Altered arginine metabolism in colon cancer: A sign of increased proliferative potential of tumor-adjacent tissue
Colorectal cancer (CRC) is one of the most frequent forms of malignant tumors in the human population. The literature data about the role of arginine metabolism in CRC point out its double-faced role. In three tissue specimens of 50 patients who underwent surgical resection for colon adenocarcinoma...
Ausführliche Beschreibung
Autor*in: |
Branković Branko [verfasserIn] Stanojević Goran [verfasserIn] Veljković Andrej [verfasserIn] Kocić Gordana [verfasserIn] Nestorović Milica [verfasserIn] Đinđić Boris [verfasserIn] Bašić Jelena [verfasserIn] Stojanović Ivana [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Archives of Biological Sciences - University of Belgrade, University of Novi Sad, 2010, 74(2022), 3, Seite 243-250 |
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Übergeordnetes Werk: |
volume:74 ; year:2022 ; number:3 ; pages:243-250 |
Links: |
Link aufrufen |
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DOI / URN: |
10.2298/ABS220531023B |
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Katalog-ID: |
DOAJ008868123 |
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10.2298/ABS220531023B doi (DE-627)DOAJ008868123 (DE-599)DOAJ3f641ff043d340c9b14e53ec1a071b78 DE-627 ger DE-627 rakwb eng QH301-705.5 Branković Branko verfasserin aut Altered arginine metabolism in colon cancer: A sign of increased proliferative potential of tumor-adjacent tissue 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Colorectal cancer (CRC) is one of the most frequent forms of malignant tumors in the human population. The literature data about the role of arginine metabolism in CRC point out its double-faced role. In three tissue specimens of 50 patients who underwent surgical resection for colon adenocarcinoma (tumor, adjacent and healthy tissues more than 10 cm from the tumor border – at the incision margin) taken during surgery, polyamines and the concentration of NO2+NO3 and arginase activity were determined. Polyamine levels and arginase activity were significantly increased in cancer and adjacent tissue specimens compared to healthy ones, while the level of NO2+NO3 was significantly lower in cancer compared to both adjacent and healthy tissues. The high polyamine content in the adjacent colonic mucosa indicates a high proliferative potential of tumor-adjacent tissue. Although we found individual correlations indicating the possible prognostic value of arginase, the performed statistical analysis did not show a predictive significance of arginase activity in the examined tissue specimens for five-year survival of the patients. Nevertheless, the obtained results provide the rationale for further studies of arginine metabolism in tissue specimens after surgery in patients with CRC, which could be useful in the evaluation of the risk for tumor growth, recurrence, metastases and survival after surgical intervention. colon cancer arginine arginase polyamines nitric oxide Biology (General) Stanojević Goran verfasserin aut Veljković Andrej verfasserin aut Kocić Gordana verfasserin aut Nestorović Milica verfasserin aut Đinđić Boris verfasserin aut Bašić Jelena verfasserin aut Stojanović Ivana verfasserin aut In Archives of Biological Sciences University of Belgrade, University of Novi Sad, 2010 74(2022), 3, Seite 243-250 (DE-627)538998008 (DE-600)2380842-1 18214339 nnns volume:74 year:2022 number:3 pages:243-250 https://doi.org/10.2298/ABS220531023B kostenfrei https://doaj.org/article/3f641ff043d340c9b14e53ec1a071b78 kostenfrei http://www.doiserbia.nb.rs/img/doi/0354-4664/2022/0354-46642200023B.pdf kostenfrei https://doaj.org/toc/0354-4664 Journal toc kostenfrei https://doaj.org/toc/1821-4339 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 74 2022 3 243-250 |
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10.2298/ABS220531023B doi (DE-627)DOAJ008868123 (DE-599)DOAJ3f641ff043d340c9b14e53ec1a071b78 DE-627 ger DE-627 rakwb eng QH301-705.5 Branković Branko verfasserin aut Altered arginine metabolism in colon cancer: A sign of increased proliferative potential of tumor-adjacent tissue 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Colorectal cancer (CRC) is one of the most frequent forms of malignant tumors in the human population. The literature data about the role of arginine metabolism in CRC point out its double-faced role. In three tissue specimens of 50 patients who underwent surgical resection for colon adenocarcinoma (tumor, adjacent and healthy tissues more than 10 cm from the tumor border – at the incision margin) taken during surgery, polyamines and the concentration of NO2+NO3 and arginase activity were determined. Polyamine levels and arginase activity were significantly increased in cancer and adjacent tissue specimens compared to healthy ones, while the level of NO2+NO3 was significantly lower in cancer compared to both adjacent and healthy tissues. The high polyamine content in the adjacent colonic mucosa indicates a high proliferative potential of tumor-adjacent tissue. Although we found individual correlations indicating the possible prognostic value of arginase, the performed statistical analysis did not show a predictive significance of arginase activity in the examined tissue specimens for five-year survival of the patients. Nevertheless, the obtained results provide the rationale for further studies of arginine metabolism in tissue specimens after surgery in patients with CRC, which could be useful in the evaluation of the risk for tumor growth, recurrence, metastases and survival after surgical intervention. colon cancer arginine arginase polyamines nitric oxide Biology (General) Stanojević Goran verfasserin aut Veljković Andrej verfasserin aut Kocić Gordana verfasserin aut Nestorović Milica verfasserin aut Đinđić Boris verfasserin aut Bašić Jelena verfasserin aut Stojanović Ivana verfasserin aut In Archives of Biological Sciences University of Belgrade, University of Novi Sad, 2010 74(2022), 3, Seite 243-250 (DE-627)538998008 (DE-600)2380842-1 18214339 nnns volume:74 year:2022 number:3 pages:243-250 https://doi.org/10.2298/ABS220531023B kostenfrei https://doaj.org/article/3f641ff043d340c9b14e53ec1a071b78 kostenfrei http://www.doiserbia.nb.rs/img/doi/0354-4664/2022/0354-46642200023B.pdf kostenfrei https://doaj.org/toc/0354-4664 Journal toc kostenfrei https://doaj.org/toc/1821-4339 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 74 2022 3 243-250 |
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Colorectal cancer (CRC) is one of the most frequent forms of malignant tumors in the human population. The literature data about the role of arginine metabolism in CRC point out its double-faced role. In three tissue specimens of 50 patients who underwent surgical resection for colon adenocarcinoma (tumor, adjacent and healthy tissues more than 10 cm from the tumor border – at the incision margin) taken during surgery, polyamines and the concentration of NO2+NO3 and arginase activity were determined. Polyamine levels and arginase activity were significantly increased in cancer and adjacent tissue specimens compared to healthy ones, while the level of NO2+NO3 was significantly lower in cancer compared to both adjacent and healthy tissues. The high polyamine content in the adjacent colonic mucosa indicates a high proliferative potential of tumor-adjacent tissue. Although we found individual correlations indicating the possible prognostic value of arginase, the performed statistical analysis did not show a predictive significance of arginase activity in the examined tissue specimens for five-year survival of the patients. Nevertheless, the obtained results provide the rationale for further studies of arginine metabolism in tissue specimens after surgery in patients with CRC, which could be useful in the evaluation of the risk for tumor growth, recurrence, metastases and survival after surgical intervention. |
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Colorectal cancer (CRC) is one of the most frequent forms of malignant tumors in the human population. The literature data about the role of arginine metabolism in CRC point out its double-faced role. In three tissue specimens of 50 patients who underwent surgical resection for colon adenocarcinoma (tumor, adjacent and healthy tissues more than 10 cm from the tumor border – at the incision margin) taken during surgery, polyamines and the concentration of NO2+NO3 and arginase activity were determined. Polyamine levels and arginase activity were significantly increased in cancer and adjacent tissue specimens compared to healthy ones, while the level of NO2+NO3 was significantly lower in cancer compared to both adjacent and healthy tissues. The high polyamine content in the adjacent colonic mucosa indicates a high proliferative potential of tumor-adjacent tissue. Although we found individual correlations indicating the possible prognostic value of arginase, the performed statistical analysis did not show a predictive significance of arginase activity in the examined tissue specimens for five-year survival of the patients. Nevertheless, the obtained results provide the rationale for further studies of arginine metabolism in tissue specimens after surgery in patients with CRC, which could be useful in the evaluation of the risk for tumor growth, recurrence, metastases and survival after surgical intervention. |
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Colorectal cancer (CRC) is one of the most frequent forms of malignant tumors in the human population. The literature data about the role of arginine metabolism in CRC point out its double-faced role. In three tissue specimens of 50 patients who underwent surgical resection for colon adenocarcinoma (tumor, adjacent and healthy tissues more than 10 cm from the tumor border – at the incision margin) taken during surgery, polyamines and the concentration of NO2+NO3 and arginase activity were determined. Polyamine levels and arginase activity were significantly increased in cancer and adjacent tissue specimens compared to healthy ones, while the level of NO2+NO3 was significantly lower in cancer compared to both adjacent and healthy tissues. The high polyamine content in the adjacent colonic mucosa indicates a high proliferative potential of tumor-adjacent tissue. Although we found individual correlations indicating the possible prognostic value of arginase, the performed statistical analysis did not show a predictive significance of arginase activity in the examined tissue specimens for five-year survival of the patients. Nevertheless, the obtained results provide the rationale for further studies of arginine metabolism in tissue specimens after surgery in patients with CRC, which could be useful in the evaluation of the risk for tumor growth, recurrence, metastases and survival after surgical intervention. |
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