Synergized regulation of NK cell education by NKG2A and specific Ly49 family members

MHC-I-induced signalling of various natural killer (NK) inhibitory receptors is critical for regulation NK cell education, but clear genetic evidence is still lacking. Here the authors generate multiple lines of mice differentially deficient in Ly49 family and/or NKG2A NK receptors, and find that se...
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Autor*in:	Xiaoqian Zhang [verfasserIn] Jin Feng [verfasserIn] Shasha Chen [verfasserIn] Haoyan Yang [verfasserIn] Zhongjun Dong [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 10(2019), 1, Seite 12
Übergeordnetes Werk:	volume:10 ; year:2019 ; number:1 ; pages:12

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-019-13032-5

Katalog-ID:	DOAJ008593361

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author	Xiaoqian Zhang
spellingShingle	Xiaoqian Zhang misc Science misc Q Synergized regulation of NK cell education by NKG2A and specific Ly49 family members
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topic_title	Synergized regulation of NK cell education by NKG2A and specific Ly49 family members
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title	Synergized regulation of NK cell education by NKG2A and specific Ly49 family members
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title_full	Synergized regulation of NK cell education by NKG2A and specific Ly49 family members
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title_sort	synergized regulation of nk cell education by nkg2a and specific ly49 family members
title_auth	Synergized regulation of NK cell education by NKG2A and specific Ly49 family members
abstract	MHC-I-induced signalling of various natural killer (NK) inhibitory receptors is critical for regulation NK cell education, but clear genetic evidence is still lacking. Here the authors generate multiple lines of mice differentially deficient in Ly49 family and/or NKG2A NK receptors, and find that self-MHCI specific Ly49 members and NKG2A synergize to regulate NK education.
abstractGer	MHC-I-induced signalling of various natural killer (NK) inhibitory receptors is critical for regulation NK cell education, but clear genetic evidence is still lacking. Here the authors generate multiple lines of mice differentially deficient in Ly49 family and/or NKG2A NK receptors, and find that self-MHCI specific Ly49 members and NKG2A synergize to regulate NK education.
abstract_unstemmed	MHC-I-induced signalling of various natural killer (NK) inhibitory receptors is critical for regulation NK cell education, but clear genetic evidence is still lacking. Here the authors generate multiple lines of mice differentially deficient in Ly49 family and/or NKG2A NK receptors, and find that self-MHCI specific Ly49 members and NKG2A synergize to regulate NK education.
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title_short	Synergized regulation of NK cell education by NKG2A and specific Ly49 family members
url	https://doi.org/10.1038/s41467-019-13032-5 https://doaj.org/article/26d9a5825ab940e5a49b115dd12d8fe3 https://doaj.org/toc/2041-1723
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