FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells

Merkel cells are mechanoreceptors located in the epidermis whose developmental origin is unclear. Here the authors show that Merkel cells originate from SOX9 positive cells inside hair follicles and that FGFR2-mediated epithelial signalling is required for their specification.

Gespeichert in:

Autor*in:	Minh Binh Nguyen [verfasserIn] Idan Cohen [verfasserIn] Vinod Kumar [verfasserIn] Zijian Xu [verfasserIn] Carmit Bar [verfasserIn] Katherine L. Dauber-Decker [verfasserIn] Pai-Chi Tsai [verfasserIn] Pauline Marangoni [verfasserIn] Ophir D. Klein [verfasserIn] Ya-Chieh Hsu [verfasserIn] Ting Chen [verfasserIn] Marja L. Mikkola [verfasserIn] Elena Ezhkova [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 9(2018), 1, Seite 10
Übergeordnetes Werk:	volume:9 ; year:2018 ; number:1 ; pages:10

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-018-04399-y

Katalog-ID:	DOAJ008552452

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spelling	10.1038/s41467-018-04399-y doi (DE-627)DOAJ008552452 (DE-599)DOAJf06a4283856d4067bfcbe380ad9407b0 DE-627 ger DE-627 rakwb eng Minh Binh Nguyen verfasserin aut FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Merkel cells are mechanoreceptors located in the epidermis whose developmental origin is unclear. Here the authors show that Merkel cells originate from SOX9 positive cells inside hair follicles and that FGFR2-mediated epithelial signalling is required for their specification. Science Q Idan Cohen verfasserin aut Vinod Kumar verfasserin aut Zijian Xu verfasserin aut Carmit Bar verfasserin aut Katherine L. Dauber-Decker verfasserin aut Pai-Chi Tsai verfasserin aut Pauline Marangoni verfasserin aut Ophir D. Klein verfasserin aut Ya-Chieh Hsu verfasserin aut Ting Chen verfasserin aut Marja L. Mikkola verfasserin aut Elena Ezhkova verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 10 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:10 https://doi.org/10.1038/s41467-018-04399-y kostenfrei https://doaj.org/article/f06a4283856d4067bfcbe380ad9407b0 kostenfrei https://doi.org/10.1038/s41467-018-04399-y kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 10
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allfieldsSound	10.1038/s41467-018-04399-y doi (DE-627)DOAJ008552452 (DE-599)DOAJf06a4283856d4067bfcbe380ad9407b0 DE-627 ger DE-627 rakwb eng Minh Binh Nguyen verfasserin aut FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Merkel cells are mechanoreceptors located in the epidermis whose developmental origin is unclear. Here the authors show that Merkel cells originate from SOX9 positive cells inside hair follicles and that FGFR2-mediated epithelial signalling is required for their specification. Science Q Idan Cohen verfasserin aut Vinod Kumar verfasserin aut Zijian Xu verfasserin aut Carmit Bar verfasserin aut Katherine L. Dauber-Decker verfasserin aut Pai-Chi Tsai verfasserin aut Pauline Marangoni verfasserin aut Ophir D. Klein verfasserin aut Ya-Chieh Hsu verfasserin aut Ting Chen verfasserin aut Marja L. Mikkola verfasserin aut Elena Ezhkova verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 10 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:10 https://doi.org/10.1038/s41467-018-04399-y kostenfrei https://doaj.org/article/f06a4283856d4067bfcbe380ad9407b0 kostenfrei https://doi.org/10.1038/s41467-018-04399-y kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 10
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author	Minh Binh Nguyen
spellingShingle	Minh Binh Nguyen misc Science misc Q FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells
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topic_title	FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells
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title	FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells
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title_full	FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells
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author_browse	Minh Binh Nguyen Idan Cohen Vinod Kumar Zijian Xu Carmit Bar Katherine L. Dauber-Decker Pai-Chi Tsai Pauline Marangoni Ophir D. Klein Ya-Chieh Hsu Ting Chen Marja L. Mikkola Elena Ezhkova
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title_sort	fgf signalling controls the specification of hair placode-derived sox9 positive progenitors to merkel cells
title_auth	FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells
abstract	Merkel cells are mechanoreceptors located in the epidermis whose developmental origin is unclear. Here the authors show that Merkel cells originate from SOX9 positive cells inside hair follicles and that FGFR2-mediated epithelial signalling is required for their specification.
abstractGer	Merkel cells are mechanoreceptors located in the epidermis whose developmental origin is unclear. Here the authors show that Merkel cells originate from SOX9 positive cells inside hair follicles and that FGFR2-mediated epithelial signalling is required for their specification.
abstract_unstemmed	Merkel cells are mechanoreceptors located in the epidermis whose developmental origin is unclear. Here the authors show that Merkel cells originate from SOX9 positive cells inside hair follicles and that FGFR2-mediated epithelial signalling is required for their specification.
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title_short	FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells
url	https://doi.org/10.1038/s41467-018-04399-y https://doaj.org/article/f06a4283856d4067bfcbe380ad9407b0 https://doaj.org/toc/2041-1723
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FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells

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