Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study
Abstract Background One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and ne...
Ausführliche Beschreibung
Autor*in: |
Ron Nudel [verfasserIn] Camilla A. J. Christiani [verfasserIn] Jessica Ohland [verfasserIn] Md Jamal Uddin [verfasserIn] Nicoline Hemager [verfasserIn] Ditte Ellersgaard [verfasserIn] Katrine S. Spang [verfasserIn] Birgitte K. Burton [verfasserIn] Aja N. Greve [verfasserIn] Ditte L. Gantriis [verfasserIn] Jonas Bybjerg-Grauholm [verfasserIn] Jens Richardt M. Jepsen [verfasserIn] Anne A. E. Thorup [verfasserIn] Ole Mors [verfasserIn] Thomas Werge [verfasserIn] Merete Nordentoft [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2020 |
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Übergeordnetes Werk: |
In: BMC Neuroscience - BMC, 2003, 21(2020), 1, Seite 14 |
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Übergeordnetes Werk: |
volume:21 ; year:2020 ; number:1 ; pages:14 |
Links: |
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DOI / URN: |
10.1186/s12868-020-00581-5 |
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Katalog-ID: |
DOAJ008447322 |
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520 | |a Abstract Background One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and neurodevelopmental phenotypes. Moreover, most genetic studies examining such phenotypes do not incorporate parent-of-origin effects, which could account for some of the heritability of the investigated trait. We performed a genome-wide association study of receptive language, examining both child genetic effects and parent-of-origin effects. Results Using a family-based cohort with 400 children with receptive language scores, we found a genome-wide significant paternal parent-of-origin effect with a SNP, rs11787922, on chromosome 9q21.31, whereby the T allele reduced the mean receptive language score by ~ 23, constituting a reduction of more than 1.5 times the population SD (P = 1.04 × 10−8). We further confirmed that this association was not driven by broader neurodevelopmental diagnoses in the child or a family history of psychiatric diagnoses by incorporating covariates for the above and repeating the analysis. Conclusions Our study reports a genome-wide significant association for receptive language skills; to our knowledge, this is the first documented genome-wide significant association for this phenotype. Furthermore, our study illustrates the importance of considering parent-of-origin effects in association studies, particularly in the case of cognitive or neurodevelopmental traits, in which parental genetic data are not always incorporated. | ||
650 | 4 | |a Linguistics | |
650 | 4 | |a Genetics | |
650 | 4 | |a GWAS | |
650 | 4 | |a Parent-of-origin | |
650 | 4 | |a Receptive language | |
650 | 4 | |a Danish High Risk and Resilience Study | |
653 | 0 | |a Neurosciences. Biological psychiatry. Neuropsychiatry | |
653 | 0 | |a Neurophysiology and neuropsychology | |
700 | 0 | |a Camilla A. J. Christiani |e verfasserin |4 aut | |
700 | 0 | |a Jessica Ohland |e verfasserin |4 aut | |
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700 | 0 | |a Ditte L. Gantriis |e verfasserin |4 aut | |
700 | 0 | |a Jonas Bybjerg-Grauholm |e verfasserin |4 aut | |
700 | 0 | |a Jens Richardt M. Jepsen |e verfasserin |4 aut | |
700 | 0 | |a Anne A. E. Thorup |e verfasserin |4 aut | |
700 | 0 | |a Ole Mors |e verfasserin |4 aut | |
700 | 0 | |a Thomas Werge |e verfasserin |4 aut | |
700 | 0 | |a Merete Nordentoft |e verfasserin |4 aut | |
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10.1186/s12868-020-00581-5 doi (DE-627)DOAJ008447322 (DE-599)DOAJ141a508ffc74464089730f8ab3ca5d63 DE-627 ger DE-627 rakwb eng RC321-571 QP351-495 Ron Nudel verfasserin aut Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and neurodevelopmental phenotypes. Moreover, most genetic studies examining such phenotypes do not incorporate parent-of-origin effects, which could account for some of the heritability of the investigated trait. We performed a genome-wide association study of receptive language, examining both child genetic effects and parent-of-origin effects. Results Using a family-based cohort with 400 children with receptive language scores, we found a genome-wide significant paternal parent-of-origin effect with a SNP, rs11787922, on chromosome 9q21.31, whereby the T allele reduced the mean receptive language score by ~ 23, constituting a reduction of more than 1.5 times the population SD (P = 1.04 × 10−8). We further confirmed that this association was not driven by broader neurodevelopmental diagnoses in the child or a family history of psychiatric diagnoses by incorporating covariates for the above and repeating the analysis. Conclusions Our study reports a genome-wide significant association for receptive language skills; to our knowledge, this is the first documented genome-wide significant association for this phenotype. Furthermore, our study illustrates the importance of considering parent-of-origin effects in association studies, particularly in the case of cognitive or neurodevelopmental traits, in which parental genetic data are not always incorporated. Linguistics Genetics GWAS Parent-of-origin Receptive language Danish High Risk and Resilience Study Neurosciences. Biological psychiatry. Neuropsychiatry Neurophysiology and neuropsychology Camilla A. J. Christiani verfasserin aut Jessica Ohland verfasserin aut Md Jamal Uddin verfasserin aut Nicoline Hemager verfasserin aut Ditte Ellersgaard verfasserin aut Katrine S. Spang verfasserin aut Birgitte K. Burton verfasserin aut Aja N. Greve verfasserin aut Ditte L. Gantriis verfasserin aut Jonas Bybjerg-Grauholm verfasserin aut Jens Richardt M. Jepsen verfasserin aut Anne A. E. Thorup verfasserin aut Ole Mors verfasserin aut Thomas Werge verfasserin aut Merete Nordentoft verfasserin aut In BMC Neuroscience BMC, 2003 21(2020), 1, Seite 14 (DE-627)326643648 (DE-600)2041344-0 14712202 nnns volume:21 year:2020 number:1 pages:14 https://doi.org/10.1186/s12868-020-00581-5 kostenfrei https://doaj.org/article/141a508ffc74464089730f8ab3ca5d63 kostenfrei http://link.springer.com/article/10.1186/s12868-020-00581-5 kostenfrei https://doaj.org/toc/1471-2202 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 1 14 |
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10.1186/s12868-020-00581-5 doi (DE-627)DOAJ008447322 (DE-599)DOAJ141a508ffc74464089730f8ab3ca5d63 DE-627 ger DE-627 rakwb eng RC321-571 QP351-495 Ron Nudel verfasserin aut Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and neurodevelopmental phenotypes. Moreover, most genetic studies examining such phenotypes do not incorporate parent-of-origin effects, which could account for some of the heritability of the investigated trait. We performed a genome-wide association study of receptive language, examining both child genetic effects and parent-of-origin effects. Results Using a family-based cohort with 400 children with receptive language scores, we found a genome-wide significant paternal parent-of-origin effect with a SNP, rs11787922, on chromosome 9q21.31, whereby the T allele reduced the mean receptive language score by ~ 23, constituting a reduction of more than 1.5 times the population SD (P = 1.04 × 10−8). We further confirmed that this association was not driven by broader neurodevelopmental diagnoses in the child or a family history of psychiatric diagnoses by incorporating covariates for the above and repeating the analysis. Conclusions Our study reports a genome-wide significant association for receptive language skills; to our knowledge, this is the first documented genome-wide significant association for this phenotype. Furthermore, our study illustrates the importance of considering parent-of-origin effects in association studies, particularly in the case of cognitive or neurodevelopmental traits, in which parental genetic data are not always incorporated. Linguistics Genetics GWAS Parent-of-origin Receptive language Danish High Risk and Resilience Study Neurosciences. Biological psychiatry. Neuropsychiatry Neurophysiology and neuropsychology Camilla A. J. Christiani verfasserin aut Jessica Ohland verfasserin aut Md Jamal Uddin verfasserin aut Nicoline Hemager verfasserin aut Ditte Ellersgaard verfasserin aut Katrine S. Spang verfasserin aut Birgitte K. Burton verfasserin aut Aja N. Greve verfasserin aut Ditte L. Gantriis verfasserin aut Jonas Bybjerg-Grauholm verfasserin aut Jens Richardt M. Jepsen verfasserin aut Anne A. E. Thorup verfasserin aut Ole Mors verfasserin aut Thomas Werge verfasserin aut Merete Nordentoft verfasserin aut In BMC Neuroscience BMC, 2003 21(2020), 1, Seite 14 (DE-627)326643648 (DE-600)2041344-0 14712202 nnns volume:21 year:2020 number:1 pages:14 https://doi.org/10.1186/s12868-020-00581-5 kostenfrei https://doaj.org/article/141a508ffc74464089730f8ab3ca5d63 kostenfrei http://link.springer.com/article/10.1186/s12868-020-00581-5 kostenfrei https://doaj.org/toc/1471-2202 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 1 14 |
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10.1186/s12868-020-00581-5 doi (DE-627)DOAJ008447322 (DE-599)DOAJ141a508ffc74464089730f8ab3ca5d63 DE-627 ger DE-627 rakwb eng RC321-571 QP351-495 Ron Nudel verfasserin aut Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and neurodevelopmental phenotypes. Moreover, most genetic studies examining such phenotypes do not incorporate parent-of-origin effects, which could account for some of the heritability of the investigated trait. We performed a genome-wide association study of receptive language, examining both child genetic effects and parent-of-origin effects. Results Using a family-based cohort with 400 children with receptive language scores, we found a genome-wide significant paternal parent-of-origin effect with a SNP, rs11787922, on chromosome 9q21.31, whereby the T allele reduced the mean receptive language score by ~ 23, constituting a reduction of more than 1.5 times the population SD (P = 1.04 × 10−8). We further confirmed that this association was not driven by broader neurodevelopmental diagnoses in the child or a family history of psychiatric diagnoses by incorporating covariates for the above and repeating the analysis. Conclusions Our study reports a genome-wide significant association for receptive language skills; to our knowledge, this is the first documented genome-wide significant association for this phenotype. Furthermore, our study illustrates the importance of considering parent-of-origin effects in association studies, particularly in the case of cognitive or neurodevelopmental traits, in which parental genetic data are not always incorporated. Linguistics Genetics GWAS Parent-of-origin Receptive language Danish High Risk and Resilience Study Neurosciences. Biological psychiatry. Neuropsychiatry Neurophysiology and neuropsychology Camilla A. J. Christiani verfasserin aut Jessica Ohland verfasserin aut Md Jamal Uddin verfasserin aut Nicoline Hemager verfasserin aut Ditte Ellersgaard verfasserin aut Katrine S. Spang verfasserin aut Birgitte K. Burton verfasserin aut Aja N. Greve verfasserin aut Ditte L. Gantriis verfasserin aut Jonas Bybjerg-Grauholm verfasserin aut Jens Richardt M. Jepsen verfasserin aut Anne A. E. Thorup verfasserin aut Ole Mors verfasserin aut Thomas Werge verfasserin aut Merete Nordentoft verfasserin aut In BMC Neuroscience BMC, 2003 21(2020), 1, Seite 14 (DE-627)326643648 (DE-600)2041344-0 14712202 nnns volume:21 year:2020 number:1 pages:14 https://doi.org/10.1186/s12868-020-00581-5 kostenfrei https://doaj.org/article/141a508ffc74464089730f8ab3ca5d63 kostenfrei http://link.springer.com/article/10.1186/s12868-020-00581-5 kostenfrei https://doaj.org/toc/1471-2202 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 1 14 |
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10.1186/s12868-020-00581-5 doi (DE-627)DOAJ008447322 (DE-599)DOAJ141a508ffc74464089730f8ab3ca5d63 DE-627 ger DE-627 rakwb eng RC321-571 QP351-495 Ron Nudel verfasserin aut Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and neurodevelopmental phenotypes. Moreover, most genetic studies examining such phenotypes do not incorporate parent-of-origin effects, which could account for some of the heritability of the investigated trait. We performed a genome-wide association study of receptive language, examining both child genetic effects and parent-of-origin effects. Results Using a family-based cohort with 400 children with receptive language scores, we found a genome-wide significant paternal parent-of-origin effect with a SNP, rs11787922, on chromosome 9q21.31, whereby the T allele reduced the mean receptive language score by ~ 23, constituting a reduction of more than 1.5 times the population SD (P = 1.04 × 10−8). We further confirmed that this association was not driven by broader neurodevelopmental diagnoses in the child or a family history of psychiatric diagnoses by incorporating covariates for the above and repeating the analysis. Conclusions Our study reports a genome-wide significant association for receptive language skills; to our knowledge, this is the first documented genome-wide significant association for this phenotype. Furthermore, our study illustrates the importance of considering parent-of-origin effects in association studies, particularly in the case of cognitive or neurodevelopmental traits, in which parental genetic data are not always incorporated. Linguistics Genetics GWAS Parent-of-origin Receptive language Danish High Risk and Resilience Study Neurosciences. Biological psychiatry. Neuropsychiatry Neurophysiology and neuropsychology Camilla A. J. Christiani verfasserin aut Jessica Ohland verfasserin aut Md Jamal Uddin verfasserin aut Nicoline Hemager verfasserin aut Ditte Ellersgaard verfasserin aut Katrine S. Spang verfasserin aut Birgitte K. Burton verfasserin aut Aja N. Greve verfasserin aut Ditte L. Gantriis verfasserin aut Jonas Bybjerg-Grauholm verfasserin aut Jens Richardt M. Jepsen verfasserin aut Anne A. E. Thorup verfasserin aut Ole Mors verfasserin aut Thomas Werge verfasserin aut Merete Nordentoft verfasserin aut In BMC Neuroscience BMC, 2003 21(2020), 1, Seite 14 (DE-627)326643648 (DE-600)2041344-0 14712202 nnns volume:21 year:2020 number:1 pages:14 https://doi.org/10.1186/s12868-020-00581-5 kostenfrei https://doaj.org/article/141a508ffc74464089730f8ab3ca5d63 kostenfrei http://link.springer.com/article/10.1186/s12868-020-00581-5 kostenfrei https://doaj.org/toc/1471-2202 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 1 14 |
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10.1186/s12868-020-00581-5 doi (DE-627)DOAJ008447322 (DE-599)DOAJ141a508ffc74464089730f8ab3ca5d63 DE-627 ger DE-627 rakwb eng RC321-571 QP351-495 Ron Nudel verfasserin aut Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and neurodevelopmental phenotypes. Moreover, most genetic studies examining such phenotypes do not incorporate parent-of-origin effects, which could account for some of the heritability of the investigated trait. We performed a genome-wide association study of receptive language, examining both child genetic effects and parent-of-origin effects. Results Using a family-based cohort with 400 children with receptive language scores, we found a genome-wide significant paternal parent-of-origin effect with a SNP, rs11787922, on chromosome 9q21.31, whereby the T allele reduced the mean receptive language score by ~ 23, constituting a reduction of more than 1.5 times the population SD (P = 1.04 × 10−8). We further confirmed that this association was not driven by broader neurodevelopmental diagnoses in the child or a family history of psychiatric diagnoses by incorporating covariates for the above and repeating the analysis. Conclusions Our study reports a genome-wide significant association for receptive language skills; to our knowledge, this is the first documented genome-wide significant association for this phenotype. Furthermore, our study illustrates the importance of considering parent-of-origin effects in association studies, particularly in the case of cognitive or neurodevelopmental traits, in which parental genetic data are not always incorporated. Linguistics Genetics GWAS Parent-of-origin Receptive language Danish High Risk and Resilience Study Neurosciences. Biological psychiatry. Neuropsychiatry Neurophysiology and neuropsychology Camilla A. J. Christiani verfasserin aut Jessica Ohland verfasserin aut Md Jamal Uddin verfasserin aut Nicoline Hemager verfasserin aut Ditte Ellersgaard verfasserin aut Katrine S. Spang verfasserin aut Birgitte K. Burton verfasserin aut Aja N. Greve verfasserin aut Ditte L. Gantriis verfasserin aut Jonas Bybjerg-Grauholm verfasserin aut Jens Richardt M. Jepsen verfasserin aut Anne A. E. Thorup verfasserin aut Ole Mors verfasserin aut Thomas Werge verfasserin aut Merete Nordentoft verfasserin aut In BMC Neuroscience BMC, 2003 21(2020), 1, Seite 14 (DE-627)326643648 (DE-600)2041344-0 14712202 nnns volume:21 year:2020 number:1 pages:14 https://doi.org/10.1186/s12868-020-00581-5 kostenfrei https://doaj.org/article/141a508ffc74464089730f8ab3ca5d63 kostenfrei http://link.springer.com/article/10.1186/s12868-020-00581-5 kostenfrei https://doaj.org/toc/1471-2202 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 1 14 |
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Ron Nudel @@aut@@ Camilla A. J. Christiani @@aut@@ Jessica Ohland @@aut@@ Md Jamal Uddin @@aut@@ Nicoline Hemager @@aut@@ Ditte Ellersgaard @@aut@@ Katrine S. Spang @@aut@@ Birgitte K. Burton @@aut@@ Aja N. Greve @@aut@@ Ditte L. Gantriis @@aut@@ Jonas Bybjerg-Grauholm @@aut@@ Jens Richardt M. Jepsen @@aut@@ Anne A. E. Thorup @@aut@@ Ole Mors @@aut@@ Thomas Werge @@aut@@ Merete Nordentoft @@aut@@ |
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RC321-571 QP351-495 Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study Linguistics Genetics GWAS Parent-of-origin Receptive language Danish High Risk and Resilience Study |
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Ron Nudel Camilla A. J. Christiani Jessica Ohland Md Jamal Uddin Nicoline Hemager Ditte Ellersgaard Katrine S. Spang Birgitte K. Burton Aja N. Greve Ditte L. Gantriis Jonas Bybjerg-Grauholm Jens Richardt M. Jepsen Anne A. E. Thorup Ole Mors Thomas Werge Merete Nordentoft |
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quantitative genome-wide association analyses of receptive language in the danish high risk and resilience study |
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Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study |
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Abstract Background One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and neurodevelopmental phenotypes. Moreover, most genetic studies examining such phenotypes do not incorporate parent-of-origin effects, which could account for some of the heritability of the investigated trait. We performed a genome-wide association study of receptive language, examining both child genetic effects and parent-of-origin effects. Results Using a family-based cohort with 400 children with receptive language scores, we found a genome-wide significant paternal parent-of-origin effect with a SNP, rs11787922, on chromosome 9q21.31, whereby the T allele reduced the mean receptive language score by ~ 23, constituting a reduction of more than 1.5 times the population SD (P = 1.04 × 10−8). We further confirmed that this association was not driven by broader neurodevelopmental diagnoses in the child or a family history of psychiatric diagnoses by incorporating covariates for the above and repeating the analysis. Conclusions Our study reports a genome-wide significant association for receptive language skills; to our knowledge, this is the first documented genome-wide significant association for this phenotype. Furthermore, our study illustrates the importance of considering parent-of-origin effects in association studies, particularly in the case of cognitive or neurodevelopmental traits, in which parental genetic data are not always incorporated. |
abstractGer |
Abstract Background One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and neurodevelopmental phenotypes. Moreover, most genetic studies examining such phenotypes do not incorporate parent-of-origin effects, which could account for some of the heritability of the investigated trait. We performed a genome-wide association study of receptive language, examining both child genetic effects and parent-of-origin effects. Results Using a family-based cohort with 400 children with receptive language scores, we found a genome-wide significant paternal parent-of-origin effect with a SNP, rs11787922, on chromosome 9q21.31, whereby the T allele reduced the mean receptive language score by ~ 23, constituting a reduction of more than 1.5 times the population SD (P = 1.04 × 10−8). We further confirmed that this association was not driven by broader neurodevelopmental diagnoses in the child or a family history of psychiatric diagnoses by incorporating covariates for the above and repeating the analysis. Conclusions Our study reports a genome-wide significant association for receptive language skills; to our knowledge, this is the first documented genome-wide significant association for this phenotype. Furthermore, our study illustrates the importance of considering parent-of-origin effects in association studies, particularly in the case of cognitive or neurodevelopmental traits, in which parental genetic data are not always incorporated. |
abstract_unstemmed |
Abstract Background One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and neurodevelopmental phenotypes. Moreover, most genetic studies examining such phenotypes do not incorporate parent-of-origin effects, which could account for some of the heritability of the investigated trait. We performed a genome-wide association study of receptive language, examining both child genetic effects and parent-of-origin effects. Results Using a family-based cohort with 400 children with receptive language scores, we found a genome-wide significant paternal parent-of-origin effect with a SNP, rs11787922, on chromosome 9q21.31, whereby the T allele reduced the mean receptive language score by ~ 23, constituting a reduction of more than 1.5 times the population SD (P = 1.04 × 10−8). We further confirmed that this association was not driven by broader neurodevelopmental diagnoses in the child or a family history of psychiatric diagnoses by incorporating covariates for the above and repeating the analysis. Conclusions Our study reports a genome-wide significant association for receptive language skills; to our knowledge, this is the first documented genome-wide significant association for this phenotype. Furthermore, our study illustrates the importance of considering parent-of-origin effects in association studies, particularly in the case of cognitive or neurodevelopmental traits, in which parental genetic data are not always incorporated. |
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Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study |
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Camilla A. J. Christiani Jessica Ohland Md Jamal Uddin Nicoline Hemager Ditte Ellersgaard Katrine S. Spang Birgitte K. Burton Aja N. Greve Ditte L. Gantriis Jonas Bybjerg-Grauholm Jens Richardt M. Jepsen Anne A. E. Thorup Ole Mors Thomas Werge Merete Nordentoft |
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