The individual and common repertoire of DNA-binding transcriptional regulators of <it<Corynebacterium glutamicum</it<, <it<Corynebacterium efficiens</it<, <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium </it<deduced from the complete genome sequences

<p<Abstract</p< <p<Background</p< <p<The genus <it<Corynebacterium </it<includes Gram-positive microorganisms of great biotechnologically importance, such as <it<Corynebacterium glutamicum </it<and <it<Corynebacterium efficiens</it<, as well as serious human pathogens, such as <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium. </it<Although genome sequences of the respective species have been determined recently, the knowledge about the repertoire of transcriptional regulators and the architecture of global regulatory networks is scarce. Here, we apply a combination of bioinformatic tools and a comparative genomic approach to identify and characterize a set of conserved DNA-binding transcriptional regulators in the four corynebacterial genomes.</p< <p<Results</p< <p<A collection of 127 DNA-binding transcriptional regulators was identified in the <it<C. glutamicum </it<ATCC 13032 genome, whereas 103 regulators were detected in <it<C. efficiens </it<YS-314, 63 in <it<C. diphtheriae </it<NCTC 13129 and 55 in <it<C. jeikeium </it<K411. According to amino acid sequence similarities and protein structure predictions, the DNA-binding transcriptional regulators were grouped into 25 regulatory protein families. The common set of DNA-binding transcriptional regulators present in the four corynebacterial genomes consists of 28 proteins that are apparently involved in the regulation of cell division and septation, SOS and stress response, carbohydrate metabolism and macroelement and metal homeostasis.</p< <p<Conclusion</p< <p<This work describes characteristic features of a set of conserved DNA-binding transcriptional regulators present within the corynebacterial core genome. The knowledge on the physiological function of these proteins should not only contribute to our understanding of the regulation of gene expression but will also provide the basis for comprehensive modeling of transcriptional regulatory networks of these species.</p< Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Kalinowski Jörn [verfasserIn] Brinkrolf Karina [verfasserIn] Brune Iris [verfasserIn] Pühler Alfred [verfasserIn] Tauch Andreas [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2005

Übergeordnetes Werk:	In: BMC Genomics - BMC, 2003, 6(2005), 1, p 86
Übergeordnetes Werk:	volume:6 ; year:2005 ; number:1, p 86

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1471-2164-6-86

Katalog-ID:	DOAJ009010335

Internformat


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245	1	4	\|a The individual and common repertoire of DNA-binding transcriptional regulators of <it<Corynebacterium glutamicum</it<, <it<Corynebacterium efficiens</it<, <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium </it<deduced from the complete genome sequences
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700	0		\|a Tauch Andreas \|e verfasserin \|4 aut
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912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 6 \|j 2005 \|e 1, p 86

Indexfelder

author_variant	k j kj b k bk b i bi p a pa t a ta
matchkey_str	article:14712164:2005----::hidvdaadomneetiefnbnigrncitoargltroicrnbceimltmcmttoyeatruefcesttoyeatrudpteietnicrn
hierarchy_sort_str	2005
callnumber-subject-code	TP
publishDate	2005
allfields	10.1186/1471-2164-6-86 doi (DE-627)DOAJ009010335 (DE-599)DOAJ9300898c8cd84baf9156af58bb5310f0 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Kalinowski Jörn verfasserin aut The individual and common repertoire of DNA-binding transcriptional regulators of <it<Corynebacterium glutamicum</it<, <it<Corynebacterium efficiens</it<, <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium </it<deduced from the complete genome sequences 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The genus <it<Corynebacterium </it<includes Gram-positive microorganisms of great biotechnologically importance, such as <it<Corynebacterium glutamicum </it<and <it<Corynebacterium efficiens</it<, as well as serious human pathogens, such as <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium. </it<Although genome sequences of the respective species have been determined recently, the knowledge about the repertoire of transcriptional regulators and the architecture of global regulatory networks is scarce. Here, we apply a combination of bioinformatic tools and a comparative genomic approach to identify and characterize a set of conserved DNA-binding transcriptional regulators in the four corynebacterial genomes.</p< <p<Results</p< <p<A collection of 127 DNA-binding transcriptional regulators was identified in the <it<C. glutamicum </it<ATCC 13032 genome, whereas 103 regulators were detected in <it<C. efficiens </it<YS-314, 63 in <it<C. diphtheriae </it<NCTC 13129 and 55 in <it<C. jeikeium </it<K411. According to amino acid sequence similarities and protein structure predictions, the DNA-binding transcriptional regulators were grouped into 25 regulatory protein families. The common set of DNA-binding transcriptional regulators present in the four corynebacterial genomes consists of 28 proteins that are apparently involved in the regulation of cell division and septation, SOS and stress response, carbohydrate metabolism and macroelement and metal homeostasis.</p< <p<Conclusion</p< <p<This work describes characteristic features of a set of conserved DNA-binding transcriptional regulators present within the corynebacterial core genome. The knowledge on the physiological function of these proteins should not only contribute to our understanding of the regulation of gene expression but will also provide the basis for comprehensive modeling of transcriptional regulatory networks of these species.</p< Biotechnology Genetics Brinkrolf Karina verfasserin aut Brune Iris verfasserin aut Pühler Alfred verfasserin aut Tauch Andreas verfasserin aut In BMC Genomics BMC, 2003 6(2005), 1, p 86 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:6 year:2005 number:1, p 86 https://doi.org/10.1186/1471-2164-6-86 kostenfrei https://doaj.org/article/9300898c8cd84baf9156af58bb5310f0 kostenfrei http://www.biomedcentral.com/1471-2164/6/86 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2005 1, p 86
spelling	10.1186/1471-2164-6-86 doi (DE-627)DOAJ009010335 (DE-599)DOAJ9300898c8cd84baf9156af58bb5310f0 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Kalinowski Jörn verfasserin aut The individual and common repertoire of DNA-binding transcriptional regulators of <it<Corynebacterium glutamicum</it<, <it<Corynebacterium efficiens</it<, <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium </it<deduced from the complete genome sequences 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The genus <it<Corynebacterium </it<includes Gram-positive microorganisms of great biotechnologically importance, such as <it<Corynebacterium glutamicum </it<and <it<Corynebacterium efficiens</it<, as well as serious human pathogens, such as <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium. </it<Although genome sequences of the respective species have been determined recently, the knowledge about the repertoire of transcriptional regulators and the architecture of global regulatory networks is scarce. Here, we apply a combination of bioinformatic tools and a comparative genomic approach to identify and characterize a set of conserved DNA-binding transcriptional regulators in the four corynebacterial genomes.</p< <p<Results</p< <p<A collection of 127 DNA-binding transcriptional regulators was identified in the <it<C. glutamicum </it<ATCC 13032 genome, whereas 103 regulators were detected in <it<C. efficiens </it<YS-314, 63 in <it<C. diphtheriae </it<NCTC 13129 and 55 in <it<C. jeikeium </it<K411. According to amino acid sequence similarities and protein structure predictions, the DNA-binding transcriptional regulators were grouped into 25 regulatory protein families. The common set of DNA-binding transcriptional regulators present in the four corynebacterial genomes consists of 28 proteins that are apparently involved in the regulation of cell division and septation, SOS and stress response, carbohydrate metabolism and macroelement and metal homeostasis.</p< <p<Conclusion</p< <p<This work describes characteristic features of a set of conserved DNA-binding transcriptional regulators present within the corynebacterial core genome. The knowledge on the physiological function of these proteins should not only contribute to our understanding of the regulation of gene expression but will also provide the basis for comprehensive modeling of transcriptional regulatory networks of these species.</p< Biotechnology Genetics Brinkrolf Karina verfasserin aut Brune Iris verfasserin aut Pühler Alfred verfasserin aut Tauch Andreas verfasserin aut In BMC Genomics BMC, 2003 6(2005), 1, p 86 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:6 year:2005 number:1, p 86 https://doi.org/10.1186/1471-2164-6-86 kostenfrei https://doaj.org/article/9300898c8cd84baf9156af58bb5310f0 kostenfrei http://www.biomedcentral.com/1471-2164/6/86 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2005 1, p 86
allfields_unstemmed	10.1186/1471-2164-6-86 doi (DE-627)DOAJ009010335 (DE-599)DOAJ9300898c8cd84baf9156af58bb5310f0 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Kalinowski Jörn verfasserin aut The individual and common repertoire of DNA-binding transcriptional regulators of <it<Corynebacterium glutamicum</it<, <it<Corynebacterium efficiens</it<, <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium </it<deduced from the complete genome sequences 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The genus <it<Corynebacterium </it<includes Gram-positive microorganisms of great biotechnologically importance, such as <it<Corynebacterium glutamicum </it<and <it<Corynebacterium efficiens</it<, as well as serious human pathogens, such as <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium. </it<Although genome sequences of the respective species have been determined recently, the knowledge about the repertoire of transcriptional regulators and the architecture of global regulatory networks is scarce. Here, we apply a combination of bioinformatic tools and a comparative genomic approach to identify and characterize a set of conserved DNA-binding transcriptional regulators in the four corynebacterial genomes.</p< <p<Results</p< <p<A collection of 127 DNA-binding transcriptional regulators was identified in the <it<C. glutamicum </it<ATCC 13032 genome, whereas 103 regulators were detected in <it<C. efficiens </it<YS-314, 63 in <it<C. diphtheriae </it<NCTC 13129 and 55 in <it<C. jeikeium </it<K411. According to amino acid sequence similarities and protein structure predictions, the DNA-binding transcriptional regulators were grouped into 25 regulatory protein families. The common set of DNA-binding transcriptional regulators present in the four corynebacterial genomes consists of 28 proteins that are apparently involved in the regulation of cell division and septation, SOS and stress response, carbohydrate metabolism and macroelement and metal homeostasis.</p< <p<Conclusion</p< <p<This work describes characteristic features of a set of conserved DNA-binding transcriptional regulators present within the corynebacterial core genome. The knowledge on the physiological function of these proteins should not only contribute to our understanding of the regulation of gene expression but will also provide the basis for comprehensive modeling of transcriptional regulatory networks of these species.</p< Biotechnology Genetics Brinkrolf Karina verfasserin aut Brune Iris verfasserin aut Pühler Alfred verfasserin aut Tauch Andreas verfasserin aut In BMC Genomics BMC, 2003 6(2005), 1, p 86 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:6 year:2005 number:1, p 86 https://doi.org/10.1186/1471-2164-6-86 kostenfrei https://doaj.org/article/9300898c8cd84baf9156af58bb5310f0 kostenfrei http://www.biomedcentral.com/1471-2164/6/86 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2005 1, p 86
allfieldsGer	10.1186/1471-2164-6-86 doi (DE-627)DOAJ009010335 (DE-599)DOAJ9300898c8cd84baf9156af58bb5310f0 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Kalinowski Jörn verfasserin aut The individual and common repertoire of DNA-binding transcriptional regulators of <it<Corynebacterium glutamicum</it<, <it<Corynebacterium efficiens</it<, <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium </it<deduced from the complete genome sequences 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The genus <it<Corynebacterium </it<includes Gram-positive microorganisms of great biotechnologically importance, such as <it<Corynebacterium glutamicum </it<and <it<Corynebacterium efficiens</it<, as well as serious human pathogens, such as <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium. </it<Although genome sequences of the respective species have been determined recently, the knowledge about the repertoire of transcriptional regulators and the architecture of global regulatory networks is scarce. Here, we apply a combination of bioinformatic tools and a comparative genomic approach to identify and characterize a set of conserved DNA-binding transcriptional regulators in the four corynebacterial genomes.</p< <p<Results</p< <p<A collection of 127 DNA-binding transcriptional regulators was identified in the <it<C. glutamicum </it<ATCC 13032 genome, whereas 103 regulators were detected in <it<C. efficiens </it<YS-314, 63 in <it<C. diphtheriae </it<NCTC 13129 and 55 in <it<C. jeikeium </it<K411. According to amino acid sequence similarities and protein structure predictions, the DNA-binding transcriptional regulators were grouped into 25 regulatory protein families. The common set of DNA-binding transcriptional regulators present in the four corynebacterial genomes consists of 28 proteins that are apparently involved in the regulation of cell division and septation, SOS and stress response, carbohydrate metabolism and macroelement and metal homeostasis.</p< <p<Conclusion</p< <p<This work describes characteristic features of a set of conserved DNA-binding transcriptional regulators present within the corynebacterial core genome. The knowledge on the physiological function of these proteins should not only contribute to our understanding of the regulation of gene expression but will also provide the basis for comprehensive modeling of transcriptional regulatory networks of these species.</p< Biotechnology Genetics Brinkrolf Karina verfasserin aut Brune Iris verfasserin aut Pühler Alfred verfasserin aut Tauch Andreas verfasserin aut In BMC Genomics BMC, 2003 6(2005), 1, p 86 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:6 year:2005 number:1, p 86 https://doi.org/10.1186/1471-2164-6-86 kostenfrei https://doaj.org/article/9300898c8cd84baf9156af58bb5310f0 kostenfrei http://www.biomedcentral.com/1471-2164/6/86 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2005 1, p 86
allfieldsSound	10.1186/1471-2164-6-86 doi (DE-627)DOAJ009010335 (DE-599)DOAJ9300898c8cd84baf9156af58bb5310f0 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH426-470 Kalinowski Jörn verfasserin aut The individual and common repertoire of DNA-binding transcriptional regulators of <it<Corynebacterium glutamicum</it<, <it<Corynebacterium efficiens</it<, <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium </it<deduced from the complete genome sequences 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The genus <it<Corynebacterium </it<includes Gram-positive microorganisms of great biotechnologically importance, such as <it<Corynebacterium glutamicum </it<and <it<Corynebacterium efficiens</it<, as well as serious human pathogens, such as <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium. </it<Although genome sequences of the respective species have been determined recently, the knowledge about the repertoire of transcriptional regulators and the architecture of global regulatory networks is scarce. Here, we apply a combination of bioinformatic tools and a comparative genomic approach to identify and characterize a set of conserved DNA-binding transcriptional regulators in the four corynebacterial genomes.</p< <p<Results</p< <p<A collection of 127 DNA-binding transcriptional regulators was identified in the <it<C. glutamicum </it<ATCC 13032 genome, whereas 103 regulators were detected in <it<C. efficiens </it<YS-314, 63 in <it<C. diphtheriae </it<NCTC 13129 and 55 in <it<C. jeikeium </it<K411. According to amino acid sequence similarities and protein structure predictions, the DNA-binding transcriptional regulators were grouped into 25 regulatory protein families. The common set of DNA-binding transcriptional regulators present in the four corynebacterial genomes consists of 28 proteins that are apparently involved in the regulation of cell division and septation, SOS and stress response, carbohydrate metabolism and macroelement and metal homeostasis.</p< <p<Conclusion</p< <p<This work describes characteristic features of a set of conserved DNA-binding transcriptional regulators present within the corynebacterial core genome. The knowledge on the physiological function of these proteins should not only contribute to our understanding of the regulation of gene expression but will also provide the basis for comprehensive modeling of transcriptional regulatory networks of these species.</p< Biotechnology Genetics Brinkrolf Karina verfasserin aut Brune Iris verfasserin aut Pühler Alfred verfasserin aut Tauch Andreas verfasserin aut In BMC Genomics BMC, 2003 6(2005), 1, p 86 (DE-627)326644954 (DE-600)2041499-7 14712164 nnns volume:6 year:2005 number:1, p 86 https://doi.org/10.1186/1471-2164-6-86 kostenfrei https://doaj.org/article/9300898c8cd84baf9156af58bb5310f0 kostenfrei http://www.biomedcentral.com/1471-2164/6/86 kostenfrei https://doaj.org/toc/1471-2164 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2005 1, p 86
language	English
source	In BMC Genomics 6(2005), 1, p 86 volume:6 year:2005 number:1, p 86
sourceStr	In BMC Genomics 6(2005), 1, p 86 volume:6 year:2005 number:1, p 86
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institution	findex.gbv.de
topic_facet	Biotechnology Genetics
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container_title	BMC Genomics
authorswithroles_txt_mv	Kalinowski Jörn @@aut@@ Brinkrolf Karina @@aut@@ Brune Iris @@aut@@ Pühler Alfred @@aut@@ Tauch Andreas @@aut@@
publishDateDaySort_date	2005-01-01T00:00:00Z
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Here, we apply a combination of bioinformatic tools and a comparative genomic approach to identify and characterize a set of conserved DNA-binding transcriptional regulators in the four corynebacterial genomes.</p< <p<Results</p< <p<A collection of 127 DNA-binding transcriptional regulators was identified in the <it<C. glutamicum </it<ATCC 13032 genome, whereas 103 regulators were detected in <it<C. efficiens </it<YS-314, 63 in <it<C. diphtheriae </it<NCTC 13129 and 55 in <it<C. jeikeium </it<K411. According to amino acid sequence similarities and protein structure predictions, the DNA-binding transcriptional regulators were grouped into 25 regulatory protein families. 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callnumber-first	T - Technology
author	Kalinowski Jörn
spellingShingle	Kalinowski Jörn misc TP248.13-248.65 misc QH426-470 misc Biotechnology misc Genetics The individual and common repertoire of DNA-binding transcriptional regulators of <it<Corynebacterium glutamicum</it<, <it<Corynebacterium efficiens</it<, <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium </it<deduced from the complete genome sequences
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topic_title	TP248.13-248.65 QH426-470 The individual and common repertoire of DNA-binding transcriptional regulators of <it<Corynebacterium glutamicum</it<, <it<Corynebacterium efficiens</it<, <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium </it<deduced from the complete genome sequences
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title	The individual and common repertoire of DNA-binding transcriptional regulators of <it<Corynebacterium glutamicum</it<, <it<Corynebacterium efficiens</it<, <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium </it<deduced from the complete genome sequences
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title_full	The individual and common repertoire of DNA-binding transcriptional regulators of <it<Corynebacterium glutamicum</it<, <it<Corynebacterium efficiens</it<, <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium </it<deduced from the complete genome sequences
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author_browse	Kalinowski Jörn Brinkrolf Karina Brune Iris Pühler Alfred Tauch Andreas
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doi_str_mv	10.1186/1471-2164-6-86
author2-role	verfasserin
title_sort	individual and common repertoire of dna-binding transcriptional regulators of <it<corynebacterium glutamicum</it<, <it<corynebacterium efficiens</it<, <it<corynebacterium diphtheriae </it<and <it<corynebacterium jeikeium </it<deduced from the complete genome sequences
callnumber	TP248.13-248.65
title_auth	The individual and common repertoire of DNA-binding transcriptional regulators of <it<Corynebacterium glutamicum</it<, <it<Corynebacterium efficiens</it<, <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium </it<deduced from the complete genome sequences
abstract	<p<Abstract</p< <p<Background</p< <p<The genus <it<Corynebacterium </it<includes Gram-positive microorganisms of great biotechnologically importance, such as <it<Corynebacterium glutamicum </it<and <it<Corynebacterium efficiens</it<, as well as serious human pathogens, such as <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium. </it<Although genome sequences of the respective species have been determined recently, the knowledge about the repertoire of transcriptional regulators and the architecture of global regulatory networks is scarce. Here, we apply a combination of bioinformatic tools and a comparative genomic approach to identify and characterize a set of conserved DNA-binding transcriptional regulators in the four corynebacterial genomes.</p< <p<Results</p< <p<A collection of 127 DNA-binding transcriptional regulators was identified in the <it<C. glutamicum </it<ATCC 13032 genome, whereas 103 regulators were detected in <it<C. efficiens </it<YS-314, 63 in <it<C. diphtheriae </it<NCTC 13129 and 55 in <it<C. jeikeium </it<K411. According to amino acid sequence similarities and protein structure predictions, the DNA-binding transcriptional regulators were grouped into 25 regulatory protein families. The common set of DNA-binding transcriptional regulators present in the four corynebacterial genomes consists of 28 proteins that are apparently involved in the regulation of cell division and septation, SOS and stress response, carbohydrate metabolism and macroelement and metal homeostasis.</p< <p<Conclusion</p< <p<This work describes characteristic features of a set of conserved DNA-binding transcriptional regulators present within the corynebacterial core genome. The knowledge on the physiological function of these proteins should not only contribute to our understanding of the regulation of gene expression but will also provide the basis for comprehensive modeling of transcriptional regulatory networks of these species.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<The genus <it<Corynebacterium </it<includes Gram-positive microorganisms of great biotechnologically importance, such as <it<Corynebacterium glutamicum </it<and <it<Corynebacterium efficiens</it<, as well as serious human pathogens, such as <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium. </it<Although genome sequences of the respective species have been determined recently, the knowledge about the repertoire of transcriptional regulators and the architecture of global regulatory networks is scarce. Here, we apply a combination of bioinformatic tools and a comparative genomic approach to identify and characterize a set of conserved DNA-binding transcriptional regulators in the four corynebacterial genomes.</p< <p<Results</p< <p<A collection of 127 DNA-binding transcriptional regulators was identified in the <it<C. glutamicum </it<ATCC 13032 genome, whereas 103 regulators were detected in <it<C. efficiens </it<YS-314, 63 in <it<C. diphtheriae </it<NCTC 13129 and 55 in <it<C. jeikeium </it<K411. According to amino acid sequence similarities and protein structure predictions, the DNA-binding transcriptional regulators were grouped into 25 regulatory protein families. The common set of DNA-binding transcriptional regulators present in the four corynebacterial genomes consists of 28 proteins that are apparently involved in the regulation of cell division and septation, SOS and stress response, carbohydrate metabolism and macroelement and metal homeostasis.</p< <p<Conclusion</p< <p<This work describes characteristic features of a set of conserved DNA-binding transcriptional regulators present within the corynebacterial core genome. The knowledge on the physiological function of these proteins should not only contribute to our understanding of the regulation of gene expression but will also provide the basis for comprehensive modeling of transcriptional regulatory networks of these species.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<The genus <it<Corynebacterium </it<includes Gram-positive microorganisms of great biotechnologically importance, such as <it<Corynebacterium glutamicum </it<and <it<Corynebacterium efficiens</it<, as well as serious human pathogens, such as <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium. </it<Although genome sequences of the respective species have been determined recently, the knowledge about the repertoire of transcriptional regulators and the architecture of global regulatory networks is scarce. Here, we apply a combination of bioinformatic tools and a comparative genomic approach to identify and characterize a set of conserved DNA-binding transcriptional regulators in the four corynebacterial genomes.</p< <p<Results</p< <p<A collection of 127 DNA-binding transcriptional regulators was identified in the <it<C. glutamicum </it<ATCC 13032 genome, whereas 103 regulators were detected in <it<C. efficiens </it<YS-314, 63 in <it<C. diphtheriae </it<NCTC 13129 and 55 in <it<C. jeikeium </it<K411. According to amino acid sequence similarities and protein structure predictions, the DNA-binding transcriptional regulators were grouped into 25 regulatory protein families. The common set of DNA-binding transcriptional regulators present in the four corynebacterial genomes consists of 28 proteins that are apparently involved in the regulation of cell division and septation, SOS and stress response, carbohydrate metabolism and macroelement and metal homeostasis.</p< <p<Conclusion</p< <p<This work describes characteristic features of a set of conserved DNA-binding transcriptional regulators present within the corynebacterial core genome. The knowledge on the physiological function of these proteins should not only contribute to our understanding of the regulation of gene expression but will also provide the basis for comprehensive modeling of transcriptional regulatory networks of these species.</p<
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container_issue	1, p 86
title_short	The individual and common repertoire of DNA-binding transcriptional regulators of <it<Corynebacterium glutamicum</it<, <it<Corynebacterium efficiens</it<, <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium </it<deduced from the complete genome sequences
url	https://doi.org/10.1186/1471-2164-6-86 https://doaj.org/article/9300898c8cd84baf9156af58bb5310f0 http://www.biomedcentral.com/1471-2164/6/86 https://doaj.org/toc/1471-2164
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up_date	2024-07-03T21:27:58.338Z
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The common set of DNA-binding transcriptional regulators present in the four corynebacterial genomes consists of 28 proteins that are apparently involved in the regulation of cell division and septation, SOS and stress response, carbohydrate metabolism and macroelement and metal homeostasis.</p< <p<Conclusion</p< <p<This work describes characteristic features of a set of conserved DNA-binding transcriptional regulators present within the corynebacterial core genome. 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The individual and common repertoire of DNA-binding transcriptional regulators of <it<Corynebacterium glutamicum</it<, <it<Corynebacterium efficiens</it<, <it<Corynebacterium diphtheriae </it<and <it<Corynebacterium jeikeium </it<deduced from the complete genome sequences

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