Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation

Abstract Isolation on Earth can alter physiology and signaling of organs systems, including the central nervous system. Although not in complete solitude, astronauts operate in an isolated environment during spaceflight. In this study, we determined the effects of isolation and simulated microgravit...
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Autor*in:	Linda Rubinstein [verfasserIn] Ann-Sofie Schreurs [verfasserIn] Samantha M. Torres [verfasserIn] Sonette Steczina [verfasserIn] Moniece G. Lowe [verfasserIn] Frederico Kiffer [verfasserIn] Antiño R. Allen [verfasserIn] April E. Ronca [verfasserIn] Marianne B. Sowa [verfasserIn] Ruth K. Globus [verfasserIn] Candice G. T. Tahimic [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Übergeordnetes Werk:	In: npj Microgravity - Nature Portfolio, 2016, 7(2021), 1, Seite 9
Übergeordnetes Werk:	volume:7 ; year:2021 ; number:1 ; pages:9

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41526-021-00152-w

Katalog-ID:	DOAJ008964343

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callnumber-first	T - Technology
author	Linda Rubinstein
spellingShingle	Linda Rubinstein misc TP248.13-248.65 misc QP1-981 misc Biotechnology misc Physiology Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation
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topic_title	TP248.13-248.65 QP1-981 Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation
topic	misc TP248.13-248.65 misc QP1-981 misc Biotechnology misc Physiology
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title	Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation
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title_full	Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation
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author_browse	Linda Rubinstein Ann-Sofie Schreurs Samantha M. Torres Sonette Steczina Moniece G. Lowe Frederico Kiffer Antiño R. Allen April E. Ronca Marianne B. Sowa Ruth K. Globus Candice G. T. Tahimic
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title_sort	overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation
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title_auth	Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation
abstract	Abstract Isolation on Earth can alter physiology and signaling of organs systems, including the central nervous system. Although not in complete solitude, astronauts operate in an isolated environment during spaceflight. In this study, we determined the effects of isolation and simulated microgravity solely or combined, on the inflammatory cytokine milieu of the hippocampus. Adult female wild-type mice underwent simulated microgravity by hindlimb unloading for 30 days in single or social (paired) housing. In hippocampus, simulated microgravity and isolation each regulate a discrete repertoire of cytokines associated with inflammation. Their combined effects are not additive. A model for mitochondrial reactive oxygen species (ROS) quenching via targeted overexpression of the human catalase gene to the mitochondria (MCAT mice), are protected from isolation- and/or simulated microgravity-induced changes in cytokine expression. These findings suggest a key role for mitochondrial ROS signaling in neuroinflammatory responses to spaceflight and prolonged bedrest, isolation, and confinement on Earth.
abstractGer	Abstract Isolation on Earth can alter physiology and signaling of organs systems, including the central nervous system. Although not in complete solitude, astronauts operate in an isolated environment during spaceflight. In this study, we determined the effects of isolation and simulated microgravity solely or combined, on the inflammatory cytokine milieu of the hippocampus. Adult female wild-type mice underwent simulated microgravity by hindlimb unloading for 30 days in single or social (paired) housing. In hippocampus, simulated microgravity and isolation each regulate a discrete repertoire of cytokines associated with inflammation. Their combined effects are not additive. A model for mitochondrial reactive oxygen species (ROS) quenching via targeted overexpression of the human catalase gene to the mitochondria (MCAT mice), are protected from isolation- and/or simulated microgravity-induced changes in cytokine expression. These findings suggest a key role for mitochondrial ROS signaling in neuroinflammatory responses to spaceflight and prolonged bedrest, isolation, and confinement on Earth.
abstract_unstemmed	Abstract Isolation on Earth can alter physiology and signaling of organs systems, including the central nervous system. Although not in complete solitude, astronauts operate in an isolated environment during spaceflight. In this study, we determined the effects of isolation and simulated microgravity solely or combined, on the inflammatory cytokine milieu of the hippocampus. Adult female wild-type mice underwent simulated microgravity by hindlimb unloading for 30 days in single or social (paired) housing. In hippocampus, simulated microgravity and isolation each regulate a discrete repertoire of cytokines associated with inflammation. Their combined effects are not additive. A model for mitochondrial reactive oxygen species (ROS) quenching via targeted overexpression of the human catalase gene to the mitochondria (MCAT mice), are protected from isolation- and/or simulated microgravity-induced changes in cytokine expression. These findings suggest a key role for mitochondrial ROS signaling in neuroinflammatory responses to spaceflight and prolonged bedrest, isolation, and confinement on Earth.
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title_short	Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation
url	https://doi.org/10.1038/s41526-021-00152-w https://doaj.org/article/3e9da7ae8c2a4834b6f11f00fed4c348 https://doaj.org/toc/2373-8065
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