The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women

Background: The health benefits of soy are widely reported but there are queries on the effect of soy isoflavones on thyroid function and the underlying mechanism of action.Materials and Methods: We examined the effect of soy isoflavones on reverse tri-iodothyronine (or 3,3′,5′-tri-iodothyronine; rT...
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Autor*in:	Thozhukat Sathyapalan [verfasserIn] Josef Köhrle [verfasserIn] Eddy Rijntjes [verfasserIn] Alan S. Rigby [verfasserIn] Soha R. Dargham [verfasserIn] Eric S. Kilpatrick [verfasserIn] Stephen L. Atkin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	soy isoflavones phytoestrogens reverse tri-iodothyronine tri-iodothyronine thyroxine

Übergeordnetes Werk:	In: Frontiers in Endocrinology - Frontiers Media S.A., 2011, 9(2018)
Übergeordnetes Werk:	volume:9 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fendo.2018.00698

Katalog-ID:	DOAJ008566348

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520			\|a Background: The health benefits of soy are widely reported but there are queries on the effect of soy isoflavones on thyroid function and the underlying mechanism of action.Materials and Methods: We examined the effect of soy isoflavones on reverse tri-iodothyronine (or 3,3′,5′-tri-iodothyronine; rT3) in two studies comprising 400 patients: 200 men (study 1; 3 months) and 200 post-menopausal women (study 2; 6 months) who were randomized to consume 15 g soy protein with 66 mg of isoflavones (SPI) daily, or 15 g soy protein alone without isoflavones (SP) daily.Results: SPI supplementation increased rT3 serum concentration in both men 0.41 (0.12) vs. 0.45 (0.14) nmol/L and women 0.33 (0.12) vs. 0.37 (0.09) nmol/L at 3 months compared to SP that was not seen at 6 months. Thyroid stimulating hormone (TSH) serum concentrations increased while free thyroxine (fT4) concentrations decreased with 3 months of SPI compared to SP supplementation for both men and women. rT3 correlated with TSH in both studies (p = 0.03) but not with either fT3 or fT4. fT3 levels did not differ between the SPI and SP preparations.Conclusion: Soy isoflavones transiently increased rT3 levels within 3 months though reverted to baseline at 6 months. The mechanism for this would be either rT3 degrading deiodinase 1 and/or deiodinase 2 activities are transiently inhibited at 3 months, or inhibition of deiodinase 3, which generates rT3 from T4 is induced at 6 months. These changes were mirrored in the TSH concentrations, suggesting that short-term high dose isoflavone transiently impairs thyroid function in the first 3 months and may impact on general health during this period.ISRCTN Registry: ISRCTN 90604927; ISRCTN34051237.
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allfields	10.3389/fendo.2018.00698 doi (DE-627)DOAJ008566348 (DE-599)DOAJ82a4d4d0cde14c22b23cb4e3488c928f DE-627 ger DE-627 rakwb eng RC648-665 Thozhukat Sathyapalan verfasserin aut The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The health benefits of soy are widely reported but there are queries on the effect of soy isoflavones on thyroid function and the underlying mechanism of action.Materials and Methods: We examined the effect of soy isoflavones on reverse tri-iodothyronine (or 3,3′,5′-tri-iodothyronine; rT3) in two studies comprising 400 patients: 200 men (study 1; 3 months) and 200 post-menopausal women (study 2; 6 months) who were randomized to consume 15 g soy protein with 66 mg of isoflavones (SPI) daily, or 15 g soy protein alone without isoflavones (SP) daily.Results: SPI supplementation increased rT3 serum concentration in both men 0.41 (0.12) vs. 0.45 (0.14) nmol/L and women 0.33 (0.12) vs. 0.37 (0.09) nmol/L at 3 months compared to SP that was not seen at 6 months. Thyroid stimulating hormone (TSH) serum concentrations increased while free thyroxine (fT4) concentrations decreased with 3 months of SPI compared to SP supplementation for both men and women. rT3 correlated with TSH in both studies (p = 0.03) but not with either fT3 or fT4. fT3 levels did not differ between the SPI and SP preparations.Conclusion: Soy isoflavones transiently increased rT3 levels within 3 months though reverted to baseline at 6 months. The mechanism for this would be either rT3 degrading deiodinase 1 and/or deiodinase 2 activities are transiently inhibited at 3 months, or inhibition of deiodinase 3, which generates rT3 from T4 is induced at 6 months. These changes were mirrored in the TSH concentrations, suggesting that short-term high dose isoflavone transiently impairs thyroid function in the first 3 months and may impact on general health during this period.ISRCTN Registry: ISRCTN 90604927; ISRCTN34051237. soy isoflavones phytoestrogens reverse tri-iodothyronine tri-iodothyronine thyroxine Diseases of the endocrine glands. Clinical endocrinology Josef Köhrle verfasserin aut Eddy Rijntjes verfasserin aut Alan S. Rigby verfasserin aut Soha R. Dargham verfasserin aut Eric S. Kilpatrick verfasserin aut Stephen L. Atkin verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 9(2018) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:9 year:2018 https://doi.org/10.3389/fendo.2018.00698 kostenfrei https://doaj.org/article/82a4d4d0cde14c22b23cb4e3488c928f kostenfrei https://www.frontiersin.org/article/10.3389/fendo.2018.00698/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
spelling	10.3389/fendo.2018.00698 doi (DE-627)DOAJ008566348 (DE-599)DOAJ82a4d4d0cde14c22b23cb4e3488c928f DE-627 ger DE-627 rakwb eng RC648-665 Thozhukat Sathyapalan verfasserin aut The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The health benefits of soy are widely reported but there are queries on the effect of soy isoflavones on thyroid function and the underlying mechanism of action.Materials and Methods: We examined the effect of soy isoflavones on reverse tri-iodothyronine (or 3,3′,5′-tri-iodothyronine; rT3) in two studies comprising 400 patients: 200 men (study 1; 3 months) and 200 post-menopausal women (study 2; 6 months) who were randomized to consume 15 g soy protein with 66 mg of isoflavones (SPI) daily, or 15 g soy protein alone without isoflavones (SP) daily.Results: SPI supplementation increased rT3 serum concentration in both men 0.41 (0.12) vs. 0.45 (0.14) nmol/L and women 0.33 (0.12) vs. 0.37 (0.09) nmol/L at 3 months compared to SP that was not seen at 6 months. Thyroid stimulating hormone (TSH) serum concentrations increased while free thyroxine (fT4) concentrations decreased with 3 months of SPI compared to SP supplementation for both men and women. rT3 correlated with TSH in both studies (p = 0.03) but not with either fT3 or fT4. fT3 levels did not differ between the SPI and SP preparations.Conclusion: Soy isoflavones transiently increased rT3 levels within 3 months though reverted to baseline at 6 months. The mechanism for this would be either rT3 degrading deiodinase 1 and/or deiodinase 2 activities are transiently inhibited at 3 months, or inhibition of deiodinase 3, which generates rT3 from T4 is induced at 6 months. These changes were mirrored in the TSH concentrations, suggesting that short-term high dose isoflavone transiently impairs thyroid function in the first 3 months and may impact on general health during this period.ISRCTN Registry: ISRCTN 90604927; ISRCTN34051237. soy isoflavones phytoestrogens reverse tri-iodothyronine tri-iodothyronine thyroxine Diseases of the endocrine glands. Clinical endocrinology Josef Köhrle verfasserin aut Eddy Rijntjes verfasserin aut Alan S. Rigby verfasserin aut Soha R. Dargham verfasserin aut Eric S. Kilpatrick verfasserin aut Stephen L. Atkin verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 9(2018) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:9 year:2018 https://doi.org/10.3389/fendo.2018.00698 kostenfrei https://doaj.org/article/82a4d4d0cde14c22b23cb4e3488c928f kostenfrei https://www.frontiersin.org/article/10.3389/fendo.2018.00698/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
allfields_unstemmed	10.3389/fendo.2018.00698 doi (DE-627)DOAJ008566348 (DE-599)DOAJ82a4d4d0cde14c22b23cb4e3488c928f DE-627 ger DE-627 rakwb eng RC648-665 Thozhukat Sathyapalan verfasserin aut The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The health benefits of soy are widely reported but there are queries on the effect of soy isoflavones on thyroid function and the underlying mechanism of action.Materials and Methods: We examined the effect of soy isoflavones on reverse tri-iodothyronine (or 3,3′,5′-tri-iodothyronine; rT3) in two studies comprising 400 patients: 200 men (study 1; 3 months) and 200 post-menopausal women (study 2; 6 months) who were randomized to consume 15 g soy protein with 66 mg of isoflavones (SPI) daily, or 15 g soy protein alone without isoflavones (SP) daily.Results: SPI supplementation increased rT3 serum concentration in both men 0.41 (0.12) vs. 0.45 (0.14) nmol/L and women 0.33 (0.12) vs. 0.37 (0.09) nmol/L at 3 months compared to SP that was not seen at 6 months. Thyroid stimulating hormone (TSH) serum concentrations increased while free thyroxine (fT4) concentrations decreased with 3 months of SPI compared to SP supplementation for both men and women. rT3 correlated with TSH in both studies (p = 0.03) but not with either fT3 or fT4. fT3 levels did not differ between the SPI and SP preparations.Conclusion: Soy isoflavones transiently increased rT3 levels within 3 months though reverted to baseline at 6 months. The mechanism for this would be either rT3 degrading deiodinase 1 and/or deiodinase 2 activities are transiently inhibited at 3 months, or inhibition of deiodinase 3, which generates rT3 from T4 is induced at 6 months. These changes were mirrored in the TSH concentrations, suggesting that short-term high dose isoflavone transiently impairs thyroid function in the first 3 months and may impact on general health during this period.ISRCTN Registry: ISRCTN 90604927; ISRCTN34051237. soy isoflavones phytoestrogens reverse tri-iodothyronine tri-iodothyronine thyroxine Diseases of the endocrine glands. Clinical endocrinology Josef Köhrle verfasserin aut Eddy Rijntjes verfasserin aut Alan S. Rigby verfasserin aut Soha R. Dargham verfasserin aut Eric S. Kilpatrick verfasserin aut Stephen L. Atkin verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 9(2018) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:9 year:2018 https://doi.org/10.3389/fendo.2018.00698 kostenfrei https://doaj.org/article/82a4d4d0cde14c22b23cb4e3488c928f kostenfrei https://www.frontiersin.org/article/10.3389/fendo.2018.00698/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
allfieldsGer	10.3389/fendo.2018.00698 doi (DE-627)DOAJ008566348 (DE-599)DOAJ82a4d4d0cde14c22b23cb4e3488c928f DE-627 ger DE-627 rakwb eng RC648-665 Thozhukat Sathyapalan verfasserin aut The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The health benefits of soy are widely reported but there are queries on the effect of soy isoflavones on thyroid function and the underlying mechanism of action.Materials and Methods: We examined the effect of soy isoflavones on reverse tri-iodothyronine (or 3,3′,5′-tri-iodothyronine; rT3) in two studies comprising 400 patients: 200 men (study 1; 3 months) and 200 post-menopausal women (study 2; 6 months) who were randomized to consume 15 g soy protein with 66 mg of isoflavones (SPI) daily, or 15 g soy protein alone without isoflavones (SP) daily.Results: SPI supplementation increased rT3 serum concentration in both men 0.41 (0.12) vs. 0.45 (0.14) nmol/L and women 0.33 (0.12) vs. 0.37 (0.09) nmol/L at 3 months compared to SP that was not seen at 6 months. Thyroid stimulating hormone (TSH) serum concentrations increased while free thyroxine (fT4) concentrations decreased with 3 months of SPI compared to SP supplementation for both men and women. rT3 correlated with TSH in both studies (p = 0.03) but not with either fT3 or fT4. fT3 levels did not differ between the SPI and SP preparations.Conclusion: Soy isoflavones transiently increased rT3 levels within 3 months though reverted to baseline at 6 months. The mechanism for this would be either rT3 degrading deiodinase 1 and/or deiodinase 2 activities are transiently inhibited at 3 months, or inhibition of deiodinase 3, which generates rT3 from T4 is induced at 6 months. These changes were mirrored in the TSH concentrations, suggesting that short-term high dose isoflavone transiently impairs thyroid function in the first 3 months and may impact on general health during this period.ISRCTN Registry: ISRCTN 90604927; ISRCTN34051237. soy isoflavones phytoestrogens reverse tri-iodothyronine tri-iodothyronine thyroxine Diseases of the endocrine glands. Clinical endocrinology Josef Köhrle verfasserin aut Eddy Rijntjes verfasserin aut Alan S. Rigby verfasserin aut Soha R. Dargham verfasserin aut Eric S. Kilpatrick verfasserin aut Stephen L. Atkin verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 9(2018) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:9 year:2018 https://doi.org/10.3389/fendo.2018.00698 kostenfrei https://doaj.org/article/82a4d4d0cde14c22b23cb4e3488c928f kostenfrei https://www.frontiersin.org/article/10.3389/fendo.2018.00698/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
allfieldsSound	10.3389/fendo.2018.00698 doi (DE-627)DOAJ008566348 (DE-599)DOAJ82a4d4d0cde14c22b23cb4e3488c928f DE-627 ger DE-627 rakwb eng RC648-665 Thozhukat Sathyapalan verfasserin aut The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The health benefits of soy are widely reported but there are queries on the effect of soy isoflavones on thyroid function and the underlying mechanism of action.Materials and Methods: We examined the effect of soy isoflavones on reverse tri-iodothyronine (or 3,3′,5′-tri-iodothyronine; rT3) in two studies comprising 400 patients: 200 men (study 1; 3 months) and 200 post-menopausal women (study 2; 6 months) who were randomized to consume 15 g soy protein with 66 mg of isoflavones (SPI) daily, or 15 g soy protein alone without isoflavones (SP) daily.Results: SPI supplementation increased rT3 serum concentration in both men 0.41 (0.12) vs. 0.45 (0.14) nmol/L and women 0.33 (0.12) vs. 0.37 (0.09) nmol/L at 3 months compared to SP that was not seen at 6 months. Thyroid stimulating hormone (TSH) serum concentrations increased while free thyroxine (fT4) concentrations decreased with 3 months of SPI compared to SP supplementation for both men and women. rT3 correlated with TSH in both studies (p = 0.03) but not with either fT3 or fT4. fT3 levels did not differ between the SPI and SP preparations.Conclusion: Soy isoflavones transiently increased rT3 levels within 3 months though reverted to baseline at 6 months. The mechanism for this would be either rT3 degrading deiodinase 1 and/or deiodinase 2 activities are transiently inhibited at 3 months, or inhibition of deiodinase 3, which generates rT3 from T4 is induced at 6 months. These changes were mirrored in the TSH concentrations, suggesting that short-term high dose isoflavone transiently impairs thyroid function in the first 3 months and may impact on general health during this period.ISRCTN Registry: ISRCTN 90604927; ISRCTN34051237. soy isoflavones phytoestrogens reverse tri-iodothyronine tri-iodothyronine thyroxine Diseases of the endocrine glands. Clinical endocrinology Josef Köhrle verfasserin aut Eddy Rijntjes verfasserin aut Alan S. Rigby verfasserin aut Soha R. Dargham verfasserin aut Eric S. Kilpatrick verfasserin aut Stephen L. Atkin verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 9(2018) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:9 year:2018 https://doi.org/10.3389/fendo.2018.00698 kostenfrei https://doaj.org/article/82a4d4d0cde14c22b23cb4e3488c928f kostenfrei https://www.frontiersin.org/article/10.3389/fendo.2018.00698/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
language	English
source	In Frontiers in Endocrinology 9(2018) volume:9 year:2018
sourceStr	In Frontiers in Endocrinology 9(2018) volume:9 year:2018
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institution	findex.gbv.de
topic_facet	soy isoflavones phytoestrogens reverse tri-iodothyronine tri-iodothyronine thyroxine Diseases of the endocrine glands. Clinical endocrinology
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container_title	Frontiers in Endocrinology
authorswithroles_txt_mv	Thozhukat Sathyapalan @@aut@@ Josef Köhrle @@aut@@ Eddy Rijntjes @@aut@@ Alan S. Rigby @@aut@@ Soha R. Dargham @@aut@@ Eric S. Kilpatrick @@aut@@ Stephen L. Atkin @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
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callnumber-first	R - Medicine
author	Thozhukat Sathyapalan
spellingShingle	Thozhukat Sathyapalan misc RC648-665 misc soy misc isoflavones misc phytoestrogens misc reverse tri-iodothyronine misc tri-iodothyronine misc thyroxine misc Diseases of the endocrine glands. Clinical endocrinology The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women
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issn	16642392
topic_title	RC648-665 The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women soy isoflavones phytoestrogens reverse tri-iodothyronine tri-iodothyronine thyroxine
topic	misc RC648-665 misc soy misc isoflavones misc phytoestrogens misc reverse tri-iodothyronine misc tri-iodothyronine misc thyroxine misc Diseases of the endocrine glands. Clinical endocrinology
topic_unstemmed	misc RC648-665 misc soy misc isoflavones misc phytoestrogens misc reverse tri-iodothyronine misc tri-iodothyronine misc thyroxine misc Diseases of the endocrine glands. Clinical endocrinology
topic_browse	misc RC648-665 misc soy misc isoflavones misc phytoestrogens misc reverse tri-iodothyronine misc tri-iodothyronine misc thyroxine misc Diseases of the endocrine glands. Clinical endocrinology
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title	The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women
ctrlnum	(DE-627)DOAJ008566348 (DE-599)DOAJ82a4d4d0cde14c22b23cb4e3488c928f
title_full	The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women
author_sort	Thozhukat Sathyapalan
journal	Frontiers in Endocrinology
journalStr	Frontiers in Endocrinology
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lang_code	eng
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publishDateSort	2018
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author_browse	Thozhukat Sathyapalan Josef Köhrle Eddy Rijntjes Alan S. Rigby Soha R. Dargham Eric S. Kilpatrick Stephen L. Atkin
container_volume	9
class	RC648-665
format_se	Elektronische Aufsätze
author-letter	Thozhukat Sathyapalan
doi_str_mv	10.3389/fendo.2018.00698
author2-role	verfasserin
title_sort	effect of high dose isoflavone supplementation on serum reverse t3 in euthyroid men with type 2 diabetes and post-menopausal women
callnumber	RC648-665
title_auth	The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women
abstract	Background: The health benefits of soy are widely reported but there are queries on the effect of soy isoflavones on thyroid function and the underlying mechanism of action.Materials and Methods: We examined the effect of soy isoflavones on reverse tri-iodothyronine (or 3,3′,5′-tri-iodothyronine; rT3) in two studies comprising 400 patients: 200 men (study 1; 3 months) and 200 post-menopausal women (study 2; 6 months) who were randomized to consume 15 g soy protein with 66 mg of isoflavones (SPI) daily, or 15 g soy protein alone without isoflavones (SP) daily.Results: SPI supplementation increased rT3 serum concentration in both men 0.41 (0.12) vs. 0.45 (0.14) nmol/L and women 0.33 (0.12) vs. 0.37 (0.09) nmol/L at 3 months compared to SP that was not seen at 6 months. Thyroid stimulating hormone (TSH) serum concentrations increased while free thyroxine (fT4) concentrations decreased with 3 months of SPI compared to SP supplementation for both men and women. rT3 correlated with TSH in both studies (p = 0.03) but not with either fT3 or fT4. fT3 levels did not differ between the SPI and SP preparations.Conclusion: Soy isoflavones transiently increased rT3 levels within 3 months though reverted to baseline at 6 months. The mechanism for this would be either rT3 degrading deiodinase 1 and/or deiodinase 2 activities are transiently inhibited at 3 months, or inhibition of deiodinase 3, which generates rT3 from T4 is induced at 6 months. These changes were mirrored in the TSH concentrations, suggesting that short-term high dose isoflavone transiently impairs thyroid function in the first 3 months and may impact on general health during this period.ISRCTN Registry: ISRCTN 90604927; ISRCTN34051237.
abstractGer	Background: The health benefits of soy are widely reported but there are queries on the effect of soy isoflavones on thyroid function and the underlying mechanism of action.Materials and Methods: We examined the effect of soy isoflavones on reverse tri-iodothyronine (or 3,3′,5′-tri-iodothyronine; rT3) in two studies comprising 400 patients: 200 men (study 1; 3 months) and 200 post-menopausal women (study 2; 6 months) who were randomized to consume 15 g soy protein with 66 mg of isoflavones (SPI) daily, or 15 g soy protein alone without isoflavones (SP) daily.Results: SPI supplementation increased rT3 serum concentration in both men 0.41 (0.12) vs. 0.45 (0.14) nmol/L and women 0.33 (0.12) vs. 0.37 (0.09) nmol/L at 3 months compared to SP that was not seen at 6 months. Thyroid stimulating hormone (TSH) serum concentrations increased while free thyroxine (fT4) concentrations decreased with 3 months of SPI compared to SP supplementation for both men and women. rT3 correlated with TSH in both studies (p = 0.03) but not with either fT3 or fT4. fT3 levels did not differ between the SPI and SP preparations.Conclusion: Soy isoflavones transiently increased rT3 levels within 3 months though reverted to baseline at 6 months. The mechanism for this would be either rT3 degrading deiodinase 1 and/or deiodinase 2 activities are transiently inhibited at 3 months, or inhibition of deiodinase 3, which generates rT3 from T4 is induced at 6 months. These changes were mirrored in the TSH concentrations, suggesting that short-term high dose isoflavone transiently impairs thyroid function in the first 3 months and may impact on general health during this period.ISRCTN Registry: ISRCTN 90604927; ISRCTN34051237.
abstract_unstemmed	Background: The health benefits of soy are widely reported but there are queries on the effect of soy isoflavones on thyroid function and the underlying mechanism of action.Materials and Methods: We examined the effect of soy isoflavones on reverse tri-iodothyronine (or 3,3′,5′-tri-iodothyronine; rT3) in two studies comprising 400 patients: 200 men (study 1; 3 months) and 200 post-menopausal women (study 2; 6 months) who were randomized to consume 15 g soy protein with 66 mg of isoflavones (SPI) daily, or 15 g soy protein alone without isoflavones (SP) daily.Results: SPI supplementation increased rT3 serum concentration in both men 0.41 (0.12) vs. 0.45 (0.14) nmol/L and women 0.33 (0.12) vs. 0.37 (0.09) nmol/L at 3 months compared to SP that was not seen at 6 months. Thyroid stimulating hormone (TSH) serum concentrations increased while free thyroxine (fT4) concentrations decreased with 3 months of SPI compared to SP supplementation for both men and women. rT3 correlated with TSH in both studies (p = 0.03) but not with either fT3 or fT4. fT3 levels did not differ between the SPI and SP preparations.Conclusion: Soy isoflavones transiently increased rT3 levels within 3 months though reverted to baseline at 6 months. The mechanism for this would be either rT3 degrading deiodinase 1 and/or deiodinase 2 activities are transiently inhibited at 3 months, or inhibition of deiodinase 3, which generates rT3 from T4 is induced at 6 months. These changes were mirrored in the TSH concentrations, suggesting that short-term high dose isoflavone transiently impairs thyroid function in the first 3 months and may impact on general health during this period.ISRCTN Registry: ISRCTN 90604927; ISRCTN34051237.
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title_short	The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women
url	https://doi.org/10.3389/fendo.2018.00698 https://doaj.org/article/82a4d4d0cde14c22b23cb4e3488c928f https://www.frontiersin.org/article/10.3389/fendo.2018.00698/full https://doaj.org/toc/1664-2392
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author2	Josef Köhrle Eddy Rijntjes Alan S. Rigby Soha R. Dargham Eric S. Kilpatrick Stephen L. Atkin
author2Str	Josef Köhrle Eddy Rijntjes Alan S. Rigby Soha R. Dargham Eric S. Kilpatrick Stephen L. Atkin
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doi_str	10.3389/fendo.2018.00698
callnumber-a	RC648-665
up_date	2024-07-03T18:45:51.438Z
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