Mean arterial pressure for predicting preeclampsia in Asian women: a longitudinal cohort study

Objective Previous studies suggested mean arterial pressure (MAP) had moderate predictive values in the first and second trimesters for the prediction of preeclampsia. However, the performance of MAP in Asian women is still unclear. The objective of this study was to examine the predictive values of MAP in Asian population throughout gestation, and to compare the performance of MAP, angiogenic factors and uterine artery Doppler in the prediction of preeclampsia.Design A prospective cohort study.Setting KK Women’s and Children’s Hospital, Singapore.Participants A total of 926 women with singleton pregnancy less than 14 weeks of gestation were included in the prospective Neonatal and Obstetrics Risks Assessment cohort between September 2010 and October 2014. Maternal blood pressure levels, uterine artery pulsatility index (UtA-PI), serum soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF) and sFlt-1/PlGF ratio were measured at 11–14, 18–22, 28–32 and 34 weeks onward, respectively.Primary and secondary outcomes Preeclampsia was the main pregnancy outcome.Results A total of 20 women developed preeclampsia, who had significantly lower levels of PlGF, higher levels of sFlt-1/PlGF ratio and MAP throughout pregnancy than women without preeclampsia. Compared with angiogenic factors and UtA-PI, MAP had significantly higher area under the receiver operating characteristic curves (AUCs) for predicting preeclampsia and term preeclampsia throughout gestation. For predicting preeclampsia, MAP had AUCs of 0.86 (95% CI 0.78 to 0.95), 0.87 (95% CI 0.80 to 0.95) and 0.91 (95% CI 0.85 to 0.98) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting term preeclampsia, MAP yielded AUCs of 0.87 (95% CI 0.75 to 0.99), 0.87 (95% CI 0.76 to 0.98) and 0.90 (95% CI 0.80 to 0.99) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting preterm preeclampsia, the performance of MAP and PlGF was similar.Conclusion MAP is a good predictor for preeclampsia, especially term preeclampsia, in Asian women. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Jing Zhu [verfasserIn] Jun Zhang [verfasserIn] Kok Hian Tan [verfasserIn] Bernard Chern [verfasserIn] Nurul Syaza Razali [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Übergeordnetes Werk:	In: BMJ Open - BMJ Publishing Group, 2011, 11(2021), 8
Übergeordnetes Werk:	volume:11 ; year:2021 ; number:8

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1136/bmjopen-2020-046161

Katalog-ID:	DOAJ008612277

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520			\|a Objective Previous studies suggested mean arterial pressure (MAP) had moderate predictive values in the first and second trimesters for the prediction of preeclampsia. However, the performance of MAP in Asian women is still unclear. The objective of this study was to examine the predictive values of MAP in Asian population throughout gestation, and to compare the performance of MAP, angiogenic factors and uterine artery Doppler in the prediction of preeclampsia.Design A prospective cohort study.Setting KK Women’s and Children’s Hospital, Singapore.Participants A total of 926 women with singleton pregnancy less than 14 weeks of gestation were included in the prospective Neonatal and Obstetrics Risks Assessment cohort between September 2010 and October 2014. Maternal blood pressure levels, uterine artery pulsatility index (UtA-PI), serum soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF) and sFlt-1/PlGF ratio were measured at 11–14, 18–22, 28–32 and 34 weeks onward, respectively.Primary and secondary outcomes Preeclampsia was the main pregnancy outcome.Results A total of 20 women developed preeclampsia, who had significantly lower levels of PlGF, higher levels of sFlt-1/PlGF ratio and MAP throughout pregnancy than women without preeclampsia. Compared with angiogenic factors and UtA-PI, MAP had significantly higher area under the receiver operating characteristic curves (AUCs) for predicting preeclampsia and term preeclampsia throughout gestation. For predicting preeclampsia, MAP had AUCs of 0.86 (95% CI 0.78 to 0.95), 0.87 (95% CI 0.80 to 0.95) and 0.91 (95% CI 0.85 to 0.98) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting term preeclampsia, MAP yielded AUCs of 0.87 (95% CI 0.75 to 0.99), 0.87 (95% CI 0.76 to 0.98) and 0.90 (95% CI 0.80 to 0.99) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting preterm preeclampsia, the performance of MAP and PlGF was similar.Conclusion MAP is a good predictor for preeclampsia, especially term preeclampsia, in Asian women.
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allfields	10.1136/bmjopen-2020-046161 doi (DE-627)DOAJ008612277 (DE-599)DOAJ1ddac472f9b14bd48638425dea3aa15d DE-627 ger DE-627 rakwb eng Jing Zhu verfasserin aut Mean arterial pressure for predicting preeclampsia in Asian women: a longitudinal cohort study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective Previous studies suggested mean arterial pressure (MAP) had moderate predictive values in the first and second trimesters for the prediction of preeclampsia. However, the performance of MAP in Asian women is still unclear. The objective of this study was to examine the predictive values of MAP in Asian population throughout gestation, and to compare the performance of MAP, angiogenic factors and uterine artery Doppler in the prediction of preeclampsia.Design A prospective cohort study.Setting KK Women’s and Children’s Hospital, Singapore.Participants A total of 926 women with singleton pregnancy less than 14 weeks of gestation were included in the prospective Neonatal and Obstetrics Risks Assessment cohort between September 2010 and October 2014. Maternal blood pressure levels, uterine artery pulsatility index (UtA-PI), serum soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF) and sFlt-1/PlGF ratio were measured at 11–14, 18–22, 28–32 and 34 weeks onward, respectively.Primary and secondary outcomes Preeclampsia was the main pregnancy outcome.Results A total of 20 women developed preeclampsia, who had significantly lower levels of PlGF, higher levels of sFlt-1/PlGF ratio and MAP throughout pregnancy than women without preeclampsia. Compared with angiogenic factors and UtA-PI, MAP had significantly higher area under the receiver operating characteristic curves (AUCs) for predicting preeclampsia and term preeclampsia throughout gestation. For predicting preeclampsia, MAP had AUCs of 0.86 (95% CI 0.78 to 0.95), 0.87 (95% CI 0.80 to 0.95) and 0.91 (95% CI 0.85 to 0.98) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting term preeclampsia, MAP yielded AUCs of 0.87 (95% CI 0.75 to 0.99), 0.87 (95% CI 0.76 to 0.98) and 0.90 (95% CI 0.80 to 0.99) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting preterm preeclampsia, the performance of MAP and PlGF was similar.Conclusion MAP is a good predictor for preeclampsia, especially term preeclampsia, in Asian women. Medicine R Jun Zhang verfasserin aut Kok Hian Tan verfasserin aut Bernard Chern verfasserin aut Nurul Syaza Razali verfasserin aut In BMJ Open BMJ Publishing Group, 2011 11(2021), 8 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:11 year:2021 number:8 https://doi.org/10.1136/bmjopen-2020-046161 kostenfrei https://doaj.org/article/1ddac472f9b14bd48638425dea3aa15d kostenfrei https://bmjopen.bmj.com/content/11/8/e046161.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 8
spelling	10.1136/bmjopen-2020-046161 doi (DE-627)DOAJ008612277 (DE-599)DOAJ1ddac472f9b14bd48638425dea3aa15d DE-627 ger DE-627 rakwb eng Jing Zhu verfasserin aut Mean arterial pressure for predicting preeclampsia in Asian women: a longitudinal cohort study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective Previous studies suggested mean arterial pressure (MAP) had moderate predictive values in the first and second trimesters for the prediction of preeclampsia. However, the performance of MAP in Asian women is still unclear. The objective of this study was to examine the predictive values of MAP in Asian population throughout gestation, and to compare the performance of MAP, angiogenic factors and uterine artery Doppler in the prediction of preeclampsia.Design A prospective cohort study.Setting KK Women’s and Children’s Hospital, Singapore.Participants A total of 926 women with singleton pregnancy less than 14 weeks of gestation were included in the prospective Neonatal and Obstetrics Risks Assessment cohort between September 2010 and October 2014. Maternal blood pressure levels, uterine artery pulsatility index (UtA-PI), serum soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF) and sFlt-1/PlGF ratio were measured at 11–14, 18–22, 28–32 and 34 weeks onward, respectively.Primary and secondary outcomes Preeclampsia was the main pregnancy outcome.Results A total of 20 women developed preeclampsia, who had significantly lower levels of PlGF, higher levels of sFlt-1/PlGF ratio and MAP throughout pregnancy than women without preeclampsia. Compared with angiogenic factors and UtA-PI, MAP had significantly higher area under the receiver operating characteristic curves (AUCs) for predicting preeclampsia and term preeclampsia throughout gestation. For predicting preeclampsia, MAP had AUCs of 0.86 (95% CI 0.78 to 0.95), 0.87 (95% CI 0.80 to 0.95) and 0.91 (95% CI 0.85 to 0.98) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting term preeclampsia, MAP yielded AUCs of 0.87 (95% CI 0.75 to 0.99), 0.87 (95% CI 0.76 to 0.98) and 0.90 (95% CI 0.80 to 0.99) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting preterm preeclampsia, the performance of MAP and PlGF was similar.Conclusion MAP is a good predictor for preeclampsia, especially term preeclampsia, in Asian women. Medicine R Jun Zhang verfasserin aut Kok Hian Tan verfasserin aut Bernard Chern verfasserin aut Nurul Syaza Razali verfasserin aut In BMJ Open BMJ Publishing Group, 2011 11(2021), 8 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:11 year:2021 number:8 https://doi.org/10.1136/bmjopen-2020-046161 kostenfrei https://doaj.org/article/1ddac472f9b14bd48638425dea3aa15d kostenfrei https://bmjopen.bmj.com/content/11/8/e046161.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 8
allfields_unstemmed	10.1136/bmjopen-2020-046161 doi (DE-627)DOAJ008612277 (DE-599)DOAJ1ddac472f9b14bd48638425dea3aa15d DE-627 ger DE-627 rakwb eng Jing Zhu verfasserin aut Mean arterial pressure for predicting preeclampsia in Asian women: a longitudinal cohort study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective Previous studies suggested mean arterial pressure (MAP) had moderate predictive values in the first and second trimesters for the prediction of preeclampsia. However, the performance of MAP in Asian women is still unclear. The objective of this study was to examine the predictive values of MAP in Asian population throughout gestation, and to compare the performance of MAP, angiogenic factors and uterine artery Doppler in the prediction of preeclampsia.Design A prospective cohort study.Setting KK Women’s and Children’s Hospital, Singapore.Participants A total of 926 women with singleton pregnancy less than 14 weeks of gestation were included in the prospective Neonatal and Obstetrics Risks Assessment cohort between September 2010 and October 2014. Maternal blood pressure levels, uterine artery pulsatility index (UtA-PI), serum soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF) and sFlt-1/PlGF ratio were measured at 11–14, 18–22, 28–32 and 34 weeks onward, respectively.Primary and secondary outcomes Preeclampsia was the main pregnancy outcome.Results A total of 20 women developed preeclampsia, who had significantly lower levels of PlGF, higher levels of sFlt-1/PlGF ratio and MAP throughout pregnancy than women without preeclampsia. Compared with angiogenic factors and UtA-PI, MAP had significantly higher area under the receiver operating characteristic curves (AUCs) for predicting preeclampsia and term preeclampsia throughout gestation. For predicting preeclampsia, MAP had AUCs of 0.86 (95% CI 0.78 to 0.95), 0.87 (95% CI 0.80 to 0.95) and 0.91 (95% CI 0.85 to 0.98) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting term preeclampsia, MAP yielded AUCs of 0.87 (95% CI 0.75 to 0.99), 0.87 (95% CI 0.76 to 0.98) and 0.90 (95% CI 0.80 to 0.99) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting preterm preeclampsia, the performance of MAP and PlGF was similar.Conclusion MAP is a good predictor for preeclampsia, especially term preeclampsia, in Asian women. Medicine R Jun Zhang verfasserin aut Kok Hian Tan verfasserin aut Bernard Chern verfasserin aut Nurul Syaza Razali verfasserin aut In BMJ Open BMJ Publishing Group, 2011 11(2021), 8 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:11 year:2021 number:8 https://doi.org/10.1136/bmjopen-2020-046161 kostenfrei https://doaj.org/article/1ddac472f9b14bd48638425dea3aa15d kostenfrei https://bmjopen.bmj.com/content/11/8/e046161.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 8
allfieldsGer	10.1136/bmjopen-2020-046161 doi (DE-627)DOAJ008612277 (DE-599)DOAJ1ddac472f9b14bd48638425dea3aa15d DE-627 ger DE-627 rakwb eng Jing Zhu verfasserin aut Mean arterial pressure for predicting preeclampsia in Asian women: a longitudinal cohort study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective Previous studies suggested mean arterial pressure (MAP) had moderate predictive values in the first and second trimesters for the prediction of preeclampsia. However, the performance of MAP in Asian women is still unclear. The objective of this study was to examine the predictive values of MAP in Asian population throughout gestation, and to compare the performance of MAP, angiogenic factors and uterine artery Doppler in the prediction of preeclampsia.Design A prospective cohort study.Setting KK Women’s and Children’s Hospital, Singapore.Participants A total of 926 women with singleton pregnancy less than 14 weeks of gestation were included in the prospective Neonatal and Obstetrics Risks Assessment cohort between September 2010 and October 2014. Maternal blood pressure levels, uterine artery pulsatility index (UtA-PI), serum soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF) and sFlt-1/PlGF ratio were measured at 11–14, 18–22, 28–32 and 34 weeks onward, respectively.Primary and secondary outcomes Preeclampsia was the main pregnancy outcome.Results A total of 20 women developed preeclampsia, who had significantly lower levels of PlGF, higher levels of sFlt-1/PlGF ratio and MAP throughout pregnancy than women without preeclampsia. Compared with angiogenic factors and UtA-PI, MAP had significantly higher area under the receiver operating characteristic curves (AUCs) for predicting preeclampsia and term preeclampsia throughout gestation. For predicting preeclampsia, MAP had AUCs of 0.86 (95% CI 0.78 to 0.95), 0.87 (95% CI 0.80 to 0.95) and 0.91 (95% CI 0.85 to 0.98) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting term preeclampsia, MAP yielded AUCs of 0.87 (95% CI 0.75 to 0.99), 0.87 (95% CI 0.76 to 0.98) and 0.90 (95% CI 0.80 to 0.99) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting preterm preeclampsia, the performance of MAP and PlGF was similar.Conclusion MAP is a good predictor for preeclampsia, especially term preeclampsia, in Asian women. Medicine R Jun Zhang verfasserin aut Kok Hian Tan verfasserin aut Bernard Chern verfasserin aut Nurul Syaza Razali verfasserin aut In BMJ Open BMJ Publishing Group, 2011 11(2021), 8 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:11 year:2021 number:8 https://doi.org/10.1136/bmjopen-2020-046161 kostenfrei https://doaj.org/article/1ddac472f9b14bd48638425dea3aa15d kostenfrei https://bmjopen.bmj.com/content/11/8/e046161.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 8
allfieldsSound	10.1136/bmjopen-2020-046161 doi (DE-627)DOAJ008612277 (DE-599)DOAJ1ddac472f9b14bd48638425dea3aa15d DE-627 ger DE-627 rakwb eng Jing Zhu verfasserin aut Mean arterial pressure for predicting preeclampsia in Asian women: a longitudinal cohort study 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective Previous studies suggested mean arterial pressure (MAP) had moderate predictive values in the first and second trimesters for the prediction of preeclampsia. However, the performance of MAP in Asian women is still unclear. The objective of this study was to examine the predictive values of MAP in Asian population throughout gestation, and to compare the performance of MAP, angiogenic factors and uterine artery Doppler in the prediction of preeclampsia.Design A prospective cohort study.Setting KK Women’s and Children’s Hospital, Singapore.Participants A total of 926 women with singleton pregnancy less than 14 weeks of gestation were included in the prospective Neonatal and Obstetrics Risks Assessment cohort between September 2010 and October 2014. Maternal blood pressure levels, uterine artery pulsatility index (UtA-PI), serum soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF) and sFlt-1/PlGF ratio were measured at 11–14, 18–22, 28–32 and 34 weeks onward, respectively.Primary and secondary outcomes Preeclampsia was the main pregnancy outcome.Results A total of 20 women developed preeclampsia, who had significantly lower levels of PlGF, higher levels of sFlt-1/PlGF ratio and MAP throughout pregnancy than women without preeclampsia. Compared with angiogenic factors and UtA-PI, MAP had significantly higher area under the receiver operating characteristic curves (AUCs) for predicting preeclampsia and term preeclampsia throughout gestation. For predicting preeclampsia, MAP had AUCs of 0.86 (95% CI 0.78 to 0.95), 0.87 (95% CI 0.80 to 0.95) and 0.91 (95% CI 0.85 to 0.98) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting term preeclampsia, MAP yielded AUCs of 0.87 (95% CI 0.75 to 0.99), 0.87 (95% CI 0.76 to 0.98) and 0.90 (95% CI 0.80 to 0.99) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting preterm preeclampsia, the performance of MAP and PlGF was similar.Conclusion MAP is a good predictor for preeclampsia, especially term preeclampsia, in Asian women. Medicine R Jun Zhang verfasserin aut Kok Hian Tan verfasserin aut Bernard Chern verfasserin aut Nurul Syaza Razali verfasserin aut In BMJ Open BMJ Publishing Group, 2011 11(2021), 8 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:11 year:2021 number:8 https://doi.org/10.1136/bmjopen-2020-046161 kostenfrei https://doaj.org/article/1ddac472f9b14bd48638425dea3aa15d kostenfrei https://bmjopen.bmj.com/content/11/8/e046161.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 8
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However, the performance of MAP in Asian women is still unclear. The objective of this study was to examine the predictive values of MAP in Asian population throughout gestation, and to compare the performance of MAP, angiogenic factors and uterine artery Doppler in the prediction of preeclampsia.Design A prospective cohort study.Setting KK Women’s and Children’s Hospital, Singapore.Participants A total of 926 women with singleton pregnancy less than 14 weeks of gestation were included in the prospective Neonatal and Obstetrics Risks Assessment cohort between September 2010 and October 2014. Maternal blood pressure levels, uterine artery pulsatility index (UtA-PI), serum soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF) and sFlt-1/PlGF ratio were measured at 11–14, 18–22, 28–32 and 34 weeks onward, respectively.Primary and secondary outcomes Preeclampsia was the main pregnancy outcome.Results A total of 20 women developed preeclampsia, who had significantly lower levels of PlGF, higher levels of sFlt-1/PlGF ratio and MAP throughout pregnancy than women without preeclampsia. Compared with angiogenic factors and UtA-PI, MAP had significantly higher area under the receiver operating characteristic curves (AUCs) for predicting preeclampsia and term preeclampsia throughout gestation. For predicting preeclampsia, MAP had AUCs of 0.86 (95% CI 0.78 to 0.95), 0.87 (95% CI 0.80 to 0.95) and 0.91 (95% CI 0.85 to 0.98) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting term preeclampsia, MAP yielded AUCs of 0.87 (95% CI 0.75 to 0.99), 0.87 (95% CI 0.76 to 0.98) and 0.90 (95% CI 0.80 to 0.99) at 11–14, 18–22 and 28–32 weeks, respectively. 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spellingShingle	Jing Zhu misc Medicine misc R Mean arterial pressure for predicting preeclampsia in Asian women: a longitudinal cohort study
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title_sort	mean arterial pressure for predicting preeclampsia in asian women: a longitudinal cohort study
title_auth	Mean arterial pressure for predicting preeclampsia in Asian women: a longitudinal cohort study
abstract	Objective Previous studies suggested mean arterial pressure (MAP) had moderate predictive values in the first and second trimesters for the prediction of preeclampsia. However, the performance of MAP in Asian women is still unclear. The objective of this study was to examine the predictive values of MAP in Asian population throughout gestation, and to compare the performance of MAP, angiogenic factors and uterine artery Doppler in the prediction of preeclampsia.Design A prospective cohort study.Setting KK Women’s and Children’s Hospital, Singapore.Participants A total of 926 women with singleton pregnancy less than 14 weeks of gestation were included in the prospective Neonatal and Obstetrics Risks Assessment cohort between September 2010 and October 2014. Maternal blood pressure levels, uterine artery pulsatility index (UtA-PI), serum soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF) and sFlt-1/PlGF ratio were measured at 11–14, 18–22, 28–32 and 34 weeks onward, respectively.Primary and secondary outcomes Preeclampsia was the main pregnancy outcome.Results A total of 20 women developed preeclampsia, who had significantly lower levels of PlGF, higher levels of sFlt-1/PlGF ratio and MAP throughout pregnancy than women without preeclampsia. Compared with angiogenic factors and UtA-PI, MAP had significantly higher area under the receiver operating characteristic curves (AUCs) for predicting preeclampsia and term preeclampsia throughout gestation. For predicting preeclampsia, MAP had AUCs of 0.86 (95% CI 0.78 to 0.95), 0.87 (95% CI 0.80 to 0.95) and 0.91 (95% CI 0.85 to 0.98) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting term preeclampsia, MAP yielded AUCs of 0.87 (95% CI 0.75 to 0.99), 0.87 (95% CI 0.76 to 0.98) and 0.90 (95% CI 0.80 to 0.99) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting preterm preeclampsia, the performance of MAP and PlGF was similar.Conclusion MAP is a good predictor for preeclampsia, especially term preeclampsia, in Asian women.
abstractGer	Objective Previous studies suggested mean arterial pressure (MAP) had moderate predictive values in the first and second trimesters for the prediction of preeclampsia. However, the performance of MAP in Asian women is still unclear. The objective of this study was to examine the predictive values of MAP in Asian population throughout gestation, and to compare the performance of MAP, angiogenic factors and uterine artery Doppler in the prediction of preeclampsia.Design A prospective cohort study.Setting KK Women’s and Children’s Hospital, Singapore.Participants A total of 926 women with singleton pregnancy less than 14 weeks of gestation were included in the prospective Neonatal and Obstetrics Risks Assessment cohort between September 2010 and October 2014. Maternal blood pressure levels, uterine artery pulsatility index (UtA-PI), serum soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF) and sFlt-1/PlGF ratio were measured at 11–14, 18–22, 28–32 and 34 weeks onward, respectively.Primary and secondary outcomes Preeclampsia was the main pregnancy outcome.Results A total of 20 women developed preeclampsia, who had significantly lower levels of PlGF, higher levels of sFlt-1/PlGF ratio and MAP throughout pregnancy than women without preeclampsia. Compared with angiogenic factors and UtA-PI, MAP had significantly higher area under the receiver operating characteristic curves (AUCs) for predicting preeclampsia and term preeclampsia throughout gestation. For predicting preeclampsia, MAP had AUCs of 0.86 (95% CI 0.78 to 0.95), 0.87 (95% CI 0.80 to 0.95) and 0.91 (95% CI 0.85 to 0.98) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting term preeclampsia, MAP yielded AUCs of 0.87 (95% CI 0.75 to 0.99), 0.87 (95% CI 0.76 to 0.98) and 0.90 (95% CI 0.80 to 0.99) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting preterm preeclampsia, the performance of MAP and PlGF was similar.Conclusion MAP is a good predictor for preeclampsia, especially term preeclampsia, in Asian women.
abstract_unstemmed	Objective Previous studies suggested mean arterial pressure (MAP) had moderate predictive values in the first and second trimesters for the prediction of preeclampsia. However, the performance of MAP in Asian women is still unclear. The objective of this study was to examine the predictive values of MAP in Asian population throughout gestation, and to compare the performance of MAP, angiogenic factors and uterine artery Doppler in the prediction of preeclampsia.Design A prospective cohort study.Setting KK Women’s and Children’s Hospital, Singapore.Participants A total of 926 women with singleton pregnancy less than 14 weeks of gestation were included in the prospective Neonatal and Obstetrics Risks Assessment cohort between September 2010 and October 2014. Maternal blood pressure levels, uterine artery pulsatility index (UtA-PI), serum soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF) and sFlt-1/PlGF ratio were measured at 11–14, 18–22, 28–32 and 34 weeks onward, respectively.Primary and secondary outcomes Preeclampsia was the main pregnancy outcome.Results A total of 20 women developed preeclampsia, who had significantly lower levels of PlGF, higher levels of sFlt-1/PlGF ratio and MAP throughout pregnancy than women without preeclampsia. Compared with angiogenic factors and UtA-PI, MAP had significantly higher area under the receiver operating characteristic curves (AUCs) for predicting preeclampsia and term preeclampsia throughout gestation. For predicting preeclampsia, MAP had AUCs of 0.86 (95% CI 0.78 to 0.95), 0.87 (95% CI 0.80 to 0.95) and 0.91 (95% CI 0.85 to 0.98) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting term preeclampsia, MAP yielded AUCs of 0.87 (95% CI 0.75 to 0.99), 0.87 (95% CI 0.76 to 0.98) and 0.90 (95% CI 0.80 to 0.99) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting preterm preeclampsia, the performance of MAP and PlGF was similar.Conclusion MAP is a good predictor for preeclampsia, especially term preeclampsia, in Asian women.
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container_issue	8
title_short	Mean arterial pressure for predicting preeclampsia in Asian women: a longitudinal cohort study
url	https://doi.org/10.1136/bmjopen-2020-046161 https://doaj.org/article/1ddac472f9b14bd48638425dea3aa15d https://bmjopen.bmj.com/content/11/8/e046161.full https://doaj.org/toc/2044-6055
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author2	Jun Zhang Kok Hian Tan Bernard Chern Nurul Syaza Razali
author2Str	Jun Zhang Kok Hian Tan Bernard Chern Nurul Syaza Razali
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doi_str	10.1136/bmjopen-2020-046161
up_date	2024-07-03T19:02:27.614Z
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