Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

Cancer cells rely on glutamine to replenish the TCA cycle. Here, the authors show that oncogenic PIK3CAmutations drive this metabolic rewiring in colorectal cancer cells by up-regulating glutamate pyruvate transaminase expression, thus increasing sensitivity to glutamine starvation.

Gespeichert in:

Autor*in:	Yujun Hao [verfasserIn] Yardena Samuels [verfasserIn] Qingling Li [verfasserIn] Dawid Krokowski [verfasserIn] Bo-Jhih Guan [verfasserIn] Chao Wang [verfasserIn] Zhicheng Jin [verfasserIn] Bohan Dong [verfasserIn] Bo Cao [verfasserIn] Xiujing Feng [verfasserIn] Min Xiang [verfasserIn] Claire Xu [verfasserIn] Stephen Fink [verfasserIn] Neal J. Meropol [verfasserIn] Yan Xu [verfasserIn] Ronald A. Conlon [verfasserIn] Sanford Markowitz [verfasserIn] Kenneth W. Kinzler [verfasserIn] Victor E. Velculescu [verfasserIn] Henri Brunengraber [verfasserIn] Joseph E. Willis [verfasserIn] Thomas LaFramboise [verfasserIn] Maria Hatzoglou [verfasserIn] Guo-Fang Zhang [verfasserIn] Bert Vogelstein [verfasserIn] Zhenghe Wang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 7(2016), 1, Seite 13
Übergeordnetes Werk:	volume:7 ; year:2016 ; number:1 ; pages:13

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/ncomms11971

Katalog-ID:	DOAJ00846538X

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spelling	10.1038/ncomms11971 doi (DE-627)DOAJ00846538X (DE-599)DOAJ906e6679c4cc4a669a5f8d6f4ee9c634 DE-627 ger DE-627 rakwb eng Yujun Hao verfasserin aut Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cancer cells rely on glutamine to replenish the TCA cycle. Here, the authors show that oncogenic PIK3CAmutations drive this metabolic rewiring in colorectal cancer cells by up-regulating glutamate pyruvate transaminase expression, thus increasing sensitivity to glutamine starvation. Science Q Yardena Samuels verfasserin aut Qingling Li verfasserin aut Dawid Krokowski verfasserin aut Bo-Jhih Guan verfasserin aut Chao Wang verfasserin aut Zhicheng Jin verfasserin aut Bohan Dong verfasserin aut Bo Cao verfasserin aut Xiujing Feng verfasserin aut Min Xiang verfasserin aut Claire Xu verfasserin aut Stephen Fink verfasserin aut Neal J. Meropol verfasserin aut Yan Xu verfasserin aut Ronald A. Conlon verfasserin aut Sanford Markowitz verfasserin aut Kenneth W. Kinzler verfasserin aut Victor E. Velculescu verfasserin aut Henri Brunengraber verfasserin aut Joseph E. Willis verfasserin aut Thomas LaFramboise verfasserin aut Maria Hatzoglou verfasserin aut Guo-Fang Zhang verfasserin aut Bert Vogelstein verfasserin aut Zhenghe Wang verfasserin aut In Nature Communications Nature Portfolio, 2016 7(2016), 1, Seite 13 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:7 year:2016 number:1 pages:13 https://doi.org/10.1038/ncomms11971 kostenfrei https://doaj.org/article/906e6679c4cc4a669a5f8d6f4ee9c634 kostenfrei https://doi.org/10.1038/ncomms11971 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016 1 13
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authorswithroles_txt_mv	Yujun Hao @@aut@@ Yardena Samuels @@aut@@ Qingling Li @@aut@@ Dawid Krokowski @@aut@@ Bo-Jhih Guan @@aut@@ Chao Wang @@aut@@ Zhicheng Jin @@aut@@ Bohan Dong @@aut@@ Bo Cao @@aut@@ Xiujing Feng @@aut@@ Min Xiang @@aut@@ Claire Xu @@aut@@ Stephen Fink @@aut@@ Neal J. Meropol @@aut@@ Yan Xu @@aut@@ Ronald A. Conlon @@aut@@ Sanford Markowitz @@aut@@ Kenneth W. Kinzler @@aut@@ Victor E. Velculescu @@aut@@ Henri Brunengraber @@aut@@ Joseph E. Willis @@aut@@ Thomas LaFramboise @@aut@@ Maria Hatzoglou @@aut@@ Guo-Fang Zhang @@aut@@ Bert Vogelstein @@aut@@ Zhenghe Wang @@aut@@
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author	Yujun Hao
spellingShingle	Yujun Hao misc Science misc Q Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
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topic_title	Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
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title	Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
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title_full	Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
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author_browse	Yujun Hao Yardena Samuels Qingling Li Dawid Krokowski Bo-Jhih Guan Chao Wang Zhicheng Jin Bohan Dong Bo Cao Xiujing Feng Min Xiang Claire Xu Stephen Fink Neal J. Meropol Yan Xu Ronald A. Conlon Sanford Markowitz Kenneth W. Kinzler Victor E. Velculescu Henri Brunengraber Joseph E. Willis Thomas LaFramboise Maria Hatzoglou Guo-Fang Zhang Bert Vogelstein Zhenghe Wang
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title_sort	oncogenic pik3ca mutations reprogram glutamine metabolism in colorectal cancer
title_auth	Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
abstract	Cancer cells rely on glutamine to replenish the TCA cycle. Here, the authors show that oncogenic PIK3CAmutations drive this metabolic rewiring in colorectal cancer cells by up-regulating glutamate pyruvate transaminase expression, thus increasing sensitivity to glutamine starvation.
abstractGer	Cancer cells rely on glutamine to replenish the TCA cycle. Here, the authors show that oncogenic PIK3CAmutations drive this metabolic rewiring in colorectal cancer cells by up-regulating glutamate pyruvate transaminase expression, thus increasing sensitivity to glutamine starvation.
abstract_unstemmed	Cancer cells rely on glutamine to replenish the TCA cycle. Here, the authors show that oncogenic PIK3CAmutations drive this metabolic rewiring in colorectal cancer cells by up-regulating glutamate pyruvate transaminase expression, thus increasing sensitivity to glutamine starvation.
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title_short	Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
url	https://doi.org/10.1038/ncomms11971 https://doaj.org/article/906e6679c4cc4a669a5f8d6f4ee9c634 https://doaj.org/toc/2041-1723
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author2	Yardena Samuels Qingling Li Dawid Krokowski Bo-Jhih Guan Chao Wang Zhicheng Jin Bohan Dong Bo Cao Xiujing Feng Min Xiang Claire Xu Stephen Fink Neal J. Meropol Yan Xu Ronald A. Conlon Sanford Markowitz Kenneth W. Kinzler Victor E. Velculescu Henri Brunengraber Joseph E. Willis Thomas LaFramboise Maria Hatzoglou Guo-Fang Zhang Bert Vogelstein Zhenghe Wang
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up_date	2024-07-03T18:08:29.120Z
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Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

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