TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone

Parathyroid hormone (PTH) is used to treat osteoporosis, but its therapeutic mechanism remains unclear. Here, the authors show that Tgif1 is a PTH target gene, and that its deletion impairs the function of osteoblasts and PTH-induced bone formation in mice.

Gespeichert in:

Autor*in:	Hiroaki Saito [verfasserIn] Andreas Gasser [verfasserIn] Simona Bolamperti [verfasserIn] Miki Maeda [verfasserIn] Levi Matthies [verfasserIn] Katharina Jähn [verfasserIn] Courtney L. Long [verfasserIn] Hartmut Schlüter [verfasserIn] Marcel Kwiatkowski [verfasserIn] Vaibhav Saini [verfasserIn] Paola Divieti Pajevic [verfasserIn] Teresita Bellido [verfasserIn] Andre J. van Wijnen [verfasserIn] Khalid S. Mohammad [verfasserIn] Theresa A. Guise [verfasserIn] Hanna Taipaleenmäki [verfasserIn] Eric Hesse [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 10(2019), 1, Seite 14
Übergeordnetes Werk:	volume:10 ; year:2019 ; number:1 ; pages:14

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-019-08778-x

Katalog-ID:	DOAJ008366160

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spelling	10.1038/s41467-019-08778-x doi (DE-627)DOAJ008366160 (DE-599)DOAJe1b46a452798403ebde7a78a57d3c849 DE-627 ger DE-627 rakwb eng Hiroaki Saito verfasserin aut TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Parathyroid hormone (PTH) is used to treat osteoporosis, but its therapeutic mechanism remains unclear. Here, the authors show that Tgif1 is a PTH target gene, and that its deletion impairs the function of osteoblasts and PTH-induced bone formation in mice. Science Q Andreas Gasser verfasserin aut Simona Bolamperti verfasserin aut Miki Maeda verfasserin aut Levi Matthies verfasserin aut Katharina Jähn verfasserin aut Courtney L. Long verfasserin aut Hartmut Schlüter verfasserin aut Marcel Kwiatkowski verfasserin aut Vaibhav Saini verfasserin aut Paola Divieti Pajevic verfasserin aut Teresita Bellido verfasserin aut Andre J. van Wijnen verfasserin aut Khalid S. Mohammad verfasserin aut Theresa A. Guise verfasserin aut Hanna Taipaleenmäki verfasserin aut Eric Hesse verfasserin aut In Nature Communications Nature Portfolio, 2016 10(2019), 1, Seite 14 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:10 year:2019 number:1 pages:14 https://doi.org/10.1038/s41467-019-08778-x kostenfrei https://doaj.org/article/e1b46a452798403ebde7a78a57d3c849 kostenfrei https://doi.org/10.1038/s41467-019-08778-x kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019 1 14
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author	Hiroaki Saito
spellingShingle	Hiroaki Saito misc Science misc Q TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone
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topic_title	TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone
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title	TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone
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title_full	TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone
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author_browse	Hiroaki Saito Andreas Gasser Simona Bolamperti Miki Maeda Levi Matthies Katharina Jähn Courtney L. Long Hartmut Schlüter Marcel Kwiatkowski Vaibhav Saini Paola Divieti Pajevic Teresita Bellido Andre J. van Wijnen Khalid S. Mohammad Theresa A. Guise Hanna Taipaleenmäki Eric Hesse
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title_sort	tg-interacting factor 1 (tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone
title_auth	TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone
abstract	Parathyroid hormone (PTH) is used to treat osteoporosis, but its therapeutic mechanism remains unclear. Here, the authors show that Tgif1 is a PTH target gene, and that its deletion impairs the function of osteoblasts and PTH-induced bone formation in mice.
abstractGer	Parathyroid hormone (PTH) is used to treat osteoporosis, but its therapeutic mechanism remains unclear. Here, the authors show that Tgif1 is a PTH target gene, and that its deletion impairs the function of osteoblasts and PTH-induced bone formation in mice.
abstract_unstemmed	Parathyroid hormone (PTH) is used to treat osteoporosis, but its therapeutic mechanism remains unclear. Here, the authors show that Tgif1 is a PTH target gene, and that its deletion impairs the function of osteoblasts and PTH-induced bone formation in mice.
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title_short	TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone
url	https://doi.org/10.1038/s41467-019-08778-x https://doaj.org/article/e1b46a452798403ebde7a78a57d3c849 https://doaj.org/toc/2041-1723
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