Human organoid biofilm model for assessing antibiofilm activity of novel agents
Abstract Bacterial biofilms cause 65% of all human infections and are highly resistant to antibiotic therapy but lack specific treatments. To provide a human organoid model for studying host-microbe interplay and enabling screening for novel antibiofilm agents, a human epidermis organoid model with...
Ausführliche Beschreibung
Autor*in: |
Bing (Catherine) Wu [verfasserIn] Evan F. Haney [verfasserIn] Noushin Akhoundsadegh [verfasserIn] Daniel Pletzer [verfasserIn] Michael J. Trimble [verfasserIn] Alwin E. Adriaans [verfasserIn] Peter H. Nibbering [verfasserIn] Robert E. W. Hancock [verfasserIn] |
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E-Artikel |
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Englisch |
Erschienen: |
2021 |
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Übergeordnetes Werk: |
In: npj Biofilms and Microbiomes - Nature Portfolio, 2016, 7(2021), 1, Seite 13 |
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Übergeordnetes Werk: |
volume:7 ; year:2021 ; number:1 ; pages:13 |
Links: |
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DOI / URN: |
10.1038/s41522-020-00182-4 |
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Katalog-ID: |
DOAJ008797684 |
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10.1038/s41522-020-00182-4 doi (DE-627)DOAJ008797684 (DE-599)DOAJ6edc97ff207d4c43ab33703f19b764a3 DE-627 ger DE-627 rakwb eng QR100-130 Bing (Catherine) Wu verfasserin aut Human organoid biofilm model for assessing antibiofilm activity of novel agents 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Bacterial biofilms cause 65% of all human infections and are highly resistant to antibiotic therapy but lack specific treatments. To provide a human organoid model for studying host-microbe interplay and enabling screening for novel antibiofilm agents, a human epidermis organoid model with robust methicillin-resistant Staphylococcus aureus (MRSA) USA300 and Pseudomonas aeruginosa PAO1 biofilm was developed. Treatment of 1-day and 3-day MRSA and PAO1 biofilms with antibiofilm peptide DJK-5 significantly and substantially reduced the bacterial burden. This model enabled the screening of synthetic host defense peptides, revealing their superior antibiofilm activity against MRSA compared to the antibiotic mupirocin. The model was extended to evaluate thermally wounded skin infected with MRSA biofilms resulting in increased bacterial load, cytotoxicity, and pro-inflammatory cytokine levels that were all reduced upon treatment with DJK-5. Combination treatment of DJK-5 with an anti-inflammatory peptide, 1002, further reduced cytotoxicity and skin inflammation. Microbial ecology Evan F. Haney verfasserin aut Noushin Akhoundsadegh verfasserin aut Daniel Pletzer verfasserin aut Michael J. Trimble verfasserin aut Alwin E. Adriaans verfasserin aut Peter H. Nibbering verfasserin aut Robert E. W. Hancock verfasserin aut In npj Biofilms and Microbiomes Nature Portfolio, 2016 7(2021), 1, Seite 13 (DE-627)821807315 (DE-600)2817021-0 20555008 nnns volume:7 year:2021 number:1 pages:13 https://doi.org/10.1038/s41522-020-00182-4 kostenfrei https://doaj.org/article/6edc97ff207d4c43ab33703f19b764a3 kostenfrei https://doi.org/10.1038/s41522-020-00182-4 kostenfrei https://doaj.org/toc/2055-5008 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 1 13 |
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10.1038/s41522-020-00182-4 doi (DE-627)DOAJ008797684 (DE-599)DOAJ6edc97ff207d4c43ab33703f19b764a3 DE-627 ger DE-627 rakwb eng QR100-130 Bing (Catherine) Wu verfasserin aut Human organoid biofilm model for assessing antibiofilm activity of novel agents 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Bacterial biofilms cause 65% of all human infections and are highly resistant to antibiotic therapy but lack specific treatments. To provide a human organoid model for studying host-microbe interplay and enabling screening for novel antibiofilm agents, a human epidermis organoid model with robust methicillin-resistant Staphylococcus aureus (MRSA) USA300 and Pseudomonas aeruginosa PAO1 biofilm was developed. Treatment of 1-day and 3-day MRSA and PAO1 biofilms with antibiofilm peptide DJK-5 significantly and substantially reduced the bacterial burden. This model enabled the screening of synthetic host defense peptides, revealing their superior antibiofilm activity against MRSA compared to the antibiotic mupirocin. The model was extended to evaluate thermally wounded skin infected with MRSA biofilms resulting in increased bacterial load, cytotoxicity, and pro-inflammatory cytokine levels that were all reduced upon treatment with DJK-5. Combination treatment of DJK-5 with an anti-inflammatory peptide, 1002, further reduced cytotoxicity and skin inflammation. Microbial ecology Evan F. Haney verfasserin aut Noushin Akhoundsadegh verfasserin aut Daniel Pletzer verfasserin aut Michael J. Trimble verfasserin aut Alwin E. Adriaans verfasserin aut Peter H. Nibbering verfasserin aut Robert E. W. Hancock verfasserin aut In npj Biofilms and Microbiomes Nature Portfolio, 2016 7(2021), 1, Seite 13 (DE-627)821807315 (DE-600)2817021-0 20555008 nnns volume:7 year:2021 number:1 pages:13 https://doi.org/10.1038/s41522-020-00182-4 kostenfrei https://doaj.org/article/6edc97ff207d4c43ab33703f19b764a3 kostenfrei https://doi.org/10.1038/s41522-020-00182-4 kostenfrei https://doaj.org/toc/2055-5008 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2021 1 13 |
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Abstract Bacterial biofilms cause 65% of all human infections and are highly resistant to antibiotic therapy but lack specific treatments. To provide a human organoid model for studying host-microbe interplay and enabling screening for novel antibiofilm agents, a human epidermis organoid model with robust methicillin-resistant Staphylococcus aureus (MRSA) USA300 and Pseudomonas aeruginosa PAO1 biofilm was developed. Treatment of 1-day and 3-day MRSA and PAO1 biofilms with antibiofilm peptide DJK-5 significantly and substantially reduced the bacterial burden. This model enabled the screening of synthetic host defense peptides, revealing their superior antibiofilm activity against MRSA compared to the antibiotic mupirocin. The model was extended to evaluate thermally wounded skin infected with MRSA biofilms resulting in increased bacterial load, cytotoxicity, and pro-inflammatory cytokine levels that were all reduced upon treatment with DJK-5. Combination treatment of DJK-5 with an anti-inflammatory peptide, 1002, further reduced cytotoxicity and skin inflammation. |
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Abstract Bacterial biofilms cause 65% of all human infections and are highly resistant to antibiotic therapy but lack specific treatments. To provide a human organoid model for studying host-microbe interplay and enabling screening for novel antibiofilm agents, a human epidermis organoid model with robust methicillin-resistant Staphylococcus aureus (MRSA) USA300 and Pseudomonas aeruginosa PAO1 biofilm was developed. Treatment of 1-day and 3-day MRSA and PAO1 biofilms with antibiofilm peptide DJK-5 significantly and substantially reduced the bacterial burden. This model enabled the screening of synthetic host defense peptides, revealing their superior antibiofilm activity against MRSA compared to the antibiotic mupirocin. The model was extended to evaluate thermally wounded skin infected with MRSA biofilms resulting in increased bacterial load, cytotoxicity, and pro-inflammatory cytokine levels that were all reduced upon treatment with DJK-5. Combination treatment of DJK-5 with an anti-inflammatory peptide, 1002, further reduced cytotoxicity and skin inflammation. |
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Abstract Bacterial biofilms cause 65% of all human infections and are highly resistant to antibiotic therapy but lack specific treatments. To provide a human organoid model for studying host-microbe interplay and enabling screening for novel antibiofilm agents, a human epidermis organoid model with robust methicillin-resistant Staphylococcus aureus (MRSA) USA300 and Pseudomonas aeruginosa PAO1 biofilm was developed. Treatment of 1-day and 3-day MRSA and PAO1 biofilms with antibiofilm peptide DJK-5 significantly and substantially reduced the bacterial burden. This model enabled the screening of synthetic host defense peptides, revealing their superior antibiofilm activity against MRSA compared to the antibiotic mupirocin. The model was extended to evaluate thermally wounded skin infected with MRSA biofilms resulting in increased bacterial load, cytotoxicity, and pro-inflammatory cytokine levels that were all reduced upon treatment with DJK-5. Combination treatment of DJK-5 with an anti-inflammatory peptide, 1002, further reduced cytotoxicity and skin inflammation. |
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