A dietary intervention to improve the microbiome composition of pregnant women with Crohn's disease and their offspring: The MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial design
Crohn's disease (CD), a type of inflammatory bowel disease (IBD), is a chronic condition of the gastrointestinal tract that is caused by the loss of mucosal tolerance towards the commensal bacteria resulting in inflammatory responses. It has long been postulated that the gut microbiota, a compl...
Ausführliche Beschreibung
Autor*in: |
Inga Peter [verfasserIn] Ana Maldonado-Contreras [verfasserIn] Caroline Eisele [verfasserIn] Christine Frisard [verfasserIn] Shauna Simpson [verfasserIn] Nilendra Nair [verfasserIn] Alexa Rendon [verfasserIn] Kelly Hawkins [verfasserIn] Caitlin Cawley [verfasserIn] Anketse Debebe [verfasserIn] Leonid Tarassishin [verfasserIn] Sierra White [verfasserIn] Marla Dubinsky [verfasserIn] Joanne Stone [verfasserIn] Jose C Clemente [verfasserIn] Joao Sabino [verfasserIn] Joana Torres [verfasserIn] Jianzhong Hu [verfasserIn] Jean-Frederic Columbel [verfasserIn] Barbara Olendzki [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2020 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Contemporary Clinical Trials Communications - Elsevier, 2017, 18(2020), Seite 100573- |
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Übergeordnetes Werk: |
volume:18 ; year:2020 ; pages:100573- |
Links: |
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DOI / URN: |
10.1016/j.conctc.2020.100573 |
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Katalog-ID: |
DOAJ008964580 |
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245 | 1 | 2 | |a A dietary intervention to improve the microbiome composition of pregnant women with Crohn's disease and their offspring: The MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial design |
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520 | |a Crohn's disease (CD), a type of inflammatory bowel disease (IBD), is a chronic condition of the gastrointestinal tract that is caused by the loss of mucosal tolerance towards the commensal bacteria resulting in inflammatory responses. It has long been postulated that the gut microbiota, a complex and dynamic population of microorganisms, plays a key role in the pathogenesis of IBD. Maternal diagnosis of IBD has been identified as the greatest risk factor for IBD in offspring increasing the odds of developing the disease <4.5-fold. Moreover, babies born to mothers with IBD have demonstrated reduced gut bacterial diversity. There is accumulating evidence that the early life microbiota colonization is informed by maternal diet within the 3rd trimester of pregnancy. While babies born to mothers with IBD would pose an ideal cohort for intervention, no primary prevention measures are currently available. Therefore, we designed the MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial to test whether the IBD-AID™ dietary intervention during the last trimester of pregnancy can beneficially shift the microbiome of CD patients and their babies, thereby promoting a strong, effective immune system during a critical time of the immune system development. We will also test if favorable changes in the microbiome can lead to a reduced risk of postpartum CD relapse and lower mucosal inflammation in the offspring. This study will help create new opportunities to foster a healthy microbiome in the offspring at high risk of other immune-mediated diseases, potentially reducing their risk later in life. | ||
650 | 4 | |a Crohn's disease | |
650 | 4 | |a Pregnancy | |
650 | 4 | |a Diet | |
650 | 4 | |a IBD-AID™ | |
650 | 4 | |a Microbiome | |
653 | 0 | |a Medicine (General) | |
700 | 0 | |a Ana Maldonado-Contreras |e verfasserin |4 aut | |
700 | 0 | |a Caroline Eisele |e verfasserin |4 aut | |
700 | 0 | |a Christine Frisard |e verfasserin |4 aut | |
700 | 0 | |a Shauna Simpson |e verfasserin |4 aut | |
700 | 0 | |a Nilendra Nair |e verfasserin |4 aut | |
700 | 0 | |a Alexa Rendon |e verfasserin |4 aut | |
700 | 0 | |a Kelly Hawkins |e verfasserin |4 aut | |
700 | 0 | |a Caitlin Cawley |e verfasserin |4 aut | |
700 | 0 | |a Anketse Debebe |e verfasserin |4 aut | |
700 | 0 | |a Leonid Tarassishin |e verfasserin |4 aut | |
700 | 0 | |a Sierra White |e verfasserin |4 aut | |
700 | 0 | |a Marla Dubinsky |e verfasserin |4 aut | |
700 | 0 | |a Joanne Stone |e verfasserin |4 aut | |
700 | 0 | |a Jose C Clemente |e verfasserin |4 aut | |
700 | 0 | |a Joao Sabino |e verfasserin |4 aut | |
700 | 0 | |a Joana Torres |e verfasserin |4 aut | |
700 | 0 | |a Jianzhong Hu |e verfasserin |4 aut | |
700 | 0 | |a Jean-Frederic Columbel |e verfasserin |4 aut | |
700 | 0 | |a Barbara Olendzki |e verfasserin |4 aut | |
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10.1016/j.conctc.2020.100573 doi (DE-627)DOAJ008964580 (DE-599)DOAJ2a2b2ea8c9854e2195bf70b58b624dcd DE-627 ger DE-627 rakwb eng R5-920 Inga Peter verfasserin aut A dietary intervention to improve the microbiome composition of pregnant women with Crohn's disease and their offspring: The MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial design 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Crohn's disease (CD), a type of inflammatory bowel disease (IBD), is a chronic condition of the gastrointestinal tract that is caused by the loss of mucosal tolerance towards the commensal bacteria resulting in inflammatory responses. It has long been postulated that the gut microbiota, a complex and dynamic population of microorganisms, plays a key role in the pathogenesis of IBD. Maternal diagnosis of IBD has been identified as the greatest risk factor for IBD in offspring increasing the odds of developing the disease <4.5-fold. Moreover, babies born to mothers with IBD have demonstrated reduced gut bacterial diversity. There is accumulating evidence that the early life microbiota colonization is informed by maternal diet within the 3rd trimester of pregnancy. While babies born to mothers with IBD would pose an ideal cohort for intervention, no primary prevention measures are currently available. Therefore, we designed the MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial to test whether the IBD-AID™ dietary intervention during the last trimester of pregnancy can beneficially shift the microbiome of CD patients and their babies, thereby promoting a strong, effective immune system during a critical time of the immune system development. We will also test if favorable changes in the microbiome can lead to a reduced risk of postpartum CD relapse and lower mucosal inflammation in the offspring. This study will help create new opportunities to foster a healthy microbiome in the offspring at high risk of other immune-mediated diseases, potentially reducing their risk later in life. Crohn's disease Pregnancy Diet IBD-AID™ Microbiome Medicine (General) Ana Maldonado-Contreras verfasserin aut Caroline Eisele verfasserin aut Christine Frisard verfasserin aut Shauna Simpson verfasserin aut Nilendra Nair verfasserin aut Alexa Rendon verfasserin aut Kelly Hawkins verfasserin aut Caitlin Cawley verfasserin aut Anketse Debebe verfasserin aut Leonid Tarassishin verfasserin aut Sierra White verfasserin aut Marla Dubinsky verfasserin aut Joanne Stone verfasserin aut Jose C Clemente verfasserin aut Joao Sabino verfasserin aut Joana Torres verfasserin aut Jianzhong Hu verfasserin aut Jean-Frederic Columbel verfasserin aut Barbara Olendzki verfasserin aut In Contemporary Clinical Trials Communications Elsevier, 2017 18(2020), Seite 100573- (DE-627)86138069X (DE-600)2858947-6 24518654 nnns volume:18 year:2020 pages:100573- https://doi.org/10.1016/j.conctc.2020.100573 kostenfrei https://doaj.org/article/2a2b2ea8c9854e2195bf70b58b624dcd kostenfrei http://www.sciencedirect.com/science/article/pii/S2451865420300570 kostenfrei https://doaj.org/toc/2451-8654 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 18 2020 100573- |
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10.1016/j.conctc.2020.100573 doi (DE-627)DOAJ008964580 (DE-599)DOAJ2a2b2ea8c9854e2195bf70b58b624dcd DE-627 ger DE-627 rakwb eng R5-920 Inga Peter verfasserin aut A dietary intervention to improve the microbiome composition of pregnant women with Crohn's disease and their offspring: The MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial design 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Crohn's disease (CD), a type of inflammatory bowel disease (IBD), is a chronic condition of the gastrointestinal tract that is caused by the loss of mucosal tolerance towards the commensal bacteria resulting in inflammatory responses. It has long been postulated that the gut microbiota, a complex and dynamic population of microorganisms, plays a key role in the pathogenesis of IBD. Maternal diagnosis of IBD has been identified as the greatest risk factor for IBD in offspring increasing the odds of developing the disease <4.5-fold. Moreover, babies born to mothers with IBD have demonstrated reduced gut bacterial diversity. There is accumulating evidence that the early life microbiota colonization is informed by maternal diet within the 3rd trimester of pregnancy. While babies born to mothers with IBD would pose an ideal cohort for intervention, no primary prevention measures are currently available. Therefore, we designed the MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial to test whether the IBD-AID™ dietary intervention during the last trimester of pregnancy can beneficially shift the microbiome of CD patients and their babies, thereby promoting a strong, effective immune system during a critical time of the immune system development. We will also test if favorable changes in the microbiome can lead to a reduced risk of postpartum CD relapse and lower mucosal inflammation in the offspring. This study will help create new opportunities to foster a healthy microbiome in the offspring at high risk of other immune-mediated diseases, potentially reducing their risk later in life. Crohn's disease Pregnancy Diet IBD-AID™ Microbiome Medicine (General) Ana Maldonado-Contreras verfasserin aut Caroline Eisele verfasserin aut Christine Frisard verfasserin aut Shauna Simpson verfasserin aut Nilendra Nair verfasserin aut Alexa Rendon verfasserin aut Kelly Hawkins verfasserin aut Caitlin Cawley verfasserin aut Anketse Debebe verfasserin aut Leonid Tarassishin verfasserin aut Sierra White verfasserin aut Marla Dubinsky verfasserin aut Joanne Stone verfasserin aut Jose C Clemente verfasserin aut Joao Sabino verfasserin aut Joana Torres verfasserin aut Jianzhong Hu verfasserin aut Jean-Frederic Columbel verfasserin aut Barbara Olendzki verfasserin aut In Contemporary Clinical Trials Communications Elsevier, 2017 18(2020), Seite 100573- (DE-627)86138069X (DE-600)2858947-6 24518654 nnns volume:18 year:2020 pages:100573- https://doi.org/10.1016/j.conctc.2020.100573 kostenfrei https://doaj.org/article/2a2b2ea8c9854e2195bf70b58b624dcd kostenfrei http://www.sciencedirect.com/science/article/pii/S2451865420300570 kostenfrei https://doaj.org/toc/2451-8654 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 18 2020 100573- |
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10.1016/j.conctc.2020.100573 doi (DE-627)DOAJ008964580 (DE-599)DOAJ2a2b2ea8c9854e2195bf70b58b624dcd DE-627 ger DE-627 rakwb eng R5-920 Inga Peter verfasserin aut A dietary intervention to improve the microbiome composition of pregnant women with Crohn's disease and their offspring: The MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial design 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Crohn's disease (CD), a type of inflammatory bowel disease (IBD), is a chronic condition of the gastrointestinal tract that is caused by the loss of mucosal tolerance towards the commensal bacteria resulting in inflammatory responses. It has long been postulated that the gut microbiota, a complex and dynamic population of microorganisms, plays a key role in the pathogenesis of IBD. Maternal diagnosis of IBD has been identified as the greatest risk factor for IBD in offspring increasing the odds of developing the disease <4.5-fold. Moreover, babies born to mothers with IBD have demonstrated reduced gut bacterial diversity. There is accumulating evidence that the early life microbiota colonization is informed by maternal diet within the 3rd trimester of pregnancy. While babies born to mothers with IBD would pose an ideal cohort for intervention, no primary prevention measures are currently available. Therefore, we designed the MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial to test whether the IBD-AID™ dietary intervention during the last trimester of pregnancy can beneficially shift the microbiome of CD patients and their babies, thereby promoting a strong, effective immune system during a critical time of the immune system development. We will also test if favorable changes in the microbiome can lead to a reduced risk of postpartum CD relapse and lower mucosal inflammation in the offspring. This study will help create new opportunities to foster a healthy microbiome in the offspring at high risk of other immune-mediated diseases, potentially reducing their risk later in life. Crohn's disease Pregnancy Diet IBD-AID™ Microbiome Medicine (General) Ana Maldonado-Contreras verfasserin aut Caroline Eisele verfasserin aut Christine Frisard verfasserin aut Shauna Simpson verfasserin aut Nilendra Nair verfasserin aut Alexa Rendon verfasserin aut Kelly Hawkins verfasserin aut Caitlin Cawley verfasserin aut Anketse Debebe verfasserin aut Leonid Tarassishin verfasserin aut Sierra White verfasserin aut Marla Dubinsky verfasserin aut Joanne Stone verfasserin aut Jose C Clemente verfasserin aut Joao Sabino verfasserin aut Joana Torres verfasserin aut Jianzhong Hu verfasserin aut Jean-Frederic Columbel verfasserin aut Barbara Olendzki verfasserin aut In Contemporary Clinical Trials Communications Elsevier, 2017 18(2020), Seite 100573- (DE-627)86138069X (DE-600)2858947-6 24518654 nnns volume:18 year:2020 pages:100573- https://doi.org/10.1016/j.conctc.2020.100573 kostenfrei https://doaj.org/article/2a2b2ea8c9854e2195bf70b58b624dcd kostenfrei http://www.sciencedirect.com/science/article/pii/S2451865420300570 kostenfrei https://doaj.org/toc/2451-8654 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 18 2020 100573- |
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10.1016/j.conctc.2020.100573 doi (DE-627)DOAJ008964580 (DE-599)DOAJ2a2b2ea8c9854e2195bf70b58b624dcd DE-627 ger DE-627 rakwb eng R5-920 Inga Peter verfasserin aut A dietary intervention to improve the microbiome composition of pregnant women with Crohn's disease and their offspring: The MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial design 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Crohn's disease (CD), a type of inflammatory bowel disease (IBD), is a chronic condition of the gastrointestinal tract that is caused by the loss of mucosal tolerance towards the commensal bacteria resulting in inflammatory responses. It has long been postulated that the gut microbiota, a complex and dynamic population of microorganisms, plays a key role in the pathogenesis of IBD. Maternal diagnosis of IBD has been identified as the greatest risk factor for IBD in offspring increasing the odds of developing the disease <4.5-fold. Moreover, babies born to mothers with IBD have demonstrated reduced gut bacterial diversity. There is accumulating evidence that the early life microbiota colonization is informed by maternal diet within the 3rd trimester of pregnancy. While babies born to mothers with IBD would pose an ideal cohort for intervention, no primary prevention measures are currently available. Therefore, we designed the MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial to test whether the IBD-AID™ dietary intervention during the last trimester of pregnancy can beneficially shift the microbiome of CD patients and their babies, thereby promoting a strong, effective immune system during a critical time of the immune system development. We will also test if favorable changes in the microbiome can lead to a reduced risk of postpartum CD relapse and lower mucosal inflammation in the offspring. This study will help create new opportunities to foster a healthy microbiome in the offspring at high risk of other immune-mediated diseases, potentially reducing their risk later in life. Crohn's disease Pregnancy Diet IBD-AID™ Microbiome Medicine (General) Ana Maldonado-Contreras verfasserin aut Caroline Eisele verfasserin aut Christine Frisard verfasserin aut Shauna Simpson verfasserin aut Nilendra Nair verfasserin aut Alexa Rendon verfasserin aut Kelly Hawkins verfasserin aut Caitlin Cawley verfasserin aut Anketse Debebe verfasserin aut Leonid Tarassishin verfasserin aut Sierra White verfasserin aut Marla Dubinsky verfasserin aut Joanne Stone verfasserin aut Jose C Clemente verfasserin aut Joao Sabino verfasserin aut Joana Torres verfasserin aut Jianzhong Hu verfasserin aut Jean-Frederic Columbel verfasserin aut Barbara Olendzki verfasserin aut In Contemporary Clinical Trials Communications Elsevier, 2017 18(2020), Seite 100573- (DE-627)86138069X (DE-600)2858947-6 24518654 nnns volume:18 year:2020 pages:100573- https://doi.org/10.1016/j.conctc.2020.100573 kostenfrei https://doaj.org/article/2a2b2ea8c9854e2195bf70b58b624dcd kostenfrei http://www.sciencedirect.com/science/article/pii/S2451865420300570 kostenfrei https://doaj.org/toc/2451-8654 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 18 2020 100573- |
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10.1016/j.conctc.2020.100573 doi (DE-627)DOAJ008964580 (DE-599)DOAJ2a2b2ea8c9854e2195bf70b58b624dcd DE-627 ger DE-627 rakwb eng R5-920 Inga Peter verfasserin aut A dietary intervention to improve the microbiome composition of pregnant women with Crohn's disease and their offspring: The MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial design 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Crohn's disease (CD), a type of inflammatory bowel disease (IBD), is a chronic condition of the gastrointestinal tract that is caused by the loss of mucosal tolerance towards the commensal bacteria resulting in inflammatory responses. It has long been postulated that the gut microbiota, a complex and dynamic population of microorganisms, plays a key role in the pathogenesis of IBD. Maternal diagnosis of IBD has been identified as the greatest risk factor for IBD in offspring increasing the odds of developing the disease <4.5-fold. Moreover, babies born to mothers with IBD have demonstrated reduced gut bacterial diversity. There is accumulating evidence that the early life microbiota colonization is informed by maternal diet within the 3rd trimester of pregnancy. While babies born to mothers with IBD would pose an ideal cohort for intervention, no primary prevention measures are currently available. Therefore, we designed the MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial to test whether the IBD-AID™ dietary intervention during the last trimester of pregnancy can beneficially shift the microbiome of CD patients and their babies, thereby promoting a strong, effective immune system during a critical time of the immune system development. We will also test if favorable changes in the microbiome can lead to a reduced risk of postpartum CD relapse and lower mucosal inflammation in the offspring. This study will help create new opportunities to foster a healthy microbiome in the offspring at high risk of other immune-mediated diseases, potentially reducing their risk later in life. Crohn's disease Pregnancy Diet IBD-AID™ Microbiome Medicine (General) Ana Maldonado-Contreras verfasserin aut Caroline Eisele verfasserin aut Christine Frisard verfasserin aut Shauna Simpson verfasserin aut Nilendra Nair verfasserin aut Alexa Rendon verfasserin aut Kelly Hawkins verfasserin aut Caitlin Cawley verfasserin aut Anketse Debebe verfasserin aut Leonid Tarassishin verfasserin aut Sierra White verfasserin aut Marla Dubinsky verfasserin aut Joanne Stone verfasserin aut Jose C Clemente verfasserin aut Joao Sabino verfasserin aut Joana Torres verfasserin aut Jianzhong Hu verfasserin aut Jean-Frederic Columbel verfasserin aut Barbara Olendzki verfasserin aut In Contemporary Clinical Trials Communications Elsevier, 2017 18(2020), Seite 100573- (DE-627)86138069X (DE-600)2858947-6 24518654 nnns volume:18 year:2020 pages:100573- https://doi.org/10.1016/j.conctc.2020.100573 kostenfrei https://doaj.org/article/2a2b2ea8c9854e2195bf70b58b624dcd kostenfrei http://www.sciencedirect.com/science/article/pii/S2451865420300570 kostenfrei https://doaj.org/toc/2451-8654 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 18 2020 100573- |
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Inga Peter @@aut@@ Ana Maldonado-Contreras @@aut@@ Caroline Eisele @@aut@@ Christine Frisard @@aut@@ Shauna Simpson @@aut@@ Nilendra Nair @@aut@@ Alexa Rendon @@aut@@ Kelly Hawkins @@aut@@ Caitlin Cawley @@aut@@ Anketse Debebe @@aut@@ Leonid Tarassishin @@aut@@ Sierra White @@aut@@ Marla Dubinsky @@aut@@ Joanne Stone @@aut@@ Jose C Clemente @@aut@@ Joao Sabino @@aut@@ Joana Torres @@aut@@ Jianzhong Hu @@aut@@ Jean-Frederic Columbel @@aut@@ Barbara Olendzki @@aut@@ |
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Inga Peter misc R5-920 misc Crohn's disease misc Pregnancy misc Diet misc IBD-AID™ misc Microbiome misc Medicine (General) A dietary intervention to improve the microbiome composition of pregnant women with Crohn's disease and their offspring: The MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial design |
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R5-920 A dietary intervention to improve the microbiome composition of pregnant women with Crohn's disease and their offspring: The MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial design Crohn's disease Pregnancy Diet IBD-AID™ Microbiome |
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A dietary intervention to improve the microbiome composition of pregnant women with Crohn's disease and their offspring: The MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial design |
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A dietary intervention to improve the microbiome composition of pregnant women with Crohn's disease and their offspring: The MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial design |
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Inga Peter Ana Maldonado-Contreras Caroline Eisele Christine Frisard Shauna Simpson Nilendra Nair Alexa Rendon Kelly Hawkins Caitlin Cawley Anketse Debebe Leonid Tarassishin Sierra White Marla Dubinsky Joanne Stone Jose C Clemente Joao Sabino Joana Torres Jianzhong Hu Jean-Frederic Columbel Barbara Olendzki |
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dietary intervention to improve the microbiome composition of pregnant women with crohn's disease and their offspring: the melody (modulating early life microbiome through dietary intervention in pregnancy) trial design |
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A dietary intervention to improve the microbiome composition of pregnant women with Crohn's disease and their offspring: The MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial design |
abstract |
Crohn's disease (CD), a type of inflammatory bowel disease (IBD), is a chronic condition of the gastrointestinal tract that is caused by the loss of mucosal tolerance towards the commensal bacteria resulting in inflammatory responses. It has long been postulated that the gut microbiota, a complex and dynamic population of microorganisms, plays a key role in the pathogenesis of IBD. Maternal diagnosis of IBD has been identified as the greatest risk factor for IBD in offspring increasing the odds of developing the disease <4.5-fold. Moreover, babies born to mothers with IBD have demonstrated reduced gut bacterial diversity. There is accumulating evidence that the early life microbiota colonization is informed by maternal diet within the 3rd trimester of pregnancy. While babies born to mothers with IBD would pose an ideal cohort for intervention, no primary prevention measures are currently available. Therefore, we designed the MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial to test whether the IBD-AID™ dietary intervention during the last trimester of pregnancy can beneficially shift the microbiome of CD patients and their babies, thereby promoting a strong, effective immune system during a critical time of the immune system development. We will also test if favorable changes in the microbiome can lead to a reduced risk of postpartum CD relapse and lower mucosal inflammation in the offspring. This study will help create new opportunities to foster a healthy microbiome in the offspring at high risk of other immune-mediated diseases, potentially reducing their risk later in life. |
abstractGer |
Crohn's disease (CD), a type of inflammatory bowel disease (IBD), is a chronic condition of the gastrointestinal tract that is caused by the loss of mucosal tolerance towards the commensal bacteria resulting in inflammatory responses. It has long been postulated that the gut microbiota, a complex and dynamic population of microorganisms, plays a key role in the pathogenesis of IBD. Maternal diagnosis of IBD has been identified as the greatest risk factor for IBD in offspring increasing the odds of developing the disease <4.5-fold. Moreover, babies born to mothers with IBD have demonstrated reduced gut bacterial diversity. There is accumulating evidence that the early life microbiota colonization is informed by maternal diet within the 3rd trimester of pregnancy. While babies born to mothers with IBD would pose an ideal cohort for intervention, no primary prevention measures are currently available. Therefore, we designed the MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial to test whether the IBD-AID™ dietary intervention during the last trimester of pregnancy can beneficially shift the microbiome of CD patients and their babies, thereby promoting a strong, effective immune system during a critical time of the immune system development. We will also test if favorable changes in the microbiome can lead to a reduced risk of postpartum CD relapse and lower mucosal inflammation in the offspring. This study will help create new opportunities to foster a healthy microbiome in the offspring at high risk of other immune-mediated diseases, potentially reducing their risk later in life. |
abstract_unstemmed |
Crohn's disease (CD), a type of inflammatory bowel disease (IBD), is a chronic condition of the gastrointestinal tract that is caused by the loss of mucosal tolerance towards the commensal bacteria resulting in inflammatory responses. It has long been postulated that the gut microbiota, a complex and dynamic population of microorganisms, plays a key role in the pathogenesis of IBD. Maternal diagnosis of IBD has been identified as the greatest risk factor for IBD in offspring increasing the odds of developing the disease <4.5-fold. Moreover, babies born to mothers with IBD have demonstrated reduced gut bacterial diversity. There is accumulating evidence that the early life microbiota colonization is informed by maternal diet within the 3rd trimester of pregnancy. While babies born to mothers with IBD would pose an ideal cohort for intervention, no primary prevention measures are currently available. Therefore, we designed the MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial to test whether the IBD-AID™ dietary intervention during the last trimester of pregnancy can beneficially shift the microbiome of CD patients and their babies, thereby promoting a strong, effective immune system during a critical time of the immune system development. We will also test if favorable changes in the microbiome can lead to a reduced risk of postpartum CD relapse and lower mucosal inflammation in the offspring. This study will help create new opportunities to foster a healthy microbiome in the offspring at high risk of other immune-mediated diseases, potentially reducing their risk later in life. |
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title_short |
A dietary intervention to improve the microbiome composition of pregnant women with Crohn's disease and their offspring: The MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial design |
url |
https://doi.org/10.1016/j.conctc.2020.100573 https://doaj.org/article/2a2b2ea8c9854e2195bf70b58b624dcd http://www.sciencedirect.com/science/article/pii/S2451865420300570 https://doaj.org/toc/2451-8654 |
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Ana Maldonado-Contreras Caroline Eisele Christine Frisard Shauna Simpson Nilendra Nair Alexa Rendon Kelly Hawkins Caitlin Cawley Anketse Debebe Leonid Tarassishin Sierra White Marla Dubinsky Joanne Stone Jose C Clemente Joao Sabino Joana Torres Jianzhong Hu Jean-Frederic Columbel Barbara Olendzki |
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Ana Maldonado-Contreras Caroline Eisele Christine Frisard Shauna Simpson Nilendra Nair Alexa Rendon Kelly Hawkins Caitlin Cawley Anketse Debebe Leonid Tarassishin Sierra White Marla Dubinsky Joanne Stone Jose C Clemente Joao Sabino Joana Torres Jianzhong Hu Jean-Frederic Columbel Barbara Olendzki |
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doi_str |
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callnumber-a |
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up_date |
2024-07-03T21:11:18.737Z |
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