following three approaches to CSC algorithms: Sequential Organ Failure Assessment (SOFA) scores grouped into ranges, SOFA score ranges plus comorbidities, and a hypothetical approach using raw SOFA scores not grouped into ranges. We find that area under receiver operating characteristic (AUROC) curves for all three algorithms demonstrate only modest discrimination for 28-day mortality. Adding comorbidity scoring modestly improves algorithm performance over SOFA scores alone. The algorithm incorporating comorbidities has modestly worse predictive performance for Black compared to white patients. CSC algorithms should be empirically examined to refine approaches to the allocation of scarce resources during pandemics and to avoid potential exacerbation of racial inequities. |
| abstract_unstemmed |
Summary: Many US states published crisis standards of care (CSC) guidelines for allocating scarce critical care resources during the COVID-19 pandemic. However, the performance of these guidelines in maximizing their population benefit has not been well tested. In 2,272 adults with COVID-19 requiring mechanical ventilation drawn from the Study of the Treatment and Outcomes in Critically Ill Patients with COVID-19 (STOP-COVID) multicenter cohort, we test the following three approaches to CSC algorithms: Sequential Organ Failure Assessment (SOFA) scores grouped into ranges, SOFA score ranges plus comorbidities, and a hypothetical approach using raw SOFA scores not grouped into ranges. We find that area under receiver operating characteristic (AUROC) curves for all three algorithms demonstrate only modest discrimination for 28-day mortality. Adding comorbidity scoring modestly improves algorithm performance over SOFA scores alone. The algorithm incorporating comorbidities has modestly worse predictive performance for Black compared to white patients. CSC algorithms should be empirically examined to refine approaches to the allocation of scarce resources during pandemics and to avoid potential exacerbation of racial inequities. |
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Performance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States |
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https://doi.org/10.1016/j.xcrm.2021.100376 https://doaj.org/article/e507af4fd08b4bc8875ca9ab94685a56 http://www.sciencedirect.com/science/article/pii/S2666379121002305 https://doaj.org/toc/2666-3791 |
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Maheetha Bharadwaj Alexander Chaitoff Bradford Diephuis Conor P. Crowley Sandeep P. Kishore Eric Goralnick Louis T. Merriam Aimee Milliken Chanu Rhee Nicholas Sadovnikoff Sejal B. Shah Shruti Gupta David E. Leaf William B. Feldman Edy Y. Kim Carl P. Walther Samaya J. Anumudu Justin Arunthamakun Kathleen F. Kopecky Gregory P. Milligan Peter A. McCullough Thuy-Duyen Nguyen Shahzad Shaefi Megan L. Krajewski Sidharth Shankar Ameeka Pannu Juan D. Valencia Sushrut S. Waikar Zoe A. Kibbelaar Ambarish M. Athavale Peter Hart Shristi Upadhyay Ishaan Vohra Ajiboye Oyintayo Adam Green Jean-Sebastien Rachoin Christa A. Schorr Lisa Shea Daniel L. Edmonston Christopher L. Mosher Alexandre M. Shehata Zaza Cohen Valerie Allusson Gabriela Bambrick-Santoyo Noor ul aain Bhatti Bijal Mehta Aquino Williams Samantha K. Brenner Patricia Walters Ronaldo C. Go Keith M. Rose Miguel A. Hernán Amy M. Zhou Ethan C. Kim Rebecca Lisk Lili Chan Kusum S. Mathews Steven G. Coca Deena R. Altman Aparna Saha Howard Soh Huei Hsun Wen Sonali Bose Emily A. Leven Jing G. Wang Gohar Mosoyan Girish N. Nadkarni Pattharawin Pattharanitima Allon N. Friedman John Guirguis Rajat Kapoor Christopher Meshberger Katherine J. Kelly Chirag R. Parikh Brian T. Garibaldi Celia P. Corona-Villalobos Yumeng Wen Steven Menez Rubab F. Malik Elena Cervantes Samir Gautam Mary C. Mallappallil Jie Ouyang Sabu John Ernie Yap Yohannes Melaku Ibrahim Mohamed Siddartha Bajracharya Isha Puri Mariah Thaxton Jyotsna Bhattacharya John Wagner Leon Boudourakis H. Bryant Nguyen Afshin Ahoubim Leslie F. Thomas Dheeraj Reddy Sirganagari Pramod K. Guru Kianoush Kashani Yan Zhou Paul A. Bergl Jesus Rodriguez Jatan A. Shah Mrigank S. Gupta Princy N. Kumar Deepa G. Lazarous Seble G. Kassaye Michal L. Melamed Tanya S. Johns Ryan Mocerino Kalyan Prudhvi Denzel Zhu Rebecca V. Levy Yorg Azzi Molly Fisher Milagros Yunes Kaltrina Sedaliu Ladan Golestaneh Maureen Brogan Neelja Kumar Michael Chang Ritesh Raichoudhury Akshay Athreya Mohamed Farag Edward J. Schenck Soo Jung Cho Maria Plataki Sergio L. Alvarez-Mulett Luis G. Gomez-Escobar Di Pan Stefi Lee Jamuna Krishnan William Whalen David Charytan Ashley Macina Sobaata Chaudhry Benjamin Wu Frank Modersitzki Anand Srivastava Alexander S. Leidner Carlos Martinez Jacqueline M. Kruser Richard G. Wunderink Alexander J. Hodakowski Juan Carlos Q. Velez Eboni G. Price-Haywood Luis A. Matute-Trochez Anna E. Hasty Muner MB. Mohamed Rupali S. Avasare David Zonies Meghan E. Sise Erik T. Newman Samah Abu Omar Kapil K. Pokharel Shreyak Sharma Harkarandeep Singh Simon Correa Tanveer Shaukat Omer Kamal Wei Wang Heather Yang Jeffery O. Boateng Meghan Lee Ian A. Strohbehn Jiahua Li Ariel L. Mueller Roberta Redfern Nicholas S. Cairl Gabriel Naimy Abeer Abu-Saif Danyell Hall Laura Bickley Chris Rowan Farah Madhani-Lovely Vivian S. Cruz Kristen M. Hess Alanna L. Jacobs Vasil Peev Jochen Reiser John J. Byun Andrew Vissing Esha M. Kapania Zoe Post Nilam P. Patel Joy-Marie Hermes Anne K. Sutherland Amee Patrawalla Diana G. Finkel Barbara A. Danek Sowminya Arikapudi Jeffrey M. Paer Peter Cangialosi Mark Liotta Jared Radbel Sonika Puri Jag Sunderram Matthew T. Scharf Ayesha Ahmed Ilya Berim Jayanth S. Vatson Shuchi Anand Joseph E. Levitt Suzanne M. Boyle Rui Song Jingjing Zhang Sang Hoon Woo Xiaoying Deng Goni Katz-Greenberg Katharine Senter Moh’d A. Sharshir Vadym V. Rusnak Muhammad Imran Ali Anip Bansal Amber S. Podoll Michel Chonchol Sunita Sharma Ellen L. Burnham Arash Rashidi Rana Hejal Eric Judd Laura Latta Ashita Tolwani Timothy E. Albertson Jason Y. Adams Steven Y. Chang Rebecca M. Beutler Etienne Macedo Harin Rhee Kathleen D. Liu Vasantha K. Jotwani Jay L. Koyner Chintan V. Shah Vishal Jaikaransingh Stephanie M. Toth-Manikowski Min J. Joo James P. Lash Javier A. Neyra Nourhan Chaaban Madona Elias Yahya Ahmad Alfredo Iardino Elizabeth H. Au Jill H. Sharma Marie Anne Sosa Sabrina Taldone Gabriel Contreras David De La Zerda Hayley B. Gershengorn Bhavarth Shukla Alessia Fornoni Tanira Ferreira Salim S. Hayek Pennelope Blakely Hanna Berlin Tariq U. Azam Husam Shadid Michael Pan Patrick O’ Hayer Chelsea Meloche Rafey Feroze Rayan Kaakati Danny Perry Abbas Bitar Elizabeth Anderson Kishan J. Padalia John P. Donnelly Andrew J. Admon Jennifer E. Flythe Matthew J. Tugman Emily H. Chang Brent R. Brown Amanda K. Leonberg-Yoo Ryan C. Spiardi Todd A. Miano Meaghan S. Roche Charles R. Vasquez Amar D. Bansal Natalie C. Ernecoff Sanjana Kapoor Siddharth Verma Csaba P. Kovesdy Miklos Z. Molnar Ambreen Azhar S. Susan Hedayati Mridula V. Nadamuni Shani Shastri Duwayne L. Willett Samuel A.P. Short Amanda D. Renaghan Kyle B. Enfield Pavan K. Bhatraju A. Bilal Malik Matthew W. Semler Anitha Vijayan Christina Mariyam Joy Tingting Li Seth Goldberg Patricia F. Kao Greg L. Schumaker Nitender Goyal Anthony J. Faugno Caroline M. Hsu Asma Tariq Leah Meyer Ravi K. Kshirsagar Daniel E. Weiner Aju Jose Marta Christov Jennifer Griffiths Sanjeev Gupta Aromma Kapoor Perry Wilson Tanima Arora Ugochukwu Ugwuowo |
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Maheetha Bharadwaj Alexander Chaitoff Bradford Diephuis Conor P. Crowley Sandeep P. Kishore Eric Goralnick Louis T. Merriam Aimee Milliken Chanu Rhee Nicholas Sadovnikoff Sejal B. Shah Shruti Gupta David E. Leaf William B. Feldman Edy Y. Kim Carl P. Walther Samaya J. Anumudu Justin Arunthamakun Kathleen F. Kopecky Gregory P. Milligan Peter A. McCullough Thuy-Duyen Nguyen Shahzad Shaefi Megan L. Krajewski Sidharth Shankar Ameeka Pannu Juan D. Valencia Sushrut S. Waikar Zoe A. Kibbelaar Ambarish M. Athavale Peter Hart Shristi Upadhyay Ishaan Vohra Ajiboye Oyintayo Adam Green Jean-Sebastien Rachoin Christa A. Schorr Lisa Shea Daniel L. Edmonston Christopher L. Mosher Alexandre M. Shehata Zaza Cohen Valerie Allusson Gabriela Bambrick-Santoyo Noor ul aain Bhatti Bijal Mehta Aquino Williams Samantha K. Brenner Patricia Walters Ronaldo C. Go Keith M. Rose Miguel A. Hernán Amy M. Zhou Ethan C. Kim Rebecca Lisk Lili Chan Kusum S. Mathews Steven G. Coca Deena R. Altman Aparna Saha Howard Soh Huei Hsun Wen Sonali Bose Emily A. Leven Jing G. Wang Gohar Mosoyan Girish N. Nadkarni Pattharawin Pattharanitima Allon N. Friedman John Guirguis Rajat Kapoor Christopher Meshberger Katherine J. Kelly Chirag R. Parikh Brian T. Garibaldi Celia P. Corona-Villalobos Yumeng Wen Steven Menez Rubab F. Malik Elena Cervantes Samir Gautam Mary C. Mallappallil Jie Ouyang Sabu John Ernie Yap Yohannes Melaku Ibrahim Mohamed Siddartha Bajracharya Isha Puri Mariah Thaxton Jyotsna Bhattacharya John Wagner Leon Boudourakis H. Bryant Nguyen Afshin Ahoubim Leslie F. Thomas Dheeraj Reddy Sirganagari Pramod K. Guru Kianoush Kashani Yan Zhou Paul A. Bergl Jesus Rodriguez Jatan A. Shah Mrigank S. Gupta Princy N. Kumar Deepa G. Lazarous Seble G. Kassaye Michal L. Melamed Tanya S. Johns Ryan Mocerino Kalyan Prudhvi Denzel Zhu Rebecca V. Levy Yorg Azzi Molly Fisher Milagros Yunes Kaltrina Sedaliu Ladan Golestaneh Maureen Brogan Neelja Kumar Michael Chang Ritesh Raichoudhury Akshay Athreya Mohamed Farag Edward J. Schenck Soo Jung Cho Maria Plataki Sergio L. Alvarez-Mulett Luis G. Gomez-Escobar Di Pan Stefi Lee Jamuna Krishnan William Whalen David Charytan Ashley Macina Sobaata Chaudhry Benjamin Wu Frank Modersitzki Anand Srivastava Alexander S. Leidner Carlos Martinez Jacqueline M. Kruser Richard G. Wunderink Alexander J. Hodakowski Juan Carlos Q. Velez Eboni G. Price-Haywood Luis A. Matute-Trochez Anna E. Hasty Muner MB. Mohamed Rupali S. Avasare David Zonies Meghan E. Sise Erik T. Newman Samah Abu Omar Kapil K. Pokharel Shreyak Sharma Harkarandeep Singh Simon Correa Tanveer Shaukat Omer Kamal Wei Wang Heather Yang Jeffery O. Boateng Meghan Lee Ian A. Strohbehn Jiahua Li Ariel L. Mueller Roberta Redfern Nicholas S. Cairl Gabriel Naimy Abeer Abu-Saif Danyell Hall Laura Bickley Chris Rowan Farah Madhani-Lovely Vivian S. Cruz Kristen M. Hess Alanna L. Jacobs Vasil Peev Jochen Reiser John J. Byun Andrew Vissing Esha M. Kapania Zoe Post Nilam P. Patel Joy-Marie Hermes Anne K. Sutherland Amee Patrawalla Diana G. Finkel Barbara A. Danek Sowminya Arikapudi Jeffrey M. Paer Peter Cangialosi Mark Liotta Jared Radbel Sonika Puri Jag Sunderram Matthew T. Scharf Ayesha Ahmed Ilya Berim Jayanth S. Vatson Shuchi Anand Joseph E. Levitt Suzanne M. Boyle Rui Song Jingjing Zhang Sang Hoon Woo Xiaoying Deng Goni Katz-Greenberg Katharine Senter Moh’d A. Sharshir Vadym V. Rusnak Muhammad Imran Ali Anip Bansal Amber S. Podoll Michel Chonchol Sunita Sharma Ellen L. Burnham Arash Rashidi Rana Hejal Eric Judd Laura Latta Ashita Tolwani Timothy E. Albertson Jason Y. Adams Steven Y. Chang Rebecca M. Beutler Etienne Macedo Harin Rhee Kathleen D. Liu Vasantha K. Jotwani Jay L. Koyner Chintan V. Shah Vishal Jaikaransingh Stephanie M. Toth-Manikowski Min J. Joo James P. Lash Javier A. Neyra Nourhan Chaaban Madona Elias Yahya Ahmad Alfredo Iardino Elizabeth H. Au Jill H. Sharma Marie Anne Sosa Sabrina Taldone Gabriel Contreras David De La Zerda Hayley B. Gershengorn Bhavarth Shukla Alessia Fornoni Tanira Ferreira Salim S. Hayek Pennelope Blakely Hanna Berlin Tariq U. Azam Husam Shadid Michael Pan Patrick O’ Hayer Chelsea Meloche Rafey Feroze Rayan Kaakati Danny Perry Abbas Bitar Elizabeth Anderson Kishan J. Padalia John P. Donnelly Andrew J. Admon Jennifer E. Flythe Matthew J. Tugman Emily H. Chang Brent R. Brown Amanda K. Leonberg-Yoo Ryan C. Spiardi Todd A. Miano Meaghan S. Roche Charles R. Vasquez Amar D. Bansal Natalie C. Ernecoff Sanjana Kapoor Siddharth Verma Csaba P. Kovesdy Miklos Z. Molnar Ambreen Azhar S. Susan Hedayati Mridula V. Nadamuni Shani Shastri Duwayne L. Willett Samuel A.P. Short Amanda D. Renaghan Kyle B. Enfield Pavan K. Bhatraju A. Bilal Malik Matthew W. Semler Anitha Vijayan Christina Mariyam Joy Tingting Li Seth Goldberg Patricia F. Kao Greg L. Schumaker Nitender Goyal Anthony J. Faugno Caroline M. Hsu Asma Tariq Leah Meyer Ravi K. Kshirsagar Daniel E. Weiner Aju Jose Marta Christov Jennifer Griffiths Sanjeev Gupta Aromma Kapoor Perry Wilson Tanima Arora Ugochukwu Ugwuowo |
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Schorr</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lisa Shea</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniel L. Edmonston</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Christopher L. Mosher</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alexandre M. 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Brenner</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Patricia Walters</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ronaldo C. Go</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Keith M. Rose</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Miguel A. Hernán</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Amy M. Zhou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ethan C. Kim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rebecca Lisk</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lili Chan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kusum S. Mathews</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Steven G. Coca</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Deena R. Altman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Aparna Saha</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Howard Soh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Huei Hsun Wen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sonali Bose</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emily A. Leven</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jing G. Wang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gohar Mosoyan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Girish N. Nadkarni</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Pattharawin Pattharanitima</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Allon N. Friedman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">John Guirguis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rajat Kapoor</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Christopher Meshberger</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Katherine J. Kelly</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Chirag R. Parikh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Brian T. Garibaldi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Celia P. Corona-Villalobos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yumeng Wen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Steven Menez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rubab F. Malik</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elena Cervantes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Samir Gautam</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mary C. Mallappallil</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jie Ouyang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sabu John</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ernie Yap</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yohannes Melaku</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ibrahim Mohamed</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Siddartha Bajracharya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Isha Puri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mariah Thaxton</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jyotsna Bhattacharya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">John Wagner</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Leon Boudourakis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">H. Bryant Nguyen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Afshin Ahoubim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Leslie F. Thomas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Dheeraj Reddy Sirganagari</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Pramod K. 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Melamed</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tanya S. Johns</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ryan Mocerino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kalyan Prudhvi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Denzel Zhu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rebecca V. 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Schenck</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Soo Jung Cho</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Plataki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sergio L. Alvarez-Mulett</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Luis G. Gomez-Escobar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Di Pan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stefi Lee</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jamuna Krishnan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">William Whalen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David Charytan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ashley Macina</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sobaata Chaudhry</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Benjamin Wu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Frank Modersitzki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anand Srivastava</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alexander S. Leidner</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carlos Martinez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jacqueline M. Kruser</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Richard G. Wunderink</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alexander J. Hodakowski</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Juan Carlos Q. Velez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Eboni G. Price-Haywood</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Luis A. Matute-Trochez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anna E. Hasty</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Muner MB. Mohamed</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rupali S. Avasare</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David Zonies</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David E. Leaf</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shruti Gupta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Meghan E. Sise</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Erik T. 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Danek</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sowminya Arikapudi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jeffrey M. 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Scharf</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ayesha Ahmed</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ilya Berim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jayanth S. Vatson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shuchi Anand</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Joseph E. Levitt</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Suzanne M. Boyle</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rui Song</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jingjing Zhang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sang Hoon Woo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Xiaoying Deng</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Goni Katz-Greenberg</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Katharine Senter</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Moh’d A. Sharshir</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Vadym V. Rusnak</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Muhammad Imran Ali</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anip Bansal</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Amber S. Podoll</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michel Chonchol</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sunita Sharma</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ellen L. Burnham</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Arash Rashidi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rana Hejal</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Eric Judd</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Laura Latta</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ashita Tolwani</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Timothy E. Albertson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jason Y. Adams</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Steven Y. Chang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rebecca M. Beutler</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Etienne Macedo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Harin Rhee</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kathleen D. Liu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Vasantha K. Jotwani</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jay L. Koyner</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Chintan V. Shah</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Vishal Jaikaransingh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stephanie M. Toth-Manikowski</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Min J. Joo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">James P. Lash</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Javier A. Neyra</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nourhan Chaaban</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Madona Elias</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yahya Ahmad</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alfredo Iardino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elizabeth H. Au</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jill H. Sharma</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marie Anne Sosa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sabrina Taldone</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gabriel Contreras</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David De La Zerda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hayley B. Gershengorn</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Bhavarth Shukla</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alessia Fornoni</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tanira Ferreira</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Salim S. Hayek</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Pennelope Blakely</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hanna Berlin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tariq U. Azam</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Husam Shadid</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michael Pan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Patrick O’ Hayer</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Chelsea Meloche</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rafey Feroze</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rayan Kaakati</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Danny Perry</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Abbas Bitar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elizabeth Anderson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kishan J. Padalia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">John P. Donnelly</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrew J. Admon</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jennifer E. Flythe</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Matthew J. Tugman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emily H. Chang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Brent R. Brown</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Amanda K. Leonberg-Yoo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ryan C. Spiardi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Todd A. Miano</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Meaghan S. Roche</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Charles R. Vasquez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Amar D. Bansal</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Natalie C. 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