Altered arginine metabolism in colon cancer: A sign of increased proliferative potential of tumor-adjacent tissue

Colorectal cancer (CRC) is one of the most frequent forms of malignant tumors in the human population. The literature data about the role of arginine metabolism in CRC point out its double-faced role. In three tissue specimens of 50 patients who underwent surgical resection for colon adenocarcinoma...
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Autor*in:	Branković Branko [verfasserIn] Stanojević Goran [verfasserIn] Veljković Andrej [verfasserIn] Kocić Gordana [verfasserIn] Nestorović Milica [verfasserIn] Đinđić Boris [verfasserIn] Bašić Jelena [verfasserIn] Stojanović Ivana [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	colon cancer arginine arginase polyamines nitric oxide

Übergeordnetes Werk:	In: Archives of Biological Sciences - University of Belgrade, University of Novi Sad, 2010, 74(2022), 3, Seite 243-250
Übergeordnetes Werk:	volume:74 ; year:2022 ; number:3 ; pages:243-250

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.2298/ABS220531023B

Katalog-ID:	DOAJ008868123

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520			\|a Colorectal cancer (CRC) is one of the most frequent forms of malignant tumors in the human population. The literature data about the role of arginine metabolism in CRC point out its double-faced role. In three tissue specimens of 50 patients who underwent surgical resection for colon adenocarcinoma (tumor, adjacent and healthy tissues more than 10 cm from the tumor border – at the incision margin) taken during surgery, polyamines and the concentration of NO2+NO3 and arginase activity were determined. Polyamine levels and arginase activity were significantly increased in cancer and adjacent tissue specimens compared to healthy ones, while the level of NO2+NO3 was significantly lower in cancer compared to both adjacent and healthy tissues. The high polyamine content in the adjacent colonic mucosa indicates a high proliferative potential of tumor-adjacent tissue. Although we found individual correlations indicating the possible prognostic value of arginase, the performed statistical analysis did not show a predictive significance of arginase activity in the examined tissue specimens for five-year survival of the patients. Nevertheless, the obtained results provide the rationale for further studies of arginine metabolism in tissue specimens after surgery in patients with CRC, which could be useful in the evaluation of the risk for tumor growth, recurrence, metastases and survival after surgical intervention.
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author	Branković Branko
spellingShingle	Branković Branko misc QH301-705.5 misc colon cancer misc arginine misc arginase misc polyamines misc nitric oxide misc Biology (General) Altered arginine metabolism in colon cancer: A sign of increased proliferative potential of tumor-adjacent tissue
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topic_title	QH301-705.5 Altered arginine metabolism in colon cancer: A sign of increased proliferative potential of tumor-adjacent tissue colon cancer arginine arginase polyamines nitric oxide
topic	misc QH301-705.5 misc colon cancer misc arginine misc arginase misc polyamines misc nitric oxide misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc colon cancer misc arginine misc arginase misc polyamines misc nitric oxide misc Biology (General)
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title	Altered arginine metabolism in colon cancer: A sign of increased proliferative potential of tumor-adjacent tissue
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title_full	Altered arginine metabolism in colon cancer: A sign of increased proliferative potential of tumor-adjacent tissue
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title_sort	altered arginine metabolism in colon cancer: a sign of increased proliferative potential of tumor-adjacent tissue
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title_auth	Altered arginine metabolism in colon cancer: A sign of increased proliferative potential of tumor-adjacent tissue
abstract	Colorectal cancer (CRC) is one of the most frequent forms of malignant tumors in the human population. The literature data about the role of arginine metabolism in CRC point out its double-faced role. In three tissue specimens of 50 patients who underwent surgical resection for colon adenocarcinoma (tumor, adjacent and healthy tissues more than 10 cm from the tumor border – at the incision margin) taken during surgery, polyamines and the concentration of NO2+NO3 and arginase activity were determined. Polyamine levels and arginase activity were significantly increased in cancer and adjacent tissue specimens compared to healthy ones, while the level of NO2+NO3 was significantly lower in cancer compared to both adjacent and healthy tissues. The high polyamine content in the adjacent colonic mucosa indicates a high proliferative potential of tumor-adjacent tissue. Although we found individual correlations indicating the possible prognostic value of arginase, the performed statistical analysis did not show a predictive significance of arginase activity in the examined tissue specimens for five-year survival of the patients. Nevertheless, the obtained results provide the rationale for further studies of arginine metabolism in tissue specimens after surgery in patients with CRC, which could be useful in the evaluation of the risk for tumor growth, recurrence, metastases and survival after surgical intervention.
abstractGer	Colorectal cancer (CRC) is one of the most frequent forms of malignant tumors in the human population. The literature data about the role of arginine metabolism in CRC point out its double-faced role. In three tissue specimens of 50 patients who underwent surgical resection for colon adenocarcinoma (tumor, adjacent and healthy tissues more than 10 cm from the tumor border – at the incision margin) taken during surgery, polyamines and the concentration of NO2+NO3 and arginase activity were determined. Polyamine levels and arginase activity were significantly increased in cancer and adjacent tissue specimens compared to healthy ones, while the level of NO2+NO3 was significantly lower in cancer compared to both adjacent and healthy tissues. The high polyamine content in the adjacent colonic mucosa indicates a high proliferative potential of tumor-adjacent tissue. Although we found individual correlations indicating the possible prognostic value of arginase, the performed statistical analysis did not show a predictive significance of arginase activity in the examined tissue specimens for five-year survival of the patients. Nevertheless, the obtained results provide the rationale for further studies of arginine metabolism in tissue specimens after surgery in patients with CRC, which could be useful in the evaluation of the risk for tumor growth, recurrence, metastases and survival after surgical intervention.
abstract_unstemmed	Colorectal cancer (CRC) is one of the most frequent forms of malignant tumors in the human population. The literature data about the role of arginine metabolism in CRC point out its double-faced role. In three tissue specimens of 50 patients who underwent surgical resection for colon adenocarcinoma (tumor, adjacent and healthy tissues more than 10 cm from the tumor border – at the incision margin) taken during surgery, polyamines and the concentration of NO2+NO3 and arginase activity were determined. Polyamine levels and arginase activity were significantly increased in cancer and adjacent tissue specimens compared to healthy ones, while the level of NO2+NO3 was significantly lower in cancer compared to both adjacent and healthy tissues. The high polyamine content in the adjacent colonic mucosa indicates a high proliferative potential of tumor-adjacent tissue. Although we found individual correlations indicating the possible prognostic value of arginase, the performed statistical analysis did not show a predictive significance of arginase activity in the examined tissue specimens for five-year survival of the patients. Nevertheless, the obtained results provide the rationale for further studies of arginine metabolism in tissue specimens after surgery in patients with CRC, which could be useful in the evaluation of the risk for tumor growth, recurrence, metastases and survival after surgical intervention.
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title_short	Altered arginine metabolism in colon cancer: A sign of increased proliferative potential of tumor-adjacent tissue
url	https://doi.org/10.2298/ABS220531023B https://doaj.org/article/3f641ff043d340c9b14e53ec1a071b78 http://www.doiserbia.nb.rs/img/doi/0354-4664/2022/0354-46642200023B.pdf https://doaj.org/toc/0354-4664 https://doaj.org/toc/1821-4339
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author2	Stanojević Goran Veljković Andrej Kocić Gordana Nestorović Milica Đinđić Boris Bašić Jelena Stojanović Ivana
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up_date	2024-07-03T20:36:34.758Z
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Altered arginine metabolism in colon cancer: A sign of increased proliferative potential of tumor-adjacent tissue

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