MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography
MAL and MyD88 are downstream adaptors of Toll-like receptors (TLR) and the MAL TIR domain forms filaments in vitro, which in turn nucleate the assembly of crystalline arrays of the MyD88 TIR domain. Here, the authors present the structure of these MyD88 TIR crystalline arrays solved by both microcry...
Ausführliche Beschreibung
Autor*in: |
Max T. B. Clabbers [verfasserIn] Susannah Holmes [verfasserIn] Timothy W. Muusse [verfasserIn] Parimala R. Vajjhala [verfasserIn] Sara J. Thygesen [verfasserIn] Alpeshkumar K. Malde [verfasserIn] Dominic J. B. Hunter [verfasserIn] Tristan I. Croll [verfasserIn] Leonie Flueckiger [verfasserIn] Jeffrey D. Nanson [verfasserIn] Md. Habibur Rahaman [verfasserIn] Andrew Aquila [verfasserIn] Mark S. Hunter [verfasserIn] Mengning Liang [verfasserIn] Chun Hong Yoon [verfasserIn] Jingjing Zhao [verfasserIn] Nadia A. Zatsepin [verfasserIn] Brian Abbey [verfasserIn] Emma Sierecki [verfasserIn] Yann Gambin [verfasserIn] Katryn J. Stacey [verfasserIn] Connie Darmanin [verfasserIn] Bostjan Kobe [verfasserIn] Hongyi Xu [verfasserIn] Thomas Ve [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2021 |
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Übergeordnetes Werk: |
In: Nature Communications - Nature Portfolio, 2016, 12(2021), 1, Seite 14 |
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Übergeordnetes Werk: |
volume:12 ; year:2021 ; number:1 ; pages:14 |
Links: |
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DOI / URN: |
10.1038/s41467-021-22590-6 |
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DOAJ008653364 |
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MAL and MyD88 are downstream adaptors of Toll-like receptors (TLR) and the MAL TIR domain forms filaments in vitro, which in turn nucleate the assembly of crystalline arrays of the MyD88 TIR domain. Here, the authors present the structure of these MyD88 TIR crystalline arrays solved by both microcrystal electron diffraction and serial femtosecond crystallography, and they show with mutagenesis experiments that MyD88 interface residues are important for TLR4 signaling in vivo. |
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MAL and MyD88 are downstream adaptors of Toll-like receptors (TLR) and the MAL TIR domain forms filaments in vitro, which in turn nucleate the assembly of crystalline arrays of the MyD88 TIR domain. Here, the authors present the structure of these MyD88 TIR crystalline arrays solved by both microcrystal electron diffraction and serial femtosecond crystallography, and they show with mutagenesis experiments that MyD88 interface residues are important for TLR4 signaling in vivo. |
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MAL and MyD88 are downstream adaptors of Toll-like receptors (TLR) and the MAL TIR domain forms filaments in vitro, which in turn nucleate the assembly of crystalline arrays of the MyD88 TIR domain. Here, the authors present the structure of these MyD88 TIR crystalline arrays solved by both microcrystal electron diffraction and serial femtosecond crystallography, and they show with mutagenesis experiments that MyD88 interface residues are important for TLR4 signaling in vivo. |
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Here, the authors present the structure of these MyD88 TIR crystalline arrays solved by both microcrystal electron diffraction and serial femtosecond crystallography, and they show with mutagenesis experiments that MyD88 interface residues are important for TLR4 signaling in vivo.</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Science</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Q</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Susannah Holmes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Timothy W. Muusse</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Parimala R. Vajjhala</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sara J. Thygesen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alpeshkumar K. Malde</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Dominic J. B. Hunter</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tristan I. 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