Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells

2-Cys peroxiredoxin (Prx) enzymes are highly expressed in most cancers but how they promote cancer progression is unclear. Here the authors show that in colorectal cancers with APC mutation, PrxII binds to tankyrase and prevents its oxidative inactivation, thereby preventing Axin1-dependent degradat...
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Autor*in:	Dong Hoon Kang [verfasserIn] Doo Jae Lee [verfasserIn] Sunmi Lee [verfasserIn] So-Young Lee [verfasserIn] Yukyung Jun [verfasserIn] Yerin Kim [verfasserIn] Youngeun Kim [verfasserIn] Ju-Seog Lee [verfasserIn] Dae-Kee Lee [verfasserIn] Sanghyuk Lee [verfasserIn] Eek-Hoon Jho [verfasserIn] Dae-Yeul Yu [verfasserIn] Sang Won Kang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 8(2017), 1, Seite 15
Übergeordnetes Werk:	volume:8 ; year:2017 ; number:1 ; pages:15

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-017-00054-0

Katalog-ID:	DOAJ008796246

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source	In Nature Communications 8(2017), 1, Seite 15 volume:8 year:2017 number:1 pages:15
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author	Dong Hoon Kang
spellingShingle	Dong Hoon Kang misc Science misc Q Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells
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topic_title	Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells
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title	Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells
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title_full	Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells
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author_browse	Dong Hoon Kang Doo Jae Lee Sunmi Lee So-Young Lee Yukyung Jun Yerin Kim Youngeun Kim Ju-Seog Lee Dae-Kee Lee Sanghyuk Lee Eek-Hoon Jho Dae-Yeul Yu Sang Won Kang
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title_sort	interaction of tankyrase and peroxiredoxin ii is indispensable for the survival of colorectal cancer cells
title_auth	Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells
abstract	2-Cys peroxiredoxin (Prx) enzymes are highly expressed in most cancers but how they promote cancer progression is unclear. Here the authors show that in colorectal cancers with APC mutation, PrxII binds to tankyrase and prevents its oxidative inactivation, thereby preventing Axin1-dependent degradation of ²b-catenin.
abstractGer	2-Cys peroxiredoxin (Prx) enzymes are highly expressed in most cancers but how they promote cancer progression is unclear. Here the authors show that in colorectal cancers with APC mutation, PrxII binds to tankyrase and prevents its oxidative inactivation, thereby preventing Axin1-dependent degradation of ²b-catenin.
abstract_unstemmed	2-Cys peroxiredoxin (Prx) enzymes are highly expressed in most cancers but how they promote cancer progression is unclear. Here the authors show that in colorectal cancers with APC mutation, PrxII binds to tankyrase and prevents its oxidative inactivation, thereby preventing Axin1-dependent degradation of ²b-catenin.
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title_short	Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells
url	https://doi.org/10.1038/s41467-017-00054-0 https://doaj.org/article/e27578deda874e92af1b15fb7b61a1bd https://doaj.org/toc/2041-1723
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up_date	2024-07-03T20:10:50.757Z
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Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells

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