Extensive immune reconstitution inflammatory syndrome in Fingolimod-associated PML: a case report with 7 Tesla MRI data

Abstract Background Progressive multifocal leukoencephalopathy (PML) is a rare complication of patients treated with fingolimod. Case presentation Routine MRI eventually led to diagnosis of asymptomatic early PML that remained stable after discontinuation of fingolimod. As blood lymphocyte counts no...
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Autor*in:	Tim Sinnecker [verfasserIn] Jeffrie Hadisurya [verfasserIn] Tilman Schneider-Hohendorf [verfasserIn] Nicholas Schwab [verfasserIn] Karsten Wrede [verfasserIn] Oliver Gembruch [verfasserIn] Ralf Gold [verfasserIn] Kerstin Hellwig [verfasserIn] Sara Pilgram-Pastor [verfasserIn] Ortwin Adams [verfasserIn] Philipp Albrecht [verfasserIn] Hans-Peter Hartung [verfasserIn] Orhan Aktas [verfasserIn] Markus Kraemer [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Progressive multifocal leucencephalopathy Immune reconstitution inflammatory syndrome Fingolimod Multiple sclerosis 7 tesla MRI

Übergeordnetes Werk:	In: BMC Neurology - BMC, 2003, 19(2019), 1, Seite 6
Übergeordnetes Werk:	volume:19 ; year:2019 ; number:1 ; pages:6

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12883-019-1407-2

Katalog-ID:	DOAJ008429049

Internformat


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245	1	0	\|a Extensive immune reconstitution inflammatory syndrome in Fingolimod-associated PML: a case report with 7 Tesla MRI data
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520			\|a Abstract Background Progressive multifocal leukoencephalopathy (PML) is a rare complication of patients treated with fingolimod. Case presentation Routine MRI eventually led to diagnosis of asymptomatic early PML that remained stable after discontinuation of fingolimod. As blood lymphocyte counts normalized, signs of immune reconstitution inflammatory syndrome (IRIS) and renewed MS activity developed. Both, advanced laboratory and ultrahigh field MRI findings elucidated differences between PML and MS. Conclusions In our case, early discontinuation of fingolimod yielded a good outcome, lymphocyte counts reflected immune system activity, and paraclinical findings helped to differentiate between PML-IRIS and MS.
650		4	\|a Progressive multifocal leucencephalopathy
650		4	\|a Immune reconstitution inflammatory syndrome
650		4	\|a Fingolimod
650		4	\|a Multiple sclerosis
650		4	\|a 7 tesla MRI
653		0	\|a Neurology. Diseases of the nervous system
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Indexfelder

author_variant	t s ts j h jh t s h tsh n s ns k w kw o g og r g rg k h kh s p p spp o a oa p a pa h p h hph o a oa m k mk
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publishDate	2019
allfields	10.1186/s12883-019-1407-2 doi (DE-627)DOAJ008429049 (DE-599)DOAJ8dce3d9d8095499684b97bc2bf7715e1 DE-627 ger DE-627 rakwb eng RC346-429 Tim Sinnecker verfasserin aut Extensive immune reconstitution inflammatory syndrome in Fingolimod-associated PML: a case report with 7 Tesla MRI data 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Progressive multifocal leukoencephalopathy (PML) is a rare complication of patients treated with fingolimod. Case presentation Routine MRI eventually led to diagnosis of asymptomatic early PML that remained stable after discontinuation of fingolimod. As blood lymphocyte counts normalized, signs of immune reconstitution inflammatory syndrome (IRIS) and renewed MS activity developed. Both, advanced laboratory and ultrahigh field MRI findings elucidated differences between PML and MS. Conclusions In our case, early discontinuation of fingolimod yielded a good outcome, lymphocyte counts reflected immune system activity, and paraclinical findings helped to differentiate between PML-IRIS and MS. Progressive multifocal leucencephalopathy Immune reconstitution inflammatory syndrome Fingolimod Multiple sclerosis 7 tesla MRI Neurology. Diseases of the nervous system Jeffrie Hadisurya verfasserin aut Tilman Schneider-Hohendorf verfasserin aut Nicholas Schwab verfasserin aut Karsten Wrede verfasserin aut Oliver Gembruch verfasserin aut Ralf Gold verfasserin aut Kerstin Hellwig verfasserin aut Sara Pilgram-Pastor verfasserin aut Ortwin Adams verfasserin aut Philipp Albrecht verfasserin aut Hans-Peter Hartung verfasserin aut Orhan Aktas verfasserin aut Markus Kraemer verfasserin aut In BMC Neurology BMC, 2003 19(2019), 1, Seite 6 (DE-627)326643664 (DE-600)2041347-6 14712377 nnns volume:19 year:2019 number:1 pages:6 https://doi.org/10.1186/s12883-019-1407-2 kostenfrei https://doaj.org/article/8dce3d9d8095499684b97bc2bf7715e1 kostenfrei http://link.springer.com/article/10.1186/s12883-019-1407-2 kostenfrei https://doaj.org/toc/1471-2377 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 6
spelling	10.1186/s12883-019-1407-2 doi (DE-627)DOAJ008429049 (DE-599)DOAJ8dce3d9d8095499684b97bc2bf7715e1 DE-627 ger DE-627 rakwb eng RC346-429 Tim Sinnecker verfasserin aut Extensive immune reconstitution inflammatory syndrome in Fingolimod-associated PML: a case report with 7 Tesla MRI data 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Progressive multifocal leukoencephalopathy (PML) is a rare complication of patients treated with fingolimod. Case presentation Routine MRI eventually led to diagnosis of asymptomatic early PML that remained stable after discontinuation of fingolimod. As blood lymphocyte counts normalized, signs of immune reconstitution inflammatory syndrome (IRIS) and renewed MS activity developed. Both, advanced laboratory and ultrahigh field MRI findings elucidated differences between PML and MS. Conclusions In our case, early discontinuation of fingolimod yielded a good outcome, lymphocyte counts reflected immune system activity, and paraclinical findings helped to differentiate between PML-IRIS and MS. Progressive multifocal leucencephalopathy Immune reconstitution inflammatory syndrome Fingolimod Multiple sclerosis 7 tesla MRI Neurology. Diseases of the nervous system Jeffrie Hadisurya verfasserin aut Tilman Schneider-Hohendorf verfasserin aut Nicholas Schwab verfasserin aut Karsten Wrede verfasserin aut Oliver Gembruch verfasserin aut Ralf Gold verfasserin aut Kerstin Hellwig verfasserin aut Sara Pilgram-Pastor verfasserin aut Ortwin Adams verfasserin aut Philipp Albrecht verfasserin aut Hans-Peter Hartung verfasserin aut Orhan Aktas verfasserin aut Markus Kraemer verfasserin aut In BMC Neurology BMC, 2003 19(2019), 1, Seite 6 (DE-627)326643664 (DE-600)2041347-6 14712377 nnns volume:19 year:2019 number:1 pages:6 https://doi.org/10.1186/s12883-019-1407-2 kostenfrei https://doaj.org/article/8dce3d9d8095499684b97bc2bf7715e1 kostenfrei http://link.springer.com/article/10.1186/s12883-019-1407-2 kostenfrei https://doaj.org/toc/1471-2377 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 6
allfields_unstemmed	10.1186/s12883-019-1407-2 doi (DE-627)DOAJ008429049 (DE-599)DOAJ8dce3d9d8095499684b97bc2bf7715e1 DE-627 ger DE-627 rakwb eng RC346-429 Tim Sinnecker verfasserin aut Extensive immune reconstitution inflammatory syndrome in Fingolimod-associated PML: a case report with 7 Tesla MRI data 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Progressive multifocal leukoencephalopathy (PML) is a rare complication of patients treated with fingolimod. Case presentation Routine MRI eventually led to diagnosis of asymptomatic early PML that remained stable after discontinuation of fingolimod. As blood lymphocyte counts normalized, signs of immune reconstitution inflammatory syndrome (IRIS) and renewed MS activity developed. Both, advanced laboratory and ultrahigh field MRI findings elucidated differences between PML and MS. Conclusions In our case, early discontinuation of fingolimod yielded a good outcome, lymphocyte counts reflected immune system activity, and paraclinical findings helped to differentiate between PML-IRIS and MS. Progressive multifocal leucencephalopathy Immune reconstitution inflammatory syndrome Fingolimod Multiple sclerosis 7 tesla MRI Neurology. Diseases of the nervous system Jeffrie Hadisurya verfasserin aut Tilman Schneider-Hohendorf verfasserin aut Nicholas Schwab verfasserin aut Karsten Wrede verfasserin aut Oliver Gembruch verfasserin aut Ralf Gold verfasserin aut Kerstin Hellwig verfasserin aut Sara Pilgram-Pastor verfasserin aut Ortwin Adams verfasserin aut Philipp Albrecht verfasserin aut Hans-Peter Hartung verfasserin aut Orhan Aktas verfasserin aut Markus Kraemer verfasserin aut In BMC Neurology BMC, 2003 19(2019), 1, Seite 6 (DE-627)326643664 (DE-600)2041347-6 14712377 nnns volume:19 year:2019 number:1 pages:6 https://doi.org/10.1186/s12883-019-1407-2 kostenfrei https://doaj.org/article/8dce3d9d8095499684b97bc2bf7715e1 kostenfrei http://link.springer.com/article/10.1186/s12883-019-1407-2 kostenfrei https://doaj.org/toc/1471-2377 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 6
allfieldsGer	10.1186/s12883-019-1407-2 doi (DE-627)DOAJ008429049 (DE-599)DOAJ8dce3d9d8095499684b97bc2bf7715e1 DE-627 ger DE-627 rakwb eng RC346-429 Tim Sinnecker verfasserin aut Extensive immune reconstitution inflammatory syndrome in Fingolimod-associated PML: a case report with 7 Tesla MRI data 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Progressive multifocal leukoencephalopathy (PML) is a rare complication of patients treated with fingolimod. Case presentation Routine MRI eventually led to diagnosis of asymptomatic early PML that remained stable after discontinuation of fingolimod. As blood lymphocyte counts normalized, signs of immune reconstitution inflammatory syndrome (IRIS) and renewed MS activity developed. Both, advanced laboratory and ultrahigh field MRI findings elucidated differences between PML and MS. Conclusions In our case, early discontinuation of fingolimod yielded a good outcome, lymphocyte counts reflected immune system activity, and paraclinical findings helped to differentiate between PML-IRIS and MS. Progressive multifocal leucencephalopathy Immune reconstitution inflammatory syndrome Fingolimod Multiple sclerosis 7 tesla MRI Neurology. Diseases of the nervous system Jeffrie Hadisurya verfasserin aut Tilman Schneider-Hohendorf verfasserin aut Nicholas Schwab verfasserin aut Karsten Wrede verfasserin aut Oliver Gembruch verfasserin aut Ralf Gold verfasserin aut Kerstin Hellwig verfasserin aut Sara Pilgram-Pastor verfasserin aut Ortwin Adams verfasserin aut Philipp Albrecht verfasserin aut Hans-Peter Hartung verfasserin aut Orhan Aktas verfasserin aut Markus Kraemer verfasserin aut In BMC Neurology BMC, 2003 19(2019), 1, Seite 6 (DE-627)326643664 (DE-600)2041347-6 14712377 nnns volume:19 year:2019 number:1 pages:6 https://doi.org/10.1186/s12883-019-1407-2 kostenfrei https://doaj.org/article/8dce3d9d8095499684b97bc2bf7715e1 kostenfrei http://link.springer.com/article/10.1186/s12883-019-1407-2 kostenfrei https://doaj.org/toc/1471-2377 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 6
allfieldsSound	10.1186/s12883-019-1407-2 doi (DE-627)DOAJ008429049 (DE-599)DOAJ8dce3d9d8095499684b97bc2bf7715e1 DE-627 ger DE-627 rakwb eng RC346-429 Tim Sinnecker verfasserin aut Extensive immune reconstitution inflammatory syndrome in Fingolimod-associated PML: a case report with 7 Tesla MRI data 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Progressive multifocal leukoencephalopathy (PML) is a rare complication of patients treated with fingolimod. Case presentation Routine MRI eventually led to diagnosis of asymptomatic early PML that remained stable after discontinuation of fingolimod. As blood lymphocyte counts normalized, signs of immune reconstitution inflammatory syndrome (IRIS) and renewed MS activity developed. Both, advanced laboratory and ultrahigh field MRI findings elucidated differences between PML and MS. Conclusions In our case, early discontinuation of fingolimod yielded a good outcome, lymphocyte counts reflected immune system activity, and paraclinical findings helped to differentiate between PML-IRIS and MS. Progressive multifocal leucencephalopathy Immune reconstitution inflammatory syndrome Fingolimod Multiple sclerosis 7 tesla MRI Neurology. Diseases of the nervous system Jeffrie Hadisurya verfasserin aut Tilman Schneider-Hohendorf verfasserin aut Nicholas Schwab verfasserin aut Karsten Wrede verfasserin aut Oliver Gembruch verfasserin aut Ralf Gold verfasserin aut Kerstin Hellwig verfasserin aut Sara Pilgram-Pastor verfasserin aut Ortwin Adams verfasserin aut Philipp Albrecht verfasserin aut Hans-Peter Hartung verfasserin aut Orhan Aktas verfasserin aut Markus Kraemer verfasserin aut In BMC Neurology BMC, 2003 19(2019), 1, Seite 6 (DE-627)326643664 (DE-600)2041347-6 14712377 nnns volume:19 year:2019 number:1 pages:6 https://doi.org/10.1186/s12883-019-1407-2 kostenfrei https://doaj.org/article/8dce3d9d8095499684b97bc2bf7715e1 kostenfrei http://link.springer.com/article/10.1186/s12883-019-1407-2 kostenfrei https://doaj.org/toc/1471-2377 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2019 1 6
language	English
source	In BMC Neurology 19(2019), 1, Seite 6 volume:19 year:2019 number:1 pages:6
sourceStr	In BMC Neurology 19(2019), 1, Seite 6 volume:19 year:2019 number:1 pages:6
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Progressive multifocal leucencephalopathy Immune reconstitution inflammatory syndrome Fingolimod Multiple sclerosis 7 tesla MRI Neurology. Diseases of the nervous system
isfreeaccess_bool	true
container_title	BMC Neurology
authorswithroles_txt_mv	Tim Sinnecker @@aut@@ Jeffrie Hadisurya @@aut@@ Tilman Schneider-Hohendorf @@aut@@ Nicholas Schwab @@aut@@ Karsten Wrede @@aut@@ Oliver Gembruch @@aut@@ Ralf Gold @@aut@@ Kerstin Hellwig @@aut@@ Sara Pilgram-Pastor @@aut@@ Ortwin Adams @@aut@@ Philipp Albrecht @@aut@@ Hans-Peter Hartung @@aut@@ Orhan Aktas @@aut@@ Markus Kraemer @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	326643664
id	DOAJ008429049
language_de	englisch
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callnumber-first	R - Medicine
author	Tim Sinnecker
spellingShingle	Tim Sinnecker misc RC346-429 misc Progressive multifocal leucencephalopathy misc Immune reconstitution inflammatory syndrome misc Fingolimod misc Multiple sclerosis misc 7 tesla MRI misc Neurology. Diseases of the nervous system Extensive immune reconstitution inflammatory syndrome in Fingolimod-associated PML: a case report with 7 Tesla MRI data
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topic_title	RC346-429 Extensive immune reconstitution inflammatory syndrome in Fingolimod-associated PML: a case report with 7 Tesla MRI data Progressive multifocal leucencephalopathy Immune reconstitution inflammatory syndrome Fingolimod Multiple sclerosis 7 tesla MRI
topic	misc RC346-429 misc Progressive multifocal leucencephalopathy misc Immune reconstitution inflammatory syndrome misc Fingolimod misc Multiple sclerosis misc 7 tesla MRI misc Neurology. Diseases of the nervous system
topic_unstemmed	misc RC346-429 misc Progressive multifocal leucencephalopathy misc Immune reconstitution inflammatory syndrome misc Fingolimod misc Multiple sclerosis misc 7 tesla MRI misc Neurology. Diseases of the nervous system
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title	Extensive immune reconstitution inflammatory syndrome in Fingolimod-associated PML: a case report with 7 Tesla MRI data
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title_full	Extensive immune reconstitution inflammatory syndrome in Fingolimod-associated PML: a case report with 7 Tesla MRI data
author_sort	Tim Sinnecker
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author_browse	Tim Sinnecker Jeffrie Hadisurya Tilman Schneider-Hohendorf Nicholas Schwab Karsten Wrede Oliver Gembruch Ralf Gold Kerstin Hellwig Sara Pilgram-Pastor Ortwin Adams Philipp Albrecht Hans-Peter Hartung Orhan Aktas Markus Kraemer
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title_sort	extensive immune reconstitution inflammatory syndrome in fingolimod-associated pml: a case report with 7 tesla mri data
callnumber	RC346-429
title_auth	Extensive immune reconstitution inflammatory syndrome in Fingolimod-associated PML: a case report with 7 Tesla MRI data
abstract	Abstract Background Progressive multifocal leukoencephalopathy (PML) is a rare complication of patients treated with fingolimod. Case presentation Routine MRI eventually led to diagnosis of asymptomatic early PML that remained stable after discontinuation of fingolimod. As blood lymphocyte counts normalized, signs of immune reconstitution inflammatory syndrome (IRIS) and renewed MS activity developed. Both, advanced laboratory and ultrahigh field MRI findings elucidated differences between PML and MS. Conclusions In our case, early discontinuation of fingolimod yielded a good outcome, lymphocyte counts reflected immune system activity, and paraclinical findings helped to differentiate between PML-IRIS and MS.
abstractGer	Abstract Background Progressive multifocal leukoencephalopathy (PML) is a rare complication of patients treated with fingolimod. Case presentation Routine MRI eventually led to diagnosis of asymptomatic early PML that remained stable after discontinuation of fingolimod. As blood lymphocyte counts normalized, signs of immune reconstitution inflammatory syndrome (IRIS) and renewed MS activity developed. Both, advanced laboratory and ultrahigh field MRI findings elucidated differences between PML and MS. Conclusions In our case, early discontinuation of fingolimod yielded a good outcome, lymphocyte counts reflected immune system activity, and paraclinical findings helped to differentiate between PML-IRIS and MS.
abstract_unstemmed	Abstract Background Progressive multifocal leukoencephalopathy (PML) is a rare complication of patients treated with fingolimod. Case presentation Routine MRI eventually led to diagnosis of asymptomatic early PML that remained stable after discontinuation of fingolimod. As blood lymphocyte counts normalized, signs of immune reconstitution inflammatory syndrome (IRIS) and renewed MS activity developed. Both, advanced laboratory and ultrahigh field MRI findings elucidated differences between PML and MS. Conclusions In our case, early discontinuation of fingolimod yielded a good outcome, lymphocyte counts reflected immune system activity, and paraclinical findings helped to differentiate between PML-IRIS and MS.
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title_short	Extensive immune reconstitution inflammatory syndrome in Fingolimod-associated PML: a case report with 7 Tesla MRI data
url	https://doi.org/10.1186/s12883-019-1407-2 https://doaj.org/article/8dce3d9d8095499684b97bc2bf7715e1 http://link.springer.com/article/10.1186/s12883-019-1407-2 https://doaj.org/toc/1471-2377
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author2Str	Jeffrie Hadisurya Tilman Schneider-Hohendorf Nicholas Schwab Karsten Wrede Oliver Gembruch Ralf Gold Kerstin Hellwig Sara Pilgram-Pastor Ortwin Adams Philipp Albrecht Hans-Peter Hartung Orhan Aktas Markus Kraemer
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up_date	2024-07-03T17:55:13.527Z
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